CancerDR: Cancer Drug Resistance Database

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Clustering of drugs



It is important to know which drugs have similar level of effectiveness for a given cell line or tissue type. This page allows the user to cluster drugs screened against selected cell line and group on the basis of IC50 or relative drug sensitivity. User can either choose the tissue type, all cell lines or can select the cell lines with mutated drug targets. The second column gives the number of drugs screened against the particular cell line as it is equal to or greater than reference IC50 (lowest of all IC50s). Subsequent columns, up to eighth, give grouping based on IC50 value equal or greater than 3, 5, 25, 100 and 250 times of reference IC50. The columns from nine to sixteen show the group of drugs with absolute value of IC50 lying in different ranges (R1, R2, R3, R4, R5, R6, R7 and R8). The drugs in groups with higher value are important for resistance-mechanism related studies. For more information, please click HERE


** Ref: Lowest of all IC50s, xRef: times of reference value (column two to seven) , Range of IC50 value (column eight to fifteen)- R1: 0-0.001 µM, R2: 0.001-0.005µM, R3: 0.005-0.025µM, R4: 0.025-0.125µM, R5: 0.125-0.625µM, R6: 0.625-15µM, R7: 15-390µM, R8: greater than 390 µM.



Select Tissue type against which you want to see Drug clusters

AUTONOMIC GANGLIA BILIARY TRACT BLADDER BLOOD BONE BREAST CENTRAL NERVOUS SYSTEM
ENDOMETRIUM GI TRACT HAEMATOPOIETIC AND LYMPHOID TISSUE KIDNEY LARGE INTESTINE LIVER LUNG
OESOPHAGUS OTHER OVARY PANCREASE PLEURA PROSTATE SALIVARY GLAND
SKIN SOFT TISSUE STOMACH THYROID UPPER AERODIGESTIVE TRACT URINARY TRACT UTERUS
ALL MUTANTS

Drug cluster for CENTRAL NERVOUS SYSTEM tissue type

Cell Line IC50 ≥ Ref IC50 ≥ 3xRef IC50 ≥ 5xRef IC50 ≥ 25xRef IC50 ≥ 50xRef IC50 ≥ 100xRef IC50 ≥ 250xRef R1 R2 R3 R4 R5 R6 R7 R8
1321N121202020191717010121700
42MGBA20191917161515010311500
8MGBANANANANANANANA6071314565012
A172NANANANANANANA30541056305
ACNNANANANANANANA709101243489
AM38NANANANANANANA20457267519
BeckerNANANANANANANA405107445315
CAS1NANANANANANANA10297655820
CCFSTTG1NANANANANANANA102361483
CHP126777574686560560026519369
CHP13425232316141070000213100
CHP212NANANANANANANA904108273010
D247MGNANANANANANANA20245395012
D263MGNANANANANANANA202811386116
D283MEDNANANANANANANA201411376221
D336MGNANANANANANANA20478274314
D392MGNANANANANANANA10359305312
D423MGNANANANANANANA2021521246
D502MGNANANANANANANA10445406717
D542MGNANANANANANANA10239234213
D566MGNANANANANANANA4032224215
DaoyNANANANANANANA5057732375
DAOY24232220191919001221900
DBTRG05MGNANANANANANANA10561347419
DKMG1221181171101061039700468474017
GAMGNANANANANANANA60641054317
GB1NANANANANANANA306121661559
GI1NANANANANANANA807812654414
GIMENNANANANANANANA2041114435113
GMS10NANANANANANANA103311444218
GOTONANANANANANANA203513366316
H4NANANANANANANA60841350329
HS68324232321212019001032000
IMR5NANANANANANANA20377172912
KALS1NANANANANANANA60881357588
KINGS1NANANANANANANA204613366017
KNS42NANANANANANANA306410497515
KNS6024232321201918010221900
KNS812423221818160000141900
KNS81FDNANANANANANANA204310346718
KPNRTBM125202015151310000058120
KPNYN9489888585817400063175117
KPNYSNANANANANANANA10568375220
KS1NANANANANANANA8091214483710
LAN6NANANANANANANA100514365527
LN182219191513110000311800
LN22923222120202017001202000
LN405NANANANANANANA10135245212
M059JNANANANANANANA40764473816
MCIXCNANANANANANANA7046732339