CancerDR: Cancer Drug Resistance Database

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Browsing of Anticancer Drugs



This module allows users to browse anticancer drugs in CancerDR. This page summarizes the drugs with different descriptors like pI, Volume, Hydrogen Bond Acceptor, Hydrogen Bond Donor, Structure link, molecular targets. For more information, please click Help



Drug Name Pubchem ID Clinical Status Molecular Targets Number of Targets Target Class Chemical Formula Molecular Weight Polarizability pI Volume HBA HBD Cells Tried Structure
68164010384072Experimental WEE1, CHK12Ser Thr KinaseC20H11ClN2O3362.76636.39282.633540
17AAG6505803Phase IIIHSP90AA1, HSP90AB1, HSP90AB4P, HSP90B1, 5Stress pathway, C31H43N3O8585.688461.685.85550.26841076
A44365410172943Experimental AKT1, AKT2, AKT33Ser Thr KinaseC24H23N5O397.472344.6211.61356.8143358
A7700419549184Experimental SRC1Tyrosine kinaseC34H39N9O3621.73268.869.67559.3482560
ABT26324978538Phase IBCL2, BCLXL, BCLW3ApoptosisC47H55ClF3N5O6S3974.613101.396.88837.13102574
ABT88811960529Phase IPARP1, PARP22DNA repairC13H16N4O244.292326.579.72220.6233503
AEW54111476171ExperimentalIGF1R1ApoptosisC27H29N5O439.552150.69405.0151479
AG0146999931953Phase I, Phase IIPARP1, PARP22DNA repairC19H21FN3O5P421.359337.1411.3923557
AICAR65110 Phase IIPRKAA1, 1MetabolismC9H15N4O8P338.211228.952.99256.5296562
AKTinhibitorVIII16218954Phase IIAKT1, AKT2, AKT33Ser Thr KinaseC36H32F3N7O4683.67961.829.7652667
AMG70611667893Phase I, Phase IIVEGFR1, VEGFR2, RET, KIT, PDGFRA, PDGFRB6Receptor Tyrosine kinaseC22H23N5O373.450939.389.05341.7453560
AP2453424826799Phase IABL11Tyrosine kinaseC29H27F3N6O532.559556.189.67461.3251667
AS60124511422035Experimental JNK1, JNK2, JNK33Ser Thr KinaseC20H16N6S372.44639.388.38317.9662661
ATRA444795ApprovedRXRB, RXRG, RAR13Transcription, C20H28O2300.435136.62312.3621573
AUY92210096043Phase IIHSP90AA1, HSP90AB1, HSP90AB4P, HSP90B1, 5ApoptosisC26H31N3O5465.541450.837.32425.0373661
Axitinib6450551ApprovedPDGFRA, PDGFRB, KIT, VEGFR24Receptor Tyrosine kinaseC22H18N4OS386.4742.679334.2732576
AZ62811676786Experimental BRAF1Receptor Tyrosine kinaseC27H25N5O2451.519748.238.81410.7552354
AZD053010302451Phase IISRC, ABL12Tyrosine kinaseC27H32ClN5O5542.02657.259.94472.15101865
AZD228123725625Phase I PARP1, PARP22DNA repairC24H23FN4O3434.462843.545.96375.6541557
AZD624410127622Phase IIMAP2K1, MAP2K22Ser Thr KinaseC17H15BrClFN4O3457.68140.737.79323.52531033
AZD648244137675Phase IPI3KCB, PI3KC2B2ApoptosisC22H24N4O4408.450442.773.32364.4372667
AZD77621152667Phase ICHK1, CHK22Ser Thr KinaseC18H21FN4O2S376.44839.4512.28324.2944574
AZD805525262965Phase IMTOR1Ser Thr KinaseC25H31N5O4465.544751.448.89425.9791553
BAY61360616760671Experimental SYK1Tyrosine kinaseC20H23ClN6O5462.88740.669.0572661
Bexarotene82146ApprovedRXRA, RXRB, RXRG3TranscriptionC24H28O2348.477940.89349.4921538
BI253611364421Phase IIPLK1, PLK2, PLK33Ser Thr Kinase, MitosisC28H39N7O3521.654459.6710491.8482359
BIBW299244569596Phase IIIEGFR, ERBB22Receptor Tyrosine kinaseC25H26ClFN4O3484.9550.810.7417.762576
Bicalutamide2375ApprovedAR1MetabolismC18H14F4N2O4S430.37336.683.95332.4552661
BID187025023738Experimental RSK1, RSK2, RSK3, PLK1, AURKB5Ser Thr KinaseC19H23F2N5O2391.41539.816.59342.8262573
BIRB0796156422Experimental MAPK11, MAPK12, MAPK13, MAPK14, JNK25Ser Thr KinaseC31H37N5O3527.657258.539.11495.6352573
Bleomycin5460769ApprovedDNAdamage1DNA repairC55H84N17O21S31415.552140.8811.411211.932820661
BMS50974420635522Experimental ITK1Tyrosine kinaseC31H39N5O4S2609.80267.999.83555.762359
BMS53692410390396Experimental IGF1R1ApoptosisC25H26ClN5O3479.95951.48.35409.9584359
BMS70816346883536Phase II Gamma-secretase1Cell cycleC20H17ClF4N4O4S520.88544.025.28394.3251358
BMS75480724785538Phase I IGF1R1Ser Thr KinaseC23H24FN9O461.494848.118.81389.573482
Bortezomib387447ApprovedProteasome1Cell cycleC19H25BN4O4384.23740.256.13364.2564661
Bosutinib5328940Phase IABL1, SRC, TEC3Tyrosine kinaseC26H29Cl2N5O3530.44656.211.96460.5181354
Bryostatin5280757Phase IIPRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCH10Angiogenesis, ApoptosisC47H68O17905.032696.013.96847.67124574
BX79510077147ExperimentalTBK1, PDK1, IKBKE, AURKB, AURKC5Ser Thr KinaseC23H26IN7O2S591.468568.96434.8764661
Camptothecin104842Approved TOP1, 1DNA repairC22H20N2O5392.404641.436.79336.2352667
CCT007093NAExperimentalPPM1D1Stress pathwayC15H12OS2272.38529.12229.1310468
CCT018159NAExperimentalHSP901Stress pathwayC17H15ClN2O3330.76633.725.27271.1853358
CEP701126565Phase IIFLT3, JAK2, NTRK1, RET4Tyrosine kinaseC26H21N3O4439.462646.95.38364.7643661
CGP08299624825971Experimental CDK41Ser Thr KinaseC27H32N6O456.582653.079.5426.4164482
CGP60474644215Experimental CDK1, CDK2, CDK5, CDK7, CDK95Cell cycleC18H18ClN5O355.82138.539.22307.1763470
CHIR990219956119Experimental GSK3B1Tyrosine kinaseC22H18Cl2N8465.33848.149.46378.7173576
CI10406918454Phase IIMAP2K1, MAP2K22Ser Thr KinaseC17H14ClF2IN2O2478.6639.333.89308.3232358
Cisplatin84691ApprovedDNAdamage1ReplicationCl2H6N2Pt300.0511.9911573
CMKNAExperimental RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS66Ser Thr KinaseC17H17ClN4O2344.79535.7611.08292.0852358
Cyclopamine442972Experimental SMO1AngiogenesisC27H41NO2411.619950.64418.2232458
Cytarabine6253ApprovedDNAsynthesis1MetabolismC9H13N3O5243.216622.216.64201.2674576
Dasatinib3062316ApprovedABL1, ABL2, PDGFRB, FYN, 4Receptor Tyrosine kinaseC22H26ClN7O2S488.00651.587.83416.4783354
DMOG560326Experimental P4HB1TranscriptionC6H9NO5175.139415.83149.4831576
Docetaxel148124ApprovedMicrotubules1MitosisC43H53NO14807.879282.064.04734.12105576
Doxorubicin31703ApprovedDNAintercalating1DNA repairC27H29NO11543.519353.879.06462.89126667
EHT1864NAExperimentalRAC11Cell cycle, CytoskeltonC25H27F3N2O4S508.55350.33433.7960354
Elesclomol300471Phase IIIHSP701Stress pathwayC19H20N4O2S2400.51840.643.88348.0922358
Embelin3218Experimental XIAP1ApoptosisC17H26O4294.385934.362.63294.6442567
EpothiloneB448013Phase IIMicrotubules1Cytoskelton, Cell cycleC27H41NO6S507.68356.428.37489.3462661
Erlotinib176870ApprovedEGFR1Receptor Tyrosine kinaseC22H23N3O4393.435743.4810.36358.7471482
Etoposide36462ApprovedTOP21DNA repairC29H32O13588.556658.772.99496.33123576
FH5353463933Experimental CTNNB11TranscriptionC13H10Cl2N2O4S361.20132.69267.9441661
FTI2773005532Experimental FNTA1Cell cycleC22H29N3O3S2447.61449.759.65408.3944661
GDC044924776445Phase IISMO1AngiogenesisC19H14Cl2N2O3S421.29739.216.99330.5841831
GDC094117755052Phase IPIK3CA, PIK3CB, PIK3CG, PIK3CD4ApoptosisC23H27N7O3S2513.63654.389.72432.5681667
Gefitinib123631ApprovedEGFR1Receptor Tyrosine kinaseC22H24ClFN4O3446.90246.1311.48383.1771357
Gemcitabine60750ApprovedDNAreplication1ReplicationC9H11F2N3O4263.198121.455.54202.8863661
GNF25311510Experimental BCR-ABL1Tyrosine kinase, C18H13F3N4O2374.316634.689.2297.5552661
GSK269962A16095342Experimental ROCK1, ROCK22Ser Thr KinaseC29H30N8O5570.599158.869.03494.1392667
GSK65039425022668Experimental SGK31Stress pathwayC25H22N2O2382.454442.813.82346.8232563
GW44175616219400Experimental NTRK1, , 1Tyrosine kinaseC17H13N3O275.304629.916.41237.4921531
GW843682X15983966Experimental PLK11Ser Thr KinaseC27H28F3N5O2S543.60454.811.08461.8651358
Imatinib5291ApprovedKIT, RET, NTRK1, ABL1, PDGFRA, PDGFRB6Receptor Tyrosine kinaseC29H31N7O493.602755.5410.2345872359
IPA3521106Experimental PAK11Ser Thr KinaseC20H14O2S2350.45436.04293.8822576
Irinotecan60838ApprovedTOP11DNA repairC33H38N4O6586.67865.9610.58528.9961576
JNJ2685416511609586Phase IMDM21ApoptosisC21H20N4328.410339.7912.57302.9733496
JNK9LNAExperimental MAPK81Ser Thr KinaseC26H27FN8O2502.543453.018.4434.1591661
JNKInhibitorVIII11624601Experimental MAPK81Ser Thr KinaseC18H20N4O4356.375836.697.12318.7172661
JW752149836027Experimental MTOR1Ser Thr KinaseC35H28F3N5O2607.624360.79515.9150361
KIN00113511626927Experimental IKBKE1DNA repairC22H19N3O5S2469.53347.7512.84385.6670317
KU559335278396Experimental ATM1Cell cycleC21H17NO3S2395.49541.5328.4240479
L6854585479543Experimental PSENEN1Cell cycle, ApoptosisC32H50N4O6586.762665.126.2582.0255667
Lapatinib208908ApprovedEGFR, ERBB22Tyrosine kinaseC29H26ClFN4O4S581.05861.1911.58482.6972358
LBW242NAExperimental SMAC1ApoptosisC27H42N4O2454.64852.7910.92459.5242573
Lenalidomide216326ApprovedTNF1AngiogenesisC13H13N3O3259.260625.556.97218.842551
LFMA139549280Experimental BTK1TranscriptionC11H8Br2N2O2360.00126.88217.7742359
Metformin4091ApprovedPRKAA1, 1MetabolismC4H11N5129.163613.18123.0753855
Methotrexate126941ApprovedDHFR1MetabolismC20H22N8O5454.439344.543.56384.14125576
MG132462382Experimental Proteasome1ApoptosisC26H41N3O5475.620853.564.62476.0143491
Midostaurin24202429Phase IKIT1Receptor Tyrosine kinaseC35H30N4O4570.637160.727.08493.3741358
MitomycinC5746ApprovedDNAcrosslinker1ReplicationC15H18N4O5334.327232.773.72276.1473530
MK220646930998Phase IAKT1, AKT22Ser Thr KinaseC25H21N5O407.467144.919.86356.7642503
MS2754261Phase IHDAC1, HDAC2, HDAC33ChromatinC21H20N4O3376.408539.618.4334.7143661
Nilotinib644241ApprovedABL1, KIT2Tyrosine kinaseC28H22F3N7O529.515852.359.07440.6662661
NSC878775459322Experimental PTPN6, PTPN112Cell cycleC19H13N3O7S2459.45244.31348.18103354
NU744111327430Experimental PRKDC, 1Ser Thr KinaseC25H19NO3S413.48843.869.74352.8140575
Nutlin311433190Experimental MDM21ApoptosisC30H30Cl2N4O4581.4960.098.45497.1851667
NVPBEZ23511977753Phase IPIK3CA, PIK3CB, PIK3CG, PIK3C, , 4ApoptosisC30H23N5O469.536551.35417.740544
NVPTAE68416038120Experimental ALK1Receptor Tyrosine kinaseC30H40ClN7O3S614.20268.0110.25552.91102667
ObatoclaxMesylate16727411Phase I, Phase IIBCL2, BCLXL, MCL13ApoptosisC21H23N3O4S413.4937.518.7432551
OSI90611640390Phase IIGF1R1Receptor Tyrosine kinaseC26H23N5O421.493748.0110.6237452551
PAC16851947Phase IIICASP31ApoptosisC23H28N4O2392.49444.619.52372.4752361
Paclitaxel36314ApprovedMicrotubules, BCL22MitosisC47H51NO14853.906187.034.65763.33104560
Panobinostat6918837Phase II HDAC11ChromatinC21H23N3O2349.426240.269.85325.2234865
Parthenolide5420805Phase II NFKB11ApoptosisC15H20O3248.317527.053.31243.420479
Pazopanib10113978Approved VEGFR, PDGFRA, PDGFRB, KIT4Receptor Tyrosine kinase, AngiogenesisC21H23N7O2S437.51846.147.74376.7772667
PD03259019826528Phase IMAP2K1, MAP2K2, 2Ser Thr KinaseC16H14F3IN2O4482.19337.964.47311.0654996
PD03329915330286Phase IICDK4, CDK62Cell cycleC24H29N7O2447.532849.0610.09406.94821064
PD1730741401Experimental FGFR1, FGFR3, SRC3Receptor Tyrosine kinase, AngiogenesisC28H41N7O3523.670260.4610.91507.1283661
PF0234106611496366Phase IMET, ALK2Receptor Tyrosine kinaseC22H24Cl2FN5O464.36347.74389.9151661
PF4708671NAExperimental RPS6KB21Ser Thr KinaseC19H23F3N6392.421337.1811.64336.9461358
PF56227111713159Experimental PTK21Tyrosine kinaseC21H20F3N7O3S507.48946.728.96399.6383722
PHA66575210461815Experimental MET1Receptor Tyrosine kinaseC32H34Cl2N4O4S641.60868.169.85541.25521057
PLX472024180719Experimental BRAF, 1Ser Thr KinaseC17H14ClF2N3O3S413.82638.124.42316.2342964
Pyrimethamine4993ApprovedDHFR1MetabolismC12H13ClN4248.71125.7912.5213.7742864
QS11NAExperimental ARFGAP1, 1ApoptosisC35H31N5O2553.652960.418.25497.91521067
RAF26511656518Phase IBRAFKDR1Ser Thr Kinase, AngiogenesisC24H18F6N6O520.429746.378.99397.2862862
Rapamycin5284616ApprovedMTOR1Ser Thr KinaseC51H79NO13914.1719100.083.7901.06123661
RDEA11944182295Phase IMAP2K1, MAP2K22Ser Thr KinaseC19H20F3IN2O5S572.33746.572.25384.5764500
RO330644450571Experimental CDK11Ser Thr Kinase, Cell cycleC18H13N3OS2351.44537.2612.64286.3141358
Roscovitine160355Phase ICDK21Cell cycleC19H26N6O354.449340.4310.19334.8163357
Salubrinal5717801Experimental EIF2S11Stress pathway, ApoptosisC21H17Cl3N4OS479.8146.486.29376.9923361
SB216763176158Experimental GSK3A, GSK3B2Ser Thr KinaseC21H16Cl2N2367.27138.2412.39305.1311661
SB59088511316960Experimental BRAF1Ser Thr KinaseC27H27N5O2453.535652.259.6406.9462460
Shikonin5208Phase IICCR51C16H16O5288.295228.973.25255.2353351
SL0101114825856Experimental RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS66Ser Thr KinaseC25H24O12516.450949.941.25430.91104553
Sorafenib216239ApprovedPDGFRA, PDGFRB, KDR, KIT, FLT35Ser Thr KinaseC21H16ClF3N4O3464.82541.116.7936433557
STritylLcysteine76044Experimental KIF111CytoskeltonC22H21NO2S363.47339.425.74333.8932560
Sunitinib5329102ApprovedPDGFRA, PDGFRB, KDR, KIT, FLT35Receptor Tyrosine kinaseC22H27FN4O2398.473844.3210.25364.7633540
Temsirolimus6918289ApprovedMTOR1Cell cycle, AngiogenesisC56H87NO161030.2871111.393.831005.82144569
Thapsigargin446378Experimental ATP2A31CytoskeltonC34H50O12650.753669.583.54613.5372355
Tipifarnib159324Phase IFNTA1Ser Thr KinaseC27H22Cl2N4O489.39650.16412.6631667
TKI25844150621Phase IIIEGFR, FGFR1, PDGFRB, FLT1, KDR5Receptor Tyrosine kinaseC21H21FN6O392.429442.388.28338.252860
Topotecan60700ApprovedTOP11DNA repairC24H25N3O4419.47345.798.91372.2762358
TW3711455910Experimental BCL21ApoptosisC33H35NO6S573.69962.92.06523.5264358
Vinblastine6710780ApprovedMicrotubules1Cytoskelton, Cell cycleC46H58N4O9810.974188.559.93761.9393560
Vinorelbine60780ApprovedMicrotubules1MitosisC45H54N4O8778.932385.089.84716.8282479
Vorinostat5311ApprovedHDAC1, HDAC2, HDAC3, HDAC6, HDAC85ChromatinC14H20N2O3264.320228.392.69253.8133576
VX6805494449Phase IAURKA, AURKB, AURKC, FLT3, ABL1, JAK26Cell cycleC23H28N8OS464.58651.439.62410.3773661
VX70210341154Phase IIMAPK11, MAPK12, MAPK13, MAPK144Ser Thr Kinase, ApoptosisC19H12F4N4O2404.317834.76.49311.4632865
WH402311844351Experimental SRC, ABL12Tyrosine kinaseC32H36N6O4568.66662.0111.16523.2491661
WZ18449821040Experimental BMX1Tyrosine kinase, C23H28N8O2448.520847.687.61405.3573504
XMD88546844147Experimental MAPK71Ser Thr KinaseC25H29N7O2459.543551.1710.68418.7781358
ZD64743081361ApprovedRET, VEGFR2, EGFR3Receptor Tyrosine kinase, AngiogenesisC22H24BrFN4O2475.35446.7411.47378.0761573
ZLLNleCHO16760646Experimental PSENEN1Cell cycleC26H41N3O5475.620853.314.63475.1443576
ZM4474399914412ExperimentalAURKB1Ser Thr KinaseC29H31N5O4513.587557.589.61465.2782667