A database of FDA approved therapeutic peptides and proteins
ID | ThPPID | Name | Peptide Sequence | Length | Functional Classification | Disease | Brand | Company | Physical Appearance | Route of Administartion | Category | Target |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1005 | Th1002 | Cetuximab | Heavy chain:QVQLKQSG Full view | 243 | IIIc | Cancer | Erbitux | ImClone Systems Inc | Sterile, clear, colorless liquid of pH 7.0-7.4, which may contain a small amount of easily visible, white, amorphous cetuximab particulates | Intravenous infusion | Antineoplastic Agents | Epidermal growth factor receptor,Low affinity immunoglobulin gamma Fc region receptor III-B,Complement C1r subcomponent,Complement C1q subcomponent subunit A,Complement C1q subcomponent subunit B,Complement C1q subcomponent subunit C,Low affinity immunoglobulin gamma Fc region receptor III-A,Complement C1s subcomponent,High affinity immunoglobulin gamma Fc receptor I,Low affinity immunoglobulin gamma Fc region receptor II-a,Low affinity immunoglobulin gamma Fc region receptor II-b,Low affinity immunoglobulin gamma Fc region receptor II-c |
1025 | Th1004 | Denileukin diftitox | MGADDVVDSSKSFVMENFSS Full view | 255 | IIb | Cancer | Ontak | Seragen Inc | Sterile, white, preservative-free, lyophilized powder. | Intravenous(IV) administration | Antineoplastic Agents | Interleukin-2 receptor subunit alpha,Interleukin-2 receptor subunit beta,Cytokine receptor common subunit gamma |
1038 | Th1007 | Leuprolide | PHWSYLLR Full view | 8 | IIa | Cancer | Eligard | Atrix Labs/QLT In | Suspension | Subcutaneous Injection | Antineoplastic Agents, Hormonal and fertility agents, estrogen antagonists | Gonadotropin-releasing hormone receptor |
1039 | Th1007 | Leuprolide | PHWSYLLR Full view | 8 | IIa | Cancer | Enantone | Takeda | Solution | Injection | Antineoplastic Agents, Hormonal and fertility agents, estrogen antagonists | Gonadotropin-releasing hormone receptor |
1040 | Th1007 | Leuprolide | PHWSYLLR Full view | 8 | IIa | Cancer | Leuplin | Takeda | N.A. | Injection | Antineoplastic Agents, Hormonal and fertility agents, estrogen antagonists | Gonadotropin-releasing hormone receptor |
1041 | Th1007 | Leuprolide | PHWSYLLR Full view | 8 | IIa | Cancer | LeuProMaxx | Baxter/Teva | N.A. | N.A. | Antineoplastic Agents, Hormonal and fertility agents, estrogen antagonists | Gonadotropin-releasing hormone receptor |
1042 | Th1007 | Leuprolide | PHWSYLLR Full view | 8 | IIa | Cancer | Leupromer | N.A. | N.A. | Injection | Antineoplastic Agents, Hormonal and fertility agents, estrogen antagonists | Gonadotropin-releasing hormone receptor |
1043 | Th1007 | Leuprolide | PHWSYLLR Full view | 8 | IIa | Cancer | Lupron | Abbott/TAP Pharmaceuticals | N.A. | Injection | Antineoplastic Agents, Hormonal and fertility agents, estrogen antagonists | Gonadotropin-releasing hormone receptor |
1044 | Th1007 | Leuprolide | PHWSYLLR Full view | 8 | IIa | Cancer | Lutrate | N.A. | N.A. | N.A. | Antineoplastic Agents, Hormonal and fertility agents, estrogen antagonists | Gonadotropin-releasing hormone receptor |
1045 | Th1007 | Leuprolide | PHWSYLLR Full view | 8 | IIa | Cancer | Memryte | Curaxis | N.A. | N.A. | Antineoplastic Agents, Hormonal and fertility agents, estrogen antagonists | Gonadotropin-releasing hormone receptor |
1046 | Th1007 | Leuprolide | PHWSYLLR Full view | 8 | IIa | Cancer | Prostap 3 | Takeda UK Limited | N.A. | N.A. | Antineoplastic Agents, Hormonal and fertility agents, estrogen antagonists | Gonadotropin-releasing hormone receptor |
1047 | Th1007 | Leuprolide | PHWSYLLR Full view | 8 | IIa | Cancer | Prostap SR | Takeda UK Limited | N.A. | N.A. | Antineoplastic Agents, Hormonal and fertility agents, estrogen antagonists | Gonadotropin-releasing hormone receptor |
1048 | Th1007 | Leuprolide | PHWSYLLR Full view | 8 | IIa | Cancer | Viadur | Bayer AG | N.A. | N.A. | Antineoplastic Agents, Hormonal and fertility agents, estrogen antagonists | Gonadotropin-releasing hormone receptor |
1142 | Th1020 | Asparaginase | QMSLQQELRYIEALSAIVET Full view | 255 | Ic | Cancer | Elspar | Merck & Co. Inc | Lyophilized plug or powder | Intravenous or Intramuscular. Intravenous method dose has higher risk of allergic reaction, so often a test dose is given first. | Antineoplastic Agents | L-asparagine |
1257 | Th1036 | Aldesleukin | MAPTSSSTKKTQLQLEHLLL Full view | 134 | Ib | Cancer/Infectious | Proleukin | Chiron Corp | Sterile, white to off-white, lyophilized cake | Intravenous administration | Antineoplastic Agents, Anti-HIV agents | Interleukin-2 receptor subunit beta,Interleukin-2 receptor subunit alpha,Cytokine receptor common subunit gamma |
1337 | Th1048 | Pegaspargase | MEFFKKTALAALVMGFSGAA Full view | 255 | Ic | Cancer | Oncaspar | Enzon Inc | Solution | Intravenous or Intramuscular administration | Antineoplastic Agents | L-asparagine |
1341 | Th1049 | Interferon beta-1a | MSYNLLGFLQRSSNFQCQKL Full view | 166 | Ib | Cancer/Infectious/Immunological | Avonex | Biogen Inc | Lyophilized powder vial, Sterile liquid as single used prefilled syringe and also available as single use prefilled autoinjector. | Intramuscular Injection | Immunosuppressive Agents, Antineoplastic, Antiviral, Immunologic factors | Interferon alpha/beta receptor 1,Interferon alpha/beta receptor 2 |
1342 | Th1049 | Interferon beta-1a | MSYNLLGFLQRSSNFQCQKL Full view | 166 | Ib | Cancer/Infectious/Immunological | Betaferon | Bayer | Powder and solvent that are made upto make solution. | Subcutaneous Injection | Immunosuppressive Agents, Antineoplastic, Antiviral, Immunologic factors | Interferon alpha/beta receptor 1,Interferon alpha/beta receptor 2 |
1343 | Th1049 | Interferon beta-1a | MSYNLLGFLQRSSNFQCQKL Full view | 166 | Ib | Cancer/Infectious/Immunological | Betaseron | Merck | Sterile, white to off-white powder | Subcutaneous Injection | Immunosuppressive Agents, Antineoplastic, Antiviral, Immunologic factors | Interferon alpha/beta receptor 1,Interferon alpha/beta receptor 2 |
1344 | Th1049 | Interferon beta-1a | MSYNLLGFLQRSSNFQCQKL Full view | 166 | Ib | Cancer/Infectious/Immunological | Blastoferon | Sidus | N.A. | N.A. | Immunosuppressive Agents, Antineoplastic, Antiviral, Immunologic factors | Interferon alpha/beta receptor 1,Interferon alpha/beta receptor 2 |
1345 | Th1049 | Interferon beta-1a | MSYNLLGFLQRSSNFQCQKL Full view | 166 | Ib | Cancer/Infectious/Immunological | Extavia | Novartis | Sterile, white to off-white powder | Subcutaneous Injection | Immunosuppressive Agents, Antineoplastic, Antiviral, Immunologic factors | Interferon alpha/beta receptor 1,Interferon alpha/beta receptor 2 |
1346 | Th1049 | Interferon beta-1a | MSYNLLGFLQRSSNFQCQKL Full view | 166 | Ib | Cancer/Infectious/Immunological | Rebif | Merck | Sterile solution in a prefilled syringe or REBIF Rebidose autoinjector | Subcutaneous Injection | Immunosuppressive Agents, Antineoplastic, Antiviral, Immunologic factors | Interferon alpha/beta receptor 1,Interferon alpha/beta receptor 2 |
1385 | Th1061 | Trastuzumab | Light chain 1: DIQMT Full view | 1364 | IIa | Cancer | Herceptin | Genentech | Sterile, white to pale yellow, preservative-free lyophilized powder |  Intravenous administration | Antineoplastic Agents | Insulin receptor,Insulin-like growth factor 1 receptor,Insulin-degrading enzyme,HLA class II histocompatibility antigen, DQ alpha 2 chain,HLA class II histocompatibility antigen, DQ beta 1 chain,Retinoblastoma-associated protein,Cathepsin D,Carboxypeptidase E,Neuroendocrine convertase 2,Neuroendocrine convertase 1,Protein NOV homolog,Low-density lipoprotein receptor-related protein 2,Insulin-like growth factor-binding protein 7,Synaptotagmin-like protein 4 |
1389 | Th1062 | Rituximab | Heavy Chain: QVQLQQP Full view | 664 | IIa | Cancer/Immunological | Rituxan | Biogen Idec Inc., and Genentech USA, Inc | Sterile, clear, colorless, preservative-free liquid concentrate |  Intravenous administration | Antineoplastic Agents, Immunologic Factors and Antirheumatic Agents | B-lymphocyte antigen CD20,Low affinity immunoglobulin gamma Fc region receptor III-B,Complement C1r subcomponent,Complement C1q subcomponent subunit A,Complement C1q subcomponent subunit B,Complement C1q subcomponent subunit C,Low affinity immunoglobulin gamma Fc region receptor III-A,Complement C1s subcomponent,High affinity immunoglobulin gamma Fc receptor I,Low affinity immunoglobulin gamma Fc region receptor II-a,Low affinity immunoglobulin gamma Fc region receptor II-b,Low affinity immunoglobulin gamma Fc region receptor II-c, Receptor tyrosine-protein kinase erbB-2,Epidermal growth factor receptor,Complement C1r subcomponent,Complement C1q subcomponent subunit A,Complement C1q subcomponent subunit B,Complement C1q subcomponent subunit C,Complement C1s subcomponent,High affinity immunoglobulin gamma Fc receptor I,Low affinity immunoglobulin gamma Fc region receptor II-a,Low affinity immunoglobulin gamma Fc region receptor II-b,Low affinity immunoglobulin gamma Fc region receptor I |
1548 | Th1117 | Ipilimumab | Heavy chain: QVQLVES Full view | 663 | IIIc | Cancer | YERVOY | Bristol-Myers Squibb | Sterile, preservative-free, clear to slightly opalescent, colorless to pale-yellow solution | N.A. | Antineoplastic Agents and Monoclonal antibodies | Cytotoxic T-lymphocyte protein 4 |
1615 | Th1133 | Aflibercept | SDTGRPFVEMYSEIPEIIHM Full view | 431 | Ib | Cancer | Eylea | Regeneron Pharmaceuticals | Sterile, clear, and colorless to pale yellow solution. | Intravitreal injection | Antineoplastic Agents and Ophthalmics | Vascular endothelial growth factor A,Placenta growth factor,Vascular endothelial growth factor B |
1616 | Th1133 | Aflibercept | SDTGRPFVEMYSEIPEIIHM Full view | 431 | Ib | Cancer | Zaltrap | Sanofi and Regeneron Pharmaceuticals, Inc. | Sterile, clear, colorless to pale yellow, non-pyrogenic, preservative-free, solution. | Intravenous infusion | Antineoplastic Agents and Ophthalmics | Vascular endothelial growth factor A,Placenta growth factor,Vascular endothelial growth factor B |
1636 | Th1142 | Obinutuzumab | N.A. Full view | 0 | IIb | Cancer | Gazyva | Genentech | Sterile, clear, colorless to slightly brown, preservative free liquid concentrate | Intravenous infusion | Antineoplastic Agents | B-lymphocyte antigen CD20 |
1671 | Th1159 | Gemtuzumab ozogamicin | Light Chain 1: QIVLT Full view | 459 | IIb | Cancer | Mylotarg | Wyeth pharmaceuticals inc | Sterile, white, preservative-free lyophilized powder | Intravenous infusion | Antineoplastic agents and Immunotoxins | Myeloid cell surface antigen CD33, Low affinity immunoglobulin gamma Fc region receptor III-B, Complement C1r subcomponent, Complement C1q subcomponent subunit A, Complement C1q subcomponent subunit B, Complement C1q subcomponent subunit C, Low affinity immunoglobulin gamma Fc region receptor III-A, Complement C1s subcomponent, High affinity immunoglobulin gamma Fc receptor I, Low affinity immunoglobulin gamma Fc region receptor II-a, Low affinity immunoglobulin gamma Fc region receptor II-b, Low affinity immunoglobulin gamma Fc region receptor II-c |
1708 | Th1170 | Blinatumomab | DIQLTQSPASLAVSLGQRAT Full view | 504 | IIIc | Cancer/Genetic | Blincyto | AMGEN | Lyophilized Powder for intravenous administration | Intravenous | Antineoplastic Agents, Immunosuppressive Agents, Monoclonal antibodies, Antineoplastic and Immunomodulating Agents | B-lymphocyte antigen CD19; T-cell surface glycoprotein CD3 delta chain |
1724 | Th1174 | Daratumumab | NA Full view | 0 | IIIc | Cancer | Darzalex | Janssen Biotech, Inc. | Solution, concentrate | Intravenous | Antineoplastic Agents | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 |
1797 | Th1191 | Vedolizumab | Heavy Chain Sequence Full view | 716 | IIa | Immunological Disorders | Entyvio | Takeda Pharmaceuticals America, Inc. | Injection, Powder, Lyophilized, for Solution | Intravenous | Immunosupressive agent, Antineoplastic agent | Integrin alpha-4, Integrin beta-7 |
1798 | Th1192 | Ustekinumab | NA Full view | 0 | IIIb | Infectious Disease | Stelara | Janssen Biotech, Inc. | Solution fro Injection | Subcutaneous | Deramtologic agent, Immunosuppressive agent, antineoplastic agent | Interleukin-12 subunit beta |
1802 | Th1196 | Siltuximab | Heavy Chain Sequence Full view | 708 | IIa | Immunological Disorders | Sylvant | Janssen Inc | Lyophilized Powder | Intravenous infusion | Antineoplastic and Immunomodulating Agents, Immunosuppressive Agents | Interleukin-6 |
1805 | Th1199 | Ramucirumab | ramucirumab|Homo sap Full view | 909 | IIIc | Cancer | Cyramza | Eli Lilly and Company | Solution | Intravenous | Antineoplastic and Immunomodulating Agents | Vascular endothelial growth factor receptor 2 |
1811 | Th1202 | Pembrolizumab | Heavy Chain Sequence Full view | 711 | IIIc | Cancer | Keytruda | Merck Sharp & Dohme Corp. | Lyophilized Powder | Intravenous infusion | Antineoplastic and Immunomodulating Agents | Programmed cell death protein 1 |
1813 | Th1204 | Ofatumumab | Ofatumumab Heavy Cha Full view | 483 | IIIc | Cancer | Arzerra | Glaxo Smith Kline Llc | Liquid | Intravenous | Antineoplastic and Immunomodulating Agents | |
1815 | Th1206 | Nivolumab | Heavy Chain Sequence Full view | 710 | IIIc | Cancer | Opdivo | E.R. Squibb & Sons, L.L.C. | Liquid | Intravenous | Antineoplastic and Immunomodulating Agents | Programmed cell death protein 1 |
1819 | Th1210 | Mepolizumab | NA Full view | 0 | Ib | Respiratory Disorder | Nucala | Glaxosmithkline Inc | Lyophilized Powder | Subcutaneous | Antineoplastic and Immunomodulating Agents, Immunosuppressive Agents, Interleukin Inhibitors | Interleukin-5 |
1830 | Th1220 | Brodalumab | NA Full view | 0 | IIa | Immunological Disorders | Siliq | NA | sterile, preservative-free, clear to slightly opalescent, colorless to slightly yellow solution | Subcutaneous | Antineoplastic and Immunomodulating Agents | Interleukin 17 receptor A |
1832 | Th1222 | Canakinumab | H-GAMMA-1 Chain: QVQ Full view | 842 | IIa | Immunological Disorders | Ilaris | Novartis | Lyphilized powder | Subcutaneous | Antineoplastic and Immunomodulating Agents | Interleukin-1 beta |
1837 | Th1226 | Dinutuximab | NA Full view | 0 | IIIc | Cancer | unituxin | NA | sterile, preservative-free, clear/colorless to slightly opalescent solution | Intravenous | Antibody, Immunosuppresive agent, Antineoplastic agent | Ganglioside GD2 (small molecule) |
1844 | Th1232 | Lenograstim | NA Full view | 0 | Ib | Immunological Disorders | Granocyte | NA | Solid | Subcutaneous or Intravenous | Antineoplastic and Immunomodulating Agents | Granulocyte colony-stimulating factor receptor |
1848 | Th1236 | Sipuleucel-T | NA Full view | 0 | IIIc | Cancer | Provenge | NA | Solution | Intravenous | Antineoplastic and Immunomodulating Agents | Prostatic acid phosphatase |