Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_2196HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Ratrat brain (vasculature)Leucine-rich Repeat (LRR) DomainQ6YGU2.fastaQ6YGU2784protein ‚Üë, activation in ischemic strokeNA288015212017Pubchem_assay
PRRID_2196HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Ratrat brain (vasculature)Leucine-rich Repeat (LRR) DomainQ6YGU2.fastaQ6YGU2784protein ‚Üë, activation in ischemic strokeNA288015212017Pubchem_assay
PRRID_2197Hyaluronan

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Host (Endogenous) (others)CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONANANaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NAMouse alveolar macrophage cell lineLeucine-rich Repeat (LRR) DomainNANANANANA290283692017NA
PRRID_2197Hyaluronan

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Host (Endogenous) (others)CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONANANaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NAMouse alveolar macrophage cell lineLeucine-rich Repeat (LRR) DomainNANANANANA290283692017NA
PRRID_2198Hyaluronan

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NACC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONADamage-associated molecular patterns (DAMPs)NaturalInduce the production of TNF-α, IL-1β and IL-12 by dendritic cellsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cellsNAO60603.fastaO60603784NANA289610192017Pubchem_assay
PRRID_2198Hyaluronan

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NACC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONADamage-associated molecular patterns (DAMPs)NaturalInduce the production of TNF-α, IL-1β and IL-12 by dendritic cellsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cellsNAO60603.fastaO60603784NANA289610192017Pubchem_assay
PRRID_2200Hyaluronan

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NACC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONADamage-associated molecular patterns (DAMPs)NaturalInduce the production of TNF-α, IL-1β and IL-12 by dendritic cellsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humandendritic cellsNAO00206.fastaO00206839NANA289610192017Pubchem_assay
PRRID_2200Hyaluronan

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NACC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONADamage-associated molecular patterns (DAMPs)NaturalInduce the production of TNF-α, IL-1β and IL-12 by dendritic cellsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humandendritic cellsNAO00206.fastaO00206839NANA289610192017Pubchem_assay
PRRID_2201Hyaluronic acid

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NACC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONADamage-associated molecular patterns (DAMPs)NaturalInduce the maturation of mouse and human dendritic cells,Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanEndothelial cellsNAO60603.fastaO60603784NANA289610192017Pubchem_assay
PRRID_2201Hyaluronic acid

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NACC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONADamage-associated molecular patterns (DAMPs)NaturalInduce the maturation of mouse and human dendritic cells,Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanEndothelial cellsNAO60603.fastaO60603784NANA289610192017Pubchem_assay
PRRID_2203Hyaluronic acid

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NACC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONADamage-associated molecular patterns (DAMPs)NaturalInduce the maturation of mouse and human dendritic cells,Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanEndothelial cellsNAO00206.fastaO00206839NANA289610192017Pubchem_assay
PRRID_2203Hyaluronic acid

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NACC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONADamage-associated molecular patterns (DAMPs)NaturalInduce the maturation of mouse and human dendritic cells,Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanEndothelial cellsNAO00206.fastaO00206839NANA289610192017Pubchem_assay
PRRID_2204Hyaluronic acid

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NACC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONADamage-associated molecular patterns (DAMPs)NaturalInduce the production of TNF-α, IL-1β and IL-12 by dendritic cellsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)MacrophagesNAQ9QUN7.fastaQ9QUN7784NANA289610192017Pubchem_assay
PRRID_2204Hyaluronic acid

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NACC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONADamage-associated molecular patterns (DAMPs)NaturalInduce the production of TNF-α, IL-1β and IL-12 by dendritic cellsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)MacrophagesNAQ9QUN7.fastaQ9QUN7784NANA289610192017Pubchem_assay
PRRID_2205Hyaluronic acid

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NACC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONADamage-associated molecular patterns (DAMPs)NaturalInduce the production of TNF-α, IL-1β and IL-12 by dendritic cellsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanEndothelial cellsNAO60603.fastaO60603784NANA289610192017Pubchem_assay
PRRID_2205Hyaluronic acid

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NACC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONADamage-associated molecular patterns (DAMPs)NaturalInduce the production of TNF-α, IL-1β and IL-12 by dendritic cellsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanEndothelial cellsNAO60603.fastaO60603784NANA289610192017Pubchem_assay
PRRID_2206Hyaluronic acid

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NACC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONADamage-associated molecular patterns (DAMPs)NaturalInduce the production of TNF-α, IL-1β and IL-12 by dendritic cellsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanEndothelial cellsNAO00206.fastaO00206839NANA289610192017Pubchem_assay
PRRID_2206Hyaluronic acid

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NACC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONADamage-associated molecular patterns (DAMPs)NaturalInduce the production of TNF-α, IL-1β and IL-12 by dendritic cellsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanEndothelial cellsNAO00206.fastaO00206839NANA289610192017Pubchem_assay
PRRID_2209Imidazoquinoline

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NACCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)NaturalSynthesis of IFNα, inflammatory cytokine production by macrophages, proliferation of splenocytes or maturation of DCs , Produce type I IFNs and other cytokines, maturation of pDCs, stimulate T-cells ,Reduces plasma virus concentration in chronic hepatitis C infectionToll-like receptor 7 (TLR7)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainP58681.fastaP586811050NANA290283692017Pubchem_assay
PRRID_2209Imidazoquinoline

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NACCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)NaturalSynthesis of IFNα, inflammatory cytokine production by macrophages, proliferation of splenocytes or maturation of DCs , Produce type I IFNs and other cytokines, maturation of pDCs, stimulate T-cells ,Reduces plasma virus concentration in chronic hepatitis C infectionToll-like receptor 7 (TLR7)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainP58681.fastaP586811050NANA290283692017Pubchem_assay
PRRID_2211Imiquimod

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NACC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2NNANASyntheticOral carcinogenesisToll-like receptor 7 (TLR7)Toll-like receptor (TLR)Humanoral squamous cell carcinomasLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA289828472017Pubchem_assay
PRRID_2211Imiquimod

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NACC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2NNANASyntheticOral carcinogenesisToll-like receptor 7 (TLR7)Toll-like receptor (TLR)Humanoral squamous cell carcinomasLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA289828472017Pubchem_assay
PRRID_2212Imiquimod (R873)

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NACC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2NNANASyntheticanti- inflammatory activityToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanU937 cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA291137972017Pubchem_assay
PRRID_2212Imiquimod (R873)

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NACC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2NNANASyntheticanti- inflammatory activityToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanU937 cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA291137972017Pubchem_assay
PRRID_2222LipL32

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Gram negative bacteria(Leptospira spp.)NANALipoproteinNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micesurface of epithelial cells and macrophages.Leucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784NANA290389562017Pubchem_assay
PRRID_2222LipL32

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Gram negative bacteria(Leptospira spp.)NANALipoproteinNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micesurface of epithelial cells and macrophages.Leucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784NANA290389562017Pubchem_assay
PRRID_2223lipo-arabinomannan

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Mycobacteria (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalcauses tuberculosis-like systemic infection in sh and in other ectothermsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanTHP‚Äê1 macrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NATHP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA291833332017Pubchem_assay
PRRID_2223lipo-arabinomannan

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Mycobacteria (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalcauses tuberculosis-like systemic infection in sh and in other ectothermsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanTHP‚Äê1 macrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NATHP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA291833332017Pubchem_assay
PRRID_2225lipo-arabinomannan

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Mycobacteria (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalActivation of NF-KB-driven luciferase activity in lung inflammation, Stimulate NFκB, induce apoptosis in THP- monocytice cellsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784NANA290283692017Pubchem_assay
PRRID_2225lipo-arabinomannan

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Mycobacteria (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalActivation of NF-KB-driven luciferase activity in lung inflammation, Stimulate NFκB, induce apoptosis in THP- monocytice cellsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784NANA290283692017Pubchem_assay
PRRID_2226lipomannas

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Mycobacteria (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalcauses tuberculosis-like systemic infection in sh and in other ectothermsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanTHP‚Äê1 macrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NATHP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA291833332017Pubchem_assay
PRRID_2226lipomannas

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Mycobacteria (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalcauses tuberculosis-like systemic infection in sh and in other ectothermsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanTHP‚Äê1 macrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NATHP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA291833332017Pubchem_assay
PRRID_2228Lipopeptides or lipoteichoic acid (LTA)

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BacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAProteinNaturalNAToll-like receptor (TLR1/Toll-like receptor 2 (TLR2) or Toll-like receptor 6 (TLR6)/ Toll-like recepToll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2228Lipopeptides or lipoteichoic acid (LTA)

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BacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAProteinNaturalNAToll-like receptor (TLR1/Toll-like receptor 2 (TLR2) or Toll-like receptor 6 (TLR6)/ Toll-like recepToll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2229Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Humanhuman myeloid cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NAflow cytometry and immunofluorescence microsco- py293306752017Pubchem_assay
PRRID_2229Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Humanhuman myeloid cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NAflow cytometry and immunofluorescence microsco- py293306752017Pubchem_assay
PRRID_2230Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Rabbituterine luminal and glandular epitheliumLeucine-rich Repeat (LRR) DomainA0ELV4.fastaA0ELV4905NAIHC analy- sis293306752017Pubchem_assay
PRRID_2230Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Rabbituterine luminal and glandular epitheliumLeucine-rich Repeat (LRR) DomainA0ELV4.fastaA0ELV4905NAIHC analy- sis293306752017Pubchem_assay
PRRID_2231Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Chickencytoplasm of basal cells of the epithelium in the isthmus, uterus and vaginaLeucine-rich Repeat (LRR) DomainQ7ZTG5.fastaQ7ZTG5843NANA293306752017Pubchem_assay
PRRID_2231Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Chickencytoplasm of basal cells of the epithelium in the isthmus, uterus and vaginaLeucine-rich Repeat (LRR) DomainQ7ZTG5.fastaQ7ZTG5843NANA293306752017Pubchem_assay
PRRID_2232Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanchorioamniotic membranesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA293306752017Pubchem_assay
PRRID_2232Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanchorioamniotic membranesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA293306752017Pubchem_assay
PRRID_2233Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Humanluminal epithelial cells of the prostrateLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904NANA293306752017Pubchem_assay
PRRID_2233Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Humanluminal epithelial cells of the prostrateLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904NANA293306752017Pubchem_assay
PRRID_2234Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)Humanluminal epithelial cells of the prostrateLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041NANA293306752017Pubchem_assay
PRRID_2234Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)Humanluminal epithelial cells of the prostrateLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041NANA293306752017Pubchem_assay
PRRID_2235Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Horsecell surface and in the cytoplasm of bronchiolar epithelial cellsLeucine-rich Repeat (LRR) DomainQ2EEY0.fastaQ2EEY01031NANA293306752017Pubchem_assay
PRRID_2235Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Horsecell surface and in the cytoplasm of bronchiolar epithelial cellsLeucine-rich Repeat (LRR) DomainQ2EEY0.fastaQ2EEY01031NANA293306752017Pubchem_assay
PRRID_2236Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA292647452017Pubchem_assay
PRRID_2236Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA292647452017Pubchem_assay
PRRID_2237Lipopolysaccharide (LPS)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA292639322017Pubchem_assay
PRRID_2237Lipopolysaccharide (LPS)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA292639322017Pubchem_assay
PRRID_2238Lipopolysaccharide (LPS)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanPlateletsleucine-rich-repeat (LRR) , nucleotide-binding domain (NBD), caspase activation and recruitment domain (CARD)O00206.fastaO00206839release soluble factors to modulate the immune responseNA292205942017Pubchem_assay
PRRID_2238Lipopolysaccharide (LPS)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanPlateletsleucine-rich-repeat (LRR) , nucleotide-binding domain (NBD), caspase activation and recruitment domain (CARD)O00206.fastaO00206839release soluble factors to modulate the immune responseNA292205942017Pubchem_assay
PRRID_2239Lipopolysaccharide (LPS)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalCauses Mastitis, an infection of the mammary glandToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanmammary tissueLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA291138062017Pubchem_assay
PRRID_2239Lipopolysaccharide (LPS)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalCauses Mastitis, an infection of the mammary glandToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanmammary tissueLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA291138062017Pubchem_assay
PRRID_2240Lipopolysaccharide (LPS)

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E. coli K12(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalanti- inflammatory activityToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanU937 cellsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA291137972017Pubchem_assay
PRRID_2240Lipopolysaccharide (LPS)

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E. coli K12(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalanti- inflammatory activityToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanU937 cellsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA291137972017Pubchem_assay
PRRID_2241Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalUrinary Tract infectionToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanbladder and uroepithelial cellsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA290663052017Pubchem_assay
PRRID_2241Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalUrinary Tract infectionToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanbladder and uroepithelial cellsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA290663052017Pubchem_assay
PRRID_2242Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNANAO00206.fastaO00206839NANA290662552017Pubchem_assay
PRRID_2242Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNANAO00206.fastaO00206839NANA290662552017Pubchem_assay
PRRID_2243Lipopolysaccharide (LPS)

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Gram negative bacteria(Leptospira spp.)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalinfectionToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NAELISA290389562017Pubchem_assay
PRRID_2243Lipopolysaccharide (LPS)

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Gram negative bacteria(Leptospira spp.)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalinfectionToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NAELISA290389562017Pubchem_assay
PRRID_2245Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalFormation of a complex between PI 3-kinase and MyD88, induction of IL-1β, TNF-α and macrophage inflammatory protein (MIP)-2, induce proinflammatory cytokine production through NF-KB signaling , Functional maturation of mouse macrophages, induction of TNF-α by Human Monocyte Cultures, Production of major proinflammatory cytokines such as IL-1, IL-6, or TNF-α; activate DC and promote the development of Th-like responsesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMouse macrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA290283692017Pubchem_assay
PRRID_2245Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalFormation of a complex between PI 3-kinase and MyD88, induction of IL-1β, TNF-α and macrophage inflammatory protein (MIP)-2, induce proinflammatory cytokine production through NF-KB signaling , Functional maturation of mouse macrophages, induction of TNF-α by Human Monocyte Cultures, Production of major proinflammatory cytokines such as IL-1, IL-6, or TNF-α; activate DC and promote the development of Th-like responsesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMouse macrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA290283692017Pubchem_assay
PRRID_2247Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalinnate immunity elicitorPmToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Pinctada fucata martensiiHemocytesLeucine-rich Repeat (LRR) DomainNANANAplay a vital role in the induction of innate immunity and is therefore associated with allograft immunity in the pearl oyster P. fucata martensii.NA288936452017NA
PRRID_2247Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalinnate immunity elicitorPmToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Pinctada fucata martensiiHemocytesLeucine-rich Repeat (LRR) DomainNANANAplay a vital role in the induction of innate immunity and is therefore associated with allograft immunity in the pearl oyster P. fucata martensii.NA288936452017NA
PRRID_2255Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceBrainLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835mRNA ‚Üë in agingNA288015212017Pubchem_assay
PRRID_2255Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceBrainLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835mRNA ‚Üë in agingNA288015212017Pubchem_assay
PRRID_2256Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceBrainLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835mRNA ‚Üë in plaque- associated brain tissue of AD model miceNA288015212017Pubchem_assay
PRRID_2256Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceBrainLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835mRNA ‚Üë in plaque- associated brain tissue of AD model miceNA288015212017Pubchem_assay
PRRID_2257Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanbrain(hippocampus, superior frontal gyrus, post-central gyrus)Leucine-rich Repeat (LRR) DomainO00206.fastaO00206839mRNA ‚Üë in aging and ADNA288015212017Pubchem_assay
PRRID_2257Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanbrain(hippocampus, superior frontal gyrus, post-central gyrus)Leucine-rich Repeat (LRR) DomainO00206.fastaO00206839mRNA ‚Üë in aging and ADNA288015212017Pubchem_assay
PRRID_2258Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMicrogliaLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835involved in both amyloid-β uptake and inflammatory cytokine productionNA288015212017Pubchem_assay
PRRID_2258Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMicrogliaLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835involved in both amyloid-β uptake and inflammatory cytokine productionNA288015212017Pubchem_assay
PRRID_2259Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micemicroglia (mouse striatum)Leucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835TLR4 knockout: neuroprotective in ischemiaNA288015212017Pubchem_assay
PRRID_2259Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micemicroglia (mouse striatum)Leucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835TLR4 knockout: neuroprotective in ischemiaNA288015212017Pubchem_assay
PRRID_2260Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Miceneurons (mouse cortex)Leucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835protein ‚Üë, proapoptotic in ischemiaNA288015212017Pubchem_assay
PRRID_2260Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Miceneurons (mouse cortex)Leucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835protein ‚Üë, proapoptotic in ischemiaNA288015212017Pubchem_assay
PRRID_2261Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Ratrat brain (vasculature)Leucine-rich Repeat (LRR) DomainQ9QX05.fastaQ9QX05835protein ‚Üë, activation in ischemic strokeNA288015212017Pubchem_assay
PRRID_2261Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Ratrat brain (vasculature)Leucine-rich Repeat (LRR) DomainQ9QX05.fastaQ9QX05835protein ‚Üë, activation in ischemic strokeNA288015212017Pubchem_assay
PRRID_2262Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Miceprimary mouse astrocytesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835activation in response to α-synucleinNA288015212017Pubchem_assay
PRRID_2262Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Miceprimary mouse astrocytesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835activation in response to α-synucleinNA288015212017Pubchem_assay
PRRID_2265Lipopolysaccharide (LPS)

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P. gulae (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalCauses inflammation and activation of TLR2.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceMacrophagesLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784activate NF-κB.NA286300662017Pubchem_assay
PRRID_2265Lipopolysaccharide (LPS)

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P. gulae (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalCauses inflammation and activation of TLR2.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceMacrophagesLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784activate NF-κB.NA286300662017Pubchem_assay
PRRID_2268Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantCqTollToll-like receptor (TLR)Cherax quadricarinatusHemocytesextracellular domain of 19 leucine-rich repeats residues, a transmembrane domain and an intracellular domain of 138 amino acids.NANANACqToll involved in anti-WSSV responseqRT-PCR284793462017NA
PRRID_2268Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantCqTollToll-like receptor (TLR)Cherax quadricarinatusHemocytesextracellular domain of 19 leucine-rich repeats residues, a transmembrane domain and an intracellular domain of 138 amino acids.NANANACqToll involved in anti-WSSV responseqRT-PCR284793462017NA
PRRID_2275Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2275Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2286Lipoprotein

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BacteriaNANANANaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNANAO60603.fastaO60603784NANA290662552017Pubchem_assay
PRRID_2286Lipoprotein

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BacteriaNANANANaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNANAO60603.fastaO60603784NANA290662552017Pubchem_assay
PRRID_2287Lipoprotein

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BacteriaNANANANaturalStimulate NFκB, induce apoptosis in THP- monocytice cellsToll-like receptor 6 (TLR6)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9Y2C9.fastaQ9Y2C9796NANA290283692017Pubchem_assay
PRRID_2287Lipoprotein

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BacteriaNANANANaturalStimulate NFκB, induce apoptosis in THP- monocytice cellsToll-like receptor 6 (TLR6)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9Y2C9.fastaQ9Y2C9796NANA290283692017Pubchem_assay
PRRID_2288Lipoprotein

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S. gordonii (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalapical periodontitisToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanPDL cellsLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784induces IL-8 production through activation of TLR2 in human PDL cells.ELISA289639312017Pubchem_assay
PRRID_2288Lipoprotein

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S. gordonii (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalapical periodontitisToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanPDL cellsLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784induces IL-8 production through activation of TLR2 in human PDL cells.ELISA289639312017Pubchem_assay
PRRID_2289Lipoprotein

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micemononuclear phagocytesLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784mRNA ‚Üë in agingNA288015212017Pubchem_assay
PRRID_2289Lipoprotein

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micemononuclear phagocytesLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784mRNA ‚Üë in agingNA288015212017Pubchem_assay
PRRID_2290Lipoprotein

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceBrainLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784mRNA ‚Üë in plaque- associated brain tissue of AD model miceNA288015212017Pubchem_assay
PRRID_2290Lipoprotein

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceBrainLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784mRNA ‚Üë in plaque- associated brain tissue of AD model miceNA288015212017Pubchem_assay