Browse result page of ImmunoSPdb

The total number entries retrieved from this search are 119
IDNameSequenceLengthChiralityN-Terminal ModificationC-Terminal ModificationChemical ModificationLinear/CyclicNatureSourceTargetMechanism of ActionIn vivo/ In vitroCell LineIC-50In vivo ModelAssay TypeLethal DoseCombination TherapyPubmed IDYear of Publication
1036Cyclosporin Acyclo[Abu-Sar-N(Me)Leu-Val-N(Me)Leu-Ala-D-Ala-N(Me)Leu-N(Me)Leu-N(Me)Val-N(Me)Bmt(E)]11MixNoneNoneBmt = butenyl-methyl-threonine, Abu = L-alpha-aminobutyric acid, Sar = sarcosine, N(Me) = Amino acid is N-methylatedCyclicNaturalFrom fungus Trichoderma polysporumInhibit IL-2 production by activated CD4+ T-cellsInhibiting the calcineurin pathwayBothPeripheral blood mononuclear cells (PBMCs)61.8 nM for CD4+ T cell activation of IL-2 productionC57/B6 miceMIC assay, Immunosuppression and toxicity testNANA185998252008
1037Colutellin AVISIIPV7LNoneNoneNoneCyclicNaturalEndophytic fungus Colletotrichum dematiumInhibit IL-2 production by activated CD4+ T-cellsInhibiting the calcineurin pathwayBothPeripheral blood mononuclear cells (PBMCs)167.3±0.38 nM for CD4+ T cell activation of IL-2 productionC57/B6 miceMIC assay, Immunosuppression and toxicity testMIC of 3.6 mg/ml (48 h) against Botrytis cinerea and Sclerotinia sclerotiorum.NA185998252008
1042ISP region (Mutant D105)EVVLQNRRGLDLLTAEQGGICLALQEKCCFYANKS35LNoneNoneNoneLinearProtein DerivedWithin the transmembrane (TM) protein of Mason-Pfizer monkey virusT-cell and B-cellImmunosuppressive effect on both T-cell and B-cell mitogenic responseIn vitroHeLa, COS-1, CV-1and BHK cellsNANANANANA13164621992
1043ISP region (Mutant D33)LQNRRGLDLLT11LNoneNoneNoneLinearProtein DerivedWithin the transmembrane (TM) protein of Mason-Pfizer monkey virusT-cell and B-cellImmunosuppressive effect on both T-cell and B-cell mitogenic responseIn vitroHeLa, COS-1, CV-1and BHK cellsNANANANANA13164621992
1143HLA B-2702 (2702.75-84)RENLRIALRY10LNoneNoneNoneLinearNaturalNAT-cellInhibits the differentiation of cytotoxic T cells and also decrease natural killer (NK) cell-mediated cytotoxicityIn vivoNANAEight- to 12-week-old male Lewis.lW (RTI.u) and Lewis.lA (RTI.')ratsGraft transplation assayNANA106664822000
1144B-0701 (07.75-84)RESLRNLRGY10LNoneNoneNoneLinearNaturalNAT-cellInhibits the differentiation of cytotoxic T cells and also decrease natural killer (NK) cell-mediated cytotoxicityIn vivoNA200 micromolarEight- to 12-week-old male Lewis.lW (RTI.u) and Lewis.lA (RTI.')ratsGraft transplation assayNANA106664822000
1206NAAALKEECCFLKEEC14LNoneNoneNoneLinearSyntheticRetro virusT-cellsInhibiting T-cell proliferationIn vitroSpleen cellsNAMurine (C57BL/6 strain)Inhibition of Concanavalin A-induced T-cell Proliferation of murineNANAWO 1988005783 A11988
1207NAQEGGLCAALKEEC13LNoneNoneNoneLinearSyntheticRetro virusT-cellsInhibiting T-cell proliferationIn vitroSpleen cellsNAMurine (C57BL/6 strain)Inhibition of Concanavalin A-induced T-cell Proliferation of murineNANAWO 1988005783 A11988
1208NAQREKRAVGIGALFLGFLG18LNoneNoneNoneLinearSyntheticRetro virusT-cellsInhibiting T-cell proliferationIn vitroSpleen cellsNAMurine (C57BL/6 strain)Inhibition of Concanavalin A-induced T-cell Proliferation of murineNANAWO 1988005783 A11988
1209NAQLTVWGIKQLQARIL15LNoneNoneNoneLinearSyntheticRetro virusT-cellsInhibiting T-cell proliferationIn vitroSpleen cellsNAMurine (C57BL/6 strain)Inhibition of Concanavalin A-induced T-cell Proliferation of murineNANAWO 1988005783 A11988
1210NAAQNRRGLDLLFWEQGGLC18LNoneNoneNoneLinearSyntheticRetro virusT-cellsInhibiting T-cell proliferationIn vitroSpleen cellsNAMurine (C57BL/6 strain)Inhibition of Concanavalin A-induced T-cell Proliferation of murineNANAWO 1988005783 A11988
1223sequence no 4HFKRPLPPLPSL12LNoneNoneNoneLinearSyntheticNAT-cell, Hematopoietic cellHuman T-cell tyrosine kinase (Lck) inhibitor, Hematopoietic cell kinase (Hck) inhibitorIn vitroNANANALck-SH3 binding assay, NMR Spectroscopy, protein-protein interactions assay by PepSpot membranesNANAEP 1983050 A12008
1224SEQ ID NO:60LVCYYTSWS9LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1225SEQ ID NO:61FLCTHIIYS9LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1226SEQ ID NO:62IIYSFANIS9LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1227SEQ ID NO:63LKTLLSVGG9LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1228SEQ ID NO:64FIKSVPPFL9LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1229SEQ ID NO:65FDGLDLAWL9LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1230SEQ ID NO:66LYPGRRDKQ9LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1231SEQ ID NO:67YDIAKISQH9LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1232SEQ ID NO:68LDFISIMTY9LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1233SEQ ID NO:69FISIMTYDF9LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1234SEQ ID NO:70FRGQEDASP9LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1235SEQ ID NO:71YAVGYMLRL9LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1236SEQ ID NO:72MLRLGAPAS9LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1237SEQ ID NO:73LAYYEICDF9LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1238SEQ ID NO:74LRGATVHRT9LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1239SEQ ID NO:75YLKDRQLAG9LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1240SEQ ID NO:76LAGAMVWAL9LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1241SEQ ID NO:77VWALDLDDF9LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1242SEQ ID NO:78LDLDDFQGS9LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1243SEQ ID NO:lYKLVCYYTSWSQYREG16LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1244SEQ ID NO:2YTSWSQYREGDGSCFP16LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1245SEQ ID NO:5LDRFLCTHIIYSFANI16LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1246SEQ ID NO:6THIIYSFANISNDHID16LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1247SEQ ID NO:12PNLKTLLSVGGWNFGS16LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1248SEQ ID NO:16NTQSRRTFIKSVPPFL16LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1249SEQ ID NO:17TFIKSVPPFLRTHGFD16LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1250SEQ ID NO:18PPFLRTHGFDGLDLAW16LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1251SEQ ID NO:19HGFDGLDLAWLYPGRR16LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1252SEQ ID NO:20DLAWLYPGRRDKQHFT16LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1253SEQ ID NO:28IDSSYDIAKISQHLD16LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1254SEQ ID NO:29DIAKISQHLDFISIMT16LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1255SEQ ID NO:30QHLDFISIMTYDFHGA16LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1256SEQ ID NO:34SPLFRGQEDASPDRFS16LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1257SEQ ID NO:37DYAVGYMLRLGAPASK16LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1258SEQ ID NO:38MLRLGAPASKLVMGIP16LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1259SEQ ID NO:39PASKLVMGIPTFGRSF16LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1260SEQ ID NO:46GTLAYYEICDFLRGAT16LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997
1261SEQ ID NO:47EICDFLRGATVHRTLG16LNoneNoneNoneLinearProtein DerivedHuman Cartilage glycoprotein 39T-cellsInduce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells, specific effect on the autoreactive T cells thus leaving the other components of the immune system intactIn vitroPBMCNANAPeptide HLA-DR binding assay and Proliferative responses of blood mononuclear cells by thymidine incorporation assayNANAWO 1997040068 A11997