Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_1940b-1,3-glucans.

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAGlycoproteinNaturalNABmbGRP3Gastrin-releasing peptide receptor (GRP)Bombyx moriNANANANANANANA292294432017NA
PRRID_1940b-1,3-glucans.

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAGlycoproteinNaturalNABmbGRP3Gastrin-releasing peptide receptor (GRP)Bombyx moriNANANANANANANA292294432017NA
PRRID_1941b-1,3-glucans.

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAGlycoproteinNaturalNADmGNBP2Gram-negative Bacteria-binding Protein (GNBPs)Drosophila melanogastermembrane localisedNANANANANANA292294432017NA
PRRID_1941b-1,3-glucans.

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAGlycoproteinNaturalNADmGNBP2Gram-negative Bacteria-binding Protein (GNBPs)Drosophila melanogastermembrane localisedNANANANANANA292294432017NA
PRRID_1942b-1,3-glucans.

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAGlycoproteinNaturalNADmGNBP3Gram-negative Bacteria-binding Protein (GNBPs)Drosophila melanogastermembrane localisedβ-1,3-glucan binding domainNANANANANA292294432017NA
PRRID_1942b-1,3-glucans.

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAGlycoproteinNaturalNADmGNBP3Gram-negative Bacteria-binding Protein (GNBPs)Drosophila melanogastermembrane localisedβ-1,3-glucan binding domainNANANANANA292294432017NA
PRRID_1943b-1,3-glucans.

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONANANaturalNAMsbGRP1Gastrin-releasing peptide receptor (GRP)Manduca sextaNANANANANANANA292294432017NA
PRRID_1943b-1,3-glucans.

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONANANaturalNAMsbGRP1Gastrin-releasing peptide receptor (GRP)Manduca sextaNANANANANANANA292294432017NA
PRRID_1944b-1,3-glucans.

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Gram negative Bacteria (Bacteria)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONANANaturalNAMsMBPMannose binding protein (MBP)Manduca sextaNANANANANANANA279898372017NA
PRRID_1944b-1,3-glucans.

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Gram negative Bacteria (Bacteria)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONANANaturalNAMsMBPMannose binding protein (MBP)Manduca sextaNANANANANANANA279898372017NA
PRRID_1947b-Gentiobiosyl diaglycerides

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Mtb H37Ra (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_1947b-Gentiobiosyl diaglycerides

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Mtb H37Ra (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_1948b-Gentiobiosyl diaglycerides

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Mtb H37Ra (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_1948b-Gentiobiosyl diaglycerides

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Mtb H37Ra (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_1949Bacterial flagella

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495Fatty acid NaturalNAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA292639322017Pubchem_assay
PRRID_1949Bacterial flagella

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495Fatty acid NaturalNAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA292639322017Pubchem_assay
PRRID_1950Bacterial lipoprotein

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BacteriaNANANANaturalEnhance antigen uptake and simultaneously increases cytokine production ,IL- production, DC maturation, cell activation, induce NFκB activationToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA290283692017Pubchem_assay
PRRID_1950Bacterial lipoprotein

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BacteriaNANANANaturalEnhance antigen uptake and simultaneously increases cytokine production ,IL- production, DC maturation, cell activation, induce NFκB activationToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA290283692017Pubchem_assay
PRRID_1951Bacterial LPS

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BacteriaNANAGlycoproteinNaturalpathogenic infectionToll-like receptor 4 /MD2 (TLR4/MD2)Toll-like receptor (TLR)NAmembrane-associatedTIR domainsNANANANANA281150372017NA
PRRID_1951Bacterial LPS

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BacteriaNANAGlycoproteinNaturalpathogenic infectionToll-like receptor 4 /MD2 (TLR4/MD2)Toll-like receptor (TLR)NAmembrane-associatedTIR domainsNANANANANA281150372017NA
PRRID_1953Bacterial RNA

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BacteriaNANANANaturalNAToll-like receptor 13 (TLR13)Toll-like receptor (TLR)Epinephelus coioidesendoplasmic reticulum and early endosomeextracellular LRR region, a transmembrane domain and an intracellular TIR domainNANANANANA293053352017NA
PRRID_1953Bacterial RNA

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BacteriaNANANANaturalNAToll-like receptor 13 (TLR13)Toll-like receptor (TLR)Epinephelus coioidesendoplasmic reticulum and early endosomeextracellular LRR region, a transmembrane domain and an intracellular TIR domainNANANANANA293053352017NA
PRRID_1968CBLB502

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Salmonella flagellin (Bacteria)NANANANaturaldirect radioprotective effect in vitro via anti-apoptosis and promotes cell cycle recoveryToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanHEK293-N-T cellsLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NAReal-time PCR284070322017Pubchem_assay
PRRID_1968CBLB502

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Salmonella flagellin (Bacteria)NANANANaturaldirect radioprotective effect in vitro via anti-apoptosis and promotes cell cycle recoveryToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanHEK293-N-T cellsLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NAReal-time PCR284070322017Pubchem_assay
PRRID_1977Chlyamydia components

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Chlamydia(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulant and cause chlaymydia infections.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANAleucine-rich repeat (LRR), hydrophobic transmembrane and cytoplasmic Toll/interleukin-1 receptor (TIR) domainsNANANApromote transcription from pro-inflammatory cytokines including IL-1 and IL-12NA285040912017NA
PRRID_1977Chlyamydia components

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Chlamydia(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulant and cause chlaymydia infections.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANAleucine-rich repeat (LRR), hydrophobic transmembrane and cytoplasmic Toll/interleukin-1 receptor (TIR) domainsNANANApromote transcription from pro-inflammatory cytokines including IL-1 and IL-12NA285040912017NA
PRRID_1988CpG-ODN

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BacteriaNANANucleic AcidSyntheticOral carcinogenesisToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Humansquamous cell carcinomasLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032interferon-β production and activation of caspases 3 and 9NA289828472017Pubchem_assay
PRRID_1988CpG-ODN

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BacteriaNANANucleic AcidSyntheticOral carcinogenesisToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Humansquamous cell carcinomasLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032interferon-β production and activation of caspases 3 and 9NA289828472017Pubchem_assay
PRRID_1990Cyclopropane–fatty acid a-glucosyl diglyceride

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Lactobacillus plantarum (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_1990Cyclopropane–fatty acid a-glucosyl diglyceride

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Lactobacillus plantarum (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_1998Diacylated Lipopeptide

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BacteriaNANAFatty acid NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA292639322017Pubchem_assay
PRRID_1998Diacylated Lipopeptide

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BacteriaNANAFatty acid NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA292639322017Pubchem_assay
PRRID_1999Diacylated Lipopeptide

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BacteriaNANAFatty acid NaturalNAToll-like receptor 6 (TLR6)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainQ9Y2C9.fastaQ9Y2C9796NANA292639322017Pubchem_assay
PRRID_1999Diacylated Lipopeptide

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BacteriaNANAFatty acid NaturalNAToll-like receptor 6 (TLR6)Toll-like receptor (TLR)Humancell surfaceLeucine-rich Repeat (LRR) DomainQ9Y2C9.fastaQ9Y2C9796NANA292639322017Pubchem_assay
PRRID_2003DNA

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BacteriaNANANucleic AcidNaturalNAAIM2Pattern recognition receptor (PRR)NANANANANANANANA280630152017NA
PRRID_2003DNA

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BacteriaNANANucleic AcidNaturalNAAIM2Pattern recognition receptor (PRR)NANANANANANANANA280630152017NA
PRRID_2013dsRNA

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BacteriaNANANucleic AcidNaturalNAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2013dsRNA

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BacteriaNANANucleic AcidNaturalNAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2014dsRNA-polyinosinic- polycytidilic acid

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BacteriaNANANASyntheticOral carcinogenesisToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Humansquamous cell carcinomasLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904promote tumour growth through inflammation dependent mechanism in epithelial cells.NA289828472017Pubchem_assay
PRRID_2014dsRNA-polyinosinic- polycytidilic acid

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BacteriaNANANASyntheticOral carcinogenesisToll-like receptor 3 (TLR3)Toll-like receptor (TLR)Humansquamous cell carcinomasLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904promote tumour growth through inflammation dependent mechanism in epithelial cells.NA289828472017Pubchem_assay
PRRID_2015E. tarda

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Gram negative Bacteria (Bacteria)NANANANaturalinfectionAdPGRP-S1Peptidoglycan Recognition Receptor (PGRPs)Chinese giant salamander (Andrias davidianus)intestine and skinPGRP domainNANANANAAntibacterial activity assay292459042017NA
PRRID_2015E. tarda

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Gram negative Bacteria (Bacteria)NANANANaturalinfectionAdPGRP-S1Peptidoglycan Recognition Receptor (PGRPs)Chinese giant salamander (Andrias davidianus)intestine and skinPGRP domainNANANANAAntibacterial activity assay292459042017NA
PRRID_2033FLA-ST Flagellin

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Salmonella typhimurium(Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495NANaturalanti- inflammatory activityToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanU937 cellsLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA291137972017Pubchem_assay
PRRID_2033FLA-ST Flagellin

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Salmonella typhimurium(Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495NANaturalanti- inflammatory activityToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanU937 cellsLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA291137972017Pubchem_assay
PRRID_2035Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalNAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanNANAO60602.fastaO60602858NANA290662552017Pubchem_assay
PRRID_2035Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalNAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanNANAO60602.fastaO60602858NANA290662552017Pubchem_assay
PRRID_2037Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalInduce secretion of cytokines, chemokines and co-stimulatory molecules from T cellsToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA290283692017Pubchem_assay
PRRID_2037Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalInduce secretion of cytokines, chemokines and co-stimulatory molecules from T cellsToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA290283692017Pubchem_assay
PRRID_2038Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalBacterial infectionToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanoral squamous cell carcinomasLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA289828472017Pubchem_assay
PRRID_2038Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalBacterial infectionToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanoral squamous cell carcinomasLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NANA289828472017Pubchem_assay
PRRID_2039Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalInnate immunity elicitorToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanMembraneD0 domainO60602.fastaO60602858recognizes a conserved region within the D1 domain of flagellin, crucial for the interaction between subunits in the flagellum and for bacterial motility.Co-immunoprecipitataion Binding assay288278252017Pubchem_assay
PRRID_2039Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalInnate immunity elicitorToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanMembraneD0 domainO60602.fastaO60602858recognizes a conserved region within the D1 domain of flagellin, crucial for the interaction between subunits in the flagellum and for bacterial motility.Co-immunoprecipitataion Binding assay288278252017Pubchem_assay
PRRID_2040Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalInnate immunity elicitorNAIP5/NLRC4 inflammasome receptorNOD-like receptor (NLR)HumanintracellularNANANANARecognizes flagellin and bind it.Co-immunoprecipitataion Binding assay288278252017NA
PRRID_2040Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalInnate immunity elicitorNAIP5/NLRC4 inflammasome receptorNOD-like receptor (NLR)HumanintracellularNANANANARecognizes flagellin and bind it.Co-immunoprecipitataion Binding assay288278252017NA
PRRID_2041Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalNAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA288015212017NA
PRRID_2041Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalNAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA288015212017NA
PRRID_2042Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalNANod-like receptor C4 (NLRC4)NOD-like receptor (NLR)NANANANANANANANA288015212017NA
PRRID_2042Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalNANod-like receptor C4 (NLRC4)NOD-like receptor (NLR)NANANANANANANANA288015212017NA
PRRID_2043Flagellin

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Vibrio (Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalImmunostimulantLeulectinPattern recognition receptor (PRR)Marsupenaeus japonicusHemocytesLRRNANANAHemocytic PhagocytosisPull- down and far-Western assays282581972017NA
PRRID_2043Flagellin

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Vibrio (Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalImmunostimulantLeulectinPattern recognition receptor (PRR)Marsupenaeus japonicusHemocytesLRRNANANAHemocytic PhagocytosisPull- down and far-Western assays282581972017NA
PRRID_2044Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalImmunostimulantEcToll-like receptor 5M (TLR5M)Toll-like receptor (TLR)Epinephelus coioidesSpleenLRR domain, a transmembrane region and a TIR domainNANANArecognize flagellin and activate NF-κB,qRT-PCR281596962017NA
PRRID_2044Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalImmunostimulantEcToll-like receptor 5M (TLR5M)Toll-like receptor (TLR)Epinephelus coioidesSpleenLRR domain, a transmembrane region and a TIR domainNANANArecognize flagellin and activate NF-κB,qRT-PCR281596962017NA
PRRID_2045Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalImmunostimulantEcToll-like receptor 5s (TLR5s)Toll-like receptor (TLR)Epinephelus coioidesLiverLRR domainNANANArecognize flagellin and activate NF-κB,qRT-PCR281596962017NA
PRRID_2045Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalImmunostimulantEcToll-like receptor 5s (TLR5s)Toll-like receptor (TLR)Epinephelus coioidesLiverLRR domainNANANArecognize flagellin and activate NF-κB,qRT-PCR281596962017NA
PRRID_2046Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalImmunostimulantOfToll-like receptor 5 (TLR5)MToll-like receptor (TLR)Oplegnathus fasciatusLiverextracellular domain with 22 leucine rich repeats (LRR), a transmembrane domain and an 32 endodomain with TIR motif.NANANAresponds to flagellin challenge and activates NF-κBqRT-PCR281113582017NA
PRRID_2046Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalImmunostimulantOfToll-like receptor 5 (TLR5)MToll-like receptor (TLR)Oplegnathus fasciatusLiverextracellular domain with 22 leucine rich repeats (LRR), a transmembrane domain and an 32 endodomain with TIR motif.NANANAresponds to flagellin challenge and activates NF-κBqRT-PCR281113582017NA
PRRID_2047Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalNAIPAFNOD-like receptor (NLR)NANANANANANANANA280630152017NA
PRRID_2047Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalNAIPAFNOD-like receptor (NLR)NANANANANANANANA280630152017NA
PRRID_2048Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalNANAIPNOD-like receptor (NLR)NANANANANANANANA280630152017NA
PRRID_2048Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalNANAIPNOD-like receptor (NLR)NANANANANANANANA280630152017NA
PRRID_2049Flagellin (Legionella recognized)

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalNAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2049Flagellin (Legionella recognized)

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalNAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA280630152017NA
PRRID_2051flg22

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BacteriaQRLSTGSRINSAKDDAAGLQIA22PeptideNaturalIt bind to the FLS2 and incites the downstream cascade.Receptor Like Kinase (RLK)Pattern recognition receptor (PRR)NANALeucine-Rich-Repeat (LRR) ectodomain (LRR-RLK)NANANANANA290831162017NA
PRRID_2051flg22

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BacteriaQRLSTGSRINSAKDDAAGLQIA22PeptideNaturalIt bind to the FLS2 and incites the downstream cascade.Receptor Like Kinase (RLK)Pattern recognition receptor (PRR)NANALeucine-Rich-Repeat (LRR) ectodomain (LRR-RLK)NANANANANA290831162017NA
PRRID_2057FSL-1

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Mycoplasma (Bacteria)CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCNALipoproteinSyntheticanti- inflammatory activityToll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)HumanU937 cellsLeucine-rich Repeat (LRR) DomainNANANANANA291137972017NA
PRRID_2057FSL-1

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Mycoplasma (Bacteria)CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCNALipoproteinSyntheticanti- inflammatory activityToll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)HumanU937 cellsLeucine-rich Repeat (LRR) DomainNANANANANA291137972017NA
PRRID_2063G-rich oligonucleotides

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BacteriaNANANANaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanNANAQ9NR97.fastaQ9NR971041NANA290662552017Pubchem_assay
PRRID_2063G-rich oligonucleotides

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BacteriaNANANANaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanNANAQ9NR97.fastaQ9NR971041NANA290662552017Pubchem_assay
PRRID_2064galactose

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BacteriaC(C(C(C(C(C=O)O)O)O)O)ONANANaturalelicit innate immune responseFmLC3C type Lectin (CTL/CLR)Fenneropenaeus merguiensishepatopancreascarbohydrate recognition domain with an EPN motif and one Ca2+ binding site-2, including a double- loop region assisted by two conserved disulfide linkages.NANANANAwestern blotting290551892017NA
PRRID_2064galactose

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BacteriaC(C(C(C(C(C=O)O)O)O)O)ONANANaturalelicit innate immune responseFmLC3C type Lectin (CTL/CLR)Fenneropenaeus merguiensishepatopancreascarbohydrate recognition domain with an EPN motif and one Ca2+ binding site-2, including a double- loop region assisted by two conserved disulfide linkages.NANANANAwestern blotting290551892017NA
PRRID_2065galactose

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BacteriaC(C(C(C(C(C=O)O)O)O)O)ONANANaturalelicit innate immune responseFmLC2C type Lectin (CTL/CLR)Fenneropenaeus merguiensisNACRD with a QPD (Gln-Pro-Asp) motifNANANANANA290551892017NA
PRRID_2065galactose

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BacteriaC(C(C(C(C(C=O)O)O)O)O)ONANANaturalelicit innate immune responseFmLC2C type Lectin (CTL/CLR)Fenneropenaeus merguiensisNACRD with a QPD (Gln-Pro-Asp) motifNANANANANA290551892017NA
PRRID_2066galactose

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BacteriaC(C(C(C(C(C=O)O)O)O)O)ONANANaturalelicit innate immune responseFmLC4C type Lectin (CTL/CLR)Fenneropenaeus merguiensisNACRD with a QPD (Gln-Pro-Asp) motifNANANANANA290551892017NA
PRRID_2066galactose

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BacteriaC(C(C(C(C(C=O)O)O)O)O)ONANANaturalelicit innate immune responseFmLC4C type Lectin (CTL/CLR)Fenneropenaeus merguiensisNACRD with a QPD (Gln-Pro-Asp) motifNANANANANA290551892017NA
PRRID_2067galactose

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BacteriaC(C(C(C(C(C=O)O)O)O)O)ONANANaturalelicit innate immune responsePmLecC type Lectin (CTL/CLR)Penaeus monodonNACRD with a QPD (Gln-Pro-Asp) motifNANANANANA290551892017NA
PRRID_2067galactose

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BacteriaC(C(C(C(C(C=O)O)O)O)O)ONANANaturalelicit innate immune responsePmLecC type Lectin (CTL/CLR)Penaeus monodonNACRD with a QPD (Gln-Pro-Asp) motifNANANANANA290551892017NA
PRRID_2068galactose

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BacteriaC(C(C(C(C(C=O)O)O)O)O)ONANANaturalelicit innate immune responseFcLec4C type Lectin (CTL/CLR)Fenneropenaeus chinensishepatopancreas, gills and stomachCRD with a QPD (Gln-Pro-Asp) motifNANANANANA290551892017NA
PRRID_2068galactose

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BacteriaC(C(C(C(C(C=O)O)O)O)O)ONANANaturalelicit innate immune responseFcLec4C type Lectin (CTL/CLR)Fenneropenaeus chinensishepatopancreas, gills and stomachCRD with a QPD (Gln-Pro-Asp) motifNANANANANA290551892017NA
PRRID_2069galactose

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BacteriaC(C(C(C(C(C=O)O)O)O)O)ONANANaturalelicit innate immune responseFcLec6C type Lectin (CTL/CLR)Fenneropenaeus chinensisNACRD with a QPD (Gln-Pro-Asp) motifNANANANANA290551892017NA
PRRID_2069galactose

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BacteriaC(C(C(C(C(C=O)O)O)O)O)ONANANaturalelicit innate immune responseFcLec6C type Lectin (CTL/CLR)Fenneropenaeus chinensisNACRD with a QPD (Gln-Pro-Asp) motifNANANANANA290551892017NA
PRRID_2070galactose

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BacteriaC(C(C(C(C(C=O)O)O)O)O)ONANANaturalelicit innate immune responseLvLectin-2C type Lectin (CTL/CLR)Litopenaeus vannameiNACRD with a QPD (Gln-Pro-Asp) motifNANANANANA290551892017NA
PRRID_2070galactose

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BacteriaC(C(C(C(C(C=O)O)O)O)O)ONANANaturalelicit innate immune responseLvLectin-2C type Lectin (CTL/CLR)Litopenaeus vannameiNACRD with a QPD (Gln-Pro-Asp) motifNANANANANA290551892017NA
PRRID_2073Glucan

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalelicit innate immune responseAmphiCTL1C type Lectin (CTL/CLR)B. belcheriNANANANANANANA290551892017NA
PRRID_2073Glucan

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalelicit innate immune responseAmphiCTL1C type Lectin (CTL/CLR)B. belcheriNANANANANANANA290551892017NA
PRRID_2074Glucan

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalinnate immunity elicitorrPtCTL-2C type Lectin (CTL/CLR)Portunus trituberculatusNACarbohydrate recognition DomainNANANArecognize nonself invaders and also work as an opsonin to eliminate invadersPAMPs binding assay289163582017NA
PRRID_2074Glucan

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalinnate immunity elicitorrPtCTL-2C type Lectin (CTL/CLR)Portunus trituberculatusNACarbohydrate recognition DomainNANANArecognize nonself invaders and also work as an opsonin to eliminate invadersPAMPs binding assay289163582017NA
PRRID_2078Glucan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2078Glucan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2081Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responserPtCTL-2C type Lectin (CTL/CLR)NANANANANANANANA289163582017NA
PRRID_2081Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responserPtCTL-2C type Lectin (CTL/CLR)NANANANANANANANA289163582017NA