Detailed description page of Selected OV_ID


OV_4980 details
Primary information
OV_IDOV_4980
Virus Name Vaccinia virus
Strainvv-IL-24
Virus typeDNA
Virus familyPoxviridae
Modification in virus genomeInsertion of IL-24 gene in tk locus
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeVirus expressing IL-24 gene
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismImmunocompetant mice xenograft for LLC
In-vivo virus concentration1× 10⁷ pfu
In-vivo toxicityNA
In-vivo resultReduction in tumor volume to 5000 cubic mm compared to control 10000 cubic mm after 15 days
Mode of deliveryIntratumoral
Pathway inductionInduction of apoptosis
Immunogenic effectNA
Clinical trialNA
PMID27208781