The total number of records retrieved from this search are 68. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_717	Avian influenza A virus	H7N3 NS1-77	RNA	Orthomyxoviridae	Mutations were introduced within the IAV NS1 gene to create a truncated protein of 77 aa (NS1-77)	Yes	No	No	NA	Human pancreatic cancer cell line	BxPC-3	NA	NA	Immunoassay detection	0.001 MOI	130% cancer cell death (calculated as relative to mock-infected)	No	No	NA	No response	NA	NA	Up-regulation of IFN-aplha	NA	27417501
OV_721	Avian influenza A virus	H7N3	RNA	Orthomyxoviridae	None	Yes	No	No	NA	Human pancreatic cancer cell line	BxPC-3	NA	NA	Immunoassay detection	0.001 MOI	148% cancer cell death (calculated as relative to mock-infected)	No	No	NA	No response	NA	NA	Up-regulation of IFN-aplha	NA	27417501
OV_1408	Parovirus	H-1PV	DNA	Paroviridae	None	No	Virus strain in combination with norfloxacin (25 microgram/ml)	No	ATCC	Human pancreatic adenocarcinoma cell line	BxPC-3	NA	NA	MTT assay	0.5 MOI	70% cell survival	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19301953
OV_1409	Parovirus	H-1PV	DNA	Paroviridae	None	No	Virus strain in combination with norfloxacin (25 microgram/ml)	No	ATCC	Human pancreatic adenocarcinoma cell line	BxPC-3	NA	NA	MTT assay	1 MOI	30% cell survival	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19301953
OV_2278	Vesicular stomatitis virus	wild type	RNA	Rhabdoviridae	None	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	BxPC-3	80% confluent monolayer	NA	MTT assay	1 MOI	60% cell survival after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2292	Vesicular stomatitis virus	VSV-Delta-M51-GFP	RNA	Rhabdoviridae	Deletion of M51 gene and insertion of GFP gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	BxPC-3	80% confluent monolayer	NA	MTT assay	1 MOI	80% cell survival after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2306	Vesicular stomatitis virus	VSV-p1-GFP	RNA	Rhabdoviridae	Insertion of P gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	BxPC-3	80% confluent monolayer	NA	MTT assay	1 MOI	70% cell survival after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2320	Vesicular stomatitis virus	Sev-GFP	RNA	Rhabdoviridae	Insertion of GFP gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	BxPC-3	80% confluent monolayer	NA	MTT assay	1 MOI	100% cell survival after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2334	Vesicular stomatitis virus	RSV-GFP	RNA	Rhabdoviridae	Insertion of GFP gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	BxPC-3	80% confluent monolayer	NA	MTT assay	1 MOI	100% cell survival after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2348	Vesicular stomatitis virus	wild type	RNA	Rhabdoviridae	None	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	BxPC-3	80% confluent monolayer	NA	MTT assay	0.01 MOI	100% cell survival after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2362	Vesicular stomatitis virus	VSV-Delta-M51-GFP	RNA	Rhabdoviridae	Deletion of M51 gene and insertion of GFP gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	BxPC-3	80% confluent monolayer	NA	MTT assay	0.01 MOI	100% cell survival after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2376	Vesicular stomatitis virus	VSV-p1-GFP	RNA	Rhabdoviridae	Insertion of P gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	BxPC-3	80% confluent monolayer	NA	MTT assay	0.01 MOI	100% cell survival after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2390	Vesicular stomatitis virus	Sev-GFP	RNA	Rhabdoviridae	Virus expressing GFP gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	BxPC-3	80% confluent monolayer	NA	MTT assay	0.01 MOI	100% cell survival after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2404	Vesicular stomatitis virus	RSV-GFP	RNA	Rhabdoviridae	Virus expressing GFP gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	BxPC-3	80% confluent monolayer	NA	MTT assay	0.01 MOI	100% cell survival after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_3404	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	Yes	No	No	ATCC	Human pancreatic adenocarcinoma cell line	BxPC-3	4.0E+4 cells per well	NA	SRB assay	0.001 MOI	No cell killing after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3405	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	Yes	No	No	ATCC	Human pancreatic adenocarcinoma cell line	BxPC-3	4.0E+4 cells per well	NA	SRB assay	0.005 MOI	No cell killing after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3406	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	Yes	No	No	ATCC	Human pancreatic adenocarcinoma cell line	BxPC-3	4.0E+4 cells per well	NA	SRB assay	0.01 MOI	No cell killing after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3407	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	Yes	No	No	ATCC	Human pancreatic adenocarcinoma cell line	BxPC-3	4.0E+4 cells per well	NA	SRB assay	0.05 MOI	35% cell killing after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3408	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	Yes	No	No	ATCC	Human pancreatic adenocarcinoma cell line	BxPC-3	4.0E+4 cells per well	NA	SRB assay	0.1 MOI	30% cell killing after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3424	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	No	Virus in combination with gemcitabine (2 × 10⁻² micromolar) after 1 hour	No	ATCC	Human pancreatic adenocarcinoma cell line	BxPC-3	4.0E+4 cells per well	NA	SRB assay	0.01 MOI	75% of the tumor cell mass remain after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3425	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	No	Virus in combination with gemcitabine (2 × 10⁻² micromolar) after 24 hour	No	ATCC	Human pancreatic adenocarcinoma cell line	BxPC-3	4.0E+4 cells per well	NA	SRB assay	0.01 MOI	75% of the tumor cell mass remain after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3432	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	No	Virus in combination with nab-palcitaxel (1 × 10⁻² micromolar) after 1 hour	No	ATCC	Human pancreatic adenocarcinoma cell line	BxPC-3	4.0E+4 cells per well	NA	SRB assay	0.01 MOI	25% of the tumor cell mass remain after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3433	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	No	Virus in combination with nab-palcitaxel (1 × 10⁻² micromolar) after 24 hour	No	ATCC	Human pancreatic adenocarcinoma cell line	BxPC-3	4.0E+4 cells per well	NA	SRB assay	0.01 MOI	50% of the tumor cell mass remain after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3440	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	No	Virus in combination with nab-palcitaxel (2.5 nM)and gemcitabine (5 nM)	No	ATCC	Human pancreatic adenocarcinoma cell line	BxPC-3	4.0E+4 cells per well	NA	SRB assay	0.01 MOI	70% of the tumor cell mass remain after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3441	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	No	Virus in combination with nab-palcitaxel (2.5 nM)and gemcitabine (5 nM)	No	ATCC	Human pancreatic adenocarcinoma cell line	BxPC-3	4.0E+4 cells per well	NA	SRB assay	0.03 MOI	60% of the tumor cell mass remain after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3442	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	No	Virus in combination with nab-palcitaxel (2.5 nM)and gemcitabine (5 nM)	No	ATCC	Human pancreatic adenocarcinoma cell line	BxPC-3	4.0E+4 cells per well	NA	SRB assay	0.05 MOI	52% of the tumor cell mass remain after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3443	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	No	Virus in combination with nab-palcitaxel (2.5 nM)and gemcitabine (5 nM)	No	ATCC	Human pancreatic adenocarcinoma cell line	BxPC-3	4.0E+4 cells per well	NA	CTB assay	0.01 MOI	50% cell viability after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3444	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	No	Virus in combination with nab-palcitaxel (2.5 nM)and gemcitabine (5 nM)	No	ATCC	Human pancreatic adenocarcinoma cell line	BxPC-3	4.0E+4 cells per well	NA	CTB assay	0.03 MOI	40% cell viability after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3445	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	No	Virus in combination with nab-palcitaxel (2.5 nM)and gemcitabine (5 nM)	No	ATCC	Human pancreatic adenocarcinoma cell line	BxPC-3	4.0E+4 cells per well	NA	CTB assay	0.05 MOI	30% cell viability after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3753	Vaccinia virus	vv-smac	DNA	Poxviridae	Insertion of smac and gpt gene in TK	Yes	No	No	Type culture collection of china	Human pancreatic cancer cell line	BxPC-3	5.0E+3 cells per well	NA	MTT assay	0.0001 MOI	100% cell survival after 48 hours	No	No	NA	No response	NA	Virus induce apoptosis in cancer cell	NA	NA	30365143
OV_3754	Vaccinia virus	vv-smac	DNA	Poxviridae	Insertion of smac and gpt gene in TK	Yes	No	No	Type culture collection of china	Human pancreatic cancer cell line	BxPC-3	5.0E+3 cells per well	NA	MTT assay	0.001 MOI	100% cell survival after 48 hours	No	No	NA	No response	NA	Virus induce apoptosis in cancer cell	NA	NA	30365143
OV_3755	Vaccinia virus	vv-smac	DNA	Poxviridae	Insertion of smac and gpt gene in TK	Yes	No	No	Type culture collection of china	Human pancreatic cancer cell line	BxPC-3	5.0E+3 cells per well	NA	MTT assay	0.01 MOI	98% cell survival after 48 hours	No	No	NA	No response	NA	Virus induce apoptosis in cancer cell	NA	NA	30365143
OV_3756	Vaccinia virus	vv-smac	DNA	Poxviridae	Insertion of smac and gpt gene in TK	Yes	No	No	Type culture collection of china	Human pancreatic cancer cell line	BxPC-3	5.0E+3 cells per well	NA	MTT assay	1 MOI	20% cell survival after 48 hours	No	No	NA	No response	NA	Virus induce apoptosis in cancer cell	NA	NA	30365143
OV_3757	Vaccinia virus	vv-smac	DNA	Poxviridae	Insertion of smac and gpt gene in TK	Yes	No	No	Type culture collection of china	Human pancreatic cancer cell line	BxPC-3	5.0E+3 cells per well	NA	MTT assay	2 MOI	100% cell killing after 48 hours	No	No	NA	No response	NA	Virus induce apoptosis in cancer cell	NA	NA	30365143
OV_3758	Vaccinia virus	vv-smac	DNA	Poxviridae	Insertion of smac and gpt gene in TK	Yes	No	No	Type culture collection of china	Human pancreatic cancer cell line	BxPC-3	5.0E+3 cells per well	NA	MTT assay	3 MOI	100% cell killing after 48 hours	No	No	NA	No response	NA	Virus induce apoptosis in cancer cell	NA	NA	30365143
OV_3767	Vaccinia virus	vv-smac	DNA	Poxviridae	Insertion of smac and gpt gene in TK	No	Virus in combination with gemcitabine (1 micromolar)	No	Type culture collection of china	Human pancreatic cancer cell line	BxPC-3	5.0E+3 cells per well	NA	MTT assay	0.1 MOI	60% cell viability after 48 hours	No	No	NA	No response	NA	Virus induce apoptosis in cancer cell	NA	NA	30365143
OV_3768	Vaccinia virus	vv-smac	DNA	Poxviridae	Insertion of smac and gpt gene in TK	No	Virus in combination with gemcitabine (1 micromolar)	No	Type culture collection of china	Human pancreatic cancer cell line	BxPC-3	5.0E+3 cells per well	NA	MTT assay	0.5 MOI	50% cell viability after 48 hours	No	No	NA	No response	NA	Virus induce apoptosis in cancer cell	NA	NA	30365143
OV_3769	Vaccinia virus	vv-smac	DNA	Poxviridae	Insertion of smac and gpt gene in TK	No	Virus in combination with gemcitabine (5 micromolar)	No	Type culture collection of china	Human pancreatic cancer cell line	BxPC-3	5.0E+3 cells per well	NA	MTT assay	0.1 MOI	40% cell viability after 48 hours	No	No	NA	No response	NA	Virus induce apoptosis in cancer cell	NA	NA	30365143
OV_3770	Vaccinia virus	vv-smac	DNA	Poxviridae	Insertion of smac and gpt gene in TK	No	Virus in combination with gemcitabine (5 micromolar)	No	Type culture collection of china	Human pancreatic cancer cell line	BxPC-3	5.0E+3 cells per well	NA	MTT assay	0.5 MOI	30% cell viability after 48 hours	No	No	NA	No response	NA	Virus induce apoptosis in cancer cell	NA	NA	30365143
OV_4126	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	No	Virus in combination with drug Gemcitabine (0.01 ng/ml)	No	ATCC	Human pancreatic cancer cell line	BxPC-3	3.0E+3 cells per well	NA	MTT assay	100 vp/cell	80% cell survival	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4127	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	No	Virus in combination with drug Gemcitabine (1 ng/ml)	No	ATCC	Human pancreatic cancer cell line	BxPC-3	3.0E+3 cells per well	NA	MTT assay	1000 vp/cell	50% cell survival	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4128	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	No	Virus in combination with drug Gemcitabine (10 ng/ml)	No	ATCC	Human pancreatic cancer cell line	BxPC-3	3.0E+3 cells per well	NA	MTT assay	10000 vp/cell	20% cell survival	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4129	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	No	Virus in combination with drug Gemcitabine (100 ng/ml)	No	ATCC	Human pancreatic cancer cell line	BxPC-3	3.0E+3 cells per well	NA	MTT assay	100000 vp/cell	100% cell killing	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4130	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	No	Virus in combination with drug Gemcitabine (1000 ng/ml)	No	ATCC	Human pancreatic cancer cell line	BxPC-3	3.0E+3 cells per well	NA	MTT assay	1000000 vp/cell	100% cell killing	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4131	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	Yes	No	No	ATCC	Human pancreatic cancer cell line	BxPC-3	3.0E+3 cells per well	NA	MTT assay	100 vp/cell	100% cell survival	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4132	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	Yes	No	No	ATCC	Human pancreatic cancer cell line	BxPC-3	3.0E+3 cells per well	NA	MTT assay	1000 vp/cell	85% cell survival	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4133	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	Yes	No	No	ATCC	Human pancreatic cancer cell line	BxPC-3	3.0E+3 cells per well	NA	MTT assay	10000 vp/cell	35% cell survival	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4134	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	Yes	No	No	ATCC	Human pancreatic cancer cell line	BxPC-3	3.0E+3 cells per well	NA	MTT assay	100000 vp/cell	20% cell survival	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4135	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	Yes	No	No	ATCC	Human pancreatic cancer cell line	BxPC-3	3.0E+3 cells per well	NA	MTT assay	1000000 vp/cell	100% cell killing	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4330	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human pancreas adenocarcinoma	BxPC-3	4000 cells per well	NA	MTT assay	10 pfu	98.8 % cell viability after 72 hours	No	No	NA	No response	NA	Activation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	NA	NA	26373347
OV_5072	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	No	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	BxPC-3	1.0E+4 cells per well	NA	MTT assay	1 MOI	100% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5073	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	No	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	BxPC-3	1.0E+4 cells per well	NA	MTT assay	2 MOI	98% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5074	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	No	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	BxPC-3	1.0E+4 cells per well	NA	MTT assay	4 MOI	70% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5075	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	No	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	BxPC-3	1.0E+4 cells per well	NA	MTT assay	8 MOI	60% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5076	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	No	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	BxPC-3	1.0E+4 cells per well	NA	MTT assay	16 MOI	55% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5077	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	Virus in combination with SNS032 5ng/ml	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	BxPC-3	1.0E+4 cells per well	NA	MTT assay	1 MOI	55% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5078	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	Virus in combination with SNS032 10ng/ml	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	BxPC-3	1.0E+4 cells per well	NA	MTT assay	2 MOI	45% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5079	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	Virus in combination with SNS032 20ng/ml	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	BxPC-3	1.0E+4 cells per well	NA	MTT assay	4 MOI	30% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5080	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	Virus in combination with SNS032 40ng/ml	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	BxPC-3	1.0E+4 cells per well	NA	MTT assay	8 MOI	20% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5081	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	Virus in combination with SNS032 80ng/ml	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	BxPC-3	1.0E+4 cells per well	NA	MTT assay	16 MOI	10% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5559	Sindbis virus	AR339	RNA	Togaviridae	None	Yes	No	No	NA	Human pancreatic cell line	BxPC-3	1.0E+5 cells per well	NA	NA	1 MOI	Significant death of cancer cell line after 72 hours	No	No	NA	No response	NA	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5564	Reovirus	wild type	RNA	Reoviridae	None	Yes	No	No	NA	Human pancreatic cell line	BxPC-3	1.0E+5 cells per well	NA	NA	1 MOI	Significant death of cancer cell line after 72 hours	No	No	NA	No response	NA	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5569	Sindbis virus	AR339	RNA	Togaviridae	None	No	Sindbis virus in combination with Reovirus	No	NA	Human pancreatic cell line	BxPC-3	1.0E+5 cells per well	NA	NA	1 MOI	Enhancer cytolytic effect in combination after 72 hours	No	No	NA	No response	NA	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5575	Sindbis virus	AR339	RNA	Togaviridae	None	Yes	No	No	NA	Human pancreatic cell line	BxPC-3	NA	NA	NA	NA	NA	Nude mice xenografted subcutaneously for BxPC3	1.0E+6 pfu	NA	Tumor volume reduced to below 2.0 cm after 10 weeks	Intratumoral	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5576	Reovirus	wild type	RNA	Reoviridae	None	Yes	No	No	NA	Human pancreatic cell line	BxPC-3	NA	NA	NA	NA	NA	Nude mice xenografted subcutaneously for BxPC3	1.0E+6 pfu	NA	Tumor volume reduced to below 3.0 cm after 10 weeks	Intratumoral	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5577	Sindbis virus	AR339	RNA	Togaviridae	None	No	Sindbis virus in combination with Reovirus	No	NA	Human pancreatic cell line	BxPC-3	NA	NA	NA	NA	NA	Nude mice xenografted subcutaneously for BxPC3	1.0E+6 pfu	NA	Complete reduction in tumor volume after 10 weeks	Intratumoral	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5578	Sindbis virus	AR339	RNA	Togaviridae	None	Yes	No	No	NA	Human pancreatic cell line	BxPC-3	NA	NA	NA	NA	NA	Nude mice xenografted subcutaneously for MIAPaCa-2	1.0E+6 pfu	NA	Tumor volume reduced to below 5.0 cm after 12 weeks	Intratumoral	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5579	Reovirus	wild type	RNA	Reoviridae	None	Yes	No	No	NA	Human pancreatic cell line	BxPC-3	NA	NA	NA	NA	NA	Nude mice xenografted subcutaneously for MIAPaCa-2	1.0E+6 pfu	NA	Tumor volume reduced to below 4.0 cm after 12 weeks	Intratumoral	Induction of apoptosis by virus infection	NA	NA	US7270812B2