Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_0641 | Lipopolysaccharide (LPS) Click for more detail | E. coli(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It's binding induces the production of IL6, IL8, MMP3 and MMP2 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Fibroblast Like Synoviocytes (FLS) | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destruction | ELISA | 20571165 | 2010 | Pubchem Assay |
| PRRID_0641 | Lipopolysaccharide (LPS) Click for more detail | E. coli(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It's binding induces the production of IL6, IL8, MMP3 and MMP2 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Fibroblast Like Synoviocytes (FLS) | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destruction | ELISA | 20571165 | 2010 | Pubchem Assay |
| PRRID_0642 | Lipopolysaccharide (LPS) Click for more detail | E. coli(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | GmCP8 | Pattern recognition receptor (PRR) | Galleria mellonella | hemolymph | NA | NA | NA | NA | It has opsonin activity for the phagocytosis of the microorganisms by hemocytes. | NA | 20519517 | 2010 | NA |
| PRRID_0642 | Lipopolysaccharide (LPS) Click for more detail | E. coli(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | GmCP8 | Pattern recognition receptor (PRR) | Galleria mellonella | hemolymph | NA | NA | NA | NA | It has opsonin activity for the phagocytosis of the microorganisms by hemocytes. | NA | 20519517 | 2010 | NA |
| PRRID_0643 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It is the responsive PAMP for the FcLec5 | FcLec5 | C type Lectin (CTL/CLR) | Fenneropenaeus chinensis | hepatopancreas | CRD | NA | NA | NA | It elicit the immune response, which leads to the clearance of bacteria | ELISA | 20349323 | 2010 | NA |
| PRRID_0643 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It is the responsive PAMP for the FcLec5 | FcLec5 | C type Lectin (CTL/CLR) | Fenneropenaeus chinensis | hepatopancreas | CRD | NA | NA | NA | It elicit the immune response, which leads to the clearance of bacteria | ELISA | 20349323 | 2010 | NA |
| PRRID_0644 | Lipopolysaccharide (LPS) Click for more detail | Escherichia coli strain 0111:B4 (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It induces the release of microparticles by the macrophages | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | Macropahes | LRR | Q9QUK6.fasta | Q9QUK6 | 835 | It leads to the release of MPs which act as the novel signals for innate immunity | Griess assay | 20335312 | 2010 | Pubchem Assay |
| PRRID_0644 | Lipopolysaccharide (LPS) Click for more detail | Escherichia coli strain 0111:B4 (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It induces the release of microparticles by the macrophages | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | Macropahes | LRR | Q9QUK6.fasta | Q9QUK6 | 835 | It leads to the release of MPs which act as the novel signals for innate immunity | Griess assay | 20335312 | 2010 | Pubchem Assay |
| PRRID_0645 | Lipopolysaccharide (LPS) Click for more detail | Aspergillus fumigatus(fungi) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It induces the secretion of IL-6, IL-8, CC chemokine-ligand 20 (CCL20) and thymosin β4 (Tβ4). | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Telomerase-Immortalized Human Stroma Fibroblasts (THSFs) | NA | O00206.fasta | O00206 | 839 | It has the immunostimulatory role. | ELISA | 20305039 | 2010 | Pubchem Assay |
| PRRID_0645 | Lipopolysaccharide (LPS) Click for more detail | Aspergillus fumigatus(fungi) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It induces the secretion of IL-6, IL-8, CC chemokine-ligand 20 (CCL20) and thymosin β4 (Tβ4). | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Telomerase-Immortalized Human Stroma Fibroblasts (THSFs) | NA | O00206.fasta | O00206 | 839 | It has the immunostimulatory role. | ELISA | 20305039 | 2010 | Pubchem Assay |
| PRRID_0668 | Lipopolysaccharide (LPS) Click for more detail | Bacteria and fungi | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS and β-glucan binds to the LGBP and induce innate immunity | Lipopolysaccharide and b-1, 3-glucan binding protein (LGBP) | Pattern recognition receptor (PRR) | Drosophila melanogaster | NA | NA | NA | NA | NA | It helps in pathogen recognition, activation of proPO system, induction of antimicrobial peptide | NA | 20659562 | 2010 | NA |
| PRRID_0668 | Lipopolysaccharide (LPS) Click for more detail | Bacteria and fungi | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS and β-glucan binds to the LGBP and induce innate immunity | Lipopolysaccharide and b-1, 3-glucan binding protein (LGBP) | Pattern recognition receptor (PRR) | Drosophila melanogaster | NA | NA | NA | NA | NA | It helps in pathogen recognition, activation of proPO system, induction of antimicrobial peptide | NA | 20659562 | 2010 | NA |
| PRRID_0744 | Lipopolysaccharide (LPS) Click for more detail | Vibrio anguillarum and Micrococcus lysodeikticus (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | PGRP-S1 | Peptidoglycan Recognition Receptor (PGRPs) | Chlamys farreri | mantle, gill, kidney and gonad | NA | Q9VYX7.fasta | Q9VYX7 | 203 | It leads to the degradation of PGN, induction of phagocytosis and activation of prophenoloxidase (proPO) system | ELISA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0744 | Lipopolysaccharide (LPS) Click for more detail | Vibrio anguillarum and Micrococcus lysodeikticus (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | PGRP-S1 | Peptidoglycan Recognition Receptor (PGRPs) | Chlamys farreri | mantle, gill, kidney and gonad | NA | Q9VYX7.fasta | Q9VYX7 | 203 | It leads to the degradation of PGN, induction of phagocytosis and activation of prophenoloxidase (proPO) system | ELISA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0781 | R-Lipopolysaccharide (LPS) Click for more detail | Salmonella minnesota (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Activate monocytes and neutrophils with differential CD14 expression. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytes and Neutrophils | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leads to the inflammatory response from the immune system leads to the clearance of pathogens | NA | 20721471 | 2010 | Pubchem Assay |
| PRRID_0781 | R-Lipopolysaccharide (LPS) Click for more detail | Salmonella minnesota (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Activate monocytes and neutrophils with differential CD14 expression. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytes and Neutrophils | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leads to the inflammatory response from the immune system leads to the clearance of pathogens | NA | 20721471 | 2010 | Pubchem Assay |
| PRRID_0787 | S-Lipopolysaccharide (LPS) Click for more detail | Salmonella abortus equi (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Activate monocytes and neutrophils with differential CD14 expression. | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Monocytes and Neutrophils | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It leads to the inflammatory response from the immune system leads to the clearance of pathogens | NA | 20721471 | 2010 | Pubchem Assay |
| PRRID_0787 | S-Lipopolysaccharide (LPS) Click for more detail | Salmonella abortus equi (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Activate monocytes and neutrophils with differential CD14 expression. | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Monocytes and Neutrophils | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It leads to the inflammatory response from the immune system leads to the clearance of pathogens | NA | 20721471 | 2010 | Pubchem Assay |
| PRRID_0867 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | DmGNBP1 | Gram-negative Bacteria-binding Protein (GNBPs) | Drosophila melanogaster | NA | NA | Q9NHB0.fasta | Q9NHB0 | 494 | It induces the proteolytic cascade | NA | 20699104 | 2010 | Pubchem Assay |
| PRRID_0867 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | DmGNBP1 | Gram-negative Bacteria-binding Protein (GNBPs) | Drosophila melanogaster | NA | NA | Q9NHB0.fasta | Q9NHB0 | 494 | It induces the proteolytic cascade | NA | 20699104 | 2010 | Pubchem Assay |
| PRRID_0918 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS was also shown to play a role in alloimmune lung injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0918 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS was also shown to play a role in alloimmune lung injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0921 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS was also shown to play a role in alloimmune lung injury | Toll-like receptor 4/MD-2 (TLR4/MD-2) | Toll-like receptor (TLR) | Mice | NA | intracellular TIR domains | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21959264 | 2011 | Pubchem Assay |
| PRRID_0921 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS was also shown to play a role in alloimmune lung injury | Toll-like receptor 4/MD-2 (TLR4/MD-2) | Toll-like receptor (TLR) | Mice | NA | intracellular TIR domains | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21959264 | 2011 | Pubchem Assay |
| PRRID_0922 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS was also shown to play a role in alloimmune lung injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21955443 | 2011 | NA |
| PRRID_0922 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS was also shown to play a role in alloimmune lung injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21955443 | 2011 | NA |
| PRRID_0923 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21949866 | 2011 | NA |
| PRRID_0923 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21949866 | 2011 | NA |
| PRRID_0924 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS was also shown to play a role in alloimmune lung injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | neutrophils, macrophages, and dendritic cells | TIR domain- containing adaptor protein-inducing IFN- | Q9QUK6.fasta | Q9QUK6 | 835 | triggers the innate immune response and leads to the induction of adaptive immunity | NA | 21949773 | 2011 | Pubchem Assay |
| PRRID_0924 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS was also shown to play a role in alloimmune lung injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | neutrophils, macrophages, and dendritic cells | TIR domain- containing adaptor protein-inducing IFN- | Q9QUK6.fasta | Q9QUK6 | 835 | triggers the innate immune response and leads to the induction of adaptive immunity | NA | 21949773 | 2011 | Pubchem Assay |
| PRRID_0940 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS was also shown to play a role in alloimmune lung injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Intracellular TIR domains | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21959264 | 2011 | Pubchem Assay |
| PRRID_0940 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS was also shown to play a role in alloimmune lung injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Intracellular TIR domains | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21959264 | 2011 | Pubchem Assay |
| PRRID_0941 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS was also shown to play a role in alloimmune lung injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Drosophila melanogaster | NA | Intracellular TIR domains | NA | NA | NA | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21959264 | 2011 | NA |
| PRRID_0941 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS was also shown to play a role in alloimmune lung injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Drosophila melanogaster | NA | Intracellular TIR domains | NA | NA | NA | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21959264 | 2011 | NA |
| PRRID_1002 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | PBMCs | NA | O60603.fasta | O60603 | 784 | induction of IL-6 and IL-8 | ELISA | 22998942 | 2012 | Pubchem Assay |
| PRRID_1002 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | PBMCs | NA | O60603.fasta | O60603 | 784 | induction of IL-6 and IL-8 | ELISA | 22998942 | 2012 | Pubchem Assay |
| PRRID_1088 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | TRIF mutant (C57BL/6J-Ticam1Lps2) mice | bone marrow-derived macrophage (BMDM) culture | Toll/IL-1R (TIR) domain | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | Quantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations | 24019532 | 2013 | Pubchem_assay |
| PRRID_1088 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | TRIF mutant (C57BL/6J-Ticam1Lps2) mice | bone marrow-derived macrophage (BMDM) culture | Toll/IL-1R (TIR) domain | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | Quantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations | 24019532 | 2013 | Pubchem_assay |
| PRRID_1089 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Synthetic | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | human peripheral blood mononuclear cells (hPBMCs) | NA | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 24016850 | 2013 | Pubchem_assay |
| PRRID_1089 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Synthetic | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | human peripheral blood mononuclear cells (hPBMCs) | NA | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 24016850 | 2013 | Pubchem_assay |
| PRRID_1090 | Lipopolysaccharide (LPS) Click for more detail | outer membrane of Gram- negative bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 24005321 | 2013 | NA |
| PRRID_1090 | Lipopolysaccharide (LPS) Click for more detail | outer membrane of Gram- negative bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 24005321 | 2013 | NA |
| PRRID_1091 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) in association with CD14 and MD2 | Toll-like receptor (TLR) | Human | testis, epididymis, vasa deferens, prostate and prepuce | NA | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | RT-PCR, Quantitative real-time PCR | 23998272 | 2013 | Pubchem_assay |
| PRRID_1091 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) in association with CD14 and MD2 | Toll-like receptor (TLR) | Human | testis, epididymis, vasa deferens, prostate and prepuce | NA | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | RT-PCR, Quantitative real-time PCR | 23998272 | 2013 | Pubchem_assay |
| PRRID_1092 | Lipopolysaccharide (LPS) Click for more detail | E. coli Serotype 055:B5(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | PcLec5 | C type Lectin (CTL/CLR) | red swamp crayfish (Procambarus clarkii) | hepatopancreas, gills and intestine | carbohydrate recognition domain (CRD) | NA | NA | NA | play important roles in the innate immune system of crustaceans | ELISA | 23989040 | 2013 | NA |
| PRRID_1092 | Lipopolysaccharide (LPS) Click for more detail | E. coli Serotype 055:B5(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | PcLec5 | C type Lectin (CTL/CLR) | red swamp crayfish (Procambarus clarkii) | hepatopancreas, gills and intestine | carbohydrate recognition domain (CRD) | NA | NA | NA | play important roles in the innate immune system of crustaceans | ELISA | 23989040 | 2013 | NA |
| PRRID_1094 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1094 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1095 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS was also shown to play a role in alloimmune lung injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | graft-versus-host disease (GVHD) | NA | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1095 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS was also shown to play a role in alloimmune lung injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | graft-versus-host disease (GVHD) | NA | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1096 | Lipopolysaccharide (LPS) Click for more detail | E. coli K12(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | HEK293 cells | NA | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | NF- | 24098508 | 2013 | Pubchem_assay |
| PRRID_1096 | Lipopolysaccharide (LPS) Click for more detail | E. coli K12(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | HEK293 cells | NA | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | NF- | 24098508 | 2013 | Pubchem_assay |
| PRRID_1097 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | CgToll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | C. gigas | HEK293 cells | NA | NA | NA | NA | NA | NF- | 24098508 | 2013 | NA |
| PRRID_1097 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | CgToll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | C. gigas | HEK293 cells | NA | NA | NA | NA | NA | NF- | 24098508 | 2013 | NA |
| PRRID_1098 | Lipopolysaccharide (LPS) Click for more detail | Pseudomonas aeruginosa (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | unique, endogenous potentiator of serous secretion from tracheal gland acinar cells | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Swine | tracheal submucosal acinar glands | NA | NA | NA | NA | plays a fundamental role in pathogen recognition and activation of innate immunity | RT-PCR, Intracellular calcium assays | 24097563 | 2013 | NA |
| PRRID_1098 | Lipopolysaccharide (LPS) Click for more detail | Pseudomonas aeruginosa (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | unique, endogenous potentiator of serous secretion from tracheal gland acinar cells | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Swine | tracheal submucosal acinar glands | NA | NA | NA | NA | plays a fundamental role in pathogen recognition and activation of innate immunity | RT-PCR, Intracellular calcium assays | 24097563 | 2013 | NA |
| PRRID_1104 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1104 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1109 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS was also shown to play a role in alloimmune lung injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | graft-versus-host disease (GVHD) | NA | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1109 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS was also shown to play a role in alloimmune lung injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | graft-versus-host disease (GVHD) | NA | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1396 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | nasal mucosa Mesenchymal stromal cells (nmMSCs) inferior nasal concha of healthy individuals | cell surface | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA and Immunofluoroscence assay | 24830384 | 2014 | Pubchem_assay |
| PRRID_1396 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | nasal mucosa Mesenchymal stromal cells (nmMSCs) inferior nasal concha of healthy individuals | cell surface | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA and Immunofluoroscence assay | 24830384 | 2014 | Pubchem_assay |
| PRRID_1397 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | Cell Surface (Exogenous) | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 24830024 | 2014 | Pubchem_assay |
| PRRID_1397 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | Cell Surface (Exogenous) | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 24830024 | 2014 | Pubchem_assay |
| PRRID_1398 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | Cell Surface (Exogenous) | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | reverse transcription–polymerase chain reaction (RT–PCR), real-time RT–PCR, flow cytometry, immunocytochemistry and Western blot analysis. | 24828022 | 2014 | Pubchem_assay |
| PRRID_1398 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | Cell Surface (Exogenous) | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | reverse transcription–polymerase chain reaction (RT–PCR), real-time RT–PCR, flow cytometry, immunocytochemistry and Western blot analysis. | 24828022 | 2014 | Pubchem_assay |
| PRRID_1399 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Guinea Pig | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | cell surface | H0VSQ0.fasta | H0VSQ0 | 837 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | Real-time RT-PCR, Calcium influx assay | 24819048 | 2014 | Pubchem_assay |
| PRRID_1399 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Guinea Pig | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | cell surface | H0VSQ0.fasta | H0VSQ0 | 837 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | Real-time RT-PCR, Calcium influx assay | 24819048 | 2014 | Pubchem_assay |
| PRRID_1400 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | mast cells | cell surface | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | Real-time PCR | 24818634 | 2014 | Pubchem_assay |
| PRRID_1400 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | mast cells | cell surface | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | Real-time PCR | 24818634 | 2014 | Pubchem_assay |
| PRRID_1401 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | cell surface | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 24818579 | 2014 | Pubchem_assay |
| PRRID_1401 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | cell surface | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 24818579 | 2014 | Pubchem_assay |
| PRRID_1402 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 24818579 | 2014 | Pubchem_assay |
| PRRID_1402 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 24818579 | 2014 | Pubchem_assay |
| PRRID_1403 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Bos indicus Sahiwal cattle breed | BTA8 | cell surface | NA | NA | NA | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | Polymerase Chain Reaction | 24813219 | 2014 | NA |
| PRRID_1403 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Bos indicus Sahiwal cattle breed | BTA8 | cell surface | NA | NA | NA | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | Polymerase Chain Reaction | 24813219 | 2014 | NA |
| PRRID_1404 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human Platelets | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | TLR4 is expressed on platelets which mediates inflammatory and immune responses in a variety of diseases including PAH (pulmonary arterial hypertension) | NA | 24812346 | 2014 | Pubchem_assay |
| PRRID_1404 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human Platelets | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | TLR4 is expressed on platelets which mediates inflammatory and immune responses in a variety of diseases including PAH (pulmonary arterial hypertension) | NA | 24812346 | 2014 | Pubchem_assay |
| PRRID_1405 | Lipopolysaccharide (LPS) Click for more detail | outer cell wall component of gram- negative bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | responsible for an endotoxin shock | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1405 | Lipopolysaccharide (LPS) Click for more detail | outer cell wall component of gram- negative bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | responsible for an endotoxin shock | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1406 | Lipopolysaccharide (LPS) Click for more detail | outer cell wall component of gram- negative bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | responsible for an endotoxin shock | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | cell surface | O00206.fasta | O00206 | 839 | Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1406 | Lipopolysaccharide (LPS) Click for more detail | outer cell wall component of gram- negative bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | responsible for an endotoxin shock | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | cell surface | O00206.fasta | O00206 | 839 | Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1407 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induce inflammation | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Endotoxemic Mice | Macrophages | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR4 recognizes LPS and causes cell activation, including the production of NO and proinflammatory cytokines such as TNF-α and IL-6 | qRT-PCR, immunofluorescence assay, western blot | 24802390 | 2014 | Pubchem_assay |
| PRRID_1407 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induce inflammation | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Endotoxemic Mice | Macrophages | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR4 recognizes LPS and causes cell activation, including the production of NO and proinflammatory cytokines such as TNF-α and IL-6 | qRT-PCR, immunofluorescence assay, western blot | 24802390 | 2014 | Pubchem_assay |
| PRRID_1408 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induce inflammation | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | TLR-deficient Mice on a C57BL/6 | monocyte/macrophages | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 24801735 | 2014 | Pubchem_assay |
| PRRID_1408 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induce inflammation | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | TLR-deficient Mice on a C57BL/6 | monocyte/macrophages | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 24801735 | 2014 | Pubchem_assay |
| PRRID_1409 | Lipopolysaccharide (LPS) Click for more detail | Escherichia coli (0111:B4) (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induce inflammation | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Chicken | monocyte/macrophages | cell surface | Q7ZTG5.fasta | Q7ZTG5 | 843 | TLRs promote cellular activation and the production of cytokines such as interleukin (IL)-12 and interferon (IFN)-c In the case of antigen presenting cells (APCs), TLR stimulation also promotes the up-regulation of major histocompatibility complex class II (MHC-II) and co- stimulatory molecules including CD80 therefore elicitation of a robust adaptive immune response | ELISA | 24797893 | 2014 | Pubchem_assay |
| PRRID_1409 | Lipopolysaccharide (LPS) Click for more detail | Escherichia coli (0111:B4) (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induce inflammation | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Chicken | monocyte/macrophages | cell surface | Q7ZTG5.fasta | Q7ZTG5 | 843 | TLRs promote cellular activation and the production of cytokines such as interleukin (IL)-12 and interferon (IFN)-c In the case of antigen presenting cells (APCs), TLR stimulation also promotes the up-regulation of major histocompatibility complex class II (MHC-II) and co- stimulatory molecules including CD80 therefore elicitation of a robust adaptive immune response | ELISA | 24797893 | 2014 | Pubchem_assay |
| PRRID_1410 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Keratinocytes and mouse skin | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | play a role in UVB induced immune suppression | NA | 24786223 | 2014 | Pubchem_assay |
| PRRID_1410 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Keratinocytes and mouse skin | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | play a role in UVB induced immune suppression | NA | 24786223 | 2014 | Pubchem_assay |
| PRRID_1411 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Keratinocytes and mouse skin | cell surface | O00206.fasta | O00206 | 839 | play a role in UVB induced immune suppression | NA | 24786223 | 2014 | Pubchem_assay |
| PRRID_1411 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Keratinocytes and mouse skin | cell surface | O00206.fasta | O00206 | 839 | play a role in UVB induced immune suppression | NA | 24786223 | 2014 | Pubchem_assay |
| PRRID_1412 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | ischemic brain tissue | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR4 signaling has been implicated in post-stroke neuroinflammation and injury and is also critical in the robustly neuroprotective ischemic preconditioning phenomenon | NA | 24784586 | 2014 | Pubchem_assay |
| PRRID_1412 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | ischemic brain tissue | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR4 signaling has been implicated in post-stroke neuroinflammation and injury and is also critical in the robustly neuroprotective ischemic preconditioning phenomenon | NA | 24784586 | 2014 | Pubchem_assay |
| PRRID_1413 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | ischemic brain tissue | cell surface | O00206.fasta | O00206 | 839 | TLR4 signaling has been implicated in post-stroke neuroinflammation and injury and is also critical in the robustly neuroprotective ischemic preconditioning phenomenon | NA | 24784586 | 2014 | Pubchem_assay |
| PRRID_1413 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | ischemic brain tissue | cell surface | O00206.fasta | O00206 | 839 | TLR4 signaling has been implicated in post-stroke neuroinflammation and injury and is also critical in the robustly neuroprotective ischemic preconditioning phenomenon | NA | 24784586 | 2014 | Pubchem_assay |
| PRRID_1414 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | human MSCs (hMSCs) and murine MSCs (mMSCs) | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | the agonists of TLR3 and TLR4 in human MSCs (hMSCs) induce down- regulation of the of Notch ligand Jagged-1, and thus decrease the ability of MSCs to suppress allogeneic T cell proliferation | NA | 24780395 | 2014 | Pubchem_assay |
| PRRID_1414 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | human MSCs (hMSCs) and murine MSCs (mMSCs) | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | the agonists of TLR3 and TLR4 in human MSCs (hMSCs) induce down- regulation of the of Notch ligand Jagged-1, and thus decrease the ability of MSCs to suppress allogeneic T cell proliferation | NA | 24780395 | 2014 | Pubchem_assay |
| PRRID_1415 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | human MSCs (hMSCs) and murine MSCs (mMSCs) | cell surface | O00206.fasta | O00206 | 839 | the agonists of TLR3 and TLR4 in human MSCs (hMSCs) induce down- regulation of the of Notch ligand Jagged-1, and thus decrease the ability of MSCs to suppress allogeneic T cell proliferation | NA | 24780395 | 2014 | Pubchem_assay |
| PRRID_1415 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | human MSCs (hMSCs) and murine MSCs (mMSCs) | cell surface | O00206.fasta | O00206 | 839 | the agonists of TLR3 and TLR4 in human MSCs (hMSCs) induce down- regulation of the of Notch ligand Jagged-1, and thus decrease the ability of MSCs to suppress allogeneic T cell proliferation | NA | 24780395 | 2014 | Pubchem_assay |