681640 | 10384072 | Experimental | WEE1, CHK1 | 2 | Ser Thr Kinase | C20H11ClN2O3 | 362.766 | 36.39 | | 282.6 | 3 | 3 | 540 | |
17AAG | 6505803 | Phase III | HSP90AA1, HSP90AB1, HSP90AB4P, HSP90B1, | 5 | Stress pathway, | C31H43N3O8 | 585.6884 | 61.68 | 5.85 | 550.26 | 8 | 4 | 1076 | |
A443654 | 10172943 | Experimental | AKT1, AKT2, AKT3 | 3 | Ser Thr Kinase | C24H23N5O | 397.4723 | 44.62 | 11.61 | 356.81 | 4 | 3 | 358 | |
A770041 | 9549184 | Experimental | SRC | 1 | Tyrosine kinase | C34H39N9O3 | 621.732 | 68.86 | 9.67 | 559.34 | 8 | 2 | 560 | |
ABT263 | 24978538 | Phase I | BCL2, BCLXL, BCLW | 3 | Apoptosis | C47H55ClF3N5O6S3 | 974.613 | 101.39 | 6.88 | 837.13 | 10 | 2 | 574 | |
ABT888 | 11960529 | Phase I | PARP1, PARP2 | 2 | DNA repair | C13H16N4O | 244.2923 | 26.57 | 9.72 | 220.62 | 3 | 3 | 503 | |
AEW541 | 11476171 | Experimental | IGF1R | 1 | Apoptosis | C27H29N5O | 439.5521 | 50.69 | | 405.01 | 5 | 1 | 479 | |
AG014699 | 9931953 | Phase I, Phase II | PARP1, PARP2 | 2 | DNA repair | C19H21FN3O5P | 421.3593 | 37.14 | 11.39 | | 2 | 3 | 557 | |
AICAR | 65110 | Phase II | PRKAA1, | 1 | Metabolism | C9H15N4O8P | 338.2112 | 28.95 | 2.99 | 256.52 | 9 | 6 | 562 | |
AKTinhibitorVIII | 16218954 | Phase II | AKT1, AKT2, AKT3 | 3 | Ser Thr Kinase | C36H32F3N7O4 | 683.679 | 61.82 | 9.76 | | 5 | 2 | 667 | |
AMG706 | 11667893 | Phase I, Phase II | VEGFR1, VEGFR2, RET, KIT, PDGFRA, PDGFRB | 6 | Receptor Tyrosine kinase | C22H23N5O | 373.4509 | 39.38 | 9.05 | 341.74 | 5 | 3 | 560 | |
AP24534 | 24826799 | Phase I | ABL1 | 1 | Tyrosine kinase | C29H27F3N6O | 532.5595 | 56.18 | 9.67 | 461.32 | 5 | 1 | 667 | |
AS601245 | 11422035 | Experimental | JNK1, JNK2, JNK3 | 3 | Ser Thr Kinase | C20H16N6S | 372.446 | 39.38 | 8.38 | 317.96 | 6 | 2 | 661 | |
ATRA | 444795 | Approved | RXRB, RXRG, RAR1 | 3 | Transcription, | C20H28O2 | 300.4351 | 36.62 | | 312.36 | 2 | 1 | 573 | |
AUY922 | 10096043 | Phase II | HSP90AA1, HSP90AB1, HSP90AB4P, HSP90B1, | 5 | Apoptosis | C26H31N3O5 | 465.5414 | 50.83 | 7.32 | 425.03 | 7 | 3 | 661 | |
Axitinib | 6450551 | Approved | PDGFRA, PDGFRB, KIT, VEGFR2 | 4 | Receptor Tyrosine kinase | C22H18N4OS | 386.47 | 42.67 | 9 | 334.27 | 3 | 2 | 576 | |
AZ628 | 11676786 | Experimental | BRAF | 1 | Receptor Tyrosine kinase | C27H25N5O2 | 451.5197 | 48.23 | 8.81 | 410.75 | 5 | 2 | 354 | |
AZD0530 | 10302451 | Phase II | SRC, ABL1 | 2 | Tyrosine kinase | C27H32ClN5O5 | 542.026 | 57.25 | 9.94 | 472.15 | 10 | 1 | 865 | |
AZD2281 | 23725625 | Phase I | PARP1, PARP2 | 2 | DNA repair | C24H23FN4O3 | 434.4628 | 43.54 | 5.96 | 375.65 | 4 | 1 | 557 | |
AZD6244 | 10127622 | Phase II | MAP2K1, MAP2K2 | 2 | Ser Thr Kinase | C17H15BrClFN4O3 | 457.681 | 40.73 | 7.79 | 323.52 | 5 | 3 | 1033 | |
AZD6482 | 44137675 | Phase I | PI3KCB, PI3KC2B | 2 | Apoptosis | C22H24N4O4 | 408.4504 | 42.77 | 3.32 | 364.43 | 7 | 2 | 667 | |
AZD7762 | 1152667 | Phase I | CHK1, CHK2 | 2 | Ser Thr Kinase | C18H21FN4O2S | 376.448 | 39.45 | 12.28 | 324.29 | 4 | 4 | 574 | |
AZD8055 | 25262965 | Phase I | MTOR | 1 | Ser Thr Kinase | C25H31N5O4 | 465.5447 | 51.44 | 8.89 | 425.97 | 9 | 1 | 553 | |
BAY613606 | 16760671 | Experimental | SYK | 1 | Tyrosine kinase | C20H23ClN6O5 | 462.887 | 40.66 | 9.05 | | 7 | 2 | 661 | |
Bexarotene | 82146 | Approved | RXRA, RXRB, RXRG | 3 | Transcription | C24H28O2 | 348.4779 | 40.89 | | 349.49 | 2 | 1 | 538 | |
BI2536 | 11364421 | Phase II | PLK1, PLK2, PLK3 | 3 | Ser Thr Kinase, Mitosis | C28H39N7O3 | 521.6544 | 59.67 | 10 | 491.84 | 8 | 2 | 359 | |
BIBW2992 | 44569596 | Phase III | EGFR, ERBB2 | 2 | Receptor Tyrosine kinase | C25H26ClFN4O3 | 484.95 | 50.8 | 10.7 | 417.7 | 6 | 2 | 576 | |
Bicalutamide | 2375 | Approved | AR | 1 | Metabolism | C18H14F4N2O4S | 430.373 | 36.68 | 3.95 | 332.45 | 5 | 2 | 661 | |
BID1870 | 25023738 | Experimental | RSK1, RSK2, RSK3, PLK1, AURKB | 5 | Ser Thr Kinase | C19H23F2N5O2 | 391.415 | 39.81 | 6.59 | 342.82 | 6 | 2 | 573 | |
BIRB0796 | 156422 | Experimental | MAPK11, MAPK12, MAPK13, MAPK14, JNK2 | 5 | Ser Thr Kinase | C31H37N5O3 | 527.6572 | 58.53 | 9.11 | 495.63 | 5 | 2 | 573 | |
Bleomycin | 5460769 | Approved | DNAdamage | 1 | DNA repair | C55H84N17O21S3 | 1415.552 | 140.88 | 11.41 | 1211.93 | 28 | 20 | 661 | |
BMS509744 | 20635522 | Experimental | ITK | 1 | Tyrosine kinase | C31H39N5O4S2 | 609.802 | 67.99 | 9.83 | 555.7 | 6 | 2 | 359 | |
BMS536924 | 10390396 | Experimental | IGF1R | 1 | Apoptosis | C25H26ClN5O3 | 479.959 | 51.4 | 8.35 | 409.95 | 8 | 4 | 359 | |
BMS708163 | 46883536 | Phase II | Gamma-secretase | 1 | Cell cycle | C20H17ClF4N4O4S | 520.885 | 44.02 | 5.28 | 394.32 | 5 | 1 | 358 | |
BMS754807 | 24785538 | Phase I | IGF1R | 1 | Ser Thr Kinase | C23H24FN9O | 461.4948 | 48.11 | 8.81 | 389.5 | 7 | 3 | 482 | |
Bortezomib | 387447 | Approved | Proteasome | 1 | Cell cycle | C19H25BN4O4 | 384.237 | 40.25 | 6.13 | 364.25 | 6 | 4 | 661 | |
Bosutinib | 5328940 | Phase I | ABL1, SRC, TEC | 3 | Tyrosine kinase | C26H29Cl2N5O3 | 530.446 | 56.2 | 11.96 | 460.51 | 8 | 1 | 354 | |
Bryostatin | 5280757 | Phase II | PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCH | 10 | Angiogenesis, Apoptosis | C47H68O17 | 905.0326 | 96.01 | 3.96 | 847.67 | 12 | 4 | 574 | |
BX795 | 10077147 | Experimental | TBK1, PDK1, IKBKE, AURKB, AURKC | 5 | Ser Thr Kinase | C23H26IN7O2S | 591.468 | 56 | 8.96 | 434.87 | 6 | 4 | 661 | |
Camptothecin | 104842 | Approved | TOP1, | 1 | DNA repair | C22H20N2O5 | 392.4046 | 41.43 | 6.79 | 336.23 | 5 | 2 | 667 | |
CCT007093 | NA | Experimental | PPM1D | 1 | Stress pathway | C15H12OS2 | 272.385 | 29.12 | | 229.13 | 1 | 0 | 468 | |
CCT018159 | NA | Experimental | HSP90 | 1 | Stress pathway | C17H15ClN2O3 | 330.766 | 33.72 | 5.27 | 271.18 | 5 | 3 | 358 | |
CEP701 | 126565 | Phase II | FLT3, JAK2, NTRK1, RET | 4 | Tyrosine kinase | C26H21N3O4 | 439.4626 | 46.9 | 5.38 | 364.76 | 4 | 3 | 661 | |
CGP082996 | 24825971 | Experimental | CDK4 | 1 | Ser Thr Kinase | C27H32N6O | 456.5826 | 53.07 | 9.5 | 426.41 | 6 | 4 | 482 | |
CGP60474 | 644215 | Experimental | CDK1, CDK2, CDK5, CDK7, CDK9 | 5 | Cell cycle | C18H18ClN5O | 355.821 | 38.53 | 9.22 | 307.17 | 6 | 3 | 470 | |
CHIR99021 | 9956119 | Experimental | GSK3B | 1 | Tyrosine kinase | C22H18Cl2N8 | 465.338 | 48.14 | 9.46 | 378.71 | 7 | 3 | 576 | |
CI1040 | 6918454 | Phase II | MAP2K1, MAP2K2 | 2 | Ser Thr Kinase | C17H14ClF2IN2O2 | 478.66 | 39.33 | 3.89 | 308.32 | 3 | 2 | 358 | |
Cisplatin | 84691 | Approved | DNAdamage | 1 | Replication | Cl2H6N2Pt | 300.051 | 1.99 | | | 1 | 1 | 573 | |
CMK | NA | Experimental | RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6 | 6 | Ser Thr Kinase | C17H17ClN4O2 | 344.795 | 35.76 | 11.08 | 292.08 | 5 | 2 | 358 | |
Cyclopamine | 442972 | Experimental | SMO | 1 | Angiogenesis | C27H41NO2 | 411.6199 | 50.64 | | 418.22 | 3 | 2 | 458 | |
Cytarabine | 6253 | Approved | DNAsynthesis | 1 | Metabolism | C9H13N3O5 | 243.2166 | 22.21 | 6.64 | 201.26 | 7 | 4 | 576 | |
Dasatinib | 3062316 | Approved | ABL1, ABL2, PDGFRB, FYN, | 4 | Receptor Tyrosine kinase | C22H26ClN7O2S | 488.006 | 51.58 | 7.83 | 416.47 | 8 | 3 | 354 | |
DMOG | 560326 | Experimental | P4HB | 1 | Transcription | C6H9NO5 | 175.1394 | 15.83 | | 149.48 | 3 | 1 | 576 | |
Docetaxel | 148124 | Approved | Microtubules | 1 | Mitosis | C43H53NO14 | 807.8792 | 82.06 | 4.04 | 734.12 | 10 | 5 | 576 | |
Doxorubicin | 31703 | Approved | DNAintercalating | 1 | DNA repair | C27H29NO11 | 543.5193 | 53.87 | 9.06 | 462.89 | 12 | 6 | 667 | |
EHT1864 | NA | Experimental | RAC1 | 1 | Cell cycle, Cytoskelton | C25H27F3N2O4S | 508.553 | 50.33 | | 433.79 | 6 | 0 | 354 | |
Elesclomol | 300471 | Phase III | HSP70 | 1 | Stress pathway | C19H20N4O2S2 | 400.518 | 40.64 | 3.88 | 348.09 | 2 | 2 | 358 | |
Embelin | 3218 | Experimental | XIAP | 1 | Apoptosis | C17H26O4 | 294.3859 | 34.36 | 2.63 | 294.64 | 4 | 2 | 567 | |
EpothiloneB | 448013 | Phase II | Microtubules | 1 | Cytoskelton, Cell cycle | C27H41NO6S | 507.683 | 56.42 | 8.37 | 489.34 | 6 | 2 | 661 | |
Erlotinib | 176870 | Approved | EGFR | 1 | Receptor Tyrosine kinase | C22H23N3O4 | 393.4357 | 43.48 | 10.36 | 358.74 | 7 | 1 | 482 | |
Etoposide | 36462 | Approved | TOP2 | 1 | DNA repair | C29H32O13 | 588.5566 | 58.77 | 2.99 | 496.33 | 12 | 3 | 576 | |
FH535 | 3463933 | Experimental | CTNNB1 | 1 | Transcription | C13H10Cl2N2O4S | 361.201 | 32.69 | | 267.94 | 4 | 1 | 661 | |
FTI277 | 3005532 | Experimental | FNTA | 1 | Cell cycle | C22H29N3O3S2 | 447.614 | 49.75 | 9.65 | 408.39 | 4 | 4 | 661 | |
GDC0449 | 24776445 | Phase II | SMO | 1 | Angiogenesis | C19H14Cl2N2O3S | 421.297 | 39.21 | 6.99 | 330.58 | 4 | 1 | 831 | |
GDC0941 | 17755052 | Phase I | PIK3CA, PIK3CB, PIK3CG, PIK3CD | 4 | Apoptosis | C23H27N7O3S2 | 513.636 | 54.38 | 9.72 | 432.56 | 8 | 1 | 667 | |
Gefitinib | 123631 | Approved | EGFR | 1 | Receptor Tyrosine kinase | C22H24ClFN4O3 | 446.902 | 46.13 | 11.48 | 383.17 | 7 | 1 | 357 | |
Gemcitabine | 60750 | Approved | DNAreplication | 1 | Replication | C9H11F2N3O4 | 263.1981 | 21.45 | 5.54 | 202.88 | 6 | 3 | 661 | |
GNF2 | 5311510 | Experimental | BCR-ABL | 1 | Tyrosine kinase, | C18H13F3N4O2 | 374.3166 | 34.68 | 9.2 | 297.55 | 5 | 2 | 661 | |
GSK269962A | 16095342 | Experimental | ROCK1, ROCK2 | 2 | Ser Thr Kinase | C29H30N8O5 | 570.5991 | 58.86 | 9.03 | 494.13 | 9 | 2 | 667 | |
GSK650394 | 25022668 | Experimental | SGK3 | 1 | Stress pathway | C25H22N2O2 | 382.4544 | 42.81 | 3.82 | 346.82 | 3 | 2 | 563 | |
GW441756 | 16219400 | Experimental | NTRK1, , | 1 | Tyrosine kinase | C17H13N3O | 275.3046 | 29.91 | 6.41 | 237.49 | 2 | 1 | 531 | |
GW843682X | 15983966 | Experimental | PLK1 | 1 | Ser Thr Kinase | C27H28F3N5O2S | 543.604 | 54.8 | 11.08 | 461.86 | 5 | 1 | 358 | |
Imatinib | 5291 | Approved | KIT, RET, NTRK1, ABL1, PDGFRA, PDGFRB | 6 | Receptor Tyrosine kinase | C29H31N7O | 493.6027 | 55.54 | 10.23 | 458 | 7 | 2 | 359 | |
IPA3 | 521106 | Experimental | PAK1 | 1 | Ser Thr Kinase | C20H14O2S2 | 350.454 | 36.04 | | 293.88 | 2 | 2 | 576 | |
Irinotecan | 60838 | Approved | TOP1 | 1 | DNA repair | C33H38N4O6 | 586.678 | 65.96 | 10.58 | 528.99 | 6 | 1 | 576 | |
JNJ26854165 | 11609586 | Phase I | MDM2 | 1 | Apoptosis | C21H20N4 | 328.4103 | 39.79 | 12.57 | 302.97 | 3 | 3 | 496 | |
JNK9L | NA | Experimental | MAPK8 | 1 | Ser Thr Kinase | C26H27FN8O2 | 502.5434 | 53.01 | 8.4 | 434.15 | 9 | 1 | 661 | |
JNKInhibitorVIII | 11624601 | Experimental | MAPK8 | 1 | Ser Thr Kinase | C18H20N4O4 | 356.3758 | 36.69 | 7.12 | 318.71 | 7 | 2 | 661 | |
JW7521 | 49836027 | Experimental | MTOR | 1 | Ser Thr Kinase | C35H28F3N5O2 | 607.6243 | 60.79 | | 515.91 | 5 | 0 | 361 | |
KIN001135 | 11626927 | Experimental | IKBKE | 1 | DNA repair | C22H19N3O5S2 | 469.533 | 47.75 | 12.84 | 385.66 | 7 | 0 | 317 | |
KU55933 | 5278396 | Experimental | ATM | 1 | Cell cycle | C21H17NO3S2 | 395.495 | 41.5 | | 328.42 | 4 | 0 | 479 | |
L685458 | 5479543 | Experimental | PSENEN | 1 | Cell cycle, Apoptosis | C32H50N4O6 | 586.7626 | 65.12 | 6.2 | 582.02 | 5 | 5 | 667 | |
Lapatinib | 208908 | Approved | EGFR, ERBB2 | 2 | Tyrosine kinase | C29H26ClFN4O4S | 581.058 | 61.19 | 11.58 | 482.69 | 7 | 2 | 358 | |
LBW242 | NA | Experimental | SMAC | 1 | Apoptosis | C27H42N4O2 | 454.648 | 52.79 | 10.92 | 459.52 | 4 | 2 | 573 | |
Lenalidomide | 216326 | Approved | TNF | 1 | Angiogenesis | C13H13N3O3 | 259.2606 | 25.55 | 6.97 | 218.8 | 4 | 2 | 551 | |
LFMA13 | 9549280 | Experimental | BTK | 1 | Transcription | C11H8Br2N2O2 | 360.001 | 26.88 | | 217.77 | 4 | 2 | 359 | |
Metformin | 4091 | Approved | PRKAA1, | 1 | Metabolism | C4H11N5 | 129.1636 | 13.18 | | 123.07 | 5 | 3 | 855 | |
Methotrexate | 126941 | Approved | DHFR | 1 | Metabolism | C20H22N8O5 | 454.4393 | 44.54 | 3.56 | 384.14 | 12 | 5 | 576 | |
MG132 | 462382 | Experimental | Proteasome | 1 | Apoptosis | C26H41N3O5 | 475.6208 | 53.56 | 4.62 | 476.01 | 4 | 3 | 491 | |
Midostaurin | 24202429 | Phase I | KIT | 1 | Receptor Tyrosine kinase | C35H30N4O4 | 570.6371 | 60.72 | 7.08 | 493.37 | 4 | 1 | 358 | |
MitomycinC | 5746 | Approved | DNAcrosslinker | 1 | Replication | C15H18N4O5 | 334.3272 | 32.77 | 3.72 | 276.14 | 7 | 3 | 530 | |
MK2206 | 46930998 | Phase I | AKT1, AKT2 | 2 | Ser Thr Kinase | C25H21N5O | 407.4671 | 44.91 | 9.86 | 356.76 | 4 | 2 | 503 | |
MS275 | 4261 | Phase I | HDAC1, HDAC2, HDAC3 | 3 | Chromatin | C21H20N4O3 | 376.4085 | 39.61 | 8.4 | 334.71 | 4 | 3 | 661 | |
Nilotinib | 644241 | Approved | ABL1, KIT | 2 | Tyrosine kinase | C28H22F3N7O | 529.5158 | 52.35 | 9.07 | 440.66 | 6 | 2 | 661 | |
NSC87877 | 5459322 | Experimental | PTPN6, PTPN11 | 2 | Cell cycle | C19H13N3O7S2 | 459.452 | 44.31 | | 348.18 | 10 | 3 | 354 | |
NU7441 | 11327430 | Experimental | PRKDC, | 1 | Ser Thr Kinase | C25H19NO3S | 413.488 | 43.86 | 9.74 | 352.81 | 4 | 0 | 575 | |
Nutlin3 | 11433190 | Experimental | MDM2 | 1 | Apoptosis | C30H30Cl2N4O4 | 581.49 | 60.09 | 8.45 | 497.18 | 5 | 1 | 667 | |
NVPBEZ235 | 11977753 | Phase I | PIK3CA, PIK3CB, PIK3CG, PIK3C, , | 4 | Apoptosis | C30H23N5O | 469.5365 | 51.35 | | 417.7 | 4 | 0 | 544 | |
NVPTAE684 | 16038120 | Experimental | ALK | 1 | Receptor Tyrosine kinase | C30H40ClN7O3S | 614.202 | 68.01 | 10.25 | 552.91 | 10 | 2 | 667 | |
ObatoclaxMesylate | 16727411 | Phase I, Phase II | BCL2, BCLXL, MCL1 | 3 | Apoptosis | C21H23N3O4S | 413.49 | 37.51 | 8.74 | | 3 | 2 | 551 | |
OSI906 | 11640390 | Phase I | IGF1R | 1 | Receptor Tyrosine kinase | C26H23N5O | 421.4937 | 48.01 | 10.62 | 374 | 5 | 2 | 551 | |
PAC1 | 6851947 | Phase III | CASP3 | 1 | Apoptosis | C23H28N4O2 | 392.494 | 44.61 | 9.52 | 372.47 | 5 | 2 | 361 | |
Paclitaxel | 36314 | Approved | Microtubules, BCL2 | 2 | Mitosis | C47H51NO14 | 853.9061 | 87.03 | 4.65 | 763.33 | 10 | 4 | 560 | |
Panobinostat | 6918837 | Phase II | HDAC1 | 1 | Chromatin | C21H23N3O2 | 349.4262 | 40.26 | 9.85 | 325.22 | 3 | 4 | 865 | |
Parthenolide | 5420805 | Phase II | NFKB1 | 1 | Apoptosis | C15H20O3 | 248.3175 | 27.05 | 3.31 | 243.4 | 2 | 0 | 479 | |
Pazopanib | 10113978 | Approved | VEGFR, PDGFRA, PDGFRB, KIT | 4 | Receptor Tyrosine kinase, Angiogenesis | C21H23N7O2S | 437.518 | 46.14 | 7.74 | 376.77 | 7 | 2 | 667 | |
PD0325901 | 9826528 | Phase I | MAP2K1, MAP2K2, | 2 | Ser Thr Kinase | C16H14F3IN2O4 | 482.193 | 37.96 | 4.47 | 311.06 | 5 | 4 | 996 | |
PD0332991 | 5330286 | Phase II | CDK4, CDK6 | 2 | Cell cycle | C24H29N7O2 | 447.5328 | 49.06 | 10.09 | 406.94 | 8 | 2 | 1064 | |
PD173074 | 1401 | Experimental | FGFR1, FGFR3, SRC | 3 | Receptor Tyrosine kinase, Angiogenesis | C28H41N7O3 | 523.6702 | 60.46 | 10.91 | 507.12 | 8 | 3 | 661 | |
PF02341066 | 11496366 | Phase I | MET, ALK | 2 | Receptor Tyrosine kinase | C22H24Cl2FN5O | 464.363 | 47.74 | | 389.91 | 5 | 1 | 661 | |
PF4708671 | NA | Experimental | RPS6KB2 | 1 | Ser Thr Kinase | C19H23F3N6 | 392.4213 | 37.18 | 11.64 | 336.94 | 6 | 1 | 358 | |
PF562271 | 11713159 | Experimental | PTK2 | 1 | Tyrosine kinase | C21H20F3N7O3S | 507.489 | 46.72 | 8.96 | 399.63 | 8 | 3 | 722 | |
PHA665752 | 10461815 | Experimental | MET | 1 | Receptor Tyrosine kinase | C32H34Cl2N4O4S | 641.608 | 68.16 | 9.85 | 541.25 | 5 | 2 | 1057 | |
PLX4720 | 24180719 | Experimental | BRAF, | 1 | Ser Thr Kinase | C17H14ClF2N3O3S | 413.826 | 38.12 | 4.42 | 316.23 | 4 | 2 | 964 | |
Pyrimethamine | 4993 | Approved | DHFR | 1 | Metabolism | C12H13ClN4 | 248.711 | 25.79 | 12.5 | 213.77 | 4 | 2 | 864 | |
QS11 | NA | Experimental | ARFGAP1, | 1 | Apoptosis | C35H31N5O2 | 553.6529 | 60.41 | 8.25 | 497.91 | 5 | 2 | 1067 | |
RAF265 | 11656518 | Phase I | BRAFKDR | 1 | Ser Thr Kinase, Angiogenesis | C24H18F6N6O | 520.4297 | 46.37 | 8.99 | 397.28 | 6 | 2 | 862 | |
Rapamycin | 5284616 | Approved | MTOR | 1 | Ser Thr Kinase | C51H79NO13 | 914.1719 | 100.08 | 3.7 | 901.06 | 12 | 3 | 661 | |
RDEA119 | 44182295 | Phase I | MAP2K1, MAP2K2 | 2 | Ser Thr Kinase | C19H20F3IN2O5S | 572.337 | 46.57 | 2.25 | 384.57 | 6 | 4 | 500 | |
RO3306 | 44450571 | Experimental | CDK1 | 1 | Ser Thr Kinase, Cell cycle | C18H13N3OS2 | 351.445 | 37.26 | 12.64 | 286.31 | 4 | 1 | 358 | |
Roscovitine | 160355 | Phase I | CDK2 | 1 | Cell cycle | C19H26N6O | 354.4493 | 40.43 | 10.19 | 334.81 | 6 | 3 | 357 | |
Salubrinal | 5717801 | Experimental | EIF2S1 | 1 | Stress pathway, Apoptosis | C21H17Cl3N4OS | 479.81 | 46.48 | 6.29 | 376.99 | 2 | 3 | 361 | |
SB216763 | 176158 | Experimental | GSK3A, GSK3B | 2 | Ser Thr Kinase | C21H16Cl2N2 | 367.271 | 38.24 | 12.39 | 305.13 | 1 | 1 | 661 | |
SB590885 | 11316960 | Experimental | BRAF | 1 | Ser Thr Kinase | C27H27N5O2 | 453.5356 | 52.25 | 9.6 | 406.94 | 6 | 2 | 460 | |
Shikonin | 5208 | Phase II | CCR5 | 1 | | C16H16O5 | 288.2952 | 28.97 | 3.25 | 255.23 | 5 | 3 | 351 | |
SL01011 | 14825856 | Experimental | RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6 | 6 | Ser Thr Kinase | C25H24O12 | 516.4509 | 49.94 | 1.25 | 430.91 | 10 | 4 | 553 | |
Sorafenib | 216239 | Approved | PDGFRA, PDGFRB, KDR, KIT, FLT3 | 5 | Ser Thr Kinase | C21H16ClF3N4O3 | 464.825 | 41.11 | 6.79 | 364 | 3 | 3 | 557 | |
STritylLcysteine | 76044 | Experimental | KIF11 | 1 | Cytoskelton | C22H21NO2S | 363.473 | 39.42 | 5.74 | 333.89 | 3 | 2 | 560 | |
Sunitinib | 5329102 | Approved | PDGFRA, PDGFRB, KDR, KIT, FLT3 | 5 | Receptor Tyrosine kinase | C22H27FN4O2 | 398.4738 | 44.32 | 10.25 | 364.76 | 3 | 3 | 540 | |
Temsirolimus | 6918289 | Approved | MTOR | 1 | Cell cycle, Angiogenesis | C56H87NO16 | 1030.2871 | 111.39 | 3.83 | 1005.82 | 14 | 4 | 569 | |
Thapsigargin | 446378 | Experimental | ATP2A3 | 1 | Cytoskelton | C34H50O12 | 650.7536 | 69.58 | 3.54 | 613.53 | 7 | 2 | 355 | |
Tipifarnib | 159324 | Phase I | FNTA | 1 | Ser Thr Kinase | C27H22Cl2N4O | 489.396 | 50.16 | | 412.66 | 3 | 1 | 667 | |
TKI258 | 44150621 | Phase III | EGFR, FGFR1, PDGFRB, FLT1, KDR | 5 | Receptor Tyrosine kinase | C21H21FN6O | 392.4294 | 42.38 | 8.28 | 338.2 | 5 | 2 | 860 | |
Topotecan | 60700 | Approved | TOP1 | 1 | DNA repair | C24H25N3O4 | 419.473 | 45.79 | 8.91 | 372.27 | 6 | 2 | 358 | |
TW37 | 11455910 | Experimental | BCL2 | 1 | Apoptosis | C33H35NO6S | 573.699 | 62.9 | 2.06 | 523.52 | 6 | 4 | 358 | |
Vinblastine | 6710780 | Approved | Microtubules | 1 | Cytoskelton, Cell cycle | C46H58N4O9 | 810.9741 | 88.55 | 9.93 | 761.93 | 9 | 3 | 560 | |
Vinorelbine | 60780 | Approved | Microtubules | 1 | Mitosis | C45H54N4O8 | 778.9323 | 85.08 | 9.84 | 716.82 | 8 | 2 | 479 | |
Vorinostat | 5311 | Approved | HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 | 5 | Chromatin | C14H20N2O3 | 264.3202 | 28.39 | 2.69 | 253.81 | 3 | 3 | 576 | |
VX680 | 5494449 | Phase I | AURKA, AURKB, AURKC, FLT3, ABL1, JAK2 | 6 | Cell cycle | C23H28N8OS | 464.586 | 51.43 | 9.62 | 410.37 | 7 | 3 | 661 | |
VX702 | 10341154 | Phase II | MAPK11, MAPK12, MAPK13, MAPK14 | 4 | Ser Thr Kinase, Apoptosis | C19H12F4N4O2 | 404.3178 | 34.7 | 6.49 | 311.46 | 3 | 2 | 865 | |
WH4023 | 11844351 | Experimental | SRC, ABL1 | 2 | Tyrosine kinase | C32H36N6O4 | 568.666 | 62.01 | 11.16 | 523.24 | 9 | 1 | 661 | |
WZ184 | 49821040 | Experimental | BMX | 1 | Tyrosine kinase, | C23H28N8O2 | 448.5208 | 47.68 | 7.61 | 405.35 | 7 | 3 | 504 | |
XMD885 | 46844147 | Experimental | MAPK7 | 1 | Ser Thr Kinase | C25H29N7O2 | 459.5435 | 51.17 | 10.68 | 418.77 | 8 | 1 | 358 | |
ZD6474 | 3081361 | Approved | RET, VEGFR2, EGFR | 3 | Receptor Tyrosine kinase, Angiogenesis | C22H24BrFN4O2 | 475.354 | 46.74 | 11.47 | 378.07 | 6 | 1 | 573 | |
ZLLNleCHO | 16760646 | Experimental | PSENEN | 1 | Cell cycle | C26H41N3O5 | 475.6208 | 53.31 | 4.63 | 475.14 | 4 | 3 | 576 | |
ZM447439 | 9914412 | Experimental | AURKB | 1 | Ser Thr Kinase | C29H31N5O4 | 513.5875 | 57.58 | 9.61 | 465.27 | 8 | 2 | 667 | |