A443654 | 10172943 | Experimental | AKT1, AKT2, AKT3 | 3 | Ser Thr Kinase | C24H23N5O | 397.4723 | 44.62 | 11.61 | 356.81 | 4 | 3 | 358 | |
A770041 | 9549184 | Experimental | SRC | 1 | Tyrosine kinase | C34H39N9O3 | 621.732 | 68.86 | 9.67 | 559.34 | 8 | 2 | 560 | |
ABT263 | 24978538 | Phase I | BCL2, BCLXL, BCLW | 3 | Apoptosis | C47H55ClF3N5O6S3 | 974.613 | 101.39 | 6.88 | 837.13 | 10 | 2 | 574 | |
ABT888 | 11960529 | Phase I | PARP1, PARP2 | 2 | DNA repair | C13H16N4O | 244.2923 | 26.57 | 9.72 | 220.62 | 3 | 3 | 503 | |
AEW541 | 11476171 | Experimental | IGF1R | 1 | Apoptosis | C27H29N5O | 439.5521 | 50.69 | | 405.01 | 5 | 1 | 479 | |
AG014699 | 9931953 | Phase I, Phase II | PARP1, PARP2 | 2 | DNA repair | C19H21FN3O5P | 421.3593 | 37.14 | 11.39 | | 2 | 3 | 557 | |
AICAR | 65110 | Phase II | PRKAA1, | 1 | Metabolism | C9H15N4O8P | 338.2112 | 28.95 | 2.99 | 256.52 | 9 | 6 | 562 | |
AKTinhibitorVIII | 16218954 | Phase II | AKT1, AKT2, AKT3 | 3 | Ser Thr Kinase | C36H32F3N7O4 | 683.679 | 61.82 | 9.76 | | 5 | 2 | 667 | |
AMG706 | 11667893 | Phase I, Phase II | VEGFR1, VEGFR2, RET, KIT, PDGFRA, PDGFRB | 6 | Receptor Tyrosine kinase | C22H23N5O | 373.4509 | 39.38 | 9.05 | 341.74 | 5 | 3 | 560 | |
AP24534 | 24826799 | Phase I | ABL1 | 1 | Tyrosine kinase | C29H27F3N6O | 532.5595 | 56.18 | 9.67 | 461.32 | 5 | 1 | 667 | |
AS601245 | 11422035 | Experimental | JNK1, JNK2, JNK3 | 3 | Ser Thr Kinase | C20H16N6S | 372.446 | 39.38 | 8.38 | 317.96 | 6 | 2 | 661 | |
ATRA | 444795 | Approved | RXRB, RXRG, RAR1 | 3 | Transcription, | C20H28O2 | 300.4351 | 36.62 | | 312.36 | 2 | 1 | 573 | |
AUY922 | 10096043 | Phase II | HSP90AA1, HSP90AB1, HSP90AB4P, HSP90B1, | 5 | Apoptosis | C26H31N3O5 | 465.5414 | 50.83 | 7.32 | 425.03 | 7 | 3 | 661 | |
Axitinib | 6450551 | Approved | PDGFRA, PDGFRB, KIT, VEGFR2 | 4 | Receptor Tyrosine kinase | C22H18N4OS | 386.47 | 42.67 | 9 | 334.27 | 3 | 2 | 576 | |
AZ628 | 11676786 | Experimental | BRAF | 1 | Receptor Tyrosine kinase | C27H25N5O2 | 451.5197 | 48.23 | 8.81 | 410.75 | 5 | 2 | 354 | |
AZD0530 | 10302451 | Phase II | SRC, ABL1 | 2 | Tyrosine kinase | C27H32ClN5O5 | 542.026 | 57.25 | 9.94 | 472.15 | 10 | 1 | 865 | |
AZD2281 | 23725625 | Phase I | PARP1, PARP2 | 2 | DNA repair | C24H23FN4O3 | 434.4628 | 43.54 | 5.96 | 375.65 | 4 | 1 | 557 | |
AZD6244 | 10127622 | Phase II | MAP2K1, MAP2K2 | 2 | Ser Thr Kinase | C17H15BrClFN4O3 | 457.681 | 40.73 | 7.79 | 323.52 | 5 | 3 | 1033 | |
AZD6482 | 44137675 | Phase I | PI3KCB, PI3KC2B | 2 | Apoptosis | C22H24N4O4 | 408.4504 | 42.77 | 3.32 | 364.43 | 7 | 2 | 667 | |
AZD7762 | 1152667 | Phase I | CHK1, CHK2 | 2 | Ser Thr Kinase | C18H21FN4O2S | 376.448 | 39.45 | 12.28 | 324.29 | 4 | 4 | 574 | |
AZD8055 | 25262965 | Phase I | MTOR | 1 | Ser Thr Kinase | C25H31N5O4 | 465.5447 | 51.44 | 8.89 | 425.97 | 9 | 1 | 553 | |
BAY613606 | 16760671 | Experimental | SYK | 1 | Tyrosine kinase | C20H23ClN6O5 | 462.887 | 40.66 | 9.05 | | 7 | 2 | 661 | |
Bexarotene | 82146 | Approved | RXRA, RXRB, RXRG | 3 | Transcription | C24H28O2 | 348.4779 | 40.89 | | 349.49 | 2 | 1 | 538 | |
BI2536 | 11364421 | Phase II | PLK1, PLK2, PLK3 | 3 | Ser Thr Kinase, Mitosis | C28H39N7O3 | 521.6544 | 59.67 | 10 | 491.84 | 8 | 2 | 359 | |
BIBW2992 | 44569596 | Phase III | EGFR, ERBB2 | 2 | Receptor Tyrosine kinase | C25H26ClFN4O3 | 484.95 | 50.8 | 10.7 | 417.7 | 6 | 2 | 576 | |
Bicalutamide | 2375 | Approved | AR | 1 | Metabolism | C18H14F4N2O4S | 430.373 | 36.68 | 3.95 | 332.45 | 5 | 2 | 661 | |
BID1870 | 25023738 | Experimental | RSK1, RSK2, RSK3, PLK1, AURKB | 5 | Ser Thr Kinase | C19H23F2N5O2 | 391.415 | 39.81 | 6.59 | 342.82 | 6 | 2 | 573 | |
BIRB0796 | 156422 | Experimental | MAPK11, MAPK12, MAPK13, MAPK14, JNK2 | 5 | Ser Thr Kinase | C31H37N5O3 | 527.6572 | 58.53 | 9.11 | 495.63 | 5 | 2 | 573 | |
Bleomycin | 5460769 | Approved | DNAdamage | 1 | DNA repair | C55H84N17O21S3 | 1415.552 | 140.88 | 11.41 | 1211.93 | 28 | 20 | 661 | |
BMS509744 | 20635522 | Experimental | ITK | 1 | Tyrosine kinase | C31H39N5O4S2 | 609.802 | 67.99 | 9.83 | 555.7 | 6 | 2 | 359 | |
BMS536924 | 10390396 | Experimental | IGF1R | 1 | Apoptosis | C25H26ClN5O3 | 479.959 | 51.4 | 8.35 | 409.95 | 8 | 4 | 359 | |
BMS708163 | 46883536 | Phase II | Gamma-secretase | 1 | Cell cycle | C20H17ClF4N4O4S | 520.885 | 44.02 | 5.28 | 394.32 | 5 | 1 | 358 | |
BMS754807 | 24785538 | Phase I | IGF1R | 1 | Ser Thr Kinase | C23H24FN9O | 461.4948 | 48.11 | 8.81 | 389.5 | 7 | 3 | 482 | |
Bortezomib | 387447 | Approved | Proteasome | 1 | Cell cycle | C19H25BN4O4 | 384.237 | 40.25 | 6.13 | 364.25 | 6 | 4 | 661 | |
Bosutinib | 5328940 | Phase I | ABL1, SRC, TEC | 3 | Tyrosine kinase | C26H29Cl2N5O3 | 530.446 | 56.2 | 11.96 | 460.51 | 8 | 1 | 354 | |
Bryostatin | 5280757 | Phase II | PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCH | 10 | Angiogenesis, Apoptosis | C47H68O17 | 905.0326 | 96.01 | 3.96 | 847.67 | 12 | 4 | 574 | |
BX795 | 10077147 | Experimental | TBK1, PDK1, IKBKE, AURKB, AURKC | 5 | Ser Thr Kinase | C23H26IN7O2S | 591.468 | 56 | 8.96 | 434.87 | 6 | 4 | 661 | |
Camptothecin | 104842 | Approved | TOP1, | 1 | DNA repair | C22H20N2O5 | 392.4046 | 41.43 | 6.79 | 336.23 | 5 | 2 | 667 | |
CCT007093 | NA | Experimental | PPM1D | 1 | Stress pathway | C15H12OS2 | 272.385 | 29.12 | | 229.13 | 1 | 0 | 468 | |
CCT018159 | NA | Experimental | HSP90 | 1 | Stress pathway | C17H15ClN2O3 | 330.766 | 33.72 | 5.27 | 271.18 | 5 | 3 | 358 | |
CEP701 | 126565 | Phase II | FLT3, JAK2, NTRK1, RET | 4 | Tyrosine kinase | C26H21N3O4 | 439.4626 | 46.9 | 5.38 | 364.76 | 4 | 3 | 661 | |
CGP082996 | 24825971 | Experimental | CDK4 | 1 | Ser Thr Kinase | C27H32N6O | 456.5826 | 53.07 | 9.5 | 426.41 | 6 | 4 | 482 | |
CGP60474 | 644215 | Experimental | CDK1, CDK2, CDK5, CDK7, CDK9 | 5 | Cell cycle | C18H18ClN5O | 355.821 | 38.53 | 9.22 | 307.17 | 6 | 3 | 470 | |
CHIR99021 | 9956119 | Experimental | GSK3B | 1 | Tyrosine kinase | C22H18Cl2N8 | 465.338 | 48.14 | 9.46 | 378.71 | 7 | 3 | 576 | |
CI1040 | 6918454 | Phase II | MAP2K1, MAP2K2 | 2 | Ser Thr Kinase | C17H14ClF2IN2O2 | 478.66 | 39.33 | 3.89 | 308.32 | 3 | 2 | 358 | |
Cisplatin | 84691 | Approved | DNAdamage | 1 | Replication | Cl2H6N2Pt | 300.051 | 1.99 | | | 1 | 1 | 573 | |
CMK | NA | Experimental | RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6 | 6 | Ser Thr Kinase | C17H17ClN4O2 | 344.795 | 35.76 | 11.08 | 292.08 | 5 | 2 | 358 | |
Cyclopamine | 442972 | Experimental | SMO | 1 | Angiogenesis | C27H41NO2 | 411.6199 | 50.64 | | 418.22 | 3 | 2 | 458 | |
Cytarabine | 6253 | Approved | DNAsynthesis | 1 | Metabolism | C9H13N3O5 | 243.2166 | 22.21 | 6.64 | 201.26 | 7 | 4 | 576 | |
Dasatinib | 3062316 | Approved | ABL1, ABL2, PDGFRB, FYN, | 4 | Receptor Tyrosine kinase | C22H26ClN7O2S | 488.006 | 51.58 | 7.83 | 416.47 | 8 | 3 | 354 | |