Updated version of this database is available at ThpDB2


Welcome to Help Page of THPdb

This page provides help to the users of THPdb on how to effectively use this dataset. For each module which is implemented in THPdb, here we provide the figures and description on how to use that module. A user can click on the links given below to get help of the respective modules.











Search


Simple Search
This search module allows user to perform search on any or all fields of THPdb.

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Advance Search
This module is designed to facilitate user to search THPdb using multiple queries joined by logical operators like AND/OR.

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Browse


Disease

This module allows user to browse all the FDA approved
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Functional Classification
This page allows users to search and map a peptide in all the databases covered in THPdb.

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Drug's Form/Apperance
This page allows the users to map a protein in the repository of peptides from all the databases covered in THPdb

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Category
Blast-Search page assists users in performing BLAST search against the peptides in THPdb. User can submit their peptide with desired BLAST options for performing similarity, server will returns the BLAST output containing list of peptides similar to the query peptide.

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Route of Administration
This page allows users to search and map the secondary structure of query peptide in all the entries covered in THPdb.

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Target
This page has been created to search the peptides using structure input. The page can accept the input in major file formats (PDB, Smiles). User can also draw their stucture using Marvin applet. The page will further process the input file with the user-selected options using JCsearch program at the backend and the results will be provided in an attractive passion. The PDB input option is set to default.

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Properties


Amino Acid Composition
This page allows users to search peptide(s) satisfying the conditional search based upon the desired properties defined by the user. User can use AND, OR and NOT boolean operators to select conditions based upon the question in his/her mind. Output will be displayed with the peptides satisfying that complex condition given by the user.

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Amino Acid Frequency
This page allows the users to search peptides which are present in multiple functional categories selected by the user.

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No. of Amino Acids
This page allows the users to search peptides which have exclusive function and doesn't have functions selected by the user

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Physiological Properties Value
Blast-Search page assists users in performing BLAST search against the secondary structure of peptides in THPdb. A user needs to give the query as secondary structure states.

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Tools


Blast
This page provides facility to search SMILES notation of a given peptide against various peptide database in THPdb.

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Smith Waterman
This module had been designed with the aim to provide virtual screening facility to scientific community. Using this tool, users can screen their peptide library and identify similar or exact peptides from various databases.

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Mapping
This module was developed for searching peptides, it allows users to draw the chemcal structure using the Marvin applet. Users have the choice to either build a new molecule or edit/modify an existing molecule.

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Frequently Asked Questions (FAQs)


Q1. What is THPdb?
Ans. THPdb is a literature based database of therapeutic peptides and proteins.

Q2. What is the need for therapeutic peptides and proteins?
Ans. The clinical utilization of these helpful peptides and proteins is restricted by a few issues, for example, absence of physical and synthetic steadiness or the absence of attractive traits for sufficient retention or dissemination. Accordingly, as these restorative peptides and proteins are made accessible, it will be vital to detail these medications into sheltered, stable, and strong conveyance frameworks. The pharmaceutical researcher included in this exertion needs to call upon the learning of a few controls, for example, pharmaceutics, therapeutic science, organic chemistry, microbiology, and compound designing and needs to stay up to date with the most recent exploration in the published literature. As it is difficult to find up-to-date, relevant information on protein formulation and/or delivery, this database provides a ready to use reference of accurate information, tables, and illustrations.

Q3. How to search in THPdb?
Ans. User can search a peptide by name, peptide sequence, target affected, brand names of corresponding drugs.

Q4. What other information one can get regarding peptide sequence?
Ans. Data base is providing amino acid composition, frequency, physiochemical properties like hydrophobicity, isoelectric point, melting point, molecular weight and half life. Along with this user can also get structure information. This database also provides powerpoint presentations on individual 160 FDA approved therapeutic peptides and proteins.

Q5. Is this database useful if users have their own query sequence?
Ans. Yes, user can use tools like BLAST, SMITH-WATERMAN, peptide mapping, they can also get information regarding amino acid composition, frequency and other physiochemical properties

Q6. Have these peptides been organised in some order?
Ans. Yes, these peptides have been classified based on their functional groups, disease involved, form/appearance, number of amino acids and route of administration, their statistical distribution has also been provided

Q7. To whom can I report a discrepancy?
Ans. Please refer to the "Contact Us" page.