A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 1029 |
| PubChem ID | 32798 |
| Hormone name | Clobetasol propionate |
| Description | A derivative of PREDNISOLONE with high glucocorticoid activity and low mineralocorticoid activity. Absorbed through the skin faster than FLUOCINONIDE, it is used topically in treatment of PSORIASIS but may cause marked adrenocortical suppression. |
| Synonyms | Clobex Clobetasol Clobesol Dermovate Temovate Cormax Luxiq Temovate E Embeline Olux |
| Molecular weight | 466.97 |
| Molecular formula | C25H32ClFO5 |
| IUPAC Name | [(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17 -yl] propanoate |
| Canonical smiles | CCC(=O)OC1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)C)C(=O)CCl |
| Isomeric smiles | CCC(=O)O[C@@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)O)C)C)C(=O)CCl
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| Structure | |
| PDB file | |
| SDF file | |
| MOL file | |
| PDB ID | N/A |
| KEGG ID | D01272 |
| HMDB ID | N/A |
| Melting Point | 195.5-197(EXP) |
| Log P | 3.5(EXP) |
| Water Solubility | 3.86(EST) at 25C |
| DrugBank ID | DB01013 |
| Drugpedia | wiki |
| Receptor | P79686 Detail in HMRbase Q6XLJ0 Detail in HMRbase P49115 Detail in HMRbase P04150 Detail in HMRbase P06537 Detail in HMRbase P49843 Detail in HMRbase O73673 Detail in HMRbase Q9N1U3 Detail in HMRbase Q5R9P5 Detail in HMRbase P59667 Detail in HMRbase P06536 Detail in HMRbase P79269 Detail in HMRbase O13186 Detail in HMRbase O46567 Detail in HMRbase P35547 Detail in HMRbase Q95267 Detail in HMRbase P49844 Detail in HMRbase Q3MSN1 Detail in HMRbase Q3MSN4 Detail in HMRbase |
| Comments | !Link to Receptor is not Organism Specific |
| References | Pubchem |