Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_1720	Calcineurin B Click for more detail	NA	MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDV	170	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Activate NF-Kb	NA	27293318	2016	NA
PRRID_1720	Calcineurin B Click for more detail	NA	MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDV	170	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Activate NF-Kb	NA	27293318	2016	NA
PRRID_1721	cathepsin cysteine Click for more detail	S. mansoni (others)	MLTSILCIASLITFLEAHISVKNEKFEPLSDDIISYINEHPNAGWRAEKSNRFHSLDDARIQMGARREEPDLRRKRRPTVDHNDWNVEIPSNFDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVDLLTCCESCGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEASFTVYEDFLNYKSGIYKHITGEALGGHAIRIIGWGVENKTPYWLIANSWNEDWGENGYFRIVRGRDECSIESEVIAGRIN	340	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q99MB1.fasta	Q99MB1	905	Activate STAT1	NA	27120222	2016	Pubchem_assay
PRRID_1721	cathepsin cysteine Click for more detail	S. mansoni (others)	MLTSILCIASLITFLEAHISVKNEKFEPLSDDIISYINEHPNAGWRAEKSNRFHSLDDARIQMGARREEPDLRRKRRPTVDHNDWNVEIPSNFDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVDLLTCCESCGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEASFTVYEDFLNYKSGIYKHITGEALGGHAIRIIGWGVENKTPYWLIANSWNEDWGENGYFRIVRGRDECSIESEVIAGRIN	340	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q99MB1.fasta	Q99MB1	905	Activate STAT1	NA	27120222	2016	Pubchem_assay
PRRID_1722	cathepsin cysteine Click for more detail	Schistosoma mansoni, Fasciola hepatica (Bacteria)	MLTSILCIASLITFLEAHISVKNEKFEPLSDDIISYINEHPNAGWRAEKSNRFHSLDDARIQMGARREEPDLRRKRRPTVDHNDWNVEIPSNFDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVDLLTCCESCGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEASFTVYEDFLNYKSGIYKHITGEALGGHAIRIIGWGVENKTPYWLIANSWNEDWGENGYFRIVRGRDECSIESEVIAGRIN	340	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	NA	NA	Q99MB1.fasta	Q99MB1	905	Dampen TRIF signaling by degradation of TLR3Ôòª	NA	27120222	2016	Pubchem_assay
PRRID_1722	cathepsin cysteine Click for more detail	Schistosoma mansoni, Fasciola hepatica (Bacteria)	MLTSILCIASLITFLEAHISVKNEKFEPLSDDIISYINEHPNAGWRAEKSNRFHSLDDARIQMGARREEPDLRRKRRPTVDHNDWNVEIPSNFDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVDLLTCCESCGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEASFTVYEDFLNYKSGIYKHITGEALGGHAIRIIGWGVENKTPYWLIANSWNEDWGENGYFRIVRGRDECSIESEVIAGRIN	340	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	NA	NA	Q99MB1.fasta	Q99MB1	905	Dampen TRIF signaling by degradation of TLR3Ôòª	NA	27120222	2016	Pubchem_assay
PRRID_1724	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	B3DJW3.fasta	B3DJW3	1057	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1724	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	B3DJW3.fasta	B3DJW3	1057	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1725	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 21 (TLR21)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	F1QMN8.fasta	F1QMN8	989	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1725	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 21 (TLR21)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	F1QMN8.fasta	F1QMN8	989	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1726	DIP Click for more detail	D. indusiata(fungi)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	RAW264.7 cells	NA	NA	NA	NA	up-regulation of nitric oxide (NO), interleukin-1Œ≤ (IL-1Œ≤), interleukin-6 (IL-6) and tumour necrosis factor (TNF-Œ±) production as well as the mRNA expression levels of iNOS, IL-1Œ≤, IL-6 and TNF-Œ± in macrophages.	Flow cytometry and confocal laser-scanning microscopy analyses	27293036	2016	NA
PRRID_1726	DIP Click for more detail	D. indusiata(fungi)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	RAW264.7 cells	NA	NA	NA	NA	up-regulation of nitric oxide (NO), interleukin-1Œ≤ (IL-1Œ≤), interleukin-6 (IL-6) and tumour necrosis factor (TNF-Œ±) production as well as the mRNA expression levels of iNOS, IL-1Œ≤, IL-6 and TNF-Œ± in macrophages.	Flow cytometry and confocal laser-scanning microscopy analyses	27293036	2016	NA
PRRID_1727	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Zebrafish	Plasma membrane	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	B8JIL3.fasta	B8JIL3	903	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1727	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Zebrafish	Plasma membrane	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	B8JIL3.fasta	B8JIL3	903	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1728	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 22 (TLR22)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	B3DJL6.fasta	B3DJL6	947	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1728	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 22 (TLR22)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	B3DJL6.fasta	B3DJL6	947	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1729	dsDNA Click for more detail	S. mansoni (others)	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9QUN7.fasta	Q9QUN7	784	TLR2-dependent induction of Tregs	NA	27120222	2016	Pubchem_assay
PRRID_1729	dsDNA Click for more detail	S. mansoni (others)	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9QUN7.fasta	Q9QUN7	784	TLR2-dependent induction of Tregs	NA	27120222	2016	Pubchem_assay
PRRID_1730	dsDNA Click for more detail	S. mansoni (others)	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	NA	NA	Q99MB1.fasta	Q99MB1	905	TLR2-dependent induction of Tregs Activate STATÔõú	NA	27120222	2016	Pubchem_assay
PRRID_1730	dsDNA Click for more detail	S. mansoni (others)	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	NA	NA	Q99MB1.fasta	Q99MB1	905	TLR2-dependent induction of Tregs Activate STATÔõú	NA	27120222	2016	Pubchem_assay
PRRID_1731	ES-62 Click for more detail	Helminths (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9QUK6.fasta	Q9QUK6	835	ERK‚Üë, P38 or JNK	NA	27120222	2016	Pubchem_assay
PRRID_1731	ES-62 Click for more detail	Helminths (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9QUK6.fasta	Q9QUK6	835	ERK‚Üë, P38 or JNK	NA	27120222	2016	Pubchem_assay
PRRID_1732	ES-62 Click for more detail	Acanthocheilonema viteae(others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Acanthocheilonema viteae/lymphatic tissue	NA	Q9QUK6.fasta	Q9QUK6	835	ERK‚Üë, P38 or JNK MAP‚Üì, Transient NFŒ∫B, Block mast cell degranulation	NA	27120222	2016	Pubchem_assay
PRRID_1732	ES-62 Click for more detail	Acanthocheilonema viteae(others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Acanthocheilonema viteae/lymphatic tissue	NA	Q9QUK6.fasta	Q9QUK6	835	ERK‚Üë, P38 or JNK MAP‚Üì, Transient NFŒ∫B, Block mast cell degranulation	NA	27120222	2016	Pubchem_assay
PRRID_1733	Fag Click for more detail	Helminths (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Endotoxemia (amelioration)	NA	NA	NA	NA	NA	Inhibits LPS mediated classical activation	NA	27120222	2016	NA
PRRID_1733	Fag Click for more detail	Helminths (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Endotoxemia (amelioration)	NA	NA	NA	NA	NA	Inhibits LPS mediated classical activation	NA	27120222	2016	NA
PRRID_1734	Fag Click for more detail	Setaria Digitata (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	abdominal cavity	NA	Q9QUK6.fasta	Q9QUK6	835	Inhibits LPS mediated classical activation	NA	27120222	2016	Pubchem_assay
PRRID_1734	Fag Click for more detail	Setaria Digitata (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	abdominal cavity	NA	Q9QUK6.fasta	Q9QUK6	835	Inhibits LPS mediated classical activation	NA	27120222	2016	Pubchem_assay
PRRID_1735	FhHDM-1 Click for more detail	Helminths (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Sepsis (amelioration)	NA	NA	NA	NA	NA	Binding to LPS and inhibits signaling	NA	27120222	2016	NA
PRRID_1735	FhHDM-1 Click for more detail	Helminths (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Sepsis (amelioration)	NA	NA	NA	NA	NA	Binding to LPS and inhibits signaling	NA	27120222	2016	NA
PRRID_1736	FhHDM-1 Click for more detail	Fasciola hepatica (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Fasciola hepatica/Liver	NA	Q9QUK6.fasta	Q9QUK6	835	Binding to LPS and inhibits signaling	NA	27120222	2016	Pubchem_assay
PRRID_1736	FhHDM-1 Click for more detail	Fasciola hepatica (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Fasciola hepatica/Liver	NA	Q9QUK6.fasta	Q9QUK6	835	Binding to LPS and inhibits signaling	NA	27120222	2016	Pubchem_assay
PRRID_1737	Flagellin Click for more detail	Salmonella (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Mice	Plasma membrane	extracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domain	Q6R5P0.fasta	Q6R5P0	926	Activate NF-KB	NA	27756604	2016	Pubchem_assay
PRRID_1737	Flagellin Click for more detail	Salmonella (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Mice	Plasma membrane	extracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domain	Q6R5P0.fasta	Q6R5P0	926	Activate NF-KB	NA	27756604	2016	Pubchem_assay
PRRID_1738	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	Plasma membrane	extracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domain	Q9JLF7.fasta	Q9JLF7	859	nuclear factor NF- Œ∫B mobilization and the stimulation and secretion of cytokines.	NA	27756604	2016	Pubchem_assay
PRRID_1738	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	Plasma membrane	extracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domain	Q9JLF7.fasta	Q9JLF7	859	nuclear factor NF- Œ∫B mobilization and the stimulation and secretion of cytokines.	NA	27756604	2016	Pubchem_assay
PRRID_1739	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	Toll-like receptor 5a/b (TLR5a/b)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	NA	NA	NA	induce IFN expression	NA	27721456	2016	NA
PRRID_1739	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	Toll-like receptor 5a/b (TLR5a/b)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	NA	NA	NA	induce IFN expression	NA	27721456	2016	NA
PRRID_1740	Flagellin Click for more detail	NA	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9JLF7.fasta	Q9JLF7	859	induce asthma	NA	27120222	2016	Pubchem_assay
PRRID_1740	Flagellin Click for more detail	NA	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9JLF7.fasta	Q9JLF7	859	induce asthma	NA	27120222	2016	Pubchem_assay
PRRID_1741	Flavolipin Click for more detail	Flavobacterium meningosepticum (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Activate NF-Kb	NA	27293318	2016	NA
PRRID_1741	Flavolipin Click for more detail	Flavobacterium meningosepticum (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Activate NF-Kb	NA	27293318	2016	NA
PRRID_1744	Galactomannan Click for more detail	Aspergillus fumigatus(fungi)	C(C1C(C(C(C(O1)OCC2C(C(C(C(O2)O)O)O)OC3C(C(C(C(O3)CO)O)O)O)O)O)O)O	NA	NA	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Downregulates the IL-6 and TNF- production	NA	26775799	2016	NA
PRRID_1744	Galactomannan Click for more detail	Aspergillus fumigatus(fungi)	C(C1C(C(C(C(O1)OCC2C(C(C(C(O2)O)O)O)OC3C(C(C(C(O3)CO)O)O)O)O)O)O)O	NA	NA	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Downregulates the IL-6 and TNF- production	NA	26775799	2016	NA
PRRID_1746	GPI anchor Click for more detail	Trypanosoma Cruzi (others)	NA	NA	NA	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Proinflammatory cytokine release, interleukin12 (IL-12), nitric oxide (NO) and tumour necrosis factor (TNF) production27 Cytokine induction	NA	26775799	2016	NA
PRRID_1746	GPI anchor Click for more detail	Trypanosoma Cruzi (others)	NA	NA	NA	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Proinflammatory cytokine release, interleukin12 (IL-12), nitric oxide (NO) and tumour necrosis factor (TNF) production27 Cytokine induction	NA	26775799	2016	NA
PRRID_1749	HDM Click for more detail	Helminths (others)	RPSEESREKLRESGRKMVKALRDAVTKAYEKARDRAMAYLAKDNLGEKITEVITILLNRLTDRLEKYAGN	70	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9QUK6.fasta	Q9QUK6	835	Alter the response of B cells (‚ÜëIgGÔõú)	NA	27120222	2016	Pubchem_assay
PRRID_1749	HDM Click for more detail	Helminths (others)	RPSEESREKLRESGRKMVKALRDAVTKAYEKARDRAMAYLAKDNLGEKITEVITILLNRLTDRLEKYAGN	70	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9QUK6.fasta	Q9QUK6	835	Alter the response of B cells (‚ÜëIgGÔõú)	NA	27120222	2016	Pubchem_assay
PRRID_1750	HDM Click for more detail	Schistosoma mansoni, Fasciola hepatica (Bacteria)	RPSEESREKLRESGRKMVKALRDAVTKAYEKARDRAMAYLAKDNLGEKITEVITILLNRLTDRLEKYAGN	70	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	NA	NA	Q9QUK6.fasta	Q9QUK6	835	Alter the response of B cells (‚ÜëIgGÔõú)	NA	27120222	2016	Pubchem_assay
PRRID_1750	HDM Click for more detail	Schistosoma mansoni, Fasciola hepatica (Bacteria)	RPSEESREKLRESGRKMVKALRDAVTKAYEKARDRAMAYLAKDNLGEKITEVITILLNRLTDRLEKYAGN	70	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	NA	NA	Q9QUK6.fasta	Q9QUK6	835	Alter the response of B cells (‚ÜëIgGÔõú)	NA	27120222	2016	Pubchem_assay
PRRID_1751	Heat shock protein Click for more detail	O. tsutsugamushi (others)	MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	572	Pattern-associated molecular patterns (PAMPs)	Natural	Cause Scrub typhus, immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	HEK293 cells	TIR domain	Q9QUN7.fasta	Q9QUN7	784	secretion of TNF-Œ± and IL-6 by dendritic cells	ELISA	27620720	2016	Pubchem_assay
PRRID_1751	Heat shock protein Click for more detail	O. tsutsugamushi (others)	MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	572	Pattern-associated molecular patterns (PAMPs)	Natural	Cause Scrub typhus, immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	HEK293 cells	TIR domain	Q9QUN7.fasta	Q9QUN7	784	secretion of TNF-Œ± and IL-6 by dendritic cells	ELISA	27620720	2016	Pubchem_assay
PRRID_1754	HSP Gp96 Click for more detail	NA	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Activate NF-Kb	NA	27293318	2016	NA
PRRID_1754	HSP Gp96 Click for more detail	NA	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Activate NF-Kb	NA	27293318	2016	NA
PRRID_1755	HSP70L1 Click for more detail	NA	MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD	641	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Activate NF-Kb	NA	27293318	2016	NA
PRRID_1755	HSP70L1 Click for more detail	NA	MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD	641	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Activate NF-Kb	NA	27293318	2016	NA
PRRID_1757	Lipopeptides Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Zebrafish	Plasma membrane	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	F1QWS9.fasta	F1QWS9	818	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1757	Lipopeptides Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Zebrafish	Plasma membrane	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	F1QWS9.fasta	F1QWS9	818	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1758	Lipopeptidophosphoglycans (LPPG) Click for more detail	Entamoeba histolytica (others)	NA	NA	NA	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Leads to TNF- alpha, IL-12, IL-10, and nitric oxide release in phagocytes	NA	26775799	2016	NA
PRRID_1758	Lipopeptidophosphoglycans (LPPG) Click for more detail	Entamoeba histolytica (others)	NA	NA	NA	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Leads to TNF- alpha, IL-12, IL-10, and nitric oxide release in phagocytes	NA	26775799	2016	NA
PRRID_1759	Lipopeptidophosphoglycans (LPPG) Click for more detail	Entamoeba histolytica (others)	NA	NA	NA	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Diminish the production of proinflammatory cytokines	NA	26775799	2016	NA
PRRID_1759	Lipopeptidophosphoglycans (LPPG) Click for more detail	Entamoeba histolytica (others)	NA	NA	NA	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Diminish the production of proinflammatory cytokines	NA	26775799	2016	NA
PRRID_1760	lipophosphoglycans (LPG) Click for more detail	Leishmania infantum (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Causes visceral and cutaneous leishmaniasis, immunomodulatory	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Macrophages	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	activate MAPKs and the NF-Œ∫B inhibitor p-IŒ∫BŒ±,	NA	27508930	2016	Pubchem_assay
PRRID_1760	lipophosphoglycans (LPG) Click for more detail	Leishmania infantum (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Causes visceral and cutaneous leishmaniasis, immunomodulatory	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Macrophages	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	activate MAPKs and the NF-Œ∫B inhibitor p-IŒ∫BŒ±,	NA	27508930	2016	Pubchem_assay
PRRID_1761	lipophosphoglycans (LPG) Click for more detail	Leishmania braziliensis (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Causes visceral and cutaneous leishmaniasis, immunomodulatory	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Macrophages	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	activate MAPKs and the NF-Œ∫B inhibitor p-IŒ∫BŒ±,	NA	27508930	2016	Pubchem_assay
PRRID_1761	lipophosphoglycans (LPG) Click for more detail	Leishmania braziliensis (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Causes visceral and cutaneous leishmaniasis, immunomodulatory	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Macrophages	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	activate MAPKs and the NF-Œ∫B inhibitor p-IŒ∫BŒ±,	NA	27508930	2016	Pubchem_assay
PRRID_1762	lipophosphoglycans (LPG) Click for more detail	Leishmania major (others)	NA	NA	NA	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Induces IL-12,TNF-alpha , IFN- , NO production	NA	26775799	2016	NA
PRRID_1762	lipophosphoglycans (LPG) Click for more detail	Leishmania major (others)	NA	NA	NA	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Induces IL-12,TNF-alpha , IFN- , NO production	NA	26775799	2016	NA
PRRID_1763	lipophosphoglycans (LPG) Click for more detail	Leishmania major (others)	NA	NA	NA	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Block IFN- mediated nitric oxide (NO) production in macrophages	NA	26775799	2016	NA
PRRID_1763	lipophosphoglycans (LPG) Click for more detail	Leishmania major (others)	NA	NA	NA	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Block IFN- mediated nitric oxide (NO) production in macrophages	NA	26775799	2016	NA
PRRID_1768	Lipopolysaccharide (LPS) Click for more detail	Bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Immunostimulant	CnToll-like receptor 1 (TLR-1)	Toll-like receptor (TLR)	Chlamys nobilis	mantle, he- mocytes, gill, kidney, gonad, hepatopancreas	five leucine-rich repeats (LRR), two LRR-C-terminal (LRRCT) motifs and a LRR-N-terminal (LRRNT) motif in the extracellular domain, a transmembrane domain and a Toll/Interleukin-1 Receptor (TIR) of 138	NA	NA	NA	binds to microbes and act as PRR.	qRT-PCR	27403592	2016	NA
PRRID_1768	Lipopolysaccharide (LPS) Click for more detail	Bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Immunostimulant	CnToll-like receptor 1 (TLR-1)	Toll-like receptor (TLR)	Chlamys nobilis	mantle, he- mocytes, gill, kidney, gonad, hepatopancreas	five leucine-rich repeats (LRR), two LRR-C-terminal (LRRCT) motifs and a LRR-N-terminal (LRRNT) motif in the extracellular domain, a transmembrane domain and a Toll/Interleukin-1 Receptor (TIR) of 138	NA	NA	NA	binds to microbes and act as PRR.	qRT-PCR	27403592	2016	NA
PRRID_1773	Lipopolysaccharide (LPS) Click for more detail	Laryngo- tracheitis virus (virus)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Birds	NA	NA	NA	NA	NA	TLR (LPS)-mediated, NO-dependent antiviral response in avian macrophage cell line	NA	27233799	2016	NA
PRRID_1773	Lipopolysaccharide (LPS) Click for more detail	Laryngo- tracheitis virus (virus)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Birds	NA	NA	NA	NA	NA	TLR (LPS)-mediated, NO-dependent antiviral response in avian macrophage cell line	NA	27233799	2016	NA
PRRID_1774	Lipopolysaccharide (LPS) Click for more detail	Bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Immunostimulant	EcToll-like receptor (TLR1b)	Toll-like receptor (TLR)	Zebrafish	spleen and head kidney	leucine-rich repeat (LRR) domains (including an LRR-NT (except for EcTLR1b), several LRR motifs and an LRR-CT), a trans-membrane region and a Toll/interleukin-1 receptor (TIR) domain.	NA	NA	NA	Activate NF-Kb	NA	27037219	2016	NA
PRRID_1774	Lipopolysaccharide (LPS) Click for more detail	Bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Immunostimulant	EcToll-like receptor (TLR1b)	Toll-like receptor (TLR)	Zebrafish	spleen and head kidney	leucine-rich repeat (LRR) domains (including an LRR-NT (except for EcTLR1b), several LRR motifs and an LRR-CT), a trans-membrane region and a Toll/interleukin-1 receptor (TIR) domain.	NA	NA	NA	Activate NF-Kb	NA	27037219	2016	NA
PRRID_1777	Lipopolysaccharide (LPS) Click for more detail	Pseudomonas aeruginosa (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Induces TNF-alpha and IL-6	NA	26775799	2016	NA
PRRID_1777	Lipopolysaccharide (LPS) Click for more detail	Pseudomonas aeruginosa (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Induces TNF-alpha and IL-6	NA	26775799	2016	NA
PRRID_1778	Lipopolysaccharide (LPS) Click for more detail	Pseudomonas aeruginosa (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Induces TNF-alpha and IL-6	NA	26775799	2016	NA
PRRID_1778	Lipopolysaccharide (LPS) Click for more detail	Pseudomonas aeruginosa (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Induces TNF-alpha and IL-6	NA	26775799	2016	NA
PRRID_1794	LNFPlll Click for more detail	Helminths (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Psoriasis, TypeÔõú diabet, EAE (amelioration)	NA	NA	NA	NA	NA	NFŒ∫B‚Üë	NA	27120222	2016	NA
PRRID_1794	LNFPlll Click for more detail	Helminths (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Psoriasis, TypeÔõú diabet, EAE (amelioration)	NA	NA	NA	NA	NA	NFŒ∫B‚Üë	NA	27120222	2016	NA
PRRID_1795	LNFPlll Click for more detail	S. mansoni (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	blood vessels(human and mice)	NA	Q9QUK6.fasta	Q9QUK6	835	NFŒ∫B‚Üë	NA	27120222	2016	Pubchem_assay
PRRID_1795	LNFPlll Click for more detail	S. mansoni (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	blood vessels(human and mice)	NA	Q9QUK6.fasta	Q9QUK6	835	NFŒ∫B‚Üë	NA	27120222	2016	Pubchem_assay
PRRID_1798	LPS (HDM and fungal allergens) Click for more detail	NA	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9QUK6.fasta	Q9QUK6	835	Controversial (induce or inhibit)	NA	27120222	2016	Pubchem_assay
PRRID_1798	LPS (HDM and fungal allergens) Click for more detail	NA	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9QUK6.fasta	Q9QUK6	835	Controversial (induce or inhibit)	NA	27120222	2016	Pubchem_assay
PRRID_1799	Lyso-PS lipids Click for more detail	S. mansoni (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9QUN7.fasta	Q9QUN7	784	ND	NA	27120222	2016	Pubchem_assay
PRRID_1799	Lyso-PS lipids Click for more detail	S. mansoni (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9QUN7.fasta	Q9QUN7	784	ND	NA	27120222	2016	Pubchem_assay
PRRID_1800	Lyso-PS lipids Click for more detail	S. mansoni (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	NA	NA	Q9QUN7.fasta	Q9QUN7	784	ND	NA	27120222	2016	Pubchem_assay
PRRID_1800	Lyso-PS lipids Click for more detail	S. mansoni (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	NA	NA	Q9QUN7.fasta	Q9QUN7	784	ND	NA	27120222	2016	Pubchem_assay
PRRID_1801	Mannan Click for more detail	S. cerevisiae (Bacteria)	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)O)CO)CO)CO)O)O)O)O	NA	Polysaccharides	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Activate NF-Kb	NA	27293318	2016	NA
PRRID_1801	Mannan Click for more detail	S. cerevisiae (Bacteria)	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)O)CO)CO)CO)O)O)O)O	NA	Polysaccharides	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Activate NF-Kb	NA	27293318	2016	NA
PRRID_1807	N-linked Glycans Click for more detail	Taenia solium (others)	NA	NA	NA	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Diminish the production of proinflammatory cytokines	NA	26775799	2016	NA
PRRID_1807	N-linked Glycans Click for more detail	Taenia solium (others)	NA	NA	NA	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Diminish the production of proinflammatory cytokines	NA	26775799	2016	NA
PRRID_1810	NA Click for more detail	Propionibacterium acnes (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	role in acne vulgaris, contributing factor to the progression of prostate cancer and likely through the activation of NF-Œ∫B pathway	Toll-like receptor 2 (TLR2)homodimers	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	induced NF-Œ∫B and AP-1activation	ELISA	28024924	2016	NA
PRRID_1810	NA Click for more detail	Propionibacterium acnes (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	role in acne vulgaris, contributing factor to the progression of prostate cancer and likely through the activation of NF-Œ∫B pathway	Toll-like receptor 2 (TLR2)homodimers	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	induced NF-Œ∫B and AP-1activation	ELISA	28024924	2016	NA
PRRID_1811	NA Click for more detail	A.hydrophilla(Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 22 (TLR22)	Toll-like receptor (TLR)	Megalobrama amblycephala	blood, head kidney, spleen and intestine	16 leucine-rich repeat (LRR) motifs, an LRR C-terminal, a transmembrane region and a cytoplasmic toll‚Äìinterleukin-1 receptor (TIR) domain.	A0A2H4IQ59.fasta	A0A2H4IQ59	946	Activate NF-KB	NA	27943292	2016	Pubchem_assay
PRRID_1811	NA Click for more detail	A.hydrophilla(Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 22 (TLR22)	Toll-like receptor (TLR)	Megalobrama amblycephala	blood, head kidney, spleen and intestine	16 leucine-rich repeat (LRR) motifs, an LRR C-terminal, a transmembrane region and a cytoplasmic toll‚Äìinterleukin-1 receptor (TIR) domain.	A0A2H4IQ59.fasta	A0A2H4IQ59	946	Activate NF-KB	NA	27943292	2016	Pubchem_assay
PRRID_1815	NA Click for more detail	Uropathogenic E.coli (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Mice	bladder epithelial cells	extracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domain	Q6R5P0.fasta	Q6R5P0	926	Activate NF-KB	NA	27756604	2016	Pubchem_assay
PRRID_1815	NA Click for more detail	Uropathogenic E.coli (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Mice	bladder epithelial cells	extracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domain	Q6R5P0.fasta	Q6R5P0	926	Activate NF-KB	NA	27756604	2016	Pubchem_assay

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