Browse By Oncolytic Virus Species Result Page of OvirusTdb

The Total number of records shown on this page is 100. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_1902	Herpes simplex virus	NV1082	DNA	Herpesviridae	Insertion of HSV-2 DNA at UL and US sequences, deletion of ICP4 and gamma 34.5 gene	No	Virus alongwith radiation 2.5 Gy	No	ATCC	Human pancreatic cancer cell line	PANC-1	2.0E+4 cells per well	NA	LDH release assay	0.1 MOI	80% cell survival after day 5	No	No	NA	No response	NA	Induction of apoptosis by the virus	NA	NA	20629009
OV_1903	Herpes simplex virus	NV1082	DNA	Herpesviridae	Insertion of HSV-2 DNA at UL and US sequences, deletion of ICP4 and gamma 34.5 gene	No	Virus alongwith radiation 5 Gy	No	ATCC	Human pancreatic cancer cell line	PANC-1	2.0E+4 cells per well	NA	LDH release assay	0.2 MOI	35% cell survival after day 5	No	No	NA	No response	NA	Induction of apoptosis by the virus	NA	NA	20629009
OV_1904	Herpes simplex virus	NV1082	DNA	Herpesviridae	Insertion of HSV-2 DNA at UL and US sequences, deletion of ICP4 and gamma 34.5 gene	No	Virus alongwith radiation 10 Gy	No	ATCC	Human pancreatic cancer cell line	PANC-1	2.0E+4 cells per well	NA	LDH release assay	0.4 MOI	30% cell survival after day 5	No	No	NA	No response	NA	Induction of apoptosis by the virus	NA	NA	20629009
OV_1905	Herpes simplex virus	NV1082	DNA	Herpesviridae	Insertion of HSV-2 DNA at UL and US sequences, deletion of ICP4 and gamma 34.5 gene	No	Virus alongwith radiation 20 Gy	No	ATCC	Human pancreatic cancer cell line	PANC-1	2.0E+4 cells per well	NA	LDH release assay	0.8 MOI	20% cell survival after day 5	No	No	NA	No response	NA	Induction of apoptosis by the virus	NA	NA	20629009
OV_1906	Herpes simplex virus	NV1082	DNA	Herpesviridae	Insertion of HSV-2 DNA at UL and US sequences, deletion of ICP4 and gamma 34.5 gene	No	Virus alongwith radiation 40 Gy	No	ATCC	Human pancreatic cancer cell line	PANC-1	2.0E+4 cells per well	NA	LDH release assay	1.6 MOI	15% cell survival after day 5	No	No	NA	No response	NA	Induction of apoptosis by the virus	NA	NA	20629009
OV_2169	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	CNE-2	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	98% cell survival after day 1	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2170	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	CNE-2	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	90% cell survival after day 2	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2171	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	CNE-2	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	70% cell survival after day 3	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2172	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	CNE-2	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	30% cell survival after day 4	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2173	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	CNE-2	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	10% cell survival after day 5	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2174	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	CNE-2	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	85% cell survival after day 1	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2175	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	CNE-2	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	70% cell survival after day 2	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2176	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	CNE-2	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	30% cell survival after day 3	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2177	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	CNE-2	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	10% cell survival after day 4	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2178	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	CNE-2	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	All cells was dead after day 5	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2179	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	SUNE-1	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	90% cell survival after day 1	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2180	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	SUNE-1	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	70% cell survival after day 2	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2181	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	SUNE-1	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	20% cell survival after day 3	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2182	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	SUNE-1	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	5% cell survival after day 4	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2183	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	SUNE-1	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	All cells was dead after day 5	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2184	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	SUNE-1	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	80% cell survival after day 1	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2185	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	SUNE-1	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	30% cell survival after day 2	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2186	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	SUNE-1	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	10% cell survival after day 3	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2187	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	SUNE-1	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	All cells was dead after day 4	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2188	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	SUNE-1	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	All cells was dead after day 5	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2189	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	NPEC2/Bm1	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	98% cell survival after day 1	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2190	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	NPEC2/Bm1	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	85% cell survival after day 2	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2191	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	NPEC2/Bm1	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	70% cell survival after day 3	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2192	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	NPEC2/Bm1	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	30% cell survival after day 4	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2193	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	NPEC2/Bm1	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	20% cell survival after day 5	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2194	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	NPEC2/Bm1	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	85% cell survival after day 1	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2195	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	NPEC2/Bm1	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	70% cell survival after day 2	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2196	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	NPEC2/Bm1	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	30% cell survival after day 3	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2197	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	NPEC2/Bm1	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	10% cell survival after day 4	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2198	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	NPEC2/Bm1	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	All cells was dead after day 5	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2199	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Dr. George SW Tsao Center, Hong Komg university	Human nasopharyngeal carcinoma cell line	NP69	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	95% cell survival after day 1	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2200	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Dr. George SW Tsao Center, Hong Komg university	Human nasopharyngeal carcinoma cell line	NP69	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	95% cell survival after day 2	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2201	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Dr. George SW Tsao Center, Hong Komg university	Human nasopharyngeal carcinoma cell line	NP69	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	95% cell survival after day 3	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2202	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Dr. George SW Tsao Center, Hong Komg university	Human nasopharyngeal carcinoma cell line	NP69	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	85% cell survival after day 4	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2203	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Dr. George SW Tsao Center, Hong Komg university	Human nasopharyngeal carcinoma cell line	NP69	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	80% cell survival after day 5	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2204	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Dr. George SW Tsao Center, Hong Komg university	Human nasopharyngeal carcinoma cell line	NP69	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	78% cell survival after day 1	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2205	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Dr. George SW Tsao Center, Hong Komg university	Human nasopharyngeal carcinoma cell line	NP69	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	65% cell survival after day 2	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2206	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Dr. George SW Tsao Center, Hong Komg university	Human nasopharyngeal carcinoma cell line	NP69	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	45% cell survival after day 3	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2207	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Dr. George SW Tsao Center, Hong Komg university	Human nasopharyngeal carcinoma cell line	NP69	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	30% cell survival after day 4	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2208	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Dr. George SW Tsao Center, Hong Komg university	Human nasopharyngeal carcinoma cell line	NP69	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	20% cell survival after day 5	No	No	NA	No response	NA	NA	NA	NA	22059912
OV_2209	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	CNE-2	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for CNE-2 cell line (1.0E+6 Ã— 10â¶ cells)	2.0E+7 pfu	NA	Virus treated mice shows complete regression in tumor and exhibit longer survival time	Intratumoral	NA	NA	NA	22059912
OV_2210	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	SUNE-1	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for SUNE-1 cell line (5.0E+5 Ã— 10âµ cells)	2.0E+7 pfu	NA	Virus treated mice shows complete regression in tumor and exhibit longer survival time	Intratumoral	NA	NA	NA	22059912
OV_2212	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MDA-MB-435	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	50% cell survival after day 1	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2213	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MDA-MB-435	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	55% cell survival after day 2	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2214	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MDA-MB-435	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	60% cell survival after day 3	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2215	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MDA-MB-435	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	30% cell survival after day 4	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2216	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MDA-MB-435	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	100% cell death after day 5	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2217	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MDA-MB-435	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	40% cell survival after day 1	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2218	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MDA-MB-435	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	20% cell survival after day 2	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2219	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MDA-MB-435	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	10% cell survival after day 3	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2220	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MDA-MB-435	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	100% cell death after day 4	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2221	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MDA-MB-435	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	100% cell death after day 5	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2222	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-7	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	100% cell survival after day 1	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2223	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-7	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	100% cell survival after day 2	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2224	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-7	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	70% cell survival after day 3	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2225	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-7	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	40% cell survival after day 4	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2226	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-7	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	20% cell death after day 5	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2227	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-7	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	90% cell survival after day 1	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2228	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-7	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	60% cell survival after day 2	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2229	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-7	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	30% cell survival after day 3	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2230	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-7	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	10% cell survival after day 4	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2231	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-7	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	100% cell death after day 5	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2232	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	SK-BR-3	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	90% cell survival after day 1	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2233	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	SK-BR-3	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	60% cell survival after day 2	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2234	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	SK-BR-3	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	55% cell survival after day 3	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2235	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	SK-BR-3	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	40% cell survival after day 4	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2236	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	SK-BR-3	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	100% cell death after day 5	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2237	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	SK-BR-3	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	60% cell survival after day 1	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2238	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	SK-BR-3	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	40% cell survival after day 2	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2239	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	SK-BR-3	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	20% cell survival after day 3	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2240	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	SK-BR-3	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	10% cell survival after day 4	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2241	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	SK-BR-3	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	100% cell death after day 5	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2242	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-10A	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	100% cell survival after day 1	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2243	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-10A	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	100% cell survival after day 2	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2244	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-10A	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	100% cell survival after day 3	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2245	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-10A	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	100% cell survival after day 4	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2246	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-10A	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.01 MOI	100% cell survival after day 5	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2247	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-10A	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	100% cell survival after day 1	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2248	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-10A	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	100% cell survival after day 2	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2249	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-10A	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	100% cell survival after day 3	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2250	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-10A	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	90% cell survival after day 4	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2251	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MCF-10A	1.0E+5 cells per well	NA	X-gal staining and MTT assay	0.1 MOI	80% cell survival after day 5	No	No	NA	No response	NA	Caspase activation	NA	NA	22108767
OV_2252	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MDA-MB-435	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for MDA-MB-435(1.0E+6 Ã— 10â¶)	2.0E+7 pfu	NA	Tumor volume decreased by 9 fold after 56 days	Intratumoral	Caspase activation	NA	NA	22108767
OV_2253	Herpes simplex virus	Equine Herpesvirus type-1	DNA	Herpesviridae	None	Yes	No	No	NA	Human glioma cell line	Hs683	NA	NA	MTS assay	1 MOI	100% cell survival after 48 hours	No	No	NA	No response	NA	NA	NA	NA	22205738
OV_2254	Herpes simplex virus	Equine Herpesvirus type-1	DNA	Herpesviridae	None	Yes	No	No	NA	Human glioma cell line	U251	NA	NA	MTS assay	1 MOI	98% cell survival after 48 hours	No	No	NA	No response	NA	NA	NA	NA	22205738
OV_2255	Herpes simplex virus	Equine Herpesvirus type-1	DNA	Herpesviridae	None	Yes	No	No	NA	Human glioma cell line	SNB19	NA	NA	MTS assay	1 MOI	90% cell survival after 48 hours	No	No	NA	No response	NA	NA	NA	NA	22205738
OV_2256	Herpes simplex virus	Equine Herpesvirus type-1	DNA	Herpesviridae	None	Yes	No	No	NA	Human glioma cell line	LN-18	NA	NA	MTS assay	1 MOI	60% cell survival after 48 hours	No	No	NA	No response	NA	NA	NA	NA	22205738
OV_2257	Herpes simplex virus	Equine Herpesvirus type-1	DNA	Herpesviridae	None	Yes	No	No	NA	Human glioma cell line	A-172	NA	NA	MTS assay	1 MOI	50% cell survival after 48 hours	No	No	NA	No response	NA	NA	NA	NA	22205738
OV_2258	Herpes simplex virus	Equine Herpesvirus type-1	DNA	Herpesviridae	None	Yes	No	No	NA	Human glioma cell line	Hs683	NA	NA	MTS assay	3 MOI	100% cell survival after 48 hours	No	No	NA	No response	NA	NA	NA	NA	22205738
OV_2259	Herpes simplex virus	Equine Herpesvirus type-1	DNA	Herpesviridae	None	Yes	No	No	NA	Human glioma cell line	U251	NA	NA	MTS assay	3 MOI	90% cell survival after 48 hours	No	No	NA	No response	NA	NA	NA	NA	22205738
OV_2260	Herpes simplex virus	Equine Herpesvirus type-1	DNA	Herpesviridae	None	Yes	No	No	NA	Human glioma cell line	SNB19	NA	NA	MTS assay	3 MOI	70% cell survival after 48 hours	No	No	NA	No response	NA	NA	NA	NA	22205738
OV_2261	Herpes simplex virus	Equine Herpesvirus type-1	DNA	Herpesviridae	None	Yes	No	No	NA	Human glioma cell line	LN-18	NA	NA	MTS assay	3 MOI	40% cell survival after 48 hours	No	No	NA	No response	NA	NA	NA	NA	22205738
OV_2262	Herpes simplex virus	Equine Herpesvirus type-1	DNA	Herpesviridae	None	Yes	No	No	NA	Human glioma cell line	A-172	NA	NA	MTS assay	3 MOI	38% cell survival after 48 hours	No	No	NA	No response	NA	NA	NA	NA	22205738
OV_2263	Herpes simplex virus	Equine Herpesvirus type-1	DNA	Herpesviridae	None	Yes	No	No	NA	Human glioma cell line	Hs683	NA	NA	MTS assay	10 MOI	100% cell survival after 48 hours	No	No	NA	No response	NA	NA	NA	NA	22205738
OV_2264	Herpes simplex virus	Equine Herpesvirus type-1	DNA	Herpesviridae	None	Yes	No	No	NA	Human glioma cell line	U251	NA	NA	MTS assay	10 MOI	80% cell survival after 48 hours	No	No	NA	No response	NA	NA	NA	NA	22205738

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