Detailed description page of Selected OV_ID


OV_4979 details
Primary information
OV_IDOV_4979
Virus Name Vaccinia virus
Strainvv-IL-24
Virus typeDNA
Virus familyPoxviridae
Modification in virus genomeInsertion of IL-24 gene in tk locus
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeVirus expressing IL-24 gene
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismC54BL/6 mice xenograft for A549 cell line (5× 10⁶)
In-vivo virus concentration1× 10⁷ pfu
In-vivo toxicityNA
In-vivo resultReduction in tumor volume to 1000 cubic mm compared to control 2200 cubic mm after 27 days
Mode of deliveryIntratumoral
Pathway inductionInduction of apoptosis
Immunogenic effectNA
Clinical trialNA
PMID27208781