| Role of Ligand | Formation of a complex between PI 3-kinase and MyD88, induction of IL-1β, TNF-α and macrophage inflammatory protein (MIP)-2, induce proinflammatory cytokine production through NF-KB signaling , Functional maturation of mouse macrophages, induction of TNF-α by Human Monocyte Cultures, Production of major proinflammatory cytokines such as IL-1, IL-6, or TNF-α; activate DC and promote the development of Th-like responses |
| Primary information |
|---|
| PRRID | PRRID_2245 |
| Ligand Name | Lipopolysaccharide (LPS) |
| Source | Gram-negative bacteria |
| Sequence of ligand | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC |
| Length | NA |
| Type | Lipopolysaccharide (LPS) |
| Occurence | Natural |
| Role of Ligand | Formation of a complex between PI 3-kinase and MyD88, induction of IL-1β, TNF-α and macrophage inflammatory protein (MIP)-2, induce proinflammatory cytokine production through NF-KB signaling , Functional maturation of mouse macrophages, induction of TNF-α by Human Monocyte Cultures, Production of major proinflammatory cytokines such as IL-1, IL-6, or TNF-α; activate DC and promote the development of Th-like responses |
| Name of receptor | Toll-like receptor 4 (TLR4) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Mice |
| Localization | Mouse macrophages |
| Domain | Leucine-rich Repeat (LRR) Domain |
| Sequence of Receptor | Q9QUK6.fasta |
| Swiss prot ID | Q9QUK6 |
| Length Of Receptor | 835 |
| Function | NA |
| Assay used | NA |
| PMID | 29028369 |
| Year of Publication | 2017 |
| Pubchem assay | Pubchem_assay |