Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_1416 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Flagellin and LPS stimulate the production of CXCL1 and CXCL2 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | murine bladder epithelial cells and renal tubule cells | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA, adhesion and invasion assay | 24779433 | 2014 | Pubchem_assay |
| PRRID_1416 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Flagellin and LPS stimulate the production of CXCL1 and CXCL2 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | murine bladder epithelial cells and renal tubule cells | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA, adhesion and invasion assay | 24779433 | 2014 | Pubchem_assay |
| PRRID_1417 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Flagellin and LPS stimulate the production of CXCL1 and CXCL2 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | murine bladder epithelial cells and renal tubule cells | cell surface | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA, adhesion and invasion assay | 24779433 | 2014 | Pubchem_assay |
| PRRID_1417 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Flagellin and LPS stimulate the production of CXCL1 and CXCL2 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | murine bladder epithelial cells and renal tubule cells | cell surface | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA, adhesion and invasion assay | 24779433 | 2014 | Pubchem_assay |
| PRRID_1418 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Flagellin and LPS stimulate the production of CXCL1 and CXCL2 | Toll-like receptor 10 (TLR10) | Toll-like receptor (TLR) | Mice | expressed as a pseudo-gene | Cell Compartment/Intracellular (Endosome) | Q6R5P0.fasta | Q6R5P0 | 926 | TLR11 plays a fundamental role in both the innate and adaptive immune responses, through the activation of Tumor necrosis factor-alpha,the Interleukin 12 (IL-12) response and Interferon-gamma (IFN-gamma) secretion. | ELISA, adhesion and invasion assay | 24779433 | 2014 | Pubchem_assay |
| PRRID_1418 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Flagellin and LPS stimulate the production of CXCL1 and CXCL2 | Toll-like receptor 10 (TLR10) | Toll-like receptor (TLR) | Mice | expressed as a pseudo-gene | Cell Compartment/Intracellular (Endosome) | Q6R5P0.fasta | Q6R5P0 | 926 | TLR11 plays a fundamental role in both the innate and adaptive immune responses, through the activation of Tumor necrosis factor-alpha,the Interleukin 12 (IL-12) response and Interferon-gamma (IFN-gamma) secretion. | ELISA, adhesion and invasion assay | 24779433 | 2014 | Pubchem_assay |
| PRRID_1419 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | gingival epithelial cells | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | produce pro-inflammatory cytokines such as IL-8 | ELISA | 24773607 | 2014 | Pubchem_assay |
| PRRID_1419 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | gingival epithelial cells | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | produce pro-inflammatory cytokines such as IL-8 | ELISA | 24773607 | 2014 | Pubchem_assay |
| PRRID_1420 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | gingival epithelial cells | cell surface | O00206.fasta | O00206 | 839 | produce pro-inflammatory cytokines such as IL-8 | ELISA | 24773607 | 2014 | Pubchem_assay |
| PRRID_1420 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | gingival epithelial cells | cell surface | O00206.fasta | O00206 | 839 | produce pro-inflammatory cytokines such as IL-8 | ELISA | 24773607 | 2014 | Pubchem_assay |
| PRRID_1421 | Lipopolysaccharide (LPS) Click for more detail | E. coli O26:B6(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Macrophages | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 24771854 | 2014 | Pubchem_assay |
| PRRID_1421 | Lipopolysaccharide (LPS) Click for more detail | E. coli O26:B6(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Macrophages | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 24771854 | 2014 | Pubchem_assay |
| PRRID_1422 | Lipopolysaccharide (LPS) Click for more detail | E. coli O26:B6(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macrophages | cell surface | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 24771854 | 2014 | Pubchem_assay |
| PRRID_1422 | Lipopolysaccharide (LPS) Click for more detail | E. coli O26:B6(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macrophages | cell surface | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 24771854 | 2014 | Pubchem_assay |
| PRRID_1423 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | it plays a dominant role in the induction of sepsis and hence is referred to as endotoxin | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages | MyD88, TIRAP, TRIF and TRAM are the best characterized TIR domain-containing proteins that serve as adaptors in TLR signaling. | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 24766885 | 2014 | Pubchem_assay |
| PRRID_1423 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | it plays a dominant role in the induction of sepsis and hence is referred to as endotoxin | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages | MyD88, TIRAP, TRIF and TRAM are the best characterized TIR domain-containing proteins that serve as adaptors in TLR signaling. | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 24766885 | 2014 | Pubchem_assay |
| PRRID_1424 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | it plays a dominant role in the induction of sepsis and hence is referred to as endotoxin | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | monocyte/macrophages | MyD88, TIRAP, TRIF and TRAM are the best characterized TIR domain-containing proteins that serve as adaptors in TLR signaling. | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 24766885 | 2014 | Pubchem_assay |
| PRRID_1424 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | it plays a dominant role in the induction of sepsis and hence is referred to as endotoxin | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | monocyte/macrophages | MyD88, TIRAP, TRIF and TRAM are the best characterized TIR domain-containing proteins that serve as adaptors in TLR signaling. | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 24766885 | 2014 | Pubchem_assay |
| PRRID_1425 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Macrophages | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | whole blood assay (WBA), ELISA | 24766820 | 2014 | Pubchem_assay |
| PRRID_1425 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Macrophages | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | whole blood assay (WBA), ELISA | 24766820 | 2014 | Pubchem_assay |
| PRRID_1426 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macrophages | cell surface | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | whole blood assay (WBA), ELISA | 24766820 | 2014 | Pubchem_assay |
| PRRID_1426 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macrophages | cell surface | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | whole blood assay (WBA), ELISA | 24766820 | 2014 | Pubchem_assay |
| PRRID_1427 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | T cell differentiation assay | 24760154 | 2014 | Pubchem_assay |
| PRRID_1427 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | T cell differentiation assay | 24760154 | 2014 | Pubchem_assay |
| PRRID_1428 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | monocyte/macrophages | cell surface | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | T cell differentiation assay | 24760154 | 2014 | Pubchem_assay |
| PRRID_1428 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | monocyte/macrophages | cell surface | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | T cell differentiation assay | 24760154 | 2014 | Pubchem_assay |
| PRRID_1429 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1429 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1430 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1430 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1431 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | European and African Children | MyD88, TRIF | MyD88, TRIF | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | ELISA | 24743542 | 2014 | Pubchem_assay |
| PRRID_1431 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | European and African Children | MyD88, TRIF | MyD88, TRIF | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | ELISA | 24743542 | 2014 | Pubchem_assay |
| PRRID_1432 | Lipopolysaccharide (LPS) Click for more detail | E. coli K12(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induced significant up-regulation of IL-1b and IL-8 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | NA | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | Real-time PCR | 24736205 | 2014 | Pubchem_assay |
| PRRID_1432 | Lipopolysaccharide (LPS) Click for more detail | E. coli K12(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induced significant up-regulation of IL-1b and IL-8 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | NA | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | Real-time PCR | 24736205 | 2014 | Pubchem_assay |
| PRRID_1433 | Lipopolysaccharide (LPS) Click for more detail | Escherichia coli O26:B6 strain (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | promote lupus progression | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | C57BL/6 inbred mice | Splenocytes | extracellular domain (ECD) | Q9QUK6.fasta | Q9QUK6 | 835 | surface-expressed TLR4 is crucial to promote the lupus progression | ELISA | 24719374 | 2014 | Pubchem_assay |
| PRRID_1433 | Lipopolysaccharide (LPS) Click for more detail | Escherichia coli O26:B6 strain (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | promote lupus progression | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | C57BL/6 inbred mice | Splenocytes | extracellular domain (ECD) | Q9QUK6.fasta | Q9QUK6 | 835 | surface-expressed TLR4 is crucial to promote the lupus progression | ELISA | 24719374 | 2014 | Pubchem_assay |
| PRRID_1434 | Lipopolysaccharide (LPS) Click for more detail | cell wall of Gram-positive bacteria(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | functions as an antagonist of peroxisome proliferator-activated receptor alpha (PPARα), a nuclear transcription factor | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Lewis rats | monocytes/macrophages, and nonprofessional immune cells, such as epithelial cells | Toll/IL-1R (TIR) domain-containing adaptor molecule MyD88 (myeloid differentiation factor 88)-dependent pathway | NA | NA | NA | TLR4 plays a pivotal role in host defense, and inappropriate TLR4 activation can result in the acceleration of inflammatory and autoimmune diseases. | western blotting | 24717912 | 2014 | NA |
| PRRID_1434 | Lipopolysaccharide (LPS) Click for more detail | cell wall of Gram-positive bacteria(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | functions as an antagonist of peroxisome proliferator-activated receptor alpha (PPARα), a nuclear transcription factor | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Lewis rats | monocytes/macrophages, and nonprofessional immune cells, such as epithelial cells | Toll/IL-1R (TIR) domain-containing adaptor molecule MyD88 (myeloid differentiation factor 88)-dependent pathway | NA | NA | NA | TLR4 plays a pivotal role in host defense, and inappropriate TLR4 activation can result in the acceleration of inflammatory and autoimmune diseases. | western blotting | 24717912 | 2014 | NA |
| PRRID_1435 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Soluble CD14 (sCD14) | Pattern recognition receptor (PRR) | Mice | in bodily fluids such as tears (0.5 | TIRAP-MyD88 dependent pathway and the TRAM-TRIF dependent pathway | NA | NA | NA | signal an immune response through Toll- like receptor 4 (TLR4) | NA | 24703105 | 2014 | NA |
| PRRID_1435 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Soluble CD14 (sCD14) | Pattern recognition receptor (PRR) | Mice | in bodily fluids such as tears (0.5 | TIRAP-MyD88 dependent pathway and the TRAM-TRIF dependent pathway | NA | NA | NA | signal an immune response through Toll- like receptor 4 (TLR4) | NA | 24703105 | 2014 | NA |
| PRRID_1464 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative and Gram-positive bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | rAi- FREP-2 | Pattern recognition receptor (PRR) | NA | NA | NA | NA | NA | NA | NA | NA | 24680667 | 2014 | NA |
| PRRID_1464 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative and Gram-positive bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | rAi- FREP-2 | Pattern recognition receptor (PRR) | NA | NA | NA | NA | NA | NA | NA | NA | 24680667 | 2014 | NA |
| PRRID_1467 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | ERGIC-53 | Pattern recognition receptor (PRR) | NA | NA | NA | NA | NA | NA | NA | NA | 24796868 | 2014 | NA |
| PRRID_1467 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | ERGIC-53 | Pattern recognition receptor (PRR) | NA | NA | NA | NA | NA | NA | NA | NA | 24796868 | 2014 | NA |
| PRRID_1471 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | VIP36 | Pattern recognition receptor (PRR) | NA | NA | NA | NA | NA | NA | NA | NA | 24796868 | 2014 | NA |
| PRRID_1471 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | VIP36 | Pattern recognition receptor (PRR) | NA | NA | NA | NA | NA | NA | NA | NA | 24796868 | 2014 | NA |
| PRRID_1698 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | Brain angiogenesis inhibitor 1 (BAI1)*, adhesion G-protein coupled receptor 1 | Scavenger receptor (SR) | NA | NA | NA | NA | NA | NA | ELMO–Dock180–Rac1 module | NA | 26683144 | 2015 | NA |
| PRRID_1698 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | Brain angiogenesis inhibitor 1 (BAI1)*, adhesion G-protein coupled receptor 1 | Scavenger receptor (SR) | NA | NA | NA | NA | NA | NA | ELMO–Dock180–Rac1 module | NA | 26683144 | 2015 | NA |
| PRRID_1699 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | LvLGBP | Pattern recognition receptor (PRR) | Litopenaeus vannamei | Hemocytes | NA | NA | NA | NA | cause degranulation, and activate the proPO system that subsequently leads to an increase in PO activity, indicating the activation of innate immunity. | ELISA | 26522339 | 2015 | NA |
| PRRID_1699 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | LvLGBP | Pattern recognition receptor (PRR) | Litopenaeus vannamei | Hemocytes | NA | NA | NA | NA | cause degranulation, and activate the proPO system that subsequently leads to an increase in PO activity, indicating the activation of innate immunity. | ELISA | 26522339 | 2015 | NA |
| PRRID_1764 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | CfLRRop-3 | Leucine rich repeats (LRR) | NA | NA | NA | NA | NA | NA | NA | NA | 26826425 | 2016 | NA |
| PRRID_1764 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | CfLRRop-3 | Leucine rich repeats (LRR) | NA | NA | NA | NA | NA | NA | NA | NA | 26826425 | 2016 | NA |
| PRRID_1765 | Lipopolysaccharide (LPS) Click for more detail | Gram negative bacteria, Gram-positive bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | DjCTL | C type Lectin (CTL/CLR) | Dugesia japonica | pharyngeal and epidermis | domain of CLECT | A0A1L2DBR5.fasta | A0A1L2DBR5 | 107 | foreign invaders and phagocytize or encapsulate the aggregates of killed bacteria which have been digested in intestinal cavity. | Microbial binding assay | 27565408 | 2016 | Pubchem_assay |
| PRRID_1765 | Lipopolysaccharide (LPS) Click for more detail | Gram negative bacteria, Gram-positive bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | DjCTL | C type Lectin (CTL/CLR) | Dugesia japonica | pharyngeal and epidermis | domain of CLECT | A0A1L2DBR5.fasta | A0A1L2DBR5 | 107 | foreign invaders and phagocytize or encapsulate the aggregates of killed bacteria which have been digested in intestinal cavity. | Microbial binding assay | 27565408 | 2016 | Pubchem_assay |
| PRRID_1766 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | Lipopolysaccharide and b-1, 3-glucan binding protein (LGBP) | Pattern recognition receptor (PRR) | Fenneropenaeus merguiensis | Hepatopancreas | NA | NA | NA | NA | Activate NF-KB, synergistic effect with other TLRs to defense the pathogenic bacteria | ELISA | 27431930 | 2016 | NA |
| PRRID_1766 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | Lipopolysaccharide and b-1, 3-glucan binding protein (LGBP) | Pattern recognition receptor (PRR) | Fenneropenaeus merguiensis | Hepatopancreas | NA | NA | NA | NA | Activate NF-KB, synergistic effect with other TLRs to defense the pathogenic bacteria | ELISA | 27431930 | 2016 | NA |
| PRRID_1767 | Lipopolysaccharide (LPS) Click for more detail | A.hydrophilla(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Cause bacterial infection, immunostimulant | PcFBN1 | FREP | Procambarus clarkii | hepatopancreas and hemocyte | FBG domain in C-terminal and a putative signal peptide of 19 amino acids in N-terminal. | NA | NA | NA | trigger complement system via the lectin-dependent pathway. | Ligand binding assay | 27417229 | 2016 | NA |
| PRRID_1767 | Lipopolysaccharide (LPS) Click for more detail | A.hydrophilla(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Cause bacterial infection, immunostimulant | PcFBN1 | FREP | Procambarus clarkii | hepatopancreas and hemocyte | FBG domain in C-terminal and a putative signal peptide of 19 amino acids in N-terminal. | NA | NA | NA | trigger complement system via the lectin-dependent pathway. | Ligand binding assay | 27417229 | 2016 | NA |
| PRRID_1768 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | CnToll-like receptor 1 (TLR-1) | Toll-like receptor (TLR) | Chlamys nobilis | mantle, he- mocytes, gill, kidney, gonad, hepatopancreas | five leucine-rich repeats (LRR), two LRR-C-terminal (LRRCT) motifs and a LRR-N-terminal (LRRNT) motif in the extracellular domain, a transmembrane domain and a Toll/Interleukin-1 Receptor (TIR) of 138 | NA | NA | NA | binds to microbes and act as PRR. | qRT-PCR | 27403592 | 2016 | NA |
| PRRID_1768 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | CnToll-like receptor 1 (TLR-1) | Toll-like receptor (TLR) | Chlamys nobilis | mantle, he- mocytes, gill, kidney, gonad, hepatopancreas | five leucine-rich repeats (LRR), two LRR-C-terminal (LRRCT) motifs and a LRR-N-terminal (LRRNT) motif in the extracellular domain, a transmembrane domain and a Toll/Interleukin-1 Receptor (TIR) of 138 | NA | NA | NA | binds to microbes and act as PRR. | qRT-PCR | 27403592 | 2016 | NA |
| PRRID_1769 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | rZRANB2 | Pattern recognition receptor (PRR) | NA | NA | NA | NA | NA | NA | NA | NA | 26740623 | 2016 | NA |
| PRRID_1769 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | rZRANB2 | Pattern recognition receptor (PRR) | NA | NA | NA | NA | NA | NA | NA | NA | 26740623 | 2016 | NA |
| PRRID_1770 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | C1q | Pattern recognition receptor (PRR) | NA | NA | NA | NA | NA | NA | NA | NA | 26002640 | 2016 | NA |
| PRRID_1770 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | C1q | Pattern recognition receptor (PRR) | NA | NA | NA | NA | NA | NA | NA | NA | 26002640 | 2016 | NA |
| PRRID_1771 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | CgC1qDC-1 | Pattern recognition receptor (PRR) | NA | NA | NA | NA | NA | NA | NA | NA | 26002640 | 2016 | NA |
| PRRID_1771 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | CgC1qDC-1 | Pattern recognition receptor (PRR) | NA | NA | NA | NA | NA | NA | NA | NA | 26002640 | 2016 | NA |
| PRRID_1772 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | CD300b-Toll like receptor4 (TLR4) complex | Pattern recognition receptor (PRR) | Human | NA | NA | NA | NA | NA | led to the recruitment and activation of spleen tyrosine kinase (Syk) and phosphatidylinositol-4,5-bisphos- phate 3-kinase (PI3K). | NA | 27261276 | 2016 | NA |
| PRRID_1772 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | CD300b-Toll like receptor4 (TLR4) complex | Pattern recognition receptor (PRR) | Human | NA | NA | NA | NA | NA | led to the recruitment and activation of spleen tyrosine kinase (Syk) and phosphatidylinositol-4,5-bisphos- phate 3-kinase (PI3K). | NA | 27261276 | 2016 | NA |
| PRRID_1773 | Lipopolysaccharide (LPS) Click for more detail | Laryngo- tracheitis virus (virus) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Birds | NA | NA | NA | NA | NA | TLR (LPS)-mediated, NO-dependent antiviral response in avian macrophage cell line | NA | 27233799 | 2016 | NA |
| PRRID_1773 | Lipopolysaccharide (LPS) Click for more detail | Laryngo- tracheitis virus (virus) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Birds | NA | NA | NA | NA | NA | TLR (LPS)-mediated, NO-dependent antiviral response in avian macrophage cell line | NA | 27233799 | 2016 | NA |
| PRRID_1774 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | EcToll-like receptor (TLR1b) | Toll-like receptor (TLR) | Zebrafish | spleen and head kidney | leucine-rich repeat (LRR) domains (including an LRR-NT (except for EcTLR1b), several LRR motifs and an LRR-CT), a trans-membrane region and a Toll/interleukin-1 receptor (TIR) domain. | NA | NA | NA | Activate NF-Kb | NA | 27037219 | 2016 | NA |
| PRRID_1774 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | EcToll-like receptor (TLR1b) | Toll-like receptor (TLR) | Zebrafish | spleen and head kidney | leucine-rich repeat (LRR) domains (including an LRR-NT (except for EcTLR1b), several LRR motifs and an LRR-CT), a trans-membrane region and a Toll/interleukin-1 receptor (TIR) domain. | NA | NA | NA | Activate NF-Kb | NA | 27037219 | 2016 | NA |
| PRRID_1775 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | CgSiglec-1 | Pattern recognition receptor (PRR) | Crassostrea gigas | NA | CRD or C1q domain | NA | NA | NA | act as a bridge molecule between invader recognition and signal transduction cascade, and modulate the immune response by inhibiting various important pro- cesses of immunity in oyster. | NA | 27032602 | 2016 | NA |
| PRRID_1775 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | CgSiglec-1 | Pattern recognition receptor (PRR) | Crassostrea gigas | NA | CRD or C1q domain | NA | NA | NA | act as a bridge molecule between invader recognition and signal transduction cascade, and modulate the immune response by inhibiting various important pro- cesses of immunity in oyster. | NA | 27032602 | 2016 | NA |
| PRRID_1776 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | OfGal-1 | galectin-1 | Oplegnathus fasciatus | gills, head kidney, and liver. | NA | NA | NA | NA | OfGal-1 can recognize a wide range of microbes and is a vital pattern recognition receptor in the innate immune system of rock bream. | NA | 26792759 | 2016 | NA |
| PRRID_1776 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | OfGal-1 | galectin-1 | Oplegnathus fasciatus | gills, head kidney, and liver. | NA | NA | NA | NA | OfGal-1 can recognize a wide range of microbes and is a vital pattern recognition receptor in the innate immune system of rock bream. | NA | 26792759 | 2016 | NA |
| PRRID_1777 | Lipopolysaccharide (LPS) Click for more detail | Pseudomonas aeruginosa (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | Induces TNF-alpha and IL-6 | NA | 26775799 | 2016 | NA |
| PRRID_1777 | Lipopolysaccharide (LPS) Click for more detail | Pseudomonas aeruginosa (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | Induces TNF-alpha and IL-6 | NA | 26775799 | 2016 | NA |
| PRRID_1778 | Lipopolysaccharide (LPS) Click for more detail | Pseudomonas aeruginosa (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | Induces TNF-alpha and IL-6 | NA | 26775799 | 2016 | NA |
| PRRID_1778 | Lipopolysaccharide (LPS) Click for more detail | Pseudomonas aeruginosa (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | Induces TNF-alpha and IL-6 | NA | 26775799 | 2016 | NA |
| PRRID_1779 | Lipopolysaccharide (LPS) Click for more detail | Escherichia coli strain 0111:B4 (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It enhances microbe agglutination and haemocytes encapsulation. | Galectin | Pattern recognition receptor (PRR) | Eriocheir sinensis | Hepatopancreas | CRD | NA | NA | NA | It provies immune defense against invading microbes. | ELISA | 27095174 | 2016 | NA |
| PRRID_1779 | Lipopolysaccharide (LPS) Click for more detail | Escherichia coli strain 0111:B4 (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It enhances microbe agglutination and haemocytes encapsulation. | Galectin | Pattern recognition receptor (PRR) | Eriocheir sinensis | Hepatopancreas | CRD | NA | NA | NA | It provies immune defense against invading microbes. | ELISA | 27095174 | 2016 | NA |
| PRRID_1783 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria Escherichia coli, Vibrio anguillarum | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Bacterial infection and immunostimulant | CgPGRPS2 | Peptidoglycan Recognition Receptor (PGRPs) | Crassostrea gigas | Cytoplasm | one typical PGRP/amidase domain | NA | NA | NA | Activate NF-kB | PAMPs binding assay | 28042081 | 2016 | NA |
| PRRID_1783 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria Escherichia coli, Vibrio anguillarum | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Bacterial infection and immunostimulant | CgPGRPS2 | Peptidoglycan Recognition Receptor (PGRPs) | Crassostrea gigas | Cytoplasm | one typical PGRP/amidase domain | NA | NA | NA | Activate NF-kB | PAMPs binding assay | 28042081 | 2016 | NA |
| PRRID_1786 | Lipopolysaccharide (LPS) Click for more detail | Gram positive bacteria, Staphylococcus aureus and fungi Yarrowia lipolytica (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Bacterial infection and immunostimulant | CgPGRPS2 | Peptidoglycan Recognition Receptor (PGRPs) | Crassostrea gigas | Cytoplasm | one typical PGRP/amidase domain | NA | NA | NA | Activate NF-kB | PAMPs binding assay | 28042081 | 2016 | NA |
| PRRID_1786 | Lipopolysaccharide (LPS) Click for more detail | Gram positive bacteria, Staphylococcus aureus and fungi Yarrowia lipolytica (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Bacterial infection and immunostimulant | CgPGRPS2 | Peptidoglycan Recognition Receptor (PGRPs) | Crassostrea gigas | Cytoplasm | one typical PGRP/amidase domain | NA | NA | NA | Activate NF-kB | PAMPs binding assay | 28042081 | 2016 | NA |
| PRRID_1789 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | MnCTLDcp2 | C type Lectin (CTL/CLR) | NA | NA | NA | NA | NA | NA | NA | NA | 26208755 | 2016 | NA |
| PRRID_1789 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | MnCTLDcp2 | C type Lectin (CTL/CLR) | NA | NA | NA | NA | NA | NA | NA | NA | 26208755 | 2016 | NA |
| PRRID_1793 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | MnCTLDcp3 | C type Lectin (CTL/CLR) | NA | NA | NA | NA | NA | NA | NA | NA | 26208755 | 2016 | NA |
| PRRID_1793 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | MnCTLDcp3 | C type Lectin (CTL/CLR) | NA | NA | NA | NA | NA | NA | NA | NA | 26208755 | 2016 | NA |
| PRRID_2081 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | rPtCTL-2 | C type Lectin (CTL/CLR) | NA | NA | NA | NA | NA | NA | NA | NA | 28916358 | 2017 | NA |
| PRRID_2081 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | rPtCTL-2 | C type Lectin (CTL/CLR) | NA | NA | NA | NA | NA | NA | NA | NA | 28916358 | 2017 | NA |
| PRRID_2213 | intracellular bacterial lipopolysaccharides (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | NA | Nucleotide-binding oligomerization domain 1 | Q9Y239.fasta | Q9Y239 | 953 | NA | NA | 29066255 | 2017 | Pubchem_assay |
| PRRID_2213 | intracellular bacterial lipopolysaccharides (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | NA | Nucleotide-binding oligomerization domain 1 | Q9Y239.fasta | Q9Y239 | 953 | NA | NA | 29066255 | 2017 | Pubchem_assay |
| PRRID_2214 | intracellular bacterial lipopolysaccharides (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Human | NA | Nucleotide-binding oligomerization domain 2, | Q9HC29.fasta | Q9HC29 | 1040 | NA | NA | 29066255 | 2017 | Pubchem_assay |
| PRRID_2214 | intracellular bacterial lipopolysaccharides (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Human | NA | Nucleotide-binding oligomerization domain 2, | Q9HC29.fasta | Q9HC29 | 1040 | NA | NA | 29066255 | 2017 | Pubchem_assay |
| PRRID_2229 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | human myeloid cells | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | NA | flow cytometry and immunofluorescence microsco- py | 29330675 | 2017 | Pubchem_assay |
| PRRID_2229 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | human myeloid cells | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | NA | flow cytometry and immunofluorescence microsco- py | 29330675 | 2017 | Pubchem_assay |
| PRRID_2230 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Rabbit | uterine luminal and glandular epithelium | Leucine-rich Repeat (LRR) Domain | A0ELV4.fasta | A0ELV4 | 905 | NA | IHC analy- sis | 29330675 | 2017 | Pubchem_assay |
| PRRID_2230 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Rabbit | uterine luminal and glandular epithelium | Leucine-rich Repeat (LRR) Domain | A0ELV4.fasta | A0ELV4 | 905 | NA | IHC analy- sis | 29330675 | 2017 | Pubchem_assay |