Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_2540	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Increased gene expression and secretion of proinflammatory cytokines (IL-Ôòæ) and chemokines (IL-ÔôÄ),Activate macrophages and produce inflammatory responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Human embryonic kidney 293 (HERK 293 ) cells	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	29028369	2017	Pubchem_assay
PRRID_2540	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Increased gene expression and secretion of proinflammatory cytokines (IL-Ôòæ) and chemokines (IL-ÔôÄ),Activate macrophages and produce inflammatory responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Human embryonic kidney 293 (HERK 293 ) cells	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	29028369	2017	Pubchem_assay
PRRID_2541	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	innate immunity elicitor	rPtCTL-2	C type Lectin (CTL/CLR)	Portunus trituberculatus	NA	Carbohydrate recognition Domain	NA	NA	NA	recognize nonself invaders and also work as an opsonin to eliminate invaders	PAMPs binding assay	28916358	2017	NA
PRRID_2541	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	innate immunity elicitor	rPtCTL-2	C type Lectin (CTL/CLR)	Portunus trituberculatus	NA	Carbohydrate recognition Domain	NA	NA	NA	recognize nonself invaders and also work as an opsonin to eliminate invaders	PAMPs binding assay	28916358	2017	NA
PRRID_2542	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	innate immunity elicitor	CgLRRIG-1	Pattern recognition receptor (PRR)	oyster Crassostrea gigas	Muscle, gill, hepatopancreas, mantle, gonad and hemocytes with the highest expression level in hepatopancreas.	Leucine-rich repeat (LRR) domain and immunoglobulin (Ig) domain	NA	NA	NA	immune effectors or pro-inflammatory factors as well as PRRs in oyster.	PAMPs binding assay	28889011	2017	NA
PRRID_2542	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	innate immunity elicitor	CgLRRIG-1	Pattern recognition receptor (PRR)	oyster Crassostrea gigas	Muscle, gill, hepatopancreas, mantle, gonad and hemocytes with the highest expression level in hepatopancreas.	Leucine-rich repeat (LRR) domain and immunoglobulin (Ig) domain	NA	NA	NA	immune effectors or pro-inflammatory factors as well as PRRs in oyster.	PAMPs binding assay	28889011	2017	NA
PRRID_2543	Peptidoglycan (PGN) Click for more detail	P. gulae (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Causes inflammation and activation of NOD2.	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice	HEK cells	NA	Q8K3Z0.fasta	Q8K3Z0	1020	activate NF-Œ∫B.	NA	28630066	2017	Pubchem_assay
PRRID_2543	Peptidoglycan (PGN) Click for more detail	P. gulae (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Causes inflammation and activation of NOD2.	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice	HEK cells	NA	Q8K3Z0.fasta	Q8K3Z0	1020	activate NF-Œ∫B.	NA	28630066	2017	Pubchem_assay
PRRID_2544	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Activation of CLRs.	rCaNTC	C type Lectin (CTL/CLR)	Carassius auratus	Liver	Carbohydrate recognition domain (CRD)	NA	NA	NA	pathogen recognition in Qihe 538 crucian carp	Microbial binding assay	28602683	2017	NA
PRRID_2544	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Activation of CLRs.	rCaNTC	C type Lectin (CTL/CLR)	Carassius auratus	Liver	Carbohydrate recognition domain (CRD)	NA	NA	NA	pathogen recognition in Qihe 538 crucian carp	Microbial binding assay	28602683	2017	NA
PRRID_2545	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Immunostimulant	BjLRP	Low density lipoprotein receptor-related protein (LRP)	B. japonicum	gill, muscle, notochord and testis	LY-EGF-CRD- EGF-CRD	NA	NA	NA	phagocytosis of apoptotic cells	qRT-PCR	28400271	2017	NA
PRRID_2545	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Immunostimulant	BjLRP	Low density lipoprotein receptor-related protein (LRP)	B. japonicum	gill, muscle, notochord and testis	LY-EGF-CRD- EGF-CRD	NA	NA	NA	phagocytosis of apoptotic cells	qRT-PCR	28400271	2017	NA
PRRID_2546	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	rCgPGRPS4	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	28042081	2017	NA
PRRID_2546	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	rCgPGRPS4	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	28042081	2017	NA
PRRID_2549	Peptidoglycan (PGN) Click for more detail	Gram-negative and Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	rCgLRRIG- 1	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	28889011	2017	NA
PRRID_2549	Peptidoglycan (PGN) Click for more detail	Gram-negative and Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	rCgLRRIG- 1	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	28889011	2017	NA
PRRID_2705	Peptidoglycan (PGN) Click for more detail	gram-negative bacteria, fungi	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	rSgSABL-1	Lectins	NA	NA	NA	NA	NA	NA	induces pro-inflammatory cytokine response	NA	29146448	2018	NA
PRRID_2705	Peptidoglycan (PGN) Click for more detail	gram-negative bacteria, fungi	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	rSgSABL-1	Lectins	NA	NA	NA	NA	NA	NA	induces pro-inflammatory cytokine response	NA	29146448	2018	NA
PRRID_2730	Peptidoglycan (PGN) Click for more detail	Gram-negative bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	rSgSABL-2	Lectins	NA	NA	NA	NA	NA	NA	induces pro-inflammatory cytokine response	NA	29146448	2018	NA
PRRID_2730	Peptidoglycan (PGN) Click for more detail	Gram-negative bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	rSgSABL-2	Lectins	NA	NA	NA	NA	NA	NA	induces pro-inflammatory cytokine response	NA	29146448	2018	NA
PRRID_2732	Pseudomonas aeruginosa Click for more detail	Gram negative Bacteria (Bacteria)	NA	NA	Peptidoglycan	Natural	NA	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	cytoplasm	CARD	Q9Y239.fasta	Q9Y239	953	via outer membrane vesicles (OMVs)	NA	29353310	2018	Pubchem_assay
PRRID_2732	Pseudomonas aeruginosa Click for more detail	Gram negative Bacteria (Bacteria)	NA	NA	Peptidoglycan	Natural	NA	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	cytoplasm	CARD	Q9Y239.fasta	Q9Y239	953	via outer membrane vesicles (OMVs)	NA	29353310	2018	Pubchem_assay

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