Summary of Modifications in Cell Lines



This page is designed to facilitate users to browse assays where particular modification in cell line has been done to study the various aspects of Herceptin resistance.

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Serial No. Alterations in Cell lines Number Of Assays Number Of Cell lines
1 BT474 modified to resistant clone BT-HRc3, Infected with lentiviral GDF15 shRNA (shGDF)11
2 BT474 modified to resistant clone BT474/TR201
3 BT474 modified to resistant clone BT474/TR, Treadted with 2-DEOXY-D-GLUCOSE (Glycolysis inhibitor) 41
4 BT474 modified to resistant clone BT474/TR, Treadted withOXAMATE (Glycolysis inhibitor) 41
5 Make cell line resistant to trastuzumab121
6 NSC23766 (Inhibitor of RAC1)11
7 SKBR3 modified to resistant SKBR3/mAbHER211
8 SKBR3 modified to resistant SKBR3/mAbHER311
9 SKBR3 modified to resistant SKBR3/mAbHER411
10 SKBR3 modified to resistant SKBR3/mAbHER511
11 SKBR3 modified to resistant SKBR3/mAbHER611
12 SKBR3 modified to resistant SKBR3/mAbHER711
13 Trasfected with GRB7 siRNA153
14 Trasfected with GRB7 siRNA with Trasfected with HER2 siRNA33
15 Trasfected with GSDM1 siRNA123
16 Trasfected with HER2 siRNA423
17 Trasfected with PERLD1 siRNA123
18 Trasfected with PPP1R1B siRNA153
19 Trasfected with PPP1R1B siRNA with Trasfected with HER2 siRNA 33
20 Trasfected with PSMD3 siRNA153
21 Trasfected with PSMD3 siRNA with Trasfected with HER2 siRNA33
22 Trasfected with SCRAMBLE siRNA243
23 Trasfected with STARD3 siRNA63
24 Trasfected with STARD3 siRNA with Trasfected with HER2 siRNA33
25 Trasfected with THRA siRNA153
26 Trasfected with THRA siRNA with Trasfected with HER2 siRNA 33
27 Trasfected with ZPBP2 siRNA153
28 Trasfected with ZPBP2 siRNA with Trasfected with HER2 siRNA 33
29 Trastuzumab resistant BT474 (BT474R)81
30 Trastuzumab resistant SKBR3 (SKBR-3R)81
31 Treated with Laminin rich extracellular matrix culture (IrECM)161
3217-AAG (Down regulate ERBB2)102
33AU565 Culture in 2D MONOLAYER 61
34AU565 Culture in 3D IrECM61
35Anti-Estrogen inhibitor (Fulvestrant) , Treated MCF7Ca with Letrozole for 56 week 11
36Anti-Estrogen inhibitor (Fulvestrant)r , Treated MCF7Ca with Letrozole for 56 week 11
37Anti-Estrogen inhibitor (Tamoxifen ) , Treated MCF7Ca with Letrozole for 56 week 21
38Aromatase inhibitor (Anastrozole ), Treated MCF7Ca with letrozole for 56 week 21
39Aromatase inhibitor (Exemestane ), Treated MCF7Ca with letrozole for 56 week 21
40BT474 Transfected with p110a subunit of PI3K (BT474H1047R)81
41BT474 modifie to resitanr clone BT474-TR, Inhibition of Akt and S6K phosphorylation21
42BT474 modified to clone BT474 SC91
43BT474 modified to clone BT474-c331
44BT474 modified to resistant BT474 (HR2), Trasfected by RshRNA to knockdown IGF-IR82
45BT474 modified to resistant clone BT-HRc3, Infected with lentiviral Control sh RNA (shC)11
46BT474 modified to resistant clone BT/HerR121
47BT474 modified to resistant clone BT474 /TR31
48BT474 modified to resistant clone BT474 HR551
49BT474 modified to resistant clone BT474 HR651
50BT474 modified to resistant clone BT474- HR541