Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_2353muropeptides with a meso-diaminopimelate residue (meso-DAP)

Click for more detail

Gram negative bacteria(Leptospira spp.)C(CC(C(=O)O)N)CC(C(=O)O)NNANANaturalNANucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)MiceNANAQ8BHB0.fastaQ8BHB0953NANA290389562017Pubchem_assay
PRRID_2353muropeptides with a meso-diaminopimelate residue (meso-DAP)

Click for more detail

Gram negative bacteria(Leptospira spp.)C(CC(C(=O)O)N)CC(C(=O)O)NNANANaturalNANucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)MiceNANAQ8BHB0.fastaQ8BHB0953NANA290389562017Pubchem_assay
PRRID_2366NA

Click for more detail

NANANANANANAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Miceapical surfaces of mouse villus and crypt epithelial cellsLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA293306752017Pubchem_assay
PRRID_2366NA

Click for more detail

NANANANANANAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Miceapical surfaces of mouse villus and crypt epithelial cellsLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA293306752017Pubchem_assay
PRRID_2367NA

Click for more detail

NANANANANANAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Miceapical surfaces of mouse villus and crypt epithelial cellsLeucine-rich Repeat (LRR) DomainQ9JLF7.fastaQ9JLF7859NANA293306752017Pubchem_assay
PRRID_2367NA

Click for more detail

NANANANANANAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Miceapical surfaces of mouse villus and crypt epithelial cellsLeucine-rich Repeat (LRR) DomainQ9JLF7.fastaQ9JLF7859NANA293306752017Pubchem_assay
PRRID_2368NA

Click for more detail

NANANANANANAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Mice (Murine)apical and basal poles of mu- rine crypt epithelial cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032cells responded with increased mitogenic activity and cytokine productionNA293306752017Pubchem_assay
PRRID_2368NA

Click for more detail

NANANANANANAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Mice (Murine)apical and basal poles of mu- rine crypt epithelial cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032cells responded with increased mitogenic activity and cytokine productionNA293306752017Pubchem_assay
PRRID_2371NA

Click for more detail

NANANANANANAFAEPattern recognition receptor (PRR)Mice (Murine)apical and basolateral polesLeucine-rich Repeat (LRR) DomainNANANANANA293306752017NA
PRRID_2371NA

Click for more detail

NANANANANANAFAEPattern recognition receptor (PRR)Mice (Murine)apical and basolateral polesLeucine-rich Repeat (LRR) DomainNANANANANA293306752017NA
PRRID_2372NA

Click for more detail

NANANANANANAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Mice (Murine)apical and basolateral polesLeucine-rich Repeat (LRR) DomainQ9JLF7.fastaQ9JLF7859NANA293306752017Pubchem_assay
PRRID_2372NA

Click for more detail

NANANANANANAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Mice (Murine)apical and basolateral polesLeucine-rich Repeat (LRR) DomainQ9JLF7.fastaQ9JLF7859NANA293306752017Pubchem_assay
PRRID_2373NA

Click for more detail

NANANANANANAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Mice (Murine)apical and basolateral polesLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA293306752017Pubchem_assay
PRRID_2373NA

Click for more detail

NANANANANANAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Mice (Murine)apical and basolateral polesLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA293306752017Pubchem_assay
PRRID_2377NA

Click for more detail

NANANANANANAToll-like receptor 1 (TLR1)Toll-like receptor (TLR)Micecrypt epithelial cells,Leucine-rich Repeat (LRR) DomainQ9EPQ1.fastaQ9EPQ1795NANA293306752017Pubchem_assay
PRRID_2377NA

Click for more detail

NANANANANANAToll-like receptor 1 (TLR1)Toll-like receptor (TLR)Micecrypt epithelial cells,Leucine-rich Repeat (LRR) DomainQ9EPQ1.fastaQ9EPQ1795NANA293306752017Pubchem_assay
PRRID_2378NA

Click for more detail

NANANANANANAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micecrypt epithelial cells,Leucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784NANA293306752017Pubchem_assay
PRRID_2378NA

Click for more detail

NANANANANANAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micecrypt epithelial cells,Leucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784NANA293306752017Pubchem_assay
PRRID_2379NA

Click for more detail

NANANANANANAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micecrypt epithelial cells,Leucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA293306752017Pubchem_assay
PRRID_2379NA

Click for more detail

NANANANANANAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micecrypt epithelial cells,Leucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA293306752017Pubchem_assay
PRRID_2451NA

Click for more detail

Human cytomegalovirus (virus)NANANANANANucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)MiceMacrophagesnucleotide-binding oligomerization domainQ8K3Z0.fastaQ8K3Z01020Restriction of viral replicationNA288235102017Pubchem_assay
PRRID_2451NA

Click for more detail

Human cytomegalovirus (virus)NANANANANANucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)MiceMacrophagesnucleotide-binding oligomerization domainQ8K3Z0.fastaQ8K3Z01020Restriction of viral replicationNA288235102017Pubchem_assay
PRRID_2452NA

Click for more detail

Human cytomegalovirus (virus)NANANANANANucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)MiceMacrophagesnucleotide-binding oligomerization domainQ8BHB0.fastaQ8BHB0953Restriction of viral replicationNA288235102017Pubchem_assay
PRRID_2452NA

Click for more detail

Human cytomegalovirus (virus)NANANANANANucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)MiceMacrophagesnucleotide-binding oligomerization domainQ8BHB0.fastaQ8BHB0953Restriction of viral replicationNA288235102017Pubchem_assay
PRRID_2453NA

Click for more detail

Plasmodium berghei (fungi)NANANANANANucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)MiceMacrophagesnucleotide-binding oligomerization domainQ8BHB0.fastaQ8BHB0953Induction of IL-1b, KC, IFNgNA288235102017Pubchem_assay
PRRID_2453NA

Click for more detail

Plasmodium berghei (fungi)NANANANANANucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)MiceMacrophagesnucleotide-binding oligomerization domainQ8BHB0.fastaQ8BHB0953Induction of IL-1b, KC, IFNgNA288235102017Pubchem_assay
PRRID_2454NA

Click for more detail

Trypanosoma Cruzi (others)NANANANANANucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)Micespleen and heartnucleotide-binding oligomerization domainQ8BHB0.fastaQ8BHB0953NOD1-KO mice are highly susceptible to infectionNA288235102017Pubchem_assay
PRRID_2454NA

Click for more detail

Trypanosoma Cruzi (others)NANANANANANucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)Micespleen and heartnucleotide-binding oligomerization domainQ8BHB0.fastaQ8BHB0953NOD1-KO mice are highly susceptible to infectionNA288235102017Pubchem_assay
PRRID_2458NA

Click for more detail

NANANAPattern-associated molecular patterns (PAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Micesubstantia nigraNAQ8R4B8.fastaQ8R4B81033protein ‚Üë, activation of NLRP3 inflammasome in PD modelsNA288015212017Pubchem_assay
PRRID_2458NA

Click for more detail

NANANAPattern-associated molecular patterns (PAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Micesubstantia nigraNAQ8R4B8.fastaQ8R4B81033protein ‚Üë, activation of NLRP3 inflammasome in PD modelsNA288015212017Pubchem_assay
PRRID_2474NA

Click for more detail

Blastomyces dermatitidis(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRMiceNANAQ9Z2H6.fastaQ9Z2H6219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2474NA

Click for more detail

Blastomyces dermatitidis(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRMiceNANAQ9Z2H6.fastaQ9Z2H6219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2480NA

Click for more detail

M. tuberculosis, M. bovis, Mycobacterium smegmatis (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2480NA

Click for more detail

M. tuberculosis, M. bovis, Mycobacterium smegmatis (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2484NA

Click for more detail

Coccidioidis posadasii(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244protective role in infection modelNA281676512017Pubchem_assay
PRRID_2484NA

Click for more detail

Coccidioidis posadasii(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244protective role in infection modelNA281676512017Pubchem_assay
PRRID_2486NA

Click for more detail

Coccidioidis immitis(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2486NA

Click for more detail

Coccidioidis immitis(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2487NA

Click for more detail

H. capsulatum (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2487NA

Click for more detail

H. capsulatum (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2488NA

Click for more detail

M. audouinii (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2488NA

Click for more detail

M. audouinii (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2489NA

Click for more detail

Penicillium marneffei (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2489NA

Click for more detail

Penicillium marneffei (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2490NA

Click for more detail

Pneumocystis carnii (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2490NA

Click for more detail

Pneumocystis carnii (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2491NA

Click for more detail

 Fungi (T. rubrum, yeast)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2491NA

Click for more detail

 Fungi (T. rubrum, yeast)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2493NA

Click for more detail

Trichosporon asahii (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2493NA

Click for more detail

Trichosporon asahii (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2494NA

Click for more detail

S. pneumoniae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantcollectin kidney 1 (CL-K1)C type Lectin (CTL/CLR)MiceNANAQ3SXB8.fastaQ3SXB8272binds to microbes and activates the lectin complement pathwayNA280686632017Pubchem_assay
PRRID_2494NA

Click for more detail

S. pneumoniae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantcollectin kidney 1 (CL-K1)C type Lectin (CTL/CLR)MiceNANAQ3SXB8.fastaQ3SXB8272binds to microbes and activates the lectin complement pathwayNA280686632017Pubchem_assay
PRRID_2499Nigericin

Click for more detail

NANANAPattern-associated molecular patterns (PAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)MiceMicrogliaNAQ8R4B8.fastaQ8R4B81033NLRP3 inflammasome activation in AD modelsNA288015212017Pubchem_assay
PRRID_2499Nigericin

Click for more detail

NANANAPattern-associated molecular patterns (PAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)MiceMicrogliaNAQ8R4B8.fastaQ8R4B81033NLRP3 inflammasome activation in AD modelsNA288015212017Pubchem_assay
PRRID_2500Nigericin

Click for more detail

NANANAPattern-associated molecular patterns (PAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Micecortical neurons (cell culture, stroke model)NAQ8R4B8.fastaQ8R4B81033protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficitsNA288015212017Pubchem_assay
PRRID_2500Nigericin

Click for more detail

NANANAPattern-associated molecular patterns (PAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Micecortical neurons (cell culture, stroke model)NAQ8R4B8.fastaQ8R4B81033protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficitsNA288015212017Pubchem_assay
PRRID_2503Nigericin

Click for more detail

NANANAPattern-associated molecular patterns (PAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Micesubstantia nigraNAQ8R4B8.fastaQ8R4B81033protein ‚Üë, activation of NLRP3 inflammasome in PD modelsNA288015212017Pubchem_assay
PRRID_2503Nigericin

Click for more detail

NANANAPattern-associated molecular patterns (PAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Micesubstantia nigraNAQ8R4B8.fastaQ8R4B81033protein ‚Üë, activation of NLRP3 inflammasome in PD modelsNA288015212017Pubchem_assay
PRRID_2526OspA

Click for more detail

NAMKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGGMTVLVSKEKDKDGKYSLDATVDKLELKGTSDKNNGSGTLEGEKTDKSKVKLTIADDLSQTKFEIFKEDGKTLVSKKVTLKDKSSTEEKFNEKGETSEKTIVRANGTRLEYTDIKSDGSGKAKEVLKDFTLEGTLAADGKTTLKVTEGTVVLSKNILKSGEITVALDDSDTTQATKKTGNWDSKSSTLTISVNSQKTKNLVFTKEDTITVQKYDSAGTNLEGKAVEITTLKELKAALKNANANaturalProduction of TNF-α and IL-Toll-like receptor 1 (TLR1)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9EPQ1.fastaQ9EPQ1795NANA290283692017Pubchem_assay
PRRID_2526OspA

Click for more detail

NAMKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGGMTVLVSKEKDKDGKYSLDATVDKLELKGTSDKNNGSGTLEGEKTDKSKVKLTIADDLSQTKFEIFKEDGKTLVSKKVTLKDKSSTEEKFNEKGETSEKTIVRANGTRLEYTDIKSDGSGKAKEVLKDFTLEGTLAADGKTTLKVTEGTVVLSKNILKSGEITVALDDSDTTQATKKTGNWDSKSSTLTISVNSQKTKNLVFTKEDTITVQKYDSAGTNLEGKAVEITTLKELKAALKNANANaturalProduction of TNF-α and IL-Toll-like receptor 1 (TLR1)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9EPQ1.fastaQ9EPQ1795NANA290283692017Pubchem_assay
PRRID_2543Peptidoglycan (PGN)

Click for more detail

P. gulae (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalCauses inflammation and activation of NOD2.Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)MiceHEK cellsNAQ8K3Z0.fastaQ8K3Z01020activate NF-κB.NA286300662017Pubchem_assay
PRRID_2543Peptidoglycan (PGN)

Click for more detail

P. gulae (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalCauses inflammation and activation of NOD2.Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)MiceHEK cellsNAQ8K3Z0.fastaQ8K3Z01020activate NF-κB.NA286300662017Pubchem_assay
PRRID_2572Polysaccharide fragments of heparan sulfate

Click for more detail

NACO[C@@H]1[C@H]([C@@H]([C@@H](O[C@@H]1C(=O)[O-])O[C@H]2[C@@H](O[C@H]([C@H]([C@@H]2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)ONANANaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA290283692017Pubchem_assay
PRRID_2572Polysaccharide fragments of heparan sulfate

Click for more detail

NACO[C@@H]1[C@H]([C@@H]([C@@H](O[C@@H]1C(=O)[O-])O[C@H]2[C@@H](O[C@H]([C@H]([C@@H]2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)ONANANaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA290283692017Pubchem_assay
PRRID_2575potassium peroxychromate (PPC)

Click for more detail

NANANAReactive oxygen species (ROS)SyntheticPPC decomposition can release several oxygen- centered free radicals such as superoxide anion and hydroxyl radicalsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceRAW-Blue cellsLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NART-PCR and Western blot,291754192017Pubchem_assay
PRRID_2575potassium peroxychromate (PPC)

Click for more detail

NANANAReactive oxygen species (ROS)SyntheticPPC decomposition can release several oxygen- centered free radicals such as superoxide anion and hydroxyl radicalsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceRAW-Blue cellsLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NART-PCR and Western blot,291754192017Pubchem_assay
PRRID_2583rb-dsRNA

Click for more detail

Rice- bran (plant)NANAPattern-associated molecular patterns (PAMPs)Naturalactivate caspase 1 via TRIF, resulting in the release of IL-1b and LDHToll-like receptor 3 (TLR3)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ99MB1.fastaQ99MB1905Caspase 1 activation is specifically induced by TLR3 signaling through TRIF/RIPK/ FADD, resulting in activation of the NLRP3 inflammasomeRT-qPCR288480652017Pubchem_assay
PRRID_2583rb-dsRNA

Click for more detail

Rice- bran (plant)NANAPattern-associated molecular patterns (PAMPs)Naturalactivate caspase 1 via TRIF, resulting in the release of IL-1b and LDHToll-like receptor 3 (TLR3)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ99MB1.fastaQ99MB1905Caspase 1 activation is specifically induced by TLR3 signaling through TRIF/RIPK/ FADD, resulting in activation of the NLRP3 inflammasomeRT-qPCR288480652017Pubchem_assay
PRRID_2584rb-dsRNA

Click for more detail

Rice- bran (plant)NANAPattern-associated molecular patterns (PAMPs)Naturalactivate caspase 1 via TRIF, resulting in the release of IL-1b and LDHMDA5Rig-like receptor (RLR)MiceNANAQ8R5F7.fastaQ8R5F71025Caspase 1 activation is specifically induced by TLR3 signaling through TRIF/RIPK/ FADD.RT-qPCR288480652017Pubchem_assay
PRRID_2584rb-dsRNA

Click for more detail

Rice- bran (plant)NANAPattern-associated molecular patterns (PAMPs)Naturalactivate caspase 1 via TRIF, resulting in the release of IL-1b and LDHMDA5Rig-like receptor (RLR)MiceNANAQ8R5F7.fastaQ8R5F71025Caspase 1 activation is specifically induced by TLR3 signaling through TRIF/RIPK/ FADD.RT-qPCR288480652017Pubchem_assay
PRRID_2585rBanLec

Click for more detail

E. coli(Bacteria)NANANASyntheticImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MicePeritoneal macrophagesLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784production of TNFα and NO in BALB/c macrophages.ELISA282350502017Pubchem_assay
PRRID_2585rBanLec

Click for more detail

E. coli(Bacteria)NANANASyntheticImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MicePeritoneal macrophagesLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784production of TNFα and NO in BALB/c macrophages.ELISA282350502017Pubchem_assay
PRRID_2586rBanLec

Click for more detail

E. coli(Bacteria)NANANASyntheticImmunostimulantcluster of differentiation 4 (CD4)Pattern recognition receptor (PRR)MicePeritoneal macrophagesNAP06332.fastaP06332457production of TNFα and NO in BALB/c macrophages.ELISA282350502017Pubchem_assay
PRRID_2586rBanLec

Click for more detail

E. coli(Bacteria)NANANASyntheticImmunostimulantcluster of differentiation 4 (CD4)Pattern recognition receptor (PRR)MicePeritoneal macrophagesNAP06332.fastaP06332457production of TNFα and NO in BALB/c macrophages.ELISA282350502017Pubchem_assay
PRRID_2591RNA

Click for more detail

Type B coxsackieviruses (CVBs) (others)NANANucleic AcidNaturalmyocarditis and acute pancreatitisToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Micedendritic cellsLeucine-rich Repeat (LRR) DomainQ99MB1.fastaQ99MB1905NANA289730472017Pubchem_assay
PRRID_2591RNA

Click for more detail

Type B coxsackieviruses (CVBs) (others)NANANucleic AcidNaturalmyocarditis and acute pancreatitisToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Micedendritic cellsLeucine-rich Repeat (LRR) DomainQ99MB1.fastaQ99MB1905NANA289730472017Pubchem_assay
PRRID_2593RNA

Click for more detail

Brucella abortus(Bacteria)NANANucleic AcidNaturalOn stimulation, production of significant amount of proinflammatory cytokibes such as IL-12, IL-6, IP-10/CXCL10 and TNF-‚ç∫.Toll-like receptor 3 (TLR3)Toll-like receptor (TLR)MiceDendritic cellsLRRQ99MB1.fastaQ99MB1905This has immunostimulatory effect which leads to the clearance of pathogen from the host system.ELISA281679452017Pubchem_assay
PRRID_2593RNA

Click for more detail

Brucella abortus(Bacteria)NANANucleic AcidNaturalOn stimulation, production of significant amount of proinflammatory cytokibes such as IL-12, IL-6, IP-10/CXCL10 and TNF-‚ç∫.Toll-like receptor 3 (TLR3)Toll-like receptor (TLR)MiceDendritic cellsLRRQ99MB1.fastaQ99MB1905This has immunostimulatory effect which leads to the clearance of pathogen from the host system.ELISA281679452017Pubchem_assay
PRRID_2594RNA

Click for more detail

Brucella abortus(Bacteria)NANANucleic AcidNaturalOn stimulation, production of significant amount of proinflammatory cytokibes such as IL-12, IL-6, IP-10/CXCL10 and TNF-‚ç∫.Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)MiceDendritic cellsLRRP58681.fastaP586811050This has immunostimulatory effect which leads to the clearance of pathogen from the host system.ELISA281679452017Pubchem_assay
PRRID_2594RNA

Click for more detail

Brucella abortus(Bacteria)NANANucleic AcidNaturalOn stimulation, production of significant amount of proinflammatory cytokibes such as IL-12, IL-6, IP-10/CXCL10 and TNF-‚ç∫.Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)MiceDendritic cellsLRRP58681.fastaP586811050This has immunostimulatory effect which leads to the clearance of pathogen from the host system.ELISA281679452017Pubchem_assay
PRRID_2595ROS

Click for more detail

NANANADamage-associated molecular patterns (DAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)MiceMicrogliaNAQ8R4B8.fastaQ8R4B81033NLRP3 inflammasome activation in AD modelsNA288051212017Pubchem_assay
PRRID_2595ROS

Click for more detail

NANANADamage-associated molecular patterns (DAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)MiceMicrogliaNAQ8R4B8.fastaQ8R4B81033NLRP3 inflammasome activation in AD modelsNA288051212017Pubchem_assay
PRRID_2596ROS

Click for more detail

NANANADamage-associated molecular patterns (DAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Micecortical neurons (cell culture, stroke model)NAQ8R4B8.fastaQ8R4B81033protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficitsNA288015212017Pubchem_assay
PRRID_2596ROS

Click for more detail

NANANADamage-associated molecular patterns (DAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Micecortical neurons (cell culture, stroke model)NAQ8R4B8.fastaQ8R4B81033protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficitsNA288015212017Pubchem_assay
PRRID_2599ROS

Click for more detail

NANANADamage-associated molecular patterns (DAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Micesubstantia nigraNAQ8R4B8.fastaQ8R4B81033protein ‚Üë, activation of NLRP3 inflammasome in PD modelsNA288015212017Pubchem_assay
PRRID_2599ROS

Click for more detail

NANANADamage-associated molecular patterns (DAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Micesubstantia nigraNAQ8R4B8.fastaQ8R4B81033protein ‚Üë, activation of NLRP3 inflammasome in PD modelsNA288015212017Pubchem_assay
PRRID_2600ATP

Click for more detail

NAC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)ONADamage-associated molecular patterns (DAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)MiceMicrogliaNAQ8R4B8.fastaQ8R4B81033NLRP3 inflammasome activation in AD modelsNA288015212017Pubchem_assay
PRRID_2600ATP

Click for more detail

NAC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)ONADamage-associated molecular patterns (DAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)MiceMicrogliaNAQ8R4B8.fastaQ8R4B81033NLRP3 inflammasome activation in AD modelsNA288015212017Pubchem_assay
PRRID_2615SIN-1

Click for more detail

NANANAReactive oxygen species (ROS)SyntheticSIN-1 produces cell permeable peroxynitrite anions that can react with lipids, DNA and proteins by direct oxidative reaction or by indirect radical-induced mechanismsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceRAW-Blue cellsLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NART-PCR and Western blot,291754192017Pubchem_assay
PRRID_2615SIN-1

Click for more detail

NANANAReactive oxygen species (ROS)SyntheticSIN-1 produces cell permeable peroxynitrite anions that can react with lipids, DNA and proteins by direct oxidative reaction or by indirect radical-induced mechanismsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceRAW-Blue cellsLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NART-PCR and Western blot,291754192017Pubchem_assay
PRRID_2616Sindbis virus (SINV) RNA

Click for more detail

VirusNANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantTetrachlorodibenzo-p-dioxin (TCDD)- inducible poly(ADP ribose) polymerase (TIPARP)Pattern recognition receptor (PRR)MiceCytoplasmzinc finger domainQ8C1B2.fastaQ8C1B2657recruits an exosome to induce viral RNA degradation.RNA immunoprecipitation Assay282134972017Pubchem_assay
PRRID_2616Sindbis virus (SINV) RNA

Click for more detail

VirusNANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantTetrachlorodibenzo-p-dioxin (TCDD)- inducible poly(ADP ribose) polymerase (TIPARP)Pattern recognition receptor (PRR)MiceCytoplasmzinc finger domainQ8C1B2.fastaQ8C1B2657recruits an exosome to induce viral RNA degradation.RNA immunoprecipitation Assay282134972017Pubchem_assay
PRRID_2619single-stranded RNA

Click for more detail

Borrelia spp(Bacteria)NANANucleic AcidNaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainP58681.fastaP586811050NANA290389562017Pubchem_assay
PRRID_2619single-stranded RNA

Click for more detail

Borrelia spp(Bacteria)NANANucleic AcidNaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainP58681.fastaP586811050NANA290389562017Pubchem_assay
PRRID_2620single-stranded RNA

Click for more detail

Borrelia spp(Bacteria)NANANucleic AcidNaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainP58682.fastaP586821032NANA290389562017Pubchem_assay
PRRID_2620single-stranded RNA

Click for more detail

Borrelia spp(Bacteria)NANANucleic AcidNaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainP58682.fastaP586821032NANA290389562017Pubchem_assay
PRRID_2623single-stranded RNA

Click for more detail

Respiratory syncytial virus (virus) NANANucleic AcidNaturalRespiratory syncytial virus infection, activation of NOD2.Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)MiceCellular levelnucleotide-binding oligomerization domainQ8K3Z0.fastaQ8K3Z01020Activation of Type I interferon via detection of ssRNANA288235102017Pubchem_assay
PRRID_2623single-stranded RNA

Click for more detail

Respiratory syncytial virus (virus) NANANucleic AcidNaturalRespiratory syncytial virus infection, activation of NOD2.Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)MiceCellular levelnucleotide-binding oligomerization domainQ8K3Z0.fastaQ8K3Z01020Activation of Type I interferon via detection of ssRNANA288235102017Pubchem_assay
PRRID_2624single-stranded RNA

Click for more detail

Vesicular stomatitis (virus)NANANucleic AcidNaturalActivation of NOD2Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)MiceCellular levelnucleotide-binding oligomerization domainQ8K3Z0.fastaQ8K3Z01020Activation of Type I interferon via detection of ssRNANA288235102017Pubchem_assay
PRRID_2624single-stranded RNA

Click for more detail

Vesicular stomatitis (virus)NANANucleic AcidNaturalActivation of NOD2Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)MiceCellular levelnucleotide-binding oligomerization domainQ8K3Z0.fastaQ8K3Z01020Activation of Type I interferon via detection of ssRNANA288235102017Pubchem_assay