CancerDR: Cancer Drug Resistance Database

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Browsing of Drug Targets



This option of server allows user to browse drug targets in CancerDR. This page summarizes the Targets with Refseq IDs and their status (whether mutated or not) in different cell lines. For more information, please click Help



Drug Target Refseq ID COSMIC MINT STRING DIP Reactome QuickGO NCBI Genome Browser Ensembl Genome Browser Gene Atlas Tree Families Mutated Cell Lines Wild Type Cell Lines Target length (AA)
ABL1NP_009297ABL1MINT-97648P00519DIP-1042NREACT_111045P00519NM_007313ENSP00000323315ABL1ABL1388651130
ABL2NP_009298ABL2MINT-1347081P42684DIP-91NREACT_111045P42684NM_007314ENSP00000339209ABL2ABL21577531182
AKT1NP_005154AKT1MINT-203775P31749DIP-24269NREACT_111045P31749NM_005163ENSP00000270202AKT1AKT133874480
AKT2NP_001617AKT2MINT-87790P31751NAREACT_111045P31751NM_001626ENSP00000375892AKT2AKT221883481
AKT3NP_005456AKT3MINT-222821Q9Y243NAREACT_111045Q9Y243NM_005465ENSP00000263826AKT3AKT324880479
ALKNP_004295ALKNAQ9UM73NANAQ9UM73NM_004304ENSP00000373700ALKALK708371620
ARNP_000035ARMINT-94801P10275DIP-125NREACT_71P10275NM_000044ENSP00000363822ARAR82832919
ATMNP_000042ATMMINT-194471Q13315DIP-182NREACT_111183Q13315NM_000051ENSP00000278616ATMATM1447743056
AURKANP_940835AURKANAO14965DIP-33068NREACT_115566O14965NM_198433ENSP00000321591AURKAAURKA22882403
AURKBNP_004208AURKBMINT-1413997Q96GD4DIP-34530NREACT_115566Q96GD4NM_004217ENSP00000313950AURKBAURKB11891344
AURKCNP_001015878AURKCNAQ9UQB9NANAQ9UQB9NM_001015878ENSP00000302898AURKCAURKC390518309
BCL2NP_000624BCL2MINT-87089P10415DIP-1043NREACT_578P10415NM_000633ENSP00000329623BCL2BCL216890239
BMXNP_975010BMXMINT-1433284P51813NAREACT_578P51813NM_203281ENSP00000340082BMXBMX24881675
BRAFNP_004324BRAFMINT-1574728P15056DIP-1045NREACT_111102P15056NM_004333ENSP00000288602BRAFBRAF114788766
BTKNP_000052BTKMINT-110243Q06187DIP-34071NREACT_6900Q06187NM_000061ENSP00000308176BTKBTK30874659
CASP3NP_004337CASP3MINT-147180P42574DIP-268NREACT_111102P42574NM_004346ENSP00000311032CASP3CASP312891277
CCR5NP_001093638CCR5MINT-103024P51681DIP-5866NREACT_111102P51681NM_001100168ENSP00000292303CCR5CCR527875352
CDK1NP_001777CDK1MINT-5000894P06493DIP-35NREACT_111045P06493NM_001786ENSP00000325970CDK1CDK116888297
CDK2NP_001789CDK2MINT-96328P24941DIP-161NREACT_111183P24941NM_001798ENSP00000266970CDK2CDK215887298
CDK4NP_000066CDK4MINT-1201237P11802DIP-24211NREACT_111183P11802NM_000075ENSP00000257904CDK4CDK411891303
CDK6NP_001250CDK6MINT-232049Q00534DIP-687NREACT_115566Q00534NM_001259ENSP00000265734CDK6CDK617884326
CDK7NP_001790CDK7NAP50613NANAP50613NM_001799ENSG00000134058CDK7CDK714890346
CTNNB1NP_001895CTNNB1MINT-105089P35222DIP-122NREACT_111045P35222NM_001904ENSP00000344456CTNNB1CTNNB175830781
DHFRNP_000782DHFRNAP00374NANAP00374NM_000791ENSG00000228716DHFRDHFR10892187
EGFRNP_005219EGFRMINT-206389P00533DIP-405NREACT_111045P00533NM_005228ENSP00000275493EGFREGFR958171210
ERBB2NP_004439ERBB2MINT-158636P04626DIP-8NREACT_111045P04626NM_004448ENSP00000269571ERBB2ERBB2538481255
FGFR1NP_075598FGFR1MINT-1499363P11362DIP-4019NREACT_111045P11362NM_023110ENSP00000311337FGFR1FGFR146859822
FGFR3NP_001156685FGFR3MINT-1034697P22607DIP-4016NREACT_111102P22607NM_001163213ENSP00000260795FGFR3FGFR3467442806
FLT1NP_002010FLT1MINT-127610P17948DIP-643NREACT_111102P17948NM_002019ENSP00000282397FLT1FLT1948181338
FLT3NP_004110FLT3NAP36888NANAP36888NM_004119ENSP00000241453FLT3FLT344859993
FNTANP_002018FNTAMINT-238861P49354NAREACT_578P49354NM_002027ENSP00000303423FNTAFNTA12892379
GSK3ANP_063937GSK3AMINT-1688290P49840NAREACT_111102P49840NM_019884ENSP00000222330GSK3AGSK3A14889483
GSK3BNP_002084GSK3BMINT-105006P49841DIP-878NREACT_111045P49841NM_002093ENSP00000264235GSK3BGSK3B32875420
HDAC1NP_004955HDAC1MINT-90475Q13547DIP-24184NREACT_111102Q13547NM_004964ENSP00000362649HDAC1HDAC132871482
HDAC2NP_001518HDAC2MINT-90593Q92769DIP-24220NREACT_111102Q92769NM_001527ENSP00000357621HDAC2HDAC279827488
HDAC3NP_003874HDAC3MINT-196172O15379DIP-24253NREACT_111045O15379NM_003883ENSP00000302967HDAC3HDAC319883428
HDAC6NP_006035HDAC6MINT-238367Q9UBN7DIP-27544NREACT_111102Q9UBN7NM_006044ENSP00000334061HDAC6HDAC6578431215
HDAC8NP_060956HDAC8MINT-5207407Q9BY41NAREACT_111102Q9BY41NM_018486ENSP00000362674HDAC8HDAC818886377
HSP90AA1NP_001017963HSP90AA1MINT-132070P07900DIP-27595NREACT_111045P07900NM_001017963ENSP00000216281HSP90AA1HSP90AA143857732
HSP90AB1NP_031381HSP90AB1MINT-99712P08238DIP-413NREACT_111045P08238NM_007355ENSP00000325875HSP90AB1HSP90AB144860724
HSP90AB4PNR_002927HSP90AB4PNAQ58FF6NANAQ58FF6NR_002927NAHSP90AB4PHSP90AB4P4900505
HSP90B1NP_003290HSP90B1MINT-210408P14625DIP-36060NREACT_116125P14625NM_003299ENSP00000299767HSP90B1HSP90B1260648803
HSP90B3PNR_003130HSP90B3PNANANANANANR_003130NAHSP90B3PHSP90B3P5898453
IGF1RNP_000866IGF1RNAP08069NANAP08069NM_000875ENSP00000268035IGF1RIGF1R1267881367
IKBKENP_054721IKBKEMINT-1132084Q14164DIP-27530NREACT_6900Q14164NM_014002ENSP00000356087IKBKEIKBKE25877716
ITKNP_005537ITKNAQ08881NANAQ08881NM_005546ENSG00000113263ITKITK43859620
JAK2NP_004963JAK2MINT-158048O60674DIP-33880NREACT_111102O60674NM_004972ENSP00000371067JAK2JAK2408661132
KDRNP_002244KDRMINT-127732P35968DIP-486NREACT_111102P35968NM_002253ENSP00000263923KDRKDR838271356
KITNP_000213KITNAP10721DIP-1055NREACT_111102P10721NM_000222ENSP00000288135KITKIT49860976
MAP2K1NP_002746MAP2K1MINT-99632Q02750DIP-201NREACT_111045Q02750NM_002755ENSP00000302486MAP2K1MAP2K1204705393
MAP2K2NP_109587MAP2K2MINT-99667P36507DIP-29119NREACT_111045P36507NM_030662ENSP00000262948MAP2K2MAP2K212892400
MAPK11NP_002742MAPK11MINT-3032032Q15759NAREACT_111045Q15759NM_002751ENSP00000333685MAPK11MAPK1126876364
MAPK12NP_002960MAPK12MINT-90266P53778NAREACT_111045P53778NM_002969ENSP00000215659MAPK12MAPK1230870367
MAPK13NP_002745MAPK13MINT-1183220O15264NAREACT_111102O15264NM_002754ENSP00000211287MAPK13MAPK138894365
MAPK14NP_001306MAPK14MINT-126546Q16539NAREACT_111045Q16539NM_001315ENSP00000229794MAPK14MAPK14144754360
MAPK7NP_620602MAPK7NAQ13164NAREACT_111102Q13164NM_139033ENSP00000299612MAPK7MAPK740862816
MAPK8NP_620635MAPK8MINT-1211982P45983DIP-249NREACT_111102P45983NM_139047ENSP00000353483MAPK8MAPK827880427
MCL1NP_068779MCL1NAQ07820NANAQ07820NM_021960ENSG00000143384MCL1MCL168835350
MDM2NP_002383MDM2MINT-101583Q00987DIP-392NREACT_111102Q00987NM_002392ENSP00000258149MDM2MDM235867491
METNP_001120972METMINT-137376P08581DIP-6023NREACT_111045P08581NM_001127500ENSP00000317272METMET858231390
MTORNP_004949MTORMINT-121301P42345DIP-790NREACT_111102P42345NM_004958ENSP00000354558MTORMTOR1118122549
NFKB1NP_003989NFKB1MINT-85658P19838DIP-106NREACT_111102P19838NM_003998ENSP00000226574NFKB1NFKB181823968
NTRK1NP_002520NTRK1MINT-124106P04629DIP-1060NREACT_111102P04629NM_002529ENSP00000351486NTRK1NTRK140861796
P4HBNP_000909P4HBMINT-4999403P07237NAREACT_111217P07237NM_000918ENSP00000327801P4HBP4HB36866508
PAK1NP_001122092PAK1MINT-92897Q13153DIP-31016NREACT_111045Q13153NM_001128620ENSP00000278568PAK1PAK126879545
PARP1NP_001609PARP1MINT-104344P09874DIP-38NNAP09874NM_001618ENSP00000355759PARP1PARP1328741014
PDGFRANP_006197PDGFRANAP16234DIP-5736NREACT_111102P16234NM_006206ENSP00000257290PDGFRAPDGFRA3166181089
PDGFRBNP_002600PDGFRBMINT-148093P09619DIP-558NREACT_111102P09619NM_002609ENSP00000261799PDGFRBPDGFRB488571106
PDK1NP_002601PDK1MINT-2881420Q15118DIP-29497NREACT_111217Q15118NM_002610ENSP00000282077PDK1PDK132868436
PIK3CANP_006209PIK3CAMINT-1367228P42336DIP-42728NREACT_111102P42336NM_006218ENSP00000263967PIK3CAPIK3CA1267901068
PIK3CBNP_006210PIK3CBNAP42338DIP-44775NREACT_111102P42338NM_006219ENSP00000289153PIK3CBPIK3CB508581070
PIK3CDNP_005017PIK3CDMINT-7242357O00329NAREACT_6900O00329NM_005026ENSP00000366563PIK3CDPIK3CD358661044
PIK3CGNP_002640PIK3CGMINT-155782P48736DIP-37781NREACT_111102P48736NM_002649ENSP00000352121PIK3CGPIK3CG678421102
PLK1NP_005021PLK1MINT-86316P53350DIP-29696NREACT_115566P53350NM_005030ENSP00000300093PLK1PLK129872603
PLK2NP_006613PLK2NAQ9NYY3NANAQ9NYY3NM_006622ENSP00000274289PLK2PLK2107812685
PLK3NP_004064PLK3NAQ9H4B4NANAQ9H4B4NM_004073ENSP00000361275PLK3PLK337869646
PPM1DNP_003611PPM1DNAO15297NANAO15297NM_003620ENSG00000170836PPM1DPPM1D0904605
PRKAA1NP_996790PRKAA1MINT-6771251Q13131DIP-39973NREACT_111102Q13131NM_206907ENSP00000346148PRKAA1PRKAA117886559
PRKCANP_002728PRKCAMINT-140812P17252DIP-531NREACT_111102P17252NM_002737ENSP00000284384PRKCAPRKCA218690672
PRKCBNP_002729PRKCBMINT-240997P05771DIP-34187NREACT_111102P05771NM_002738ENSP00000305355PRKCBPRKCB72844671
PRKCDNP_006245PRKCDMINT-1346366Q05655DIP-29954NREACT_111102Q05655NM_006254ENSP00000331602PRKCDPRKCD30875676
PRKCENP_005391PRKCEMINT-88515Q02156DIP-34186NREACT_111102Q02156NM_005400ENSP00000306124PRKCEPRKCE34870737
PRKCGNP_002730PRKCGMINT-222801P05129DIP-39795NREACT_111102P05129NM_002739ENSP00000263431PRKCGPRKCG48855697
PRKCHNP_006246PRKCHMINT-3973608P24723DIP-44588NREACT_111102P24723NM_006255ENSP00000329127PRKCHPRKCH42864683
PRKCINP_002731PRKCIMINT-5004219P41743NAREACT_111102P41743NM_002740ENSP00000295797PRKCIPRKCI56856596
PRKCQNP_006248PRKCQMINT-4649766Q04759NAREACT_111045Q04759NM_006257ENSP00000263125PRKCQPRKCQ42865706
PRKCSHNP_002734PRKCSHMINT-1380114P14314NAREACT_17015P14314NM_002743ENSP00000252455PRKCSHPRKCSH5899528
PRKCZNP_002735PRKCZMINT-5004464Q05513NAREACT_604Q05513NM_002744ENSP00000367830PRKCZPRKCZ32871592
PRKDCNP_008835PRKDCMINT-5006046P78527DIP-24186NREACT_216P78527NM_006904ENSP00000313420PRKDCPRKDC985614128
PSENENNP_758844PSENENMINT-5207259Q9NZ42NAREACT_111102Q9NZ42NM_172341ENSP00000222266PSENENPSENEN2901101
PTK2NP_005598PTK2MINT-92695Q05397NAREACT_111045Q05397NM_005607ENSP00000341189PTK2PTK2358661052
PTPN11NP_002825PTPN11MINT-199832Q06124DIP-516NREACT_111045Q06124NM_002834ENSP00000340944PTPN11PTPN1130869597
PTPN6NP_536859PTPN6MINT-134053P29350NAREACT_111102P29350NM_080549ENSP00000326010PTPN6PTPN61903595
RAC1NP_061485RAC1NAP63000NANAP63000NM_018890ENSG00000136238RAC1RAC187526211
RETNP_066124RETNAP07949NANAP07949NM_020975ENSP00000344798RETRET508571114
ROCK1NP_005397ROCK1MINT-1195170Q13464NAREACT_111045Q13464NM_005406ENSP00000382697ROCK1ROCK1798401354
ROCK2NP_004841ROCK2MINT-4299744O75116NAREACT_111045O75116NM_004850ENSP00000317985ROCK2ROCK2718461388
RPS6KA1NP_001006666RPS6KA1MINT-207205Q15418DIP-29987NREACT_111045Q15418NM_001006665ENSP00000363277RPS6KA1RPS6KA127874735
RPS6KA2NP_066958RPS6KA2MINT-1542928Q15349DIP-295NREACT_111045Q15349NM_021135ENSP00000265678RPS6KA2RPS6KA247865733
RPS6KA3NP_004577RPS6KA3MINT-1542962P51812DIP-38247NREACT_111045P51812NM_004586ENSP00000368884RPS6KA3RPS6KA319884740
RPS6KA4NP_003933RPS6KA4NAO75676NAREACT_111045O75676NM_003942ENSP00000333896RPS6KA4RPS6KA420885772
RPS6KA5NP_004746RPS6KA5MINT-261060O75582NAREACT_111045O75582NM_004755ENSP00000261991RPS6KA5RPS6KA5351552802
RPS6KA6NP_055311RPS6KA6MINT-1424416Q9UK32NAREACT_111045Q9UK32NM_014496ENSP00000262752RPS6KA6RPS6KA637863745
RPS6KB2NP_003943RPS6KB2NAQ9UBS0NANAQ9UBS0NM_003952ENSG00000175634RPS6KB2RPS6KB221884482
RXRANP_002948RXRAMINT-98407P19793DIP-641NREACT_111045P19793NM_002957ENSP00000419692RXRARXRA28877462
RXRBNP_068811RXRBMINT-1365658P28702NAREACT_71P28702NM_021976ENSP00000363812RXRBRXRB2902533
SGK3NP_001028750SGK3NAQ96BR1NANAQ96BR1NM_001033578ENSP00000262211SGK3SGK348862496
SMONP_005622SMONAQ99835NAREACT_111102Q99835NM_005631ENSP00000249373SMOSMO44858787
SRCNP_005408SRCMINT-93621P12931DIP-1059NREACT_111045P12931NM_005417ENSP00000350941SRCSRC14888536
SYKNP_003168SYKMINT-148486P43405DIP-253NREACT_111102P43405NM_003177ENSP00000364898SYKSYK31875635
TBK1NP_037386TBK1MINT-1131333Q9UHD2DIP-27529NREACT_6900Q9UHD2NM_013254ENSP00000329967TBK1TBK126876729
TECNP_003206TECMINT-1498364P42680NAREACT_111102P42680NM_003215ENSP00000370912TECTEC410497631
TNFNP_000585TNFMINT-1131842P01375DIP-2895NREACT_578P01375NM_000594ENSP00000365290TNFTNF10894233
TOP1NP_003277TOP1NAP11387NANAP11387NM_003286ENSP00000354522TOP1TOP129875765
WEE1NP_003381WEE1MINT-129561P30291NAREACT_115566P30291NM_003390ENSP00000402084WEE1WEE122880646
XIAPNP_001158XIAPMINT-141734P98170DIP-27626NREACT_578P98170NM_001167ENSP00000347858XIAPXIAP27875497