CancerDR: Cancer Drug Resistance Database

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Clustering of Cell lines



This page allows user to cluster cell lines based on their sensitivity towards a drug. We group cell lines for each drug based on their relative sensitivity to reference (highest sensitivity) or inhibition IC50 value in a given range. User can either choose tissue type or all cell lines or can select the cell lines with mutated drug targets. The second column gives the number of cell lines screened against the drug as it is equal to or greater than reference IC50 (lowest of all). Subsequent columns, up to eight, give grouping based on IC50 value equal to or greater than 3, 5, 25, 100 and 250 times of reference IC50. The columns from nine to sixteen shows the group of cell lines having absolute value of IC50 lying in different ranges (R1, R2, R3, R4, R5, R6, R7 and R8). The cell line in groups with lower value are those which are very sensitive to that drug while groups with high IC50 values comprise cell lines having high resistance and are important for study of resistance-mechanism. For more information, please click HERE


** Ref: Lowest of all IC50s, xRef: times of reference value (column two to seven) , Range of IC50 value (column eight to fifteen)- R1: 0-0.001 µM, R2: 0.001-0.005µM, R3: 0.005-0.025µM, R4: 0.025-0.125µM, R5: 0.125-0.625µM, R6: 0.625-15µM, R7: 15-390µM, R8: greater than 390 µM.



Select Tissue type against which you want to see Cell Line clusters

AUTONOMIC GANGLIA BILIARY TRACT BLADDER BLOOD BONE BREAST CENTRAL NERVOUS SYSTEM
ENDOMETRIUM GI TRACT HAEMATOPOIETIC AND LYMPHOID TISSUE KIDNEY LARGE INTESTINE LIVER LUNG
OESOPHAGUS OTHER OVARY PANCREASE PLEURA PROSTATE SALIVARY GLAND
SKIN SOFT TISSUE STOMACH THYROID UPPER AERODIGESTIVE TRACT URINARY TRACT UTERUS
ALL MUTANTS

Cell Line clusters for AUTONOMIC GANGLIA tissue type

Drug IC50 ≥ Ref IC50 ≥ 3xRef IC50 ≥ 5xRef IC50 ≥ 25xRef IC50 ≥ 50xRef IC50 ≥ 100xRef IC50 ≥ 250xRef R1 R2 R3 R4 R5 R6 R7 R8
17AAG1088530000022600
681640NANANANANANANA00000000
A443654NANANANANANANA00000000
A770041NANANANANANANA00000000
ABT263NANANANANANANA00000000
ABT888NANANANANANANA00000000
AEW5411088300000002800
AG014699NANANANANANANA00000000
AICARNANANANANANANA00000000
AKTinhibitorVIIINANANANANANANA00000000
AMG706NANANANANANANA00000000
AP24534NANANANANANANA00000000
AS601245NANANANANANANA00000000
ATRANANANANANANANA00000000
AUY922NANANANANANANA00000000
AxitinibNANANANANANANA00000000
AZ628NANANANANANANA00000000
AZD053010700000000001000
AZD2281NANANANANANANA00000000
AZD62441099777700102700
AZD6482NANANANANANANA00000000
AZD7762NANANANANANANA00000000
AZD8055NANANANANANANA00000000
BAY613606NANANANANANANA00000000
BexaroteneNANANANANANANA00000000
BI2536NANANANANANANA00000000
BIBW2992NANANANANANANA00000000
BicalutamideNANANANANANANA00000000
BID1870NANANANANANANA00000000
BIRB0796NANANANANANANA00000000
BleomycinNANANANANANANA00000000
BMS509744NANANANANANANA00000000
BMS536924NANANANANANANA00000000
BMS708163NANANANANANANA00000000
BMS754807NANANANANANANA00000000
BortezomibNANANANANANANA00000000
BosutinibNANANANANANANA00000000
Bryostatin1NANANANANANANA00000000
BX795NANANANANANANA00000000
CamptothecinNANANANANANANA00000000
CCT007093NANANANANANANA00000000
CCT018159NANANANANANANA00000000
CEP701NANANANANANANA00000000
CGP082996NANANANANANANA00000000
CGP60474NANANANANANANA00000000
CHIR99021NANANANANANANA00000000
CI1040NANANANANANANA00000000
CisplatinNANANANANANANA00000000
CMKNANANANANANANA00000000
CyclopamineNANANANANANANA00000000
CytarabineNANANANANANANA00000000
DasatinibNANANANANANANA00000000
DMOGNANANANANANANA00000000
DocetaxelNANANANANANANA00000000
DoxorubicinNANANANANANANA00000000
EHT1864NANANANANANANA00000000
ElesclomolNANANANANANANA00000000
EmbelinNANANANANANANA00000000
EpothiloneBNANANANANANANA00000000
Erlotinib10000000000001000
EtoposideNANANANANANANA00000000
FH535NANANANANANANA00000000
FTI277NANANANANANANA00000000
GDC0449NANANANANANANA00000000
GDC0941NANANANANANANA00000000
GefitinibNANANANANANANA00000000
GemcitabineNANANANANANANA00000000
GNF2NANANANANANANA00000000
GSK269962ANANANANANANANA00000000
GSK650394NANANANANANANA00000000
GW441756NANANANANANANA00000000
GW843682XNANANANANANANA00000000
ImatinibNANANANANANANA00000000
IPA3NANANANANANANA00000000
Irinotecan311000000021000
JNJ26854165NANANANANANANA00000000
JNK9LNANANANANANANA00000000
JNKInhibitorVIIINANANANANANANA00000000
JW7521NANANANANANANA00000000
KIN001135NANANANANANANA00000000
KU55933NANANANANANANA00000000
L68545810000000000001000
Lapatinib10000000000001000
LBW24210000000000001000
LenalidomideNANANANANANANA00000000
LFMA13NANANANANANANA00000000
MetforminNANANANANANANA00000000
MethotrexateNANANANANANANA00000000
MG132NANANANANANANA00000000
MidostaurinNANANANANANANA00000000
MitomycinCNANANANANANANA00000000
MK2206NANANANANANANA00000000
MS275NANANANANANANA00000000
Nilotinib500000000000500
NSC87877NANANANANANANA00000000
NU7441NANANANANANANA00000000
Nutlin310000000000001000
NVPBEZ235NANANANANANANA00000000
NVPTAE684NANANANANANANA00000000
ObatoclaxMesylateNANANANANANANA00000000
OSI906NANANANANANANA00000000
PAC1NANANANANANANA00000000
Paclitaxel1053211003511000
Panobinostat1030000000550000
ParthenolideNANANANANANANA00000000
PazopanibNANANANANANANA00000000
PD03259011099777600120700
PD0332991755000000000700
PD173074NANANANANANANA00000000
PF02341066NANANANANANANA00000000
PF234106610220000000001000
PF4708671NANANANANANANA00000000
PF562271NANANANANANANA00000000
PHA66575210000000000001000
PLX472010000000000001000
PyrimethamineNANANANANANANA00000000
QS11NANANANANANANA00000000
RAF265821000000000800
RapamycinNANANANANANANA00000000
RDEA119NANANANANANANA00000000
RO3306NANANANANANANA00000000
RoscovitineNANANANANANANA00000000
SalubrinalNANANANANANANA00000000
SB216763NANANANANANANA00000000
SB590885NANANANANANANA00000000
ShikoninNANANANANANANA00000000
SL01011NANANANANANANA00000000
Sorafenib10000000000001000
STritylLcysteineNANANANANANANA00000000
SunitinibNANANANANANANA00000000
TAE6841055000000001900
TemsirolimusNANANANANANANA00000000
ThapsigarginNANANANANANANA00000000
TipifarnibNANANANANANANA00000000
TKI25810840000000001000
Topotecan1066211100134200
TW37NANANANANANANA00000000
VinblastineNANANANANANANA00000000
VinorelbineNANANANANANANA00000000
VorinostatNANANANANANANA00000000
VX680NANANANANANANA00000000
VX702NANANANANANANA00000000
WH4023NANANANANANANA00000000
WO2009093972NANANANANANANA00000000
WZ184NANANANANANANA00000000
XMD885NANANANANANANA00000000
ZD647410000000000001000
ZLLNleCHONANANANANANANA00000000
ZM447439NANANANANANANA00000000