Browse By Oncolytic Virus Species Result Page of OvirusTdb

The Total number of records shown on this page is 100. Click on ID to see further detail.
IDOV_4953Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result40% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4954Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.01 MOIIn-vitro result60% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4955Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result40% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4956Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result60% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4957Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result70% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4958Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.01 MOIIn-vitro result80% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4959Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result70% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4960Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result80% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4961Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result90% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4962Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.01 MOIIn-vitro result90% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4963Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result20% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4964Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result50% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4965Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result60% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4966Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.01 MOIIn-vitro result80% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4967Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result60% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4968Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result70% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4969Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result100% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4970Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.01 MOIIn-vitro result100% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4971Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineLewis lung cancer cell lineCell lineLLCConcentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 MOIIn-vitro result60% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4972Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineLewis lung cancer cell lineCell lineLLCConcentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration5 MOIIn-vitro result40% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4973Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineLewis lung cancer cell lineCell lineLLCConcentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 MOIIn-vitro result20% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4974Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineLewis lung cancer cell lineCell lineLLCConcentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration5 MOIIn-vitro result5% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4975Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineLewis lung cancer cell lineCell lineLLCConcentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 MOIIn-vitro result44% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4976Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineLewis lung cancer cell lineCell lineLLCConcentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration5 MOIIn-vitro result35% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4977Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineLewis lung cancer cell lineCell lineLLCConcentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 MOIIn-vitro result20% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4978Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineLewis lung cancer cell lineCell lineLLCConcentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration5 MOIIn-vitro result2% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4979Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismC54BL/6 mice xenograft for A549 cell line (5.0E+6)In-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultReduction in tumor volume to 1000 cubic mm compared to control 2200 cubic mm after 27 daysMode of deliveryIntratumoralPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4980Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismImmunocompetant mice xenograft for LLCIn-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultReduction in tumor volume to 5000 cubic mm compared to control 10000 cubic mm after 15 daysMode of deliveryIntratumoralPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_5007Virus nameVaccinia virusVirus strainVG9Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMurine melanoma cell lineCell lineB16Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result35% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5008Virus nameVaccinia virusVirus strainVG9Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMurine melanoma cell lineCell lineB16Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result22% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5009Virus nameVaccinia virusVirus strainVG9Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMurine melanoma cell lineCell lineB16Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result20% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5010Virus nameVaccinia virusVirus strainVG9-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMurine melanoma cell lineCell lineB16Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result36% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5011Virus nameVaccinia virusVirus strainVG9-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMurine melanoma cell lineCell lineB16Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result24% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5012Virus nameVaccinia virusVirus strainVG9-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMurine melanoma cell lineCell lineB16Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result20% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5013Virus nameVaccinia virusVirus strainWR-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMurine melanoma cell lineCell lineB16Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result35% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5014Virus nameVaccinia virusVirus strainWR-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMurine melanoma cell lineCell lineB16Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result22% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5015Virus nameVaccinia virusVirus strainWR-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMurine melanoma cell lineCell lineB16Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result18% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5016Virus nameVaccinia virusVirus strainVG9Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result55% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5017Virus nameVaccinia virusVirus strainVG9Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result42% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5018Virus nameVaccinia virusVirus strainVG9Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result30% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5019Virus nameVaccinia virusVirus strainVG9-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result58% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5020Virus nameVaccinia virusVirus strainVG9-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result44% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5021Virus nameVaccinia virusVirus strainVG9-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result40% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5022Virus nameVaccinia virusVirus strainWR-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result58% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5023Virus nameVaccinia virusVirus strainWR-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result46% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5024Virus nameVaccinia virusVirus strainWR-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result40% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5025Virus nameVaccinia virusVirus strainVG9Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman gastric carcinoma cell lineCell lineSCG-7901Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result68% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5026Virus nameVaccinia virusVirus strainVG9Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman gastric carcinoma cell lineCell lineSCG-7901Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result36% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5027Virus nameVaccinia virusVirus strainVG9Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman gastric carcinoma cell lineCell lineSCG-7901Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result26% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5028Virus nameVaccinia virusVirus strainVG9-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman gastric carcinoma cell lineCell lineSCG-7901Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result68% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5029Virus nameVaccinia virusVirus strainVG9-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman gastric carcinoma cell lineCell lineSCG-7901Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result40% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5030Virus nameVaccinia virusVirus strainVG9-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman gastric carcinoma cell lineCell lineSCG-7901Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result20% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5031Virus nameVaccinia virusVirus strainWR-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman gastric carcinoma cell lineCell lineSCG-7901Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result65% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5032Virus nameVaccinia virusVirus strainWR-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman gastric carcinoma cell lineCell lineSCG-7901Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result36% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5033Virus nameVaccinia virusVirus strainWR-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman gastric carcinoma cell lineCell lineSCG-7901Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result22% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5034Virus nameVaccinia virusVirus strainVG9Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMurine hepatoma cell lineCell lineHepal-6Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result50% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5035Virus nameVaccinia virusVirus strainVG9Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMurine hepatoma cell lineCell lineHepal-6Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result40% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5036Virus nameVaccinia virusVirus strainVG9Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMurine hepatoma cell lineCell lineHepal-6Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result25% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5037Virus nameVaccinia virusVirus strainVG9-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMurine hepatoma cell lineCell lineHepal-6Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result52% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5038Virus nameVaccinia virusVirus strainVG9-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMurine hepatoma cell lineCell lineHepal-6Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result38% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5039Virus nameVaccinia virusVirus strainVG9-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMurine hepatoma cell lineCell lineHepal-6Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result25% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5040Virus nameVaccinia virusVirus strainWR-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMurine hepatoma cell lineCell lineHepal-6Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result51% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5041Virus nameVaccinia virusVirus strainWR-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMurine hepatoma cell lineCell lineHepal-6Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result38% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5042Virus nameVaccinia virusVirus strainWR-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMurine hepatoma cell lineCell lineHepal-6Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result21% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5043Virus nameVaccinia virusVirus strainVG9Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman breast adenocarcinoma cell lineCell lineMDA-MB-231Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result40% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5044Virus nameVaccinia virusVirus strainVG9Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman breast adenocarcinoma cell lineCell lineMDA-MB-231Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result30% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5045Virus nameVaccinia virusVirus strainVG9Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman breast adenocarcinoma cell lineCell lineMDA-MB-231Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result20% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5046Virus nameVaccinia virusVirus strainVG9-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman breast adenocarcinoma cell lineCell lineMDA-MB-231Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result30% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5047Virus nameVaccinia virusVirus strainVG9-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman breast adenocarcinoma cell lineCell lineMDA-MB-231Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result30% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5048Virus nameVaccinia virusVirus strainVG9-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman breast adenocarcinoma cell lineCell lineMDA-MB-231Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result20% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5049Virus nameVaccinia virusVirus strainWR-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman breast adenocarcinoma cell lineCell lineMDA-MB-231Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result30% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5050Virus nameVaccinia virusVirus strainWR-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman breast adenocarcinoma cell lineCell lineMDA-MB-231Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result30% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5051Virus nameVaccinia virusVirus strainWR-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman breast adenocarcinoma cell lineCell lineMDA-MB-231Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result20% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5052Virus nameVaccinia virusVirus strainVG9Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineSMMC7721Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result50% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5053Virus nameVaccinia virusVirus strainVG9Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineSMMC7721Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result35% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5054Virus nameVaccinia virusVirus strainVG9Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineSMMC7721Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result20% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5055Virus nameVaccinia virusVirus strainVG9-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineSMMC7721Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result50% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5056Virus nameVaccinia virusVirus strainVG9-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineSMMC7721Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result35% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5057Virus nameVaccinia virusVirus strainVG9-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineSMMC7721Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result22% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5058Virus nameVaccinia virusVirus strainWR-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineSMMC7721Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result50% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5059Virus nameVaccinia virusVirus strainWR-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineSMMC7721Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result35% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5060Virus nameVaccinia virusVirus strainWR-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineSMMC7721Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result21% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5061Virus nameVaccinia virusVirus strainVG9-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismC56BL/6 mice xenograft for SMMC-7721 (1.0E+6 cells )In-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultProlongs the survival timeMode of deliveryIntratumoralPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5062Virus nameVaccinia virusVirus strainWR-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismC56BL/6 mice xenograft for SMMC-7721 (1.0E+6 cells )In-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultProlongs the survival timeMode of deliveryIntratumoralPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5092Virus nameVaccinia virusVirus strainvvdd-tdTomato-hDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of human DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing human DAI geneSource of cell lineATCCOrigin of cell lineHuman melanoma cell lineCell lineHS294TConcentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.001 MOIIn-vitro result70% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5093Virus nameVaccinia virusVirus strainvvdd-tdTomato-hDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of human DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing human DAI geneSource of cell lineATCCOrigin of cell lineHuman melanoma cell lineCell lineHS294TConcentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.01 MOIIn-vitro result50% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5094Virus nameVaccinia virusVirus strainvvdd-tdTomato-hDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of human DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing human DAI geneSource of cell lineATCCOrigin of cell lineHuman melanoma cell lineCell lineHS294TConcentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.1 MOIIn-vitro result20% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5095Virus nameVaccinia virusVirus strainvvdd-tdTomato-hDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of human DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing human DAI geneSource of cell lineATCCOrigin of cell lineHuman melanoma cell lineCell lineHS294TConcentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration1 MOIIn-vitro result10% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5096Virus nameVaccinia virusVirus strainvvdd-tdTomato-mDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of murine DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing murine DAI geneSource of cell lineATCCOrigin of cell lineHuman melanoma cell lineCell lineHS294TConcentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.001 MOIIn-vitro result70% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5097Virus nameVaccinia virusVirus strainvvdd-tdTomato-mDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of murine DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing murine DAI geneSource of cell lineATCCOrigin of cell lineHuman melanoma cell lineCell lineHS294TConcentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.01 MOIIn-vitro result60% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5098Virus nameVaccinia virusVirus strainvvdd-tdTomato-mDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of murine DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing murine DAI geneSource of cell lineATCCOrigin of cell lineHuman melanoma cell lineCell lineHS294TConcentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.1 MOIIn-vitro result40% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5099Virus nameVaccinia virusVirus strainvvdd-tdTomato-mDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of murine DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing murine DAI geneSource of cell lineATCCOrigin of cell lineHuman melanoma cell lineCell lineHS294TConcentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration1 MOIIn-vitro result10% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5100Virus nameVaccinia virusVirus strainvvdd-tdTomato-hDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of human DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing human DAI geneSource of cell lineATCCOrigin of cell lineHuman melanoma cell lineCell lineA2058Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.001 MOIIn-vitro result60% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5101Virus nameVaccinia virusVirus strainvvdd-tdTomato-hDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of human DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing human DAI geneSource of cell lineATCCOrigin of cell lineHuman melanoma cell lineCell lineA2058Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.01 MOIIn-vitro result30% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5102Virus nameVaccinia virusVirus strainvvdd-tdTomato-hDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of human DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing human DAI geneSource of cell lineATCCOrigin of cell lineHuman melanoma cell lineCell lineA2058Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.1 MOIIn-vitro result10% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5103Virus nameVaccinia virusVirus strainvvdd-tdTomato-hDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of human DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing human DAI geneSource of cell lineATCCOrigin of cell lineHuman melanoma cell lineCell lineA2058Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration1 MOIIn-vitro result100% cell killingModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5104Virus nameVaccinia virusVirus strainvvdd-tdTomato-mDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of murine DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing murine DAI geneSource of cell lineATCCOrigin of cell lineHuman melanoma cell lineCell lineA2058Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.001 MOIIn-vitro result80% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5105Virus nameVaccinia virusVirus strainvvdd-tdTomato-mDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of murine DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing murine DAI geneSource of cell lineATCCOrigin of cell lineHuman melanoma cell lineCell lineA2058Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.01 MOIIn-vitro result30% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5106Virus nameVaccinia virusVirus strainvvdd-tdTomato-mDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of murine DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing murine DAI geneSource of cell lineATCCOrigin of cell lineHuman melanoma cell lineCell lineA2058Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.1 MOIIn-vitro result10% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5107Virus nameVaccinia virusVirus strainvvdd-tdTomato-mDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of murine DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing murine DAI geneSource of cell lineATCCOrigin of cell lineHuman melanoma cell lineCell lineA2058Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration1 MOIIn-vitro result100% cell killingModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058