Browsing of Drug Targets

This option of server allows user to browse drug targets in CancerDR. This page summarizes the Targets with Refseq IDs and their status (whether mutated or not) in different cell lines. For more information, please click Help

Drug Target	Refseq ID	COSMIC	MINT	STRING	DIP	Reactome	QuickGO	NCBI Genome Browser	Ensembl Genome Browser	Gene Atlas	Tree Families	Mutated Cell Lines	Wild Type Cell Lines	Target length (AA)

ABL1	NP_009297	ABL1	MINT-97648	P00519	DIP-1042N	REACT_111045	P00519	NM_007313	ENSP00000323315	ABL1	ABL1	38	865	1130
ABL2	NP_009298	ABL2	MINT-1347081	P42684	DIP-91N	REACT_111045	P42684	NM_007314	ENSP00000339209	ABL2	ABL2	157	753	1182
AKT1	NP_005154	AKT1	MINT-203775	P31749	DIP-24269N	REACT_111045	P31749	NM_005163	ENSP00000270202	AKT1	AKT1	33	874	480
AKT2	NP_001617	AKT2	MINT-87790	P31751	NA	REACT_111045	P31751	NM_001626	ENSP00000375892	AKT2	AKT2	21	883	481
AKT3	NP_005456	AKT3	MINT-222821	Q9Y243	NA	REACT_111045	Q9Y243	NM_005465	ENSP00000263826	AKT3	AKT3	24	880	479
ALK	NP_004295	ALK	NA	Q9UM73	NA	NA	Q9UM73	NM_004304	ENSP00000373700	ALK	ALK	70	837	1620
AR	NP_000035	AR	MINT-94801	P10275	DIP-125N	REACT_71	P10275	NM_000044	ENSP00000363822	AR	AR	82	832	919
ATM	NP_000042	ATM	MINT-194471	Q13315	DIP-182N	REACT_111183	Q13315	NM_000051	ENSP00000278616	ATM	ATM	144	774	3056
AURKA	NP_940835	AURKA	NA	O14965	DIP-33068N	REACT_115566	O14965	NM_198433	ENSP00000321591	AURKA	AURKA	22	882	403
AURKB	NP_004208	AURKB	MINT-1413997	Q96GD4	DIP-34530N	REACT_115566	Q96GD4	NM_004217	ENSP00000313950	AURKB	AURKB	11	891	344
AURKC	NP_001015878	AURKC	NA	Q9UQB9	NA	NA	Q9UQB9	NM_001015878	ENSP00000302898	AURKC	AURKC	390	518	309
BCL2	NP_000624	BCL2	MINT-87089	P10415	DIP-1043N	REACT_578	P10415	NM_000633	ENSP00000329623	BCL2	BCL2	16	890	239
BMX	NP_975010	BMX	MINT-1433284	P51813	NA	REACT_578	P51813	NM_203281	ENSP00000340082	BMX	BMX	24	881	675
BRAF	NP_004324	BRAF	MINT-1574728	P15056	DIP-1045N	REACT_111102	P15056	NM_004333	ENSP00000288602	BRAF	BRAF	114	788	766
BTK	NP_000052	BTK	MINT-110243	Q06187	DIP-34071N	REACT_6900	Q06187	NM_000061	ENSP00000308176	BTK	BTK	30	874	659
CASP3	NP_004337	CASP3	MINT-147180	P42574	DIP-268N	REACT_111102	P42574	NM_004346	ENSP00000311032	CASP3	CASP3	12	891	277
CCR5	NP_001093638	CCR5	MINT-103024	P51681	DIP-5866N	REACT_111102	P51681	NM_001100168	ENSP00000292303	CCR5	CCR5	27	875	352
CDK1	NP_001777	CDK1	MINT-5000894	P06493	DIP-35N	REACT_111045	P06493	NM_001786	ENSP00000325970	CDK1	CDK1	16	888	297
CDK2	NP_001789	CDK2	MINT-96328	P24941	DIP-161N	REACT_111183	P24941	NM_001798	ENSP00000266970	CDK2	CDK2	15	887	298
CDK4	NP_000066	CDK4	MINT-1201237	P11802	DIP-24211N	REACT_111183	P11802	NM_000075	ENSP00000257904	CDK4	CDK4	11	891	303
CDK6	NP_001250	CDK6	MINT-232049	Q00534	DIP-687N	REACT_115566	Q00534	NM_001259	ENSP00000265734	CDK6	CDK6	17	884	326
CDK7	NP_001790	CDK7	NA	P50613	NA	NA	P50613	NM_001799	ENSG00000134058	CDK7	CDK7	14	890	346
CTNNB1	NP_001895	CTNNB1	MINT-105089	P35222	DIP-122N	REACT_111045	P35222	NM_001904	ENSP00000344456	CTNNB1	CTNNB1	75	830	781
DHFR	NP_000782	DHFR	NA	P00374	NA	NA	P00374	NM_000791	ENSG00000228716	DHFR	DHFR	10	892	187
EGFR	NP_005219	EGFR	MINT-206389	P00533	DIP-405N	REACT_111045	P00533	NM_005228	ENSP00000275493	EGFR	EGFR	95	817	1210
ERBB2	NP_004439	ERBB2	MINT-158636	P04626	DIP-8N	REACT_111045	P04626	NM_004448	ENSP00000269571	ERBB2	ERBB2	53	848	1255
FGFR1	NP_075598	FGFR1	MINT-1499363	P11362	DIP-4019N	REACT_111045	P11362	NM_023110	ENSP00000311337	FGFR1	FGFR1	46	859	822
FGFR3	NP_001156685	FGFR3	MINT-1034697	P22607	DIP-4016N	REACT_111102	P22607	NM_001163213	ENSP00000260795	FGFR3	FGFR3	467	442	806
FLT1	NP_002010	FLT1	MINT-127610	P17948	DIP-643N	REACT_111102	P17948	NM_002019	ENSP00000282397	FLT1	FLT1	94	818	1338
FLT3	NP_004110	FLT3	NA	P36888	NA	NA	P36888	NM_004119	ENSP00000241453	FLT3	FLT3	44	859	993
FNTA	NP_002018	FNTA	MINT-238861	P49354	NA	REACT_578	P49354	NM_002027	ENSP00000303423	FNTA	FNTA	12	892	379
GSK3A	NP_063937	GSK3A	MINT-1688290	P49840	NA	REACT_111102	P49840	NM_019884	ENSP00000222330	GSK3A	GSK3A	14	889	483
GSK3B	NP_002084	GSK3B	MINT-105006	P49841	DIP-878N	REACT_111045	P49841	NM_002093	ENSP00000264235	GSK3B	GSK3B	32	875	420
HDAC1	NP_004955	HDAC1	MINT-90475	Q13547	DIP-24184N	REACT_111102	Q13547	NM_004964	ENSP00000362649	HDAC1	HDAC1	32	871	482
HDAC2	NP_001518	HDAC2	MINT-90593	Q92769	DIP-24220N	REACT_111102	Q92769	NM_001527	ENSP00000357621	HDAC2	HDAC2	79	827	488
HDAC3	NP_003874	HDAC3	MINT-196172	O15379	DIP-24253N	REACT_111045	O15379	NM_003883	ENSP00000302967	HDAC3	HDAC3	19	883	428
HDAC6	NP_006035	HDAC6	MINT-238367	Q9UBN7	DIP-27544N	REACT_111102	Q9UBN7	NM_006044	ENSP00000334061	HDAC6	HDAC6	57	843	1215
HDAC8	NP_060956	HDAC8	MINT-5207407	Q9BY41	NA	REACT_111102	Q9BY41	NM_018486	ENSP00000362674	HDAC8	HDAC8	18	886	377
HSP90AA1	NP_001017963	HSP90AA1	MINT-132070	P07900	DIP-27595N	REACT_111045	P07900	NM_001017963	ENSP00000216281	HSP90AA1	HSP90AA1	43	857	732
HSP90AB1	NP_031381	HSP90AB1	MINT-99712	P08238	DIP-413N	REACT_111045	P08238	NM_007355	ENSP00000325875	HSP90AB1	HSP90AB1	44	860	724
HSP90AB4P	NR_002927	HSP90AB4P	NA	Q58FF6	NA	NA	Q58FF6	NR_002927	NA	HSP90AB4P	HSP90AB4P	4	900	505
HSP90B1	NP_003290	HSP90B1	MINT-210408	P14625	DIP-36060N	REACT_116125	P14625	NM_003299	ENSP00000299767	HSP90B1	HSP90B1	260	648	803
HSP90B3P	NR_003130	HSP90B3P	NA	NA	NA	NA	NA	NR_003130	NA	HSP90B3P	HSP90B3P	5	898	453
IGF1R	NP_000866	IGF1R	NA	P08069	NA	NA	P08069	NM_000875	ENSP00000268035	IGF1R	IGF1R	126	788	1367
IKBKE	NP_054721	IKBKE	MINT-1132084	Q14164	DIP-27530N	REACT_6900	Q14164	NM_014002	ENSP00000356087	IKBKE	IKBKE	25	877	716
ITK	NP_005537	ITK	NA	Q08881	NA	NA	Q08881	NM_005546	ENSG00000113263	ITK	ITK	43	859	620
JAK2	NP_004963	JAK2	MINT-158048	O60674	DIP-33880N	REACT_111102	O60674	NM_004972	ENSP00000371067	JAK2	JAK2	40	866	1132
KDR	NP_002244	KDR	MINT-127732	P35968	DIP-486N	REACT_111102	P35968	NM_002253	ENSP00000263923	KDR	KDR	83	827	1356
KIT	NP_000213	KIT	NA	P10721	DIP-1055N	REACT_111102	P10721	NM_000222	ENSP00000288135	KIT	KIT	49	860	976
MAP2K1	NP_002746	MAP2K1	MINT-99632	Q02750	DIP-201N	REACT_111045	Q02750	NM_002755	ENSP00000302486	MAP2K1	MAP2K1	204	705	393
MAP2K2	NP_109587	MAP2K2	MINT-99667	P36507	DIP-29119N	REACT_111045	P36507	NM_030662	ENSP00000262948	MAP2K2	MAP2K2	12	892	400
MAPK11	NP_002742	MAPK11	MINT-3032032	Q15759	NA	REACT_111045	Q15759	NM_002751	ENSP00000333685	MAPK11	MAPK11	26	876	364
MAPK12	NP_002960	MAPK12	MINT-90266	P53778	NA	REACT_111045	P53778	NM_002969	ENSP00000215659	MAPK12	MAPK12	30	870	367
MAPK13	NP_002745	MAPK13	MINT-1183220	O15264	NA	REACT_111102	O15264	NM_002754	ENSP00000211287	MAPK13	MAPK13	8	894	365
MAPK14	NP_001306	MAPK14	MINT-126546	Q16539	NA	REACT_111045	Q16539	NM_001315	ENSP00000229794	MAPK14	MAPK14	144	754	360
MAPK7	NP_620602	MAPK7	NA	Q13164	NA	REACT_111102	Q13164	NM_139033	ENSP00000299612	MAPK7	MAPK7	40	862	816
MAPK8	NP_620635	MAPK8	MINT-1211982	P45983	DIP-249N	REACT_111102	P45983	NM_139047	ENSP00000353483	MAPK8	MAPK8	27	880	427
MCL1	NP_068779	MCL1	NA	Q07820	NA	NA	Q07820	NM_021960	ENSG00000143384	MCL1	MCL1	68	835	350
MDM2	NP_002383	MDM2	MINT-101583	Q00987	DIP-392N	REACT_111102	Q00987	NM_002392	ENSP00000258149	MDM2	MDM2	35	867	491
MET	NP_001120972	MET	MINT-137376	P08581	DIP-6023N	REACT_111045	P08581	NM_001127500	ENSP00000317272	MET	MET	85	823	1390
MTOR	NP_004949	MTOR	MINT-121301	P42345	DIP-790N	REACT_111102	P42345	NM_004958	ENSP00000354558	MTOR	MTOR	111	812	2549
NFKB1	NP_003989	NFKB1	MINT-85658	P19838	DIP-106N	REACT_111102	P19838	NM_003998	ENSP00000226574	NFKB1	NFKB1	81	823	968
NTRK1	NP_002520	NTRK1	MINT-124106	P04629	DIP-1060N	REACT_111102	P04629	NM_002529	ENSP00000351486	NTRK1	NTRK1	40	861	796
P4HB	NP_000909	P4HB	MINT-4999403	P07237	NA	REACT_111217	P07237	NM_000918	ENSP00000327801	P4HB	P4HB	36	866	508
PAK1	NP_001122092	PAK1	MINT-92897	Q13153	DIP-31016N	REACT_111045	Q13153	NM_001128620	ENSP00000278568	PAK1	PAK1	26	879	545
PARP1	NP_001609	PARP1	MINT-104344	P09874	DIP-38N	NA	P09874	NM_001618	ENSP00000355759	PARP1	PARP1	32	874	1014
PDGFRA	NP_006197	PDGFRA	NA	P16234	DIP-5736N	REACT_111102	P16234	NM_006206	ENSP00000257290	PDGFRA	PDGFRA	316	618	1089
PDGFRB	NP_002600	PDGFRB	MINT-148093	P09619	DIP-558N	REACT_111102	P09619	NM_002609	ENSP00000261799	PDGFRB	PDGFRB	48	857	1106
PDK1	NP_002601	PDK1	MINT-2881420	Q15118	DIP-29497N	REACT_111217	Q15118	NM_002610	ENSP00000282077	PDK1	PDK1	32	868	436
PIK3CA	NP_006209	PIK3CA	MINT-1367228	P42336	DIP-42728N	REACT_111102	P42336	NM_006218	ENSP00000263967	PIK3CA	PIK3CA	126	790	1068
PIK3CB	NP_006210	PIK3CB	NA	P42338	DIP-44775N	REACT_111102	P42338	NM_006219	ENSP00000289153	PIK3CB	PIK3CB	50	858	1070
PIK3CD	NP_005017	PIK3CD	MINT-7242357	O00329	NA	REACT_6900	O00329	NM_005026	ENSP00000366563	PIK3CD	PIK3CD	35	866	1044
PIK3CG	NP_002640	PIK3CG	MINT-155782	P48736	DIP-37781N	REACT_111102	P48736	NM_002649	ENSP00000352121	PIK3CG	PIK3CG	67	842	1102
PLK1	NP_005021	PLK1	MINT-86316	P53350	DIP-29696N	REACT_115566	P53350	NM_005030	ENSP00000300093	PLK1	PLK1	29	872	603
PLK2	NP_006613	PLK2	NA	Q9NYY3	NA	NA	Q9NYY3	NM_006622	ENSP00000274289	PLK2	PLK2	107	812	685
PLK3	NP_004064	PLK3	NA	Q9H4B4	NA	NA	Q9H4B4	NM_004073	ENSP00000361275	PLK3	PLK3	37	869	646
PPM1D	NP_003611	PPM1D	NA	O15297	NA	NA	O15297	NM_003620	ENSG00000170836	PPM1D	PPM1D	0	904	605
PRKAA1	NP_996790	PRKAA1	MINT-6771251	Q13131	DIP-39973N	REACT_111102	Q13131	NM_206907	ENSP00000346148	PRKAA1	PRKAA1	17	886	559
PRKCA	NP_002728	PRKCA	MINT-140812	P17252	DIP-531N	REACT_111102	P17252	NM_002737	ENSP00000284384	PRKCA	PRKCA	218	690	672
PRKCB	NP_002729	PRKCB	MINT-240997	P05771	DIP-34187N	REACT_111102	P05771	NM_002738	ENSP00000305355	PRKCB	PRKCB	72	844	671
PRKCD	NP_006245	PRKCD	MINT-1346366	Q05655	DIP-29954N	REACT_111102	Q05655	NM_006254	ENSP00000331602	PRKCD	PRKCD	30	875	676
PRKCE	NP_005391	PRKCE	MINT-88515	Q02156	DIP-34186N	REACT_111102	Q02156	NM_005400	ENSP00000306124	PRKCE	PRKCE	34	870	737
PRKCG	NP_002730	PRKCG	MINT-222801	P05129	DIP-39795N	REACT_111102	P05129	NM_002739	ENSP00000263431	PRKCG	PRKCG	48	855	697
PRKCH	NP_006246	PRKCH	MINT-3973608	P24723	DIP-44588N	REACT_111102	P24723	NM_006255	ENSP00000329127	PRKCH	PRKCH	42	864	683
PRKCI	NP_002731	PRKCI	MINT-5004219	P41743	NA	REACT_111102	P41743	NM_002740	ENSP00000295797	PRKCI	PRKCI	56	856	596
PRKCQ	NP_006248	PRKCQ	MINT-4649766	Q04759	NA	REACT_111045	Q04759	NM_006257	ENSP00000263125	PRKCQ	PRKCQ	42	865	706
PRKCSH	NP_002734	PRKCSH	MINT-1380114	P14314	NA	REACT_17015	P14314	NM_002743	ENSP00000252455	PRKCSH	PRKCSH	5	899	528
PRKCZ	NP_002735	PRKCZ	MINT-5004464	Q05513	NA	REACT_604	Q05513	NM_002744	ENSP00000367830	PRKCZ	PRKCZ	32	871	592
PRKDC	NP_008835	PRKDC	MINT-5006046	P78527	DIP-24186N	REACT_216	P78527	NM_006904	ENSP00000313420	PRKDC	PRKDC	985	61	4128
PSENEN	NP_758844	PSENEN	MINT-5207259	Q9NZ42	NA	REACT_111102	Q9NZ42	NM_172341	ENSP00000222266	PSENEN	PSENEN	2	901	101
PTK2	NP_005598	PTK2	MINT-92695	Q05397	NA	REACT_111045	Q05397	NM_005607	ENSP00000341189	PTK2	PTK2	35	866	1052
PTPN11	NP_002825	PTPN11	MINT-199832	Q06124	DIP-516N	REACT_111045	Q06124	NM_002834	ENSP00000340944	PTPN11	PTPN11	30	869	597
PTPN6	NP_536859	PTPN6	MINT-134053	P29350	NA	REACT_111102	P29350	NM_080549	ENSP00000326010	PTPN6	PTPN6	1	903	595
RAC1	NP_061485	RAC1	NA	P63000	NA	NA	P63000	NM_018890	ENSG00000136238	RAC1	RAC1	875	26	211
RET	NP_066124	RET	NA	P07949	NA	NA	P07949	NM_020975	ENSP00000344798	RET	RET	50	857	1114
ROCK1	NP_005397	ROCK1	MINT-1195170	Q13464	NA	REACT_111045	Q13464	NM_005406	ENSP00000382697	ROCK1	ROCK1	79	840	1354
ROCK2	NP_004841	ROCK2	MINT-4299744	O75116	NA	REACT_111045	O75116	NM_004850	ENSP00000317985	ROCK2	ROCK2	71	846	1388
RPS6KA1	NP_001006666	RPS6KA1	MINT-207205	Q15418	DIP-29987N	REACT_111045	Q15418	NM_001006665	ENSP00000363277	RPS6KA1	RPS6KA1	27	874	735
RPS6KA2	NP_066958	RPS6KA2	MINT-1542928	Q15349	DIP-295N	REACT_111045	Q15349	NM_021135	ENSP00000265678	RPS6KA2	RPS6KA2	47	865	733
RPS6KA3	NP_004577	RPS6KA3	MINT-1542962	P51812	DIP-38247N	REACT_111045	P51812	NM_004586	ENSP00000368884	RPS6KA3	RPS6KA3	19	884	740
RPS6KA4	NP_003933	RPS6KA4	NA	O75676	NA	REACT_111045	O75676	NM_003942	ENSP00000333896	RPS6KA4	RPS6KA4	20	885	772
RPS6KA5	NP_004746	RPS6KA5	MINT-261060	O75582	NA	REACT_111045	O75582	NM_004755	ENSP00000261991	RPS6KA5	RPS6KA5	351	552	802
RPS6KA6	NP_055311	RPS6KA6	MINT-1424416	Q9UK32	NA	REACT_111045	Q9UK32	NM_014496	ENSP00000262752	RPS6KA6	RPS6KA6	37	863	745
RPS6KB2	NP_003943	RPS6KB2	NA	Q9UBS0	NA	NA	Q9UBS0	NM_003952	ENSG00000175634	RPS6KB2	RPS6KB2	21	884	482
RXRA	NP_002948	RXRA	MINT-98407	P19793	DIP-641N	REACT_111045	P19793	NM_002957	ENSP00000419692	RXRA	RXRA	28	877	462
RXRB	NP_068811	RXRB	MINT-1365658	P28702	NA	REACT_71	P28702	NM_021976	ENSP00000363812	RXRB	RXRB	2	902	533
SGK3	NP_001028750	SGK3	NA	Q96BR1	NA	NA	Q96BR1	NM_001033578	ENSP00000262211	SGK3	SGK3	48	862	496
SMO	NP_005622	SMO	NA	Q99835	NA	REACT_111102	Q99835	NM_005631	ENSP00000249373	SMO	SMO	44	858	787
SRC	NP_005408	SRC	MINT-93621	P12931	DIP-1059N	REACT_111045	P12931	NM_005417	ENSP00000350941	SRC	SRC	14	888	536
SYK	NP_003168	SYK	MINT-148486	P43405	DIP-253N	REACT_111102	P43405	NM_003177	ENSP00000364898	SYK	SYK	31	875	635
TBK1	NP_037386	TBK1	MINT-1131333	Q9UHD2	DIP-27529N	REACT_6900	Q9UHD2	NM_013254	ENSP00000329967	TBK1	TBK1	26	876	729
TEC	NP_003206	TEC	MINT-1498364	P42680	NA	REACT_111102	P42680	NM_003215	ENSP00000370912	TEC	TEC	410	497	631
TNF	NP_000585	TNF	MINT-1131842	P01375	DIP-2895N	REACT_578	P01375	NM_000594	ENSP00000365290	TNF	TNF	10	894	233
TOP1	NP_003277	TOP1	NA	P11387	NA	NA	P11387	NM_003286	ENSP00000354522	TOP1	TOP1	29	875	765
WEE1	NP_003381	WEE1	MINT-129561	P30291	NA	REACT_115566	P30291	NM_003390	ENSP00000402084	WEE1	WEE1	22	880	646
XIAP	NP_001158	XIAP	MINT-141734	P98170	DIP-27626N	REACT_578	P98170	NM_001167	ENSP00000347858	XIAP	XIAP	27	875	497

CancerDR: Cancer Drug Resistance Database

CSIR - Indraprastha Institute of Information Technology, India

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