PHI: Portal for Health Informatics

Biomoleucles-based Therapeutics

In the era of drug-resistance, peptides are alternate to small-molecules based drugs. Peptides have wide-range of properties (like cell-penetration, tumour homing, antihypertensive, antibacterial, anticancer) that is used by researchers for designing peptide-based therapeutics. This page provides web servers developed for designing therapeutics based on biomolecules particularly peptide.

Resources for designing therapeutics based on biomolecules (Raghava's Group)

1. ABCRpred: Prediction of antibiotic resistant strains of bacteria from their beta-lactamases protein.
2. AHTpin: Designing and virtual screening of antihypertensive peptides.
3. AntiAngiopred: A Server for Prediction of Anti-Angiogenic Peptides.
4. AntiBP: Mapping of antibacterial peptides in a protein sequence.
5. AntiBP2: Mapping of antibacterial peptides in a protein sequence.
6. AntiCP: Prediction and design of anticancer peptides.
7. AntiFP: A Prediction server for Antifungal Peptide.
8. AntiTbPdb: A database of anti-tubercular peptides.
9. BIAdb: A Database for Benzylisoquinoline Alkaloids.
10. BioTherapi: Bioinformatics for Therapeutic Peptides and Proteins.
11. CancerDP: Prioritization of anticancer drugs against a cancer using genomic features of cancer cells.
12. CanceRES: Cancer Informatics Portal.
13. CancerIN:A web server for predicting anticancer activity of molecules.
14. CancerPDF: Database of cancer-associated peptides of human bodyfluids.
15. CancerPPD:  Database of anticancer peptides and proteins.
16. CellPPD: Computer-aided Designing of efficient cell penetrating peptides.
17. DrugMint: A web server for identification of drug like molecules.
18. EbolaVCR: A web-based resource for designing therapeutics against Ebola Virus.
19. HemolytiK: A repository of experimentally validated hemolytic and non-hemolytic peptides.
20. HemoPI: Prediction and virtual screening of hemolytic peptides.
21. HLP: Designing of stable antibacterial peptides.
22. HMRbase: A manually curated database of hormones and their Receptors.
23. NPACT: A curated database of plant derived natural compounds that exhibit anti-cancerous activity.
24. ParaPep: Compilation of experimentally validated anti-parasitic peptides and their structures. 
25. PEPlife: Database of experimentally validated therapeutic peptides and their half lives.
26. PEPstr: Prediction of structure of peptides.
27. PEPstrMOD: Structural prediction of peptides containing natural, non-natural and modified residues.  
28. PlifePred: An insilico method to design and predict the half life of modified and natural peptides in blood. 
29. SATPdb: A database of structurally annotated therapeutic peptides .
30. THPdb: A database of FDA approved therapeutic peptides and proteins.
31. TopicalPdb: A Database of Topically Administered Peptide.
32. ToxinPred: An in silico method, which is developed to predict and design toxic/non-toxic peptides.
33. TumorHope: A comprehensive database of Tumor Homing Peptides.
34. TumorHPD: A webserver for predicting and designing of tumor homing peptides.
35. VaccineDA: A webserver for prediction of oligodeoxynucleotide vaccine adjuvant.
36. VaxinPAD: A webserver for designing peptide based vaccine adjuvant.
37. XIAPin: Designing of efficient inhibitors against apoptosis protein XIAP (inhibitor against drug resistance cancer).

External Links to web servers developed/maintained by other groups

This section provides URL/links to important websites developed and maintained by other researchers. It exclude servers by Raghava's group, which is given in above section. 

1. AVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses.
2. CAMP: a useful resource for research on antimicrobial peptides.
3. CAMP: Collection of sequences and structures of antimicrobial peptides.
4. DBETH: a Database of Bacterial Exotoxins for Human.
5. DIACAN: Integrated Database for Antidiabetic and Anticancer Medicinal Plants.
6. FishAMP: Development of Antimicrobial Peptide Prediction Tool for Aquaculture Industries.
7. HyPe: Prediction of peptidoglycan hydrolases- a new class of antibacterial proteins.
8. iAMPpred: Predicting antimicrobial peptides with improved accuracy by incorporating the compositional physico-chemical and structural features into Chous general PseAAC.
9. PVSUP: Supervised learning classification models for prediction of plant virus encoded RNA silencing suppressors.
10. QSPPRED: Prediction and analysis of quorum sensing peptides based on sequence features.
11. SBSPKSv2: Structure-based sequence analysis of polyketide synthases and non-ribosomal peptide synthetases.
12. Seed ProNutra Care: A tool for characterization of seed storage proteins and database of bioactive peptides having potential health benefits.
13. SMEpred workbench: A web server for predicting efficacy of chemicallymodified siRNAs.
14. VIRsiRNAdb: a curated database of experimentally validated viral siRNA/shRNA.
15. VIRsiRNApred: a web server for predicting inhibition efficacy of siRNAs targeting human viruses.