Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_2136Heat-shock proteins 60

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NAMLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573Damage-associated molecular patterns (DAMPs)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceBrainLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835mRNA ‚Üë in agingNA288015212017Pubchem_assay
PRRID_2136Heat-shock proteins 60

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NAMLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573Damage-associated molecular patterns (DAMPs)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceBrainLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835mRNA ‚Üë in agingNA288015212017Pubchem_assay
PRRID_2137Heat-shock proteins 60

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NAMLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573Damage-associated molecular patterns (DAMPs)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceBrainLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835mRNA ‚Üë in plaque- associated brain tissue of AD model miceNA288015212017Pubchem_assay
PRRID_2137Heat-shock proteins 60

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NAMLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573Damage-associated molecular patterns (DAMPs)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceBrainLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835mRNA ‚Üë in plaque- associated brain tissue of AD model miceNA288015212017Pubchem_assay
PRRID_2139Heat-shock proteins 60

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NAMLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573Damage-associated molecular patterns (DAMPs)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMicrogliaLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835involved in both amyloid-β uptake and inflammatory cytokine productionNA288015212017Pubchem_assay
PRRID_2139Heat-shock proteins 60

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NAMLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573Damage-associated molecular patterns (DAMPs)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMicrogliaLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835involved in both amyloid-β uptake and inflammatory cytokine productionNA288015212017Pubchem_assay
PRRID_2140Heat-shock proteins 60

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NAMLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573Damage-associated molecular patterns (DAMPs)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micemicroglia (mouse striatum)Leucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835TLR4 knockout: neuroprotective in ischemiaNA288015212017Pubchem_assay
PRRID_2140Heat-shock proteins 60

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NAMLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573Damage-associated molecular patterns (DAMPs)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micemicroglia (mouse striatum)Leucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835TLR4 knockout: neuroprotective in ischemiaNA288015212017Pubchem_assay
PRRID_2141Heat-shock proteins 60

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NAMLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573Damage-associated molecular patterns (DAMPs)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Miceneurons (mouse cortex)Leucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835protein ‚Üë, proapoptotic in ischemiaNA288015212017Pubchem_assay
PRRID_2141Heat-shock proteins 60

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NAMLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573Damage-associated molecular patterns (DAMPs)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Miceneurons (mouse cortex)Leucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835protein ‚Üë, proapoptotic in ischemiaNA288015212017Pubchem_assay
PRRID_2143Heat-shock proteins 60

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NAMLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573Damage-associated molecular patterns (DAMPs)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Miceprimary mouse astrocytesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835activation in response to α-synucleinNA288015212017Pubchem_assay
PRRID_2143Heat-shock proteins 60

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NAMLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573Damage-associated molecular patterns (DAMPs)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Miceprimary mouse astrocytesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835activation in response to α-synucleinNA288015212017Pubchem_assay
PRRID_2144Heat-shock proteins 60

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NAMLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573Damage-associated molecular patterns (DAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceBrainLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784mRNA ‚Üë in plaque- associated brain tissue of AD model miceNA288015212017Pubchem_assay
PRRID_2144Heat-shock proteins 60

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NAMLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573Damage-associated molecular patterns (DAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceBrainLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784mRNA ‚Üë in plaque- associated brain tissue of AD model miceNA288015212017Pubchem_assay
PRRID_2147Heat-shock proteins 60

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NAMLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573Damage-associated molecular patterns (DAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceMicrogliaLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784involved in both amyloid-β uptake and inflammatory cytokine productionNA288015212017Pubchem_assay
PRRID_2147Heat-shock proteins 60

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NAMLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573Damage-associated molecular patterns (DAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceMicrogliaLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784involved in both amyloid-β uptake and inflammatory cytokine productionNA288015212017Pubchem_assay
PRRID_2149Heat-shock proteins 60

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NAMLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573Damage-associated molecular patterns (DAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Miceneurons (mouse cortex)Leucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784protein ‚Üë, proapoptotic in ischemiaNA288015212017Pubchem_assay
PRRID_2149Heat-shock proteins 60

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NAMLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573Damage-associated molecular patterns (DAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Miceneurons (mouse cortex)Leucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784protein ‚Üë, proapoptotic in ischemiaNA288015212017Pubchem_assay
PRRID_2152Hemozoin

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Plasmodium falciparum (others)CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.[Fe+5].[Fe+5].[Fe+5].[Fe+5]NAPattern-associated molecular patterns (PAMPs)NaturalPlasmodium falciparum-infected erythro- cytes, that co-purifies with the parasite product hemozoin, stimulates NOD2 in a RIP2/CARD9- dependent manner to drive nitric oxide production by macrophagesNucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)MiceMacrophagesnucleotide-binding oligomerization domainQ8K3Z0.fastaQ8K3Z01020Hemozoin-mediated induction of NOSNA288235102017Pubchem_assay
PRRID_2152Hemozoin

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Plasmodium falciparum (others)CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.[Fe+5].[Fe+5].[Fe+5].[Fe+5]NAPattern-associated molecular patterns (PAMPs)NaturalPlasmodium falciparum-infected erythro- cytes, that co-purifies with the parasite product hemozoin, stimulates NOD2 in a RIP2/CARD9- dependent manner to drive nitric oxide production by macrophagesNucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)MiceMacrophagesnucleotide-binding oligomerization domainQ8K3Z0.fastaQ8K3Z01020Hemozoin-mediated induction of NOSNA288235102017Pubchem_assay
PRRID_2175HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalActivate the NF-κB pathway in murine embryonic fibrablasts.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)Embryonic fibroblastNAQ9QUN7.fastaQ9QUK7511NANA289610192017Pubchem_assay
PRRID_2175HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalActivate the NF-κB pathway in murine embryonic fibrablasts.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)Embryonic fibroblastNAQ9QUN7.fastaQ9QUK7511NANA289610192017Pubchem_assay
PRRID_2176HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalActivate the NF-κB pathway in murine embryonic fibrablasts.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)Embryonic fibroblastNAQ9QUK6.fastaQ9QUK6835NANA289610192017Pubchem_assay
PRRID_2176HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalActivate the NF-κB pathway in murine embryonic fibrablasts.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)Embryonic fibroblastNAQ9QUK6.fastaQ9QUK6835NANA289610192017Pubchem_assay
PRRID_2181HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micebrain (mononuclear phagocytes)Leucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784mRNA ‚Üë in agingNA288015212017Pubchem_assay
PRRID_2181HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micebrain (mononuclear phagocytes)Leucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784mRNA ‚Üë in agingNA288015212017Pubchem_assay
PRRID_2182HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceBrainLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835mRNA ‚Üë in agingNA288015212017Pubchem_assay
PRRID_2182HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceBrainLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835mRNA ‚Üë in agingNA288015212017Pubchem_assay
PRRID_2183HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceBrainLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835mRNA ‚Üë in plaque- associated brain tissue of AD model miceNA288015212017Pubchem_assay
PRRID_2183HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceBrainLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835mRNA ‚Üë in plaque- associated brain tissue of AD model miceNA288015212017Pubchem_assay
PRRID_2185HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMicrogliaLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835involved in both amyloid-β uptake and inflammatory cytokine productionNA288015212017Pubchem_assay
PRRID_2185HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMicrogliaLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835involved in both amyloid-β uptake and inflammatory cytokine productionNA288015212017Pubchem_assay
PRRID_2186HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micemicroglia (mouse striatum)Leucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835TLR4 knockout: neuroprotective in ischemiaNA288015212017Pubchem_assay
PRRID_2186HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micemicroglia (mouse striatum)Leucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835TLR4 knockout: neuroprotective in ischemiaNA288015212017Pubchem_assay
PRRID_2187HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Miceneurons (mouse cortex)Leucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835protein ‚Üë, proapoptotic in ischemiaNA288015212017Pubchem_assay
PRRID_2187HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Miceneurons (mouse cortex)Leucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835protein ‚Üë, proapoptotic in ischemiaNA288015212017Pubchem_assay
PRRID_2189HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Miceprimary mouse astrocytesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835activation in response to α-synucleinNA288015212017Pubchem_assay
PRRID_2189HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Miceprimary mouse astrocytesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835activation in response to α-synucleinNA288015212017Pubchem_assay
PRRID_2190HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceBrainLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784mRNA ‚Üë in plaque- associated brain tissue of AD model miceNA288015212017Pubchem_assay
PRRID_2190HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceBrainLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784mRNA ‚Üë in plaque- associated brain tissue of AD model miceNA288015212017Pubchem_assay
PRRID_2193HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceMicrogliaLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784involved in both amyloid-β uptake and inflammatory cytokine productionNA288015212017Pubchem_assay
PRRID_2193HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceMicrogliaLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784involved in both amyloid-β uptake and inflammatory cytokine productionNA288015212017Pubchem_assay
PRRID_2195HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Miceneurons (mouse cortex)Leucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784protein ‚Üë, proapoptotic in ischemiaNA288015212017Pubchem_assay
PRRID_2195HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Miceneurons (mouse cortex)Leucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784protein ‚Üë, proapoptotic in ischemiaNA288015212017Pubchem_assay
PRRID_2204Hyaluronic acid

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NACC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONADamage-associated molecular patterns (DAMPs)NaturalInduce the production of TNF-α, IL-1β and IL-12 by dendritic cellsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)MacrophagesNAQ9QUN7.fastaQ9QUN7784NANA289610192017Pubchem_assay
PRRID_2204Hyaluronic acid

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NACC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONADamage-associated molecular patterns (DAMPs)NaturalInduce the production of TNF-α, IL-1β and IL-12 by dendritic cellsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)MacrophagesNAQ9QUN7.fastaQ9QUN7784NANA289610192017Pubchem_assay
PRRID_2209Imidazoquinoline

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NACCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)NaturalSynthesis of IFNα, inflammatory cytokine production by macrophages, proliferation of splenocytes or maturation of DCs , Produce type I IFNs and other cytokines, maturation of pDCs, stimulate T-cells ,Reduces plasma virus concentration in chronic hepatitis C infectionToll-like receptor 7 (TLR7)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainP58681.fastaP586811050NANA290283692017Pubchem_assay
PRRID_2209Imidazoquinoline

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NACCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)NaturalSynthesis of IFNα, inflammatory cytokine production by macrophages, proliferation of splenocytes or maturation of DCs , Produce type I IFNs and other cytokines, maturation of pDCs, stimulate T-cells ,Reduces plasma virus concentration in chronic hepatitis C infectionToll-like receptor 7 (TLR7)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainP58681.fastaP586811050NANA290283692017Pubchem_assay
PRRID_2222LipL32

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Gram negative bacteria(Leptospira spp.)NANALipoproteinNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micesurface of epithelial cells and macrophages.Leucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784NANA290389562017Pubchem_assay
PRRID_2222LipL32

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Gram negative bacteria(Leptospira spp.)NANALipoproteinNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micesurface of epithelial cells and macrophages.Leucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784NANA290389562017Pubchem_assay
PRRID_2225lipo-arabinomannan

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Mycobacteria (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalActivation of NF-KB-driven luciferase activity in lung inflammation, Stimulate NFκB, induce apoptosis in THP- monocytice cellsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784NANA290283692017Pubchem_assay
PRRID_2225lipo-arabinomannan

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Mycobacteria (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalActivation of NF-KB-driven luciferase activity in lung inflammation, Stimulate NFκB, induce apoptosis in THP- monocytice cellsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784NANA290283692017Pubchem_assay
PRRID_2236Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA292647452017Pubchem_assay
PRRID_2236Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA292647452017Pubchem_assay
PRRID_2243Lipopolysaccharide (LPS)

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Gram negative bacteria(Leptospira spp.)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalinfectionToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NAELISA290389562017Pubchem_assay
PRRID_2243Lipopolysaccharide (LPS)

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Gram negative bacteria(Leptospira spp.)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalinfectionToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NAELISA290389562017Pubchem_assay
PRRID_2245Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalFormation of a complex between PI 3-kinase and MyD88, induction of IL-1β, TNF-α and macrophage inflammatory protein (MIP)-2, induce proinflammatory cytokine production through NF-KB signaling , Functional maturation of mouse macrophages, induction of TNF-α by Human Monocyte Cultures, Production of major proinflammatory cytokines such as IL-1, IL-6, or TNF-α; activate DC and promote the development of Th-like responsesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMouse macrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA290283692017Pubchem_assay
PRRID_2245Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalFormation of a complex between PI 3-kinase and MyD88, induction of IL-1β, TNF-α and macrophage inflammatory protein (MIP)-2, induce proinflammatory cytokine production through NF-KB signaling , Functional maturation of mouse macrophages, induction of TNF-α by Human Monocyte Cultures, Production of major proinflammatory cytokines such as IL-1, IL-6, or TNF-α; activate DC and promote the development of Th-like responsesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMouse macrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA290283692017Pubchem_assay
PRRID_2254Lipopolysaccharide (LPS)

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Pseudomonas aeruginosa (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalstimulation of THP-1 macrophagesMUC1 mucinPattern recognition receptor (PRR)Micesurface of epithelial cells and some hematopoietic cellsNAQ02496.fastaQ02496630phagocytic activity and cytokine productionELISA288227662017Pubchem_assay
PRRID_2254Lipopolysaccharide (LPS)

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Pseudomonas aeruginosa (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalstimulation of THP-1 macrophagesMUC1 mucinPattern recognition receptor (PRR)Micesurface of epithelial cells and some hematopoietic cellsNAQ02496.fastaQ02496630phagocytic activity and cytokine productionELISA288227662017Pubchem_assay
PRRID_2255Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceBrainLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835mRNA ‚Üë in agingNA288015212017Pubchem_assay
PRRID_2255Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceBrainLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835mRNA ‚Üë in agingNA288015212017Pubchem_assay
PRRID_2256Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceBrainLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835mRNA ‚Üë in plaque- associated brain tissue of AD model miceNA288015212017Pubchem_assay
PRRID_2256Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceBrainLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835mRNA ‚Üë in plaque- associated brain tissue of AD model miceNA288015212017Pubchem_assay
PRRID_2258Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMicrogliaLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835involved in both amyloid-β uptake and inflammatory cytokine productionNA288015212017Pubchem_assay
PRRID_2258Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMicrogliaLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835involved in both amyloid-β uptake and inflammatory cytokine productionNA288015212017Pubchem_assay
PRRID_2259Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micemicroglia (mouse striatum)Leucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835TLR4 knockout: neuroprotective in ischemiaNA288015212017Pubchem_assay
PRRID_2259Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micemicroglia (mouse striatum)Leucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835TLR4 knockout: neuroprotective in ischemiaNA288015212017Pubchem_assay
PRRID_2260Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Miceneurons (mouse cortex)Leucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835protein ‚Üë, proapoptotic in ischemiaNA288015212017Pubchem_assay
PRRID_2260Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Miceneurons (mouse cortex)Leucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835protein ‚Üë, proapoptotic in ischemiaNA288015212017Pubchem_assay
PRRID_2262Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Miceprimary mouse astrocytesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835activation in response to α-synucleinNA288015212017Pubchem_assay
PRRID_2262Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Miceprimary mouse astrocytesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835activation in response to α-synucleinNA288015212017Pubchem_assay
PRRID_2265Lipopolysaccharide (LPS)

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P. gulae (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalCauses inflammation and activation of TLR2.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceMacrophagesLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784activate NF-κB.NA286300662017Pubchem_assay
PRRID_2265Lipopolysaccharide (LPS)

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P. gulae (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalCauses inflammation and activation of TLR2.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceMacrophagesLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784activate NF-κB.NA286300662017Pubchem_assay
PRRID_2289Lipoprotein

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micemononuclear phagocytesLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784mRNA ‚Üë in agingNA288015212017Pubchem_assay
PRRID_2289Lipoprotein

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micemononuclear phagocytesLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784mRNA ‚Üë in agingNA288015212017Pubchem_assay
PRRID_2290Lipoprotein

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceBrainLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784mRNA ‚Üë in plaque- associated brain tissue of AD model miceNA288015212017Pubchem_assay
PRRID_2290Lipoprotein

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceBrainLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784mRNA ‚Üë in plaque- associated brain tissue of AD model miceNA288015212017Pubchem_assay
PRRID_2293Lipoprotein

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceMicrogliaLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784involved in both amyloid-β uptake and inflammatory cytokine productionNA288015212017Pubchem_assay
PRRID_2293Lipoprotein

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceMicrogliaLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784involved in both amyloid-β uptake and inflammatory cytokine productionNA288015212017Pubchem_assay
PRRID_2296Lipoprotein

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNeurons(cortex)Leucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784protein ‚Üë, proapoptotic in ischemiaNA288015212017Pubchem_assay
PRRID_2296Lipoprotein

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNeurons(cortex)Leucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784protein ‚Üë, proapoptotic in ischemiaNA288015212017Pubchem_assay
PRRID_2322Malassezia furfur, glycolipid

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2322Malassezia furfur, glycolipid

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2323Mannan

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Fungi(Yeast)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPolysaccharidesNaturalActivate macrophages and produce inflammatory responses, Induce NF-κB activation, induce PGE2, IL-1β, and TNF-α production, by macrophagesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA290283692017Pubchem_assay
PRRID_2323Mannan

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Fungi(Yeast)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPolysaccharidesNaturalActivate macrophages and produce inflammatory responses, Induce NF-κB activation, induce PGE2, IL-1β, and TNF-α production, by macrophagesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA290283692017Pubchem_assay
PRRID_2330Maturing conidia

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Aspergillus fumigatus(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244protective role in infection modelNA281676512017Pubchem_assay
PRRID_2330Maturing conidia

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Aspergillus fumigatus(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244protective role in infection modelNA281676512017Pubchem_assay
PRRID_2334MDP (muramyldipeptide)

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Gram-negative and Gram-positive bacteriaCC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)CNAPeptideNaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)MiceMicrogliaNAQ8R4B8.fastaQ8R4B81033NLRP3 inflammasome activation in AD modelsNA288015212017Pubchem_assay
PRRID_2334MDP (muramyldipeptide)

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Gram-negative and Gram-positive bacteriaCC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)CNAPeptideNaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)MiceMicrogliaNAQ8R4B8.fastaQ8R4B81033NLRP3 inflammasome activation in AD modelsNA288015212017Pubchem_assay
PRRID_2336MDP (muramyldipeptide)

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Gram-negative and Gram-positive bacteriaCC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)CNAPeptideNaturalNA Nod-like receptor protein 1 (NLRP1)NOD-like receptor (NLR)Micemodels of ADNAQ2LKU9.fastaQ2LKU91182protein ‚Üë in AD, role in neuronal pyroptosis and cognitive impairmentNA288015212017Pubchem_assay
PRRID_2336MDP (muramyldipeptide)

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Gram-negative and Gram-positive bacteriaCC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)CNAPeptideNaturalNA Nod-like receptor protein 1 (NLRP1)NOD-like receptor (NLR)Micemodels of ADNAQ2LKU9.fastaQ2LKU91182protein ‚Üë in AD, role in neuronal pyroptosis and cognitive impairmentNA288015212017Pubchem_assay
PRRID_2337MDP (muramyldipeptide)

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Gram-negative and Gram-positive bacteriaCC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)CNAPeptideNaturalNA Nod-like receptor protein 1 (NLRP1)NOD-like receptor (NLR)Micecortical neurons (cell culture, stroke model)NAQ2LKU9.fastaQ2LKU91182protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficitsNA288015212017Pubchem_assay
PRRID_2337MDP (muramyldipeptide)

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Gram-negative and Gram-positive bacteriaCC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)CNAPeptideNaturalNA Nod-like receptor protein 1 (NLRP1)NOD-like receptor (NLR)Micecortical neurons (cell culture, stroke model)NAQ2LKU9.fastaQ2LKU91182protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficitsNA288015212017Pubchem_assay
PRRID_2339MDP (muramyldipeptide)

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Gram-negative and Gram-positive bacteriaCC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)CNAPeptideNaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Micecortical neurons (cell culture, stroke model)NAQ8R4B8.fastaQ8R4B81033protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficitsNA288015212017Pubchem_assay
PRRID_2339MDP (muramyldipeptide)

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Gram-negative and Gram-positive bacteriaCC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)CNAPeptideNaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Micecortical neurons (cell culture, stroke model)NAQ8R4B8.fastaQ8R4B81033protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficitsNA288015212017Pubchem_assay
PRRID_2342methanol extract

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C.atratum(others)NANANANaturalanti- inflammatory activity against mastitisToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micemammary tissueLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835LPS from Gram-negative bacteria (Miyake et al., 2002). LPS activates the TLR4-mediated signal pathway and leads to the activation of NF-κB, MAPKs to regulate the release of pro-inflammatory cytokines.NA291138062017Pubchem_assay
PRRID_2342methanol extract

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C.atratum(others)NANANANaturalanti- inflammatory activity against mastitisToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micemammary tissueLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835LPS from Gram-negative bacteria (Miyake et al., 2002). LPS activates the TLR4-mediated signal pathway and leads to the activation of NF-κB, MAPKs to regulate the release of pro-inflammatory cytokines.NA291138062017Pubchem_assay
PRRID_2351muramyl dipeptide (MDP)

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BacteriaCC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)CNANANaturalNANucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)MiceNANAQ8K3Z0.fastaQ8K3Z01020NANA290389562017Pubchem_assay
PRRID_2351muramyl dipeptide (MDP)

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BacteriaCC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)CNANANaturalNANucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)MiceNANAQ8K3Z0.fastaQ8K3Z01020NANA290389562017Pubchem_assay