Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_2432NA

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gram positive bacteria, fungiNANANANaturalNArFc-hslPattern recognition receptor (PRR)F. chinensisNANANANANANANA290551892017NA
PRRID_2432NA

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gram positive bacteria, fungiNANANANaturalNArFc-hslPattern recognition receptor (PRR)F. chinensisNANANANANANANA290551892017NA
PRRID_2433NA

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gram positive bacteria, fungiNANANANaturalNAmature Fc-hslPattern recognition receptor (PRR)F. chinensisNANANANANANANA290551892017NA
PRRID_2433NA

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gram positive bacteria, fungiNANANANaturalNAmature Fc-hslPattern recognition receptor (PRR)F. chinensisNANANANANANANA290551892017NA
PRRID_2453NA

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Plasmodium berghei (fungi)NANANANANANucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)MiceMacrophagesnucleotide-binding oligomerization domainQ8BHB0.fastaQ8BHB0953Induction of IL-1b, KC, IFNgNA288235102017Pubchem_assay
PRRID_2453NA

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Plasmodium berghei (fungi)NANANANANANucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)MiceMacrophagesnucleotide-binding oligomerization domainQ8BHB0.fastaQ8BHB0953Induction of IL-1b, KC, IFNgNA288235102017Pubchem_assay
PRRID_2467NA

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F. solani (fungi)NANAPattern-associated molecular patterns (PAMPs)Naturalupregulate AMPs hBD2 and LL37 at the mRNA and protein level via a TLR2- and Dectin-1– mediated mechanism.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHuman corneal epithelial cells (HCECs)Leucine-rich Repeat (LRR) DomainO60603.fastaO60603784decreased AMP mRNA upregulationRT-PCR, antifungal assay284600482017Pubchem_assay
PRRID_2467NA

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F. solani (fungi)NANAPattern-associated molecular patterns (PAMPs)Naturalupregulate AMPs hBD2 and LL37 at the mRNA and protein level via a TLR2- and Dectin-1– mediated mechanism.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHuman corneal epithelial cells (HCECs)Leucine-rich Repeat (LRR) DomainO60603.fastaO60603784decreased AMP mRNA upregulationRT-PCR, antifungal assay284600482017Pubchem_assay
PRRID_2468NA

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F. solani (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalUpregulate AMPs hBD2 and LL37 at the mRNA and protein level via a TLR2- and Dectin-1– mediated mechanism.Dectin-1C type Lectin (CTL/CLR)HumanHuman corneal epithelial cells (HCECs)NAQ9BXN2.fastaQ9BXN2247decreased AMP mRNA upregulationRT-PCR, antifungal assay284600482017Pubchem_assay
PRRID_2468NA

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F. solani (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalUpregulate AMPs hBD2 and LL37 at the mRNA and protein level via a TLR2- and Dectin-1– mediated mechanism.Dectin-1C type Lectin (CTL/CLR)HumanHuman corneal epithelial cells (HCECs)NAQ9BXN2.fastaQ9BXN2247decreased AMP mRNA upregulationRT-PCR, antifungal assay284600482017Pubchem_assay
PRRID_2474NA

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Blastomyces dermatitidis(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRMiceNANAQ9Z2H6.fastaQ9Z2H6219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2474NA

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Blastomyces dermatitidis(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRMiceNANAQ9Z2H6.fastaQ9Z2H6219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2475NA

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Candida albicans(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRInfection modelNANANANANAControversial role in infection modelsNA281676512017NA
PRRID_2475NA

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Candida albicans(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRInfection modelNANANANANAControversial role in infection modelsNA281676512017NA
PRRID_2476NA

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Cryptococcus neoformans(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRInfection modelNACRAC motifNANANAProtective role in infection disease.NA281676512017NA
PRRID_2476NA

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Cryptococcus neoformans(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRInfection modelNACRAC motifNANANAProtective role in infection disease.NA281676512017NA
PRRID_2484NA

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Coccidioidis posadasii(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244protective role in infection modelNA281676512017Pubchem_assay
PRRID_2484NA

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Coccidioidis posadasii(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244protective role in infection modelNA281676512017Pubchem_assay
PRRID_2485NA

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Coccidioidis posadasii(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRHumanNANAQ9BXN2.fastaQ9BXN2247protective role in infection modelNA281676512017Pubchem_assay
PRRID_2485NA

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Coccidioidis posadasii(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRHumanNANAQ9BXN2.fastaQ9BXN2247protective role in infection modelNA281676512017Pubchem_assay
PRRID_2486NA

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Coccidioidis immitis(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2486NA

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Coccidioidis immitis(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2488NA

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M. audouinii (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2488NA

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M. audouinii (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2489NA

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Penicillium marneffei (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2489NA

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Penicillium marneffei (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2490NA

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Pneumocystis carnii (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2490NA

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Pneumocystis carnii (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2493NA

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Trichosporon asahii (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2493NA

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Trichosporon asahii (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2587RcCDI1

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Rhynchosporium commune (fungi)NANAPattern-associated molecular patterns (PAMPs)Naturalactivates cell death through a pathway that is distinct from that triggered by the oomycete PAMP INF1.NANAsolanaceousNANANANANANANA283869882017NA
PRRID_2587RcCDI1

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Rhynchosporium commune (fungi)NANAPattern-associated molecular patterns (PAMPs)Naturalactivates cell death through a pathway that is distinct from that triggered by the oomycete PAMP INF1.NANAsolanaceousNANANANANANANA283869882017NA
PRRID_2703Fungal chitin

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Candida albicans(fungi)NANANANaturalNACARD9NOD-like receptor (NLR)Humanmyeloid cells,Caspase Recruitment DomainQ9H257.fastaQ9H257536NAInvasive CNS candidiasis293077702018Pubchem_assay
PRRID_2703Fungal chitin

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Candida albicans(fungi)NANANANaturalNACARD9NOD-like receptor (NLR)Humanmyeloid cells,Caspase Recruitment DomainQ9H257.fastaQ9H257536NAInvasive CNS candidiasis293077702018Pubchem_assay
PRRID_2704Lipopolysaccharide (LPS)

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gram-negative bacteria, fungiCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNArSgSABL-1LectinsNANANANANANAinduces pro-inflammatory cytokine responseNA291464482018NA
PRRID_2704Lipopolysaccharide (LPS)

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gram-negative bacteria, fungiCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNArSgSABL-1LectinsNANANANANANAinduces pro-inflammatory cytokine responseNA291464482018NA
PRRID_2705Peptidoglycan (PGN)

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gram-negative bacteria, fungiCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalNArSgSABL-1LectinsNANANANANANAinduces pro-inflammatory cytokine responseNA291464482018NA
PRRID_2705Peptidoglycan (PGN)

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gram-negative bacteria, fungiCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalNArSgSABL-1LectinsNANANANANANAinduces pro-inflammatory cytokine responseNA291464482018NA
PRRID_2706β-glucan

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gram-negative bacteria, fungiC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalNArSgSABL-1LectinsNANANANANANAinduces pro-inflammatory cytokine responseNA291464482018NA
PRRID_2706β-glucan

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gram-negative bacteria, fungiC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalNArSgSABL-1LectinsNANANANANANAinduces pro-inflammatory cytokine responseNA291464482018NA