Browse By Oncolytic Virus Species Result Page of OvirusTdb

The Total number of records shown on this page is 100. Click on ID to see further detail.
IDOV_380Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cholangiocarcinoma cell lineCell lineKMCH-1Concentration of cell line3.0E+3 cells per wellIn-vitro toxicityNAAssayDojindo cell counting kitIn-vitro virus concentration0.01 MOIIn-vitro result13% cancer cell viability on 7 dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26584530
IDOV_381Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cholangiocarcinoma cell lineCell lineKMC-1Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayDojindo cell counting kitIn-vitro virus concentration0.01 MOIIn-vitro result13% cancer cell viability on 7 dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26584530
IDOV_382Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cholangiocarcinoma cell lineCell lineKMBCConcentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayDojindo cell counting kitIn-vitro virus concentration0.01 MOIIn-vitro result90% cancer cell viability on 7 dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26584530
IDOV_383Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cholangiocarcinoma cell lineCell lineKMCH-1Concentration of cell line3.0E+3 cells per wellIn-vitro toxicityNAAssayDojindo cell counting kitIn-vitro virus concentration0.1 MOIIn-vitro result13% cancer cell viability on 7 dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26584530
IDOV_384Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cholangiocarcinoma cell lineCell lineKMC-1Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayDojindo cell counting kitIn-vitro virus concentration0.1 MOIIn-vitro result13% cancer cell viability on 7 dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26584530
IDOV_385Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cholangiocarcinoma cell lineCell lineKMBCConcentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayDojindo cell counting kitIn-vitro virus concentration0.1 MOIIn-vitro result48% cancer cell viability on 7 dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26584530
IDOV_386Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cholangiocarcinoma cell lineCell lineKMCH-1Concentration of cell line3.0E+3 cells per wellIn-vitro toxicityNAAssayDojindo cell counting kitIn-vitro virus concentration1 MOIIn-vitro result13% cancer cell viability on 7 dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26584530
IDOV_387Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cholangiocarcinoma cell lineCell lineKMC-1Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayDojindo cell counting kitIn-vitro virus concentration1 MOIIn-vitro result13% cancer cell viability on 7 dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26584530
IDOV_388Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cholangiocarcinoma cell lineCell lineKMBCConcentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayDojindo cell counting kitIn-vitro virus concentration1 MOIIn-vitro result20% cancer cell viability on 7 dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26584530
IDOV_389Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cholangiocarcinoma cell lineCell lineKMCH-1Concentration of cell line3.0E+3 cells per wellIn-vitro toxicityNAAssayDojindo cell counting kitIn-vitro virus concentration5 MOIIn-vitro result13% cancer cell viability on 7 dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26584530
IDOV_390Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cholangiocarcinoma cell lineCell lineKMC-1Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayDojindo cell counting kitIn-vitro virus concentration5 MOIIn-vitro result13% cancer cell viability on 7 dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26584530
IDOV_391Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman cholangiocarcinoma cell lineCell lineKMBCConcentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayDojindo cell counting kitIn-vitro virus concentration5 MOIIn-vitro result20% cancer cell viability on 7 dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26584530
IDOV_392Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHomozygous athymic female nude mice (subcutaneously injected with KMC-1 cells suspended in 50 μl Matrigel)In-vivo virus concentration1.0E+7 PFUIn-vivo toxicityNA In-vivo resultReduction in tumor volume to 30 cubic millimeter compared to control 200 cubic millimeter after 15 daysMode of deliveryIntratumorallyPathway inducedNAImmunogenic effectNAClinical trialNAPMID26584530
IDOV_727Virus nameVaccinia virusVirus strainVV-OncoVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationThe viral thymidine kinase (TK) gene is insertionally inactivatedVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLiver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, ChinaOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineMHCC97-HConcentration of cell line5000 to 7000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result70% cancer cell viability at 96 hours post-infectionModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID27441866
IDOV_728Virus nameVaccinia virusVirus strainVV-OncoVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationThe viral thymidine kinase (TK) gene is insertionally inactivatedVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLiver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, ChinaOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineMHCC97-HConcentration of cell line5000 to 7000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result50% cancer cell viability at 96 hours post-infectionModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID27441866
IDOV_1907Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMalignan small cell canine carcinoma cell lineCell lineMTH52cConcentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result100% cell survival after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectVirus cause increase expression of ApoA1, IL-2,11,18,IFN-gamma, IP-10, MCP-1,3,5,MIP-2,MMP-9 and TNF alphaClinical trialNAPMID20631910
IDOV_1908Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMalignan small cell canine carcinoma cell lineCell lineMTH52cConcentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result50% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectVirus cause increase expression of ApoA1, IL-2,11,18,IFN-gamma, IP-10, MCP-1,3,5,MIP-2,MMP-9 and TNF alphaClinical trialNAPMID20631910
IDOV_1909Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMalignan small cell canine carcinoma cell lineCell lineMTH52cConcentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result30% cell survival after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectVirus cause increase expression of ApoA1, IL-2,11,18,IFN-gamma, IP-10, MCP-1,3,5,MIP-2,MMP-9 and TNF alphaClinical trialNAPMID20631910
IDOV_1910Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMalignan small cell canine carcinoma cell lineCell lineMTH52cConcentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result100% cell death after 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectVirus cause increase expression of ApoA1, IL-2,11,18,IFN-gamma, IP-10, MCP-1,3,5,MIP-2,MMP-9 and TNF alphaClinical trialNAPMID20631910
IDOV_1911Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMalignan small cell canine carcinoma cell lineCell lineMTH52cConcentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result50% cell survival after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectVirus cause increase expression of ApoA1, IL-2,11,18,IFN-gamma, IP-10, MCP-1,3,5,MIP-2,MMP-9 and TNF alphaClinical trialNAPMID20631910
IDOV_1912Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMalignan small cell canine carcinoma cell lineCell lineMTH52cConcentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result25% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectVirus cause increase expression of ApoA1, IL-2,11,18,IFN-gamma, IP-10, MCP-1,3,5,MIP-2,MMP-9 and TNF alphaClinical trialNAPMID20631910
IDOV_1913Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMalignan small cell canine carcinoma cell lineCell lineMTH52cConcentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result5% cell survival after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectVirus cause increase expression of ApoA1, IL-2,11,18,IFN-gamma, IP-10, MCP-1,3,5,MIP-2,MMP-9 and TNF alphaClinical trialNAPMID20631910
IDOV_1914Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMalignan small cell canine carcinoma cell lineCell lineMTH52cConcentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result100% cell death after 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectVirus cause increase expression of ApoA1, IL-2,11,18,IFN-gamma, IP-10, MCP-1,3,5,MIP-2,MMP-9 and TNF alphaClinical trialNAPMID20631910
IDOV_1915Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMalignan small cell canine carcinoma cell lineCell lineMTH52cConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for MTH52c cell lineIn-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultSignificant decrease in tumor volume after 42 daysMode of deliveryNAPathway inducedNAImmunogenic effectVirus cause increase expression of ApoA1, IL-2,11,18,IFN-gamma, IP-10, MCP-1,3,5,MIP-2,MMP-9 and TNF alphaClinical trialNAPMID20631910
IDOV_2047Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineHuh-7Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result50% cell survival after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis in cancer cell lineImmunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2Clinical trialNAPMID21779374
IDOV_2048Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineHuh-7Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result20% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis in cancer cell lineImmunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2Clinical trialNAPMID21779374
IDOV_2049Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineHuh-7Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result20% cell survival after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis in cancer cell lineImmunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2Clinical trialNAPMID21779374
IDOV_2050Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineHuh-7Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result22% cell survival after 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis in cancer cell lineImmunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2Clinical trialNAPMID21779374
IDOV_2051Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineHuh-7Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result90% cell survival after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis in cancer cell lineImmunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2Clinical trialNAPMID21779374
IDOV_2052Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineHuh-7Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result58% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis in cancer cell lineImmunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2Clinical trialNAPMID21779374
IDOV_2053Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineHuh-7Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result30% cell survial after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis in cancer cell lineImmunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2Clinical trialNAPMID21779374
IDOV_2054Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineHuh-7Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result22% cell survival after 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis in cancer cell lineImmunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2Clinical trialNAPMID21779374
IDOV_2055Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell linePLCConcentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result100% cell survival after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis in cancer cell lineImmunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2Clinical trialNAPMID21779374
IDOV_2056Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell linePLCConcentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result80% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis in cancer cell lineImmunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2Clinical trialNAPMID21779374
IDOV_2057Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell linePLCConcentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result30% cell survival after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis in cancer cell lineImmunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2Clinical trialNAPMID21779374
IDOV_2058Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell linePLCConcentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result30% cell survival after 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis in cancer cell lineImmunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2Clinical trialNAPMID21779374
IDOV_2059Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell linePLCConcentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result80% cell survival after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis in cancer cell lineImmunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2Clinical trialNAPMID21779374
IDOV_2060Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell linePLCConcentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result30% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis in cancer cell lineImmunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2Clinical trialNAPMID21779374
IDOV_2061Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell linePLCConcentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result20% cell survival after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis in cancer cell lineImmunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2Clinical trialNAPMID21779374
IDOV_2062Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell linePLCConcentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result20% cell survival after 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis in cancer cell lineImmunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2Clinical trialNAPMID21779374
IDOV_2063Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell linePLCConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismAthymic hsd nude mice xenograft for PLC cell lineIn-vivo virus concentration5.0E+6 pfuIn-vivo toxicityReduction in tumor volume below 2000mm compared to control after 45 days In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis in cancer cell lineImmunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2Clinical trialNAPMID21779374
IDOV_2064Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineHuh-7Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismAthymic hsd nude mice xenograft for PLC cell lineIn-vivo virus concentration5.0E+6 pfuIn-vivo toxicityReduction in tumor volume below 3000mm compared to control after 35 days In-vivo resultMode of deliveryNAPathway inducedInduction of apoptosis in cancer cell lineImmunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2Clinical trialNAPMID21779374
IDOV_2412Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT-8Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro resultNo cell killing after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2413Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT-8Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro resultNo cell killing after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2414Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT-8Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro resultNo cell killing after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2415Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT-8Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result50% cell killing after day 7Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2416Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT-8Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result40% cell survival after day 9Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2417Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePANC-1Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result100% cell survival after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2418Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePANC-1Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result100% cell survival after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2419Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePANC-1Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result90% cell survival after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2420Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePANC-1Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result20% cell survival after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2421Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePANC-1Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result100% cell killing after day 9Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2422Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman gastric cancer cell lineCell lineMKN-45Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result100% cell survival after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2423Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman gastric cancer cell lineCell lineMKN-45Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result100% cell survival after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2424Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman gastric cancer cell lineCell lineMKN-45Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result100% cell survival after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2425Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman gastric cancer cell lineCell lineMKN-45Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result100% cell survival after day 7Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2426Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman gastric cancer cell lineCell lineMKN-45Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result100% cell survival after day 9Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2427Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman squamous cell lineCell lineSCC-25Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result100% cell survival after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2428Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman squamous cell lineCell lineSCC-25Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result100% cell survival after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2429Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman squamous cell lineCell lineSCC-25Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result100% cell survival after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2430Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman squamous cell lineCell lineSCC-25Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result50% cell killing after day 7Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2431Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman squamous cell lineCell lineSCC-25Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result60% cell killing after day 9Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2432Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman mesothelia cell lineCell lineMSTO-211Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result100% cell survival after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2433Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman mesothelia cell lineCell lineMSTO-211Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result100% cell survival after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2434Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman mesothelia cell lineCell lineMSTO-211Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result100% cell survival after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2435Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman mesothelia cell lineCell lineMSTO-211Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result50% cell killing after day 7Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2436Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman mesothelia cell lineCell lineMSTO-211Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result60% cell killing after day 9Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2437Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH1650Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result100% cell survival after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2438Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH1650Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result100% cell survival after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2439Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH1650Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result90% cell survival after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2440Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH1650Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result90% cell survival after day 7Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2441Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH1650Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result80% cell survival after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2442Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman breast cancer cell lineCell lineMDA-MB-231Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result100% cell survival after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2443Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman breast cancer cell lineCell lineMDA-MB-231Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result100% cell survival after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2444Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman breast cancer cell lineCell lineMDA-MB-231Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result100% cell survival after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2445Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman breast cancer cell lineCell lineMDA-MB-231Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result100% cell survival after day 7Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2446Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman breast cancer cell lineCell lineMDA-MB-231Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result100% cell survival after day 9Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2447Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman thyroid cancer cell lineCell line8505cConcentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result100% cell survival after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2448Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman thyroid cancer cell lineCell line8505cConcentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result100% cell survival after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2449Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman thyroid cancer cell lineCell line8505cConcentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result90% cell survival after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2450Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman thyroid cancer cell lineCell line8505cConcentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result60% cell survival after day 7Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2451Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman thyroid cancer cell lineCell line8505cConcentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.01 MOIIn-vitro result10% cell survival after day 9Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2452Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT-8Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result100% cell survival after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2453Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT-8Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result100% cell survival after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2454Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT-8Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result100% cell survival after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2455Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT-8Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result70% cell survival after day 7Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2456Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT-8Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result30% cell survival after day 7Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2457Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePANC-1Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result100% cell survival after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2458Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePANC-1Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result90% cell survival after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2459Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePANC-1Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result50% cell survival after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2460Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePANC-1Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result10% cell survival after day 7Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2461Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePANC-1Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result100% cell death after day 9Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2462Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman gastric cancer cell lineCell lineMKN-45Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result100% cell survival after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2463Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman gastric cancer cell lineCell lineMKN-45Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result100% cell survival after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2464Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman gastric cancer cell lineCell lineMKN-45Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result100% cell survival after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2465Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman gastric cancer cell lineCell lineMKN-45Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result100% cell survival after day 7Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2466Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman gastric cancer cell lineCell lineMKN-45Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result80% cell survival after day 9Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2467Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman squamous cell lineCell lineSCC-25Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result100% cell survival after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2468Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman squamous cell lineCell lineSCC-25Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result90% cell survival after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2469Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman squamous cell lineCell lineSCC-25Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result50% cell survival after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815