Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_2385NA

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NANANANANANAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Female pigCytosolLeucine-rich Repeat (LRR) DomainQ68Y56.fastaQ68Y56841NAimmunohistofluorescent analysis293306752017Pubchem_assay
PRRID_2385NA

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NANANANANANAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Female pigCytosolLeucine-rich Repeat (LRR) DomainQ68Y56.fastaQ68Y56841NAimmunohistofluorescent analysis293306752017Pubchem_assay
PRRID_2386NA

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NANANANANaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Humanepithelial cells of the penile urethraLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA293306752017Pubchem_assay
PRRID_2386NA

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NANANANANaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Humanepithelial cells of the penile urethraLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA293306752017Pubchem_assay
PRRID_2387NA

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NANANANANANAToll-like receptor 1 (TLR1)Toll-like receptor (TLR)HumanApical surface of tracheal epithelial cellsLeucine-rich Repeat (LRR) DomainQ15399.fastaQ15399786NANA293306752017Pubchem_assay
PRRID_2387NA

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NANANANANANAToll-like receptor 1 (TLR1)Toll-like receptor (TLR)HumanApical surface of tracheal epithelial cellsLeucine-rich Repeat (LRR) DomainQ15399.fastaQ15399786NANA293306752017Pubchem_assay
PRRID_2388NA

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NANANANANANAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanApical surface of tracheal epithelial cellsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904NANA293306752017Pubchem_assay
PRRID_2388NA

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NANANANANANAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanApical surface of tracheal epithelial cellsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904NANA293306752017Pubchem_assay
PRRID_2389NA

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NANANANANANAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanApical surface of tracheal epithelial cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA293306752017Pubchem_assay
PRRID_2389NA

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NANANANANANAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanApical surface of tracheal epithelial cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA293306752017Pubchem_assay
PRRID_2390NA

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NANANANANANAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanApical surface of tracheal epithelial cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA293306752017Pubchem_assay
PRRID_2390NA

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NANANANANANAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanApical surface of tracheal epithelial cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA293306752017Pubchem_assay
PRRID_2391NA

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NANANANANANAToll-like receptor 6 (TLR6)Toll-like receptor (TLR)Humanintense basolateral staining of tracheal epithelial cellsLeucine-rich Repeat (LRR) DomainQ9Y2C9.fastaQ9Y2C9796NANA293306752017Pubchem_assay
PRRID_2391NA

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NANANANANANAToll-like receptor 6 (TLR6)Toll-like receptor (TLR)Humanintense basolateral staining of tracheal epithelial cellsLeucine-rich Repeat (LRR) DomainQ9Y2C9.fastaQ9Y2C9796NANA293306752017Pubchem_assay
PRRID_2392NA

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NANANANANANAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Horsenucleus of lung capillary endothelial cells and in the cyto- plasm and the nucleus of alveolar macrophagesLeucine-rich Repeat (LRR) DomainQ2EEY0.fastaQ2EEY01031NAimmuno-electron mi- croscopy293306752017Pubchem_assay
PRRID_2392NA

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NANANANANANAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Horsenucleus of lung capillary endothelial cells and in the cyto- plasm and the nucleus of alveolar macrophagesLeucine-rich Repeat (LRR) DomainQ2EEY0.fastaQ2EEY01031NAimmuno-electron mi- croscopy293306752017Pubchem_assay
PRRID_2393NA

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NANANANANANAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanbroncheolavage and blood cells( monocytes)Leucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA293306752017Pubchem_assay
PRRID_2393NA

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NANANANANANAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanbroncheolavage and blood cells( monocytes)Leucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA293306752017Pubchem_assay
PRRID_2394NA

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NANANANANANAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Humanhuman alveolar macrophagesLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA293306752017Pubchem_assay
PRRID_2394NA

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NANANANANANAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Humanhuman alveolar macrophagesLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA293306752017Pubchem_assay
PRRID_2395NA

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NANANANANANAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanPrimary human corneal epithelial cellsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904NAImmunofluorescence293306752017Pubchem_assay
PRRID_2395NA

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NANANANANANAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanPrimary human corneal epithelial cellsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904NAImmunofluorescence293306752017Pubchem_assay
PRRID_2396NA

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NANANANANANAToll-like receptor 1 (TLR1)Toll-like receptor (TLR)Humanplasma membrane and cytoplasmic localization in eyeLeucine-rich Repeat (LRR) DomainQ15399.fastaQ15399786NANA293306752017Pubchem_assay
PRRID_2396NA

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NANANANANANAToll-like receptor 1 (TLR1)Toll-like receptor (TLR)Humanplasma membrane and cytoplasmic localization in eyeLeucine-rich Repeat (LRR) DomainQ15399.fastaQ15399786NANA293306752017Pubchem_assay
PRRID_2397NA

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NANANANANANAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanplasma membrane and cytoplasmic localization in eyeLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA293306752017Pubchem_assay
PRRID_2397NA

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NANANANANANAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanplasma membrane and cytoplasmic localization in eyeLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA293306752017Pubchem_assay
PRRID_2398NA

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NANANANANANAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Humanplasma membrane and cytoplasmic localization in eyeLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904NANA293306752017Pubchem_assay
PRRID_2398NA

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NANANANANANAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Humanplasma membrane and cytoplasmic localization in eyeLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904NANA293306752017Pubchem_assay
PRRID_2399NA

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NANANANANANAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanplasma membrane and cytoplasmic localization in eyeLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA293306752017Pubchem_assay
PRRID_2399NA

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NANANANANANAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanplasma membrane and cytoplasmic localization in eyeLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA293306752017Pubchem_assay
PRRID_2400NA

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NANANANANANAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanplasma membrane and cytoplasmic localization in eyeLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA293306752017Pubchem_assay
PRRID_2400NA

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NANANANANANAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanplasma membrane and cytoplasmic localization in eyeLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA293306752017Pubchem_assay
PRRID_2401NA

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NANANANANANAToll-like receptor 1 (TLR1)Toll-like receptor (TLR)HumanCytoplasm through epidermal keratinocytes from normal skin,Leucine-rich Repeat (LRR) DomainQ15399.fastaQ15399786NANA293306752017Pubchem_assay
PRRID_2401NA

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NANANANANANAToll-like receptor 1 (TLR1)Toll-like receptor (TLR)HumanCytoplasm through epidermal keratinocytes from normal skin,Leucine-rich Repeat (LRR) DomainQ15399.fastaQ15399786NANA293306752017Pubchem_assay
PRRID_2402NA

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NANANANANANAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanCytoplasm through epidermal keratinocytes from normal skin,Leucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA293306752017Pubchem_assay
PRRID_2402NA

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NANANANANANAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanCytoplasm through epidermal keratinocytes from normal skin,Leucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA293306752017Pubchem_assay
PRRID_2403NA

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NANANANANANAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanbasal layer of epidermal keratinocytes from normal skin,Leucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA293306752017Pubchem_assay
PRRID_2403NA

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NANANANANANAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanbasal layer of epidermal keratinocytes from normal skin,Leucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA293306752017Pubchem_assay
PRRID_2406NA

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Respiratory syncytial virus (virus) NANANANAsevere RSV bronchiolitisrs4986790*Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANANANA292536102017NA
PRRID_2406NA

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Respiratory syncytial virus (virus) NANANANAsevere RSV bronchiolitisrs4986790*Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANANANA292536102017NA
PRRID_2407NA

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Respiratory syncytial virus (virus) NANANANAinhibit the production of interferon-in human plasmacytoid dendritic cellsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA292536102017Pubchem_assay
PRRID_2407NA

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Respiratory syncytial virus (virus) NANANANAinhibit the production of interferon-in human plasmacytoid dendritic cellsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA292536102017Pubchem_assay
PRRID_2409NA

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Respiratory syncytial virus (virus) NANANANAinhibit the production of interferon-in human plasmacytoid dendritic cellsrs7656411*Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANANANA292536102017NA
PRRID_2409NA

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Respiratory syncytial virus (virus) NANANANAinhibit the production of interferon-in human plasmacytoid dendritic cellsrs7656411*Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANANANA292536102017NA
PRRID_2412NA

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H. pylori (Bacteria)NANANANaturalinfectionToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA291350542017Pubchem_assay
PRRID_2412NA

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H. pylori (Bacteria)NANANANaturalinfectionToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA291350542017Pubchem_assay
PRRID_2424NA

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Gram-positive bacteria and fungiNANANANaturalNAToll-like receptor 6 (TLR6)Toll-like receptor (TLR)HumanNANAQ9Y2C9.fastaQ9Y2C9796NANA290662552017Pubchem_assay
PRRID_2424NA

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Gram-positive bacteria and fungiNANANANaturalNAToll-like receptor 6 (TLR6)Toll-like receptor (TLR)HumanNANAQ9Y2C9.fastaQ9Y2C9796NANA290662552017Pubchem_assay
PRRID_2436NA

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Enterovirus 71 (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA290520542017Pubchem_assay
PRRID_2436NA

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Enterovirus 71 (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA290520542017Pubchem_assay
PRRID_2437NA

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CA16(others)NANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA290520542017Pubchem_assay
PRRID_2437NA

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CA16(others)NANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA290520542017Pubchem_assay
PRRID_2447NA

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Group B Streptococcus (GBS) (Bacteria)NANANANaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)Humanhuman monocytes and monocyte-derived macrophages (MDM)Leucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041induction of the cytokines IFNβ and IL-12, and which also contributes to TNF production.western blotting290428602017Pubchem_assay
PRRID_2447NA

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Group B Streptococcus (GBS) (Bacteria)NANANANaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)Humanhuman monocytes and monocyte-derived macrophages (MDM)Leucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041induction of the cytokines IFNβ and IL-12, and which also contributes to TNF production.western blotting290428602017Pubchem_assay
PRRID_2459NA

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalBinding and activation btTOLLBtTollToll-like receptor (TLR)Bemisia tabaci (Gennadius)3rd nymphal instar.TIR domainNANANAMicrobe detection, AMPs production, phagosome regulations, inflammatory signaling and activationqRT-PCR286489962017NA
PRRID_2459NA

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalBinding and activation btTOLLBtTollToll-like receptor (TLR)Bemisia tabaci (Gennadius)3rd nymphal instar.TIR domainNANANAMicrobe detection, AMPs production, phagosome regulations, inflammatory signaling and activationqRT-PCR286489962017NA
PRRID_2461NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantPf_Toll-like receptor (TLR18)Toll-like receptor (TLR)Pelteobagrus fulvidracospleen, head kidney, trunk kidney, liver and bloodLeucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2461NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantPf_Toll-like receptor (TLR18)Toll-like receptor (TLR)Pelteobagrus fulvidracospleen, head kidney, trunk kidney, liver and bloodLeucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2462NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantPf_Toll-like receptor 19 (TLR19)Toll-like receptor (TLR)Pelteobagrus fulvidracospleen, head kidney, trunk kidney, liver and bloodLeucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2462NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantPf_Toll-like receptor 19 (TLR19)Toll-like receptor (TLR)Pelteobagrus fulvidracospleen, head kidney, trunk kidney, liver and bloodLeucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2463NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantPf_Toll-like receptor 21 (TLR21)Toll-like receptor (TLR)Pelteobagrus fulvidracospleen, head kidney, trunk kidney, liver and bloodLRR and TIR domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2463NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantPf_Toll-like receptor 21 (TLR21)Toll-like receptor (TLR)Pelteobagrus fulvidracospleen, head kidney, trunk kidney, liver and bloodLRR and TIR domainNANANAactivate NF-κB.qRT-PCR285460182017NA
PRRID_2464NA

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S. iniae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulanttbToll-like receptor 22 (TLR22)Toll-like receptor (TLR)Scophthalmus maximusLiver and spleenLeucine-rich Repeat (LRR) DomainNANANANF-κB-mediated in ammatory cytokine pro- duction.ELISA284955642017NA
PRRID_2464NA

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S. iniae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulanttbToll-like receptor 22 (TLR22)Toll-like receptor (TLR)Scophthalmus maximusLiver and spleenLeucine-rich Repeat (LRR) DomainNANANANF-κB-mediated in ammatory cytokine pro- duction.ELISA284955642017NA
PRRID_2465NA

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E.Tarda(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulanttbToll-like receptor 22 (TLR22)Toll-like receptor (TLR)Scophthalmus maximusLiver and kidneyLeucine-rich Repeat (LRR) DomainNANANANAELISA284955642017NA
PRRID_2465NA

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E.Tarda(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulanttbToll-like receptor 22 (TLR22)Toll-like receptor (TLR)Scophthalmus maximusLiver and kidneyLeucine-rich Repeat (LRR) DomainNANANANAELISA284955642017NA
PRRID_2466NA

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HIRRV (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulanttbToll-like receptor 22 (TLR22)Toll-like receptor (TLR)Scophthalmus maximusGills and kidneyLeucine-rich Repeat (LRR) DomainNANANANAELISA284955642017NA
PRRID_2466NA

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HIRRV (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulanttbToll-like receptor 22 (TLR22)Toll-like receptor (TLR)Scophthalmus maximusGills and kidneyLeucine-rich Repeat (LRR) DomainNANANANAELISA284955642017NA
PRRID_2467NA

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F. solani (fungi)NANAPattern-associated molecular patterns (PAMPs)Naturalupregulate AMPs hBD2 and LL37 at the mRNA and protein level via a TLR2- and Dectin-1– mediated mechanism.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHuman corneal epithelial cells (HCECs)Leucine-rich Repeat (LRR) DomainO60603.fastaO60603784decreased AMP mRNA upregulationRT-PCR, antifungal assay284600482017Pubchem_assay
PRRID_2467NA

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F. solani (fungi)NANAPattern-associated molecular patterns (PAMPs)Naturalupregulate AMPs hBD2 and LL37 at the mRNA and protein level via a TLR2- and Dectin-1– mediated mechanism.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHuman corneal epithelial cells (HCECs)Leucine-rich Repeat (LRR) DomainO60603.fastaO60603784decreased AMP mRNA upregulationRT-PCR, antifungal assay284600482017Pubchem_assay
PRRID_2469NA

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Grass carp reovirus (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantScToll-like receptor 2 (TLR2)2Toll-like receptor (TLR)Squaliobarbus curriculushead kidney and spleen19 leucine rich repeats (LRRs), a transmembrane (TM) and a Toll/interleukin-1 receptor (TIR) domain.NANANANF-κB activation that up-regulates secretion of proinflammatory cytokines.qRT-PCR284424182017NA
PRRID_2469NA

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Grass carp reovirus (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantScToll-like receptor 2 (TLR2)2Toll-like receptor (TLR)Squaliobarbus curriculushead kidney and spleen19 leucine rich repeats (LRRs), a transmembrane (TM) and a Toll/interleukin-1 receptor (TIR) domain.NANANANF-κB activation that up-regulates secretion of proinflammatory cytokines.qRT-PCR284424182017NA
PRRID_2471NA

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white spot syndrome virus (WSSV)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantPcToll4Toll-like receptor (TLR)Procambarus clarkiiAll tested tissueA single peptide, 13 LRR domains, 3 LRR TYP domains, 2 LRR CT do- mains, an LRR NT domain, a transmembrane region, and a TIR domain.NANANAregulates the expressions of AMPs against WSSVqRT-PCR282130412017NA
PRRID_2471NA

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white spot syndrome virus (WSSV)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantPcToll4Toll-like receptor (TLR)Procambarus clarkiiAll tested tissueA single peptide, 13 LRR domains, 3 LRR TYP domains, 2 LRR CT do- mains, an LRR NT domain, a transmembrane region, and a TIR domain.NANANAregulates the expressions of AMPs against WSSVqRT-PCR282130412017NA
PRRID_2495 non-lipopeptidic PAMPs

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Pathogens (others)NANAFatty acid NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA292639322017Pubchem_assay
PRRID_2495 non-lipopeptidic PAMPs

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Pathogens (others)NANAFatty acid NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA292639322017Pubchem_assay
PRRID_2497NhhA

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NANANANANAInduction of anti-in ammatory CD200RhiToll-like receptor (TLR1/2 (triacylated lipoproteins)Toll-like receptor (TLR)NACell surfaceLeucine-rich Repeat (LRR) DomainNANANANANA283342032017NA
PRRID_2497NhhA

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NANANANANAInduction of anti-in ammatory CD200RhiToll-like receptor (TLR1/2 (triacylated lipoproteins)Toll-like receptor (TLR)NACell surfaceLeucine-rich Repeat (LRR) DomainNANANANANA283342032017NA
PRRID_2498NhhA

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NANANANANAImmune activationToll-like receptor 2 (TLR2)/6 (diacylated lipoproteins) Toll-like receptor 4 (TLR4)/MD- 2/CD14/LBPToll-like receptor (TLR)NACell surfaceLeucine-rich Repeat (LRR) DomainNANANANANA283342032017NA
PRRID_2498NhhA

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NANANANANAImmune activationToll-like receptor 2 (TLR2)/6 (diacylated lipoproteins) Toll-like receptor 4 (TLR4)/MD- 2/CD14/LBPToll-like receptor (TLR)NACell surfaceLeucine-rich Repeat (LRR) DomainNANANANANA283342032017NA
PRRID_2511NMB0278

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NANANANANAInflammationToll-like receptor 2 (TLR2)/6 (diacylated lipoproteins) Toll-like receptor 4 (TLR4)/MD- 2/CD14/LBPToll-like receptor (TLR)NACell surfaceLeucine-rich Repeat (LRR) DomainNANANANANA283342032017NA
PRRID_2511NMB0278

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NANANANANAInflammationToll-like receptor 2 (TLR2)/6 (diacylated lipoproteins) Toll-like receptor 4 (TLR4)/MD- 2/CD14/LBPToll-like receptor (TLR)NACell surfaceLeucine-rich Repeat (LRR) DomainNANANANANA283342032017NA
PRRID_2512NMB0667

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NANANANANAInflammationToll-like receptor 2 (TLR2)/6 (diacylated lipoproteins) Toll-like receptor 4 (TLR4)/MD- 2/CD14/LBPToll-like receptor (TLR)NACell surfaceLeucine-rich Repeat (LRR) DomainNANANANANA283342032017NA
PRRID_2512NMB0667

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NANANANANAInflammationToll-like receptor 2 (TLR2)/6 (diacylated lipoproteins) Toll-like receptor 4 (TLR4)/MD- 2/CD14/LBPToll-like receptor (TLR)NACell surfaceLeucine-rich Repeat (LRR) DomainNANANANANA283342032017NA
PRRID_2513NMB0995

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NANANANANAInflammationToll-like receptor 2 (TLR2)/6 (diacylated lipoproteins) Toll-like receptor 4 (TLR4)/MD- 2/CD14/LBPToll-like receptor (TLR)NACell surfaceLeucine-rich Repeat (LRR) DomainNANANANANA283342032017NA
PRRID_2513NMB0995

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NANANANANAInflammationToll-like receptor 2 (TLR2)/6 (diacylated lipoproteins) Toll-like receptor 4 (TLR4)/MD- 2/CD14/LBPToll-like receptor (TLR)NACell surfaceLeucine-rich Repeat (LRR) DomainNANANANANA283342032017NA
PRRID_2519No known ligand

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NANANANANANAToll-like receptor 10 (TLR10)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA290283692017NA
PRRID_2519No known ligand

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NANANANANANAToll-like receptor 10 (TLR10)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA290283692017NA
PRRID_2521ODN2006

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NA5’-tcgtcgttttgtcgttttgtcgtt-3’24Pattern-associated molecular patterns (PAMPs)Syntheticanti- inflammatory activityToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanU937 cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA291137972017Pubchem_assay
PRRID_2521ODN2006

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NA5’-tcgtcgttttgtcgttttgtcgtt-3’24Pattern-associated molecular patterns (PAMPs)Syntheticanti- inflammatory activityToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanU937 cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA291137972017Pubchem_assay
PRRID_2524ODN2006

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NA5’-tcgtcgttttgtcgttttgtcgtt-3’24Pattern-associated molecular patterns (PAMPs)SyntheticNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanPeripheral blood mononuclear cells (PBMC)Leucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA290393482017Pubchem_assay
PRRID_2524ODN2006

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NA5’-tcgtcgttttgtcgttttgtcgtt-3’24Pattern-associated molecular patterns (PAMPs)SyntheticNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanPeripheral blood mononuclear cells (PBMC)Leucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA290393482017Pubchem_assay
PRRID_2525Oligosaccharides of hyaluronic acid (HA)

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NACC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONANANaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA290283692017NA
PRRID_2525Oligosaccharides of hyaluronic acid (HA)

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NACC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONANANaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA290283692017NA
PRRID_2526OspA

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NAMKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGGMTVLVSKEKDKDGKYSLDATVDKLELKGTSDKNNGSGTLEGEKTDKSKVKLTIADDLSQTKFEIFKEDGKTLVSKKVTLKDKSSTEEKFNEKGETSEKTIVRANGTRLEYTDIKSDGSGKAKEVLKDFTLEGTLAADGKTTLKVTEGTVVLSKNILKSGEITVALDDSDTTQATKKTGNWDSKSSTLTISVNSQKTKNLVFTKEDTITVQKYDSAGTNLEGKAVEITTLKELKAALKNANANaturalProduction of TNF-α and IL-Toll-like receptor 1 (TLR1)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9EPQ1.fastaQ9EPQ1795NANA290283692017Pubchem_assay
PRRID_2526OspA

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NAMKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGGMTVLVSKEKDKDGKYSLDATVDKLELKGTSDKNNGSGTLEGEKTDKSKVKLTIADDLSQTKFEIFKEDGKTLVSKKVTLKDKSSTEEKFNEKGETSEKTIVRANGTRLEYTDIKSDGSGKAKEVLKDFTLEGTLAADGKTTLKVTEGTVVLSKNILKSGEITVALDDSDTTQATKKTGNWDSKSSTLTISVNSQKTKNLVFTKEDTITVQKYDSAGTNLEGKAVEITTLKELKAALKNANANaturalProduction of TNF-α and IL-Toll-like receptor 1 (TLR1)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9EPQ1.fastaQ9EPQ1795NANA290283692017Pubchem_assay
PRRID_2529Palmitic acid

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NACCCCCCCCCCCCCCCC(=O)ONAPattern-associated molecular patterns (PAMPs)NaturalPA may func- tion as a dietary immune modifier (DIM) resulting in the induction of chronic inflammation, such as that seen in type 2 diabetes.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanDendritic cellLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839production of IL-1β in human DCs through an inflammasome dependent mechanismqRT-PCR284639852017Pubchem_assay
PRRID_2529Palmitic acid

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NACCCCCCCCCCCCCCCC(=O)ONAPattern-associated molecular patterns (PAMPs)NaturalPA may func- tion as a dietary immune modifier (DIM) resulting in the induction of chronic inflammation, such as that seen in type 2 diabetes.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanDendritic cellLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839production of IL-1β in human DCs through an inflammasome dependent mechanismqRT-PCR284639852017Pubchem_assay
PRRID_2530Pam2CS-type

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BacteriaCCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCNAimidazoquinolinesSyntheticNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANAwestern blotting290498862017NA
PRRID_2530Pam2CS-type

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BacteriaCCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCNAimidazoquinolinesSyntheticNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANAwestern blotting290498862017NA