Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_0032	Acetylated LDL Click for more detail	Endogenous (others)	CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1	NA	Lipoprotein	Natural	Immunostimulant	dSR-C1	Scavenger receptor (SR)	Drosophila melanogaster	NA	two complement control protein (CCP) domains and somatomedin B, MAM, and mucin-like domains	NA	NA	NA	NA	NA	7732030	1995	NA
PRRID_0032	Acetylated LDL Click for more detail	Endogenous (others)	CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1	NA	Lipoprotein	Natural	Immunostimulant	dSR-C1	Scavenger receptor (SR)	Drosophila melanogaster	NA	two complement control protein (CCP) domains and somatomedin B, MAM, and mucin-like domains	NA	NA	NA	NA	NA	7732030	1995	NA
PRRID_0038	Laminarin Click for more detail	laminaria (others)	C(C1C(C(C(C(O1)O)O)OC2C(C(C(C(O2)CO)O)OC3C(C(C(C(O3)CO)O)O)O)O)O)O	NA	Carbohydrate	Natural	Immunostimulant	Scavenger receptor C-1 (SR-C1)	Scavenger receptor (SR)	Drosophila melanogaster	NA	two complement control protein (CCP) domains and somatomedin B, MAM, and mucin-like domains	NA	NA	NA	NA	NA	7732030	1995	NA
PRRID_0038	Laminarin Click for more detail	laminaria (others)	C(C1C(C(C(C(O1)O)O)OC2C(C(C(C(O2)CO)O)OC3C(C(C(C(O3)CO)O)O)O)O)O)O	NA	Carbohydrate	Natural	Immunostimulant	Scavenger receptor C-1 (SR-C1)	Scavenger receptor (SR)	Drosophila melanogaster	NA	two complement control protein (CCP) domains and somatomedin B, MAM, and mucin-like domains	NA	NA	NA	NA	NA	7732030	1995	NA
PRRID_0042	poly D-glutamic acid Click for more detail	synthetic polypeptyide (others)	C(CC(=O)O)C(C(=O)O)N	NA	Peptide	Natural	Immunostimulant	Scavenger receptor C-1 (SR-C1)	Scavenger receptor (SR)	Drosophila melanogaster	NA	two complement control protein (CCP) domains and somatomedin B, MAM, and mucin-like domains	NA	NA	NA	NA	NA	7732030	1995	NA
PRRID_0042	poly D-glutamic acid Click for more detail	synthetic polypeptyide (others)	C(CC(=O)O)C(C(=O)O)N	NA	Peptide	Natural	Immunostimulant	Scavenger receptor C-1 (SR-C1)	Scavenger receptor (SR)	Drosophila melanogaster	NA	two complement control protein (CCP) domains and somatomedin B, MAM, and mucin-like domains	NA	NA	NA	NA	NA	7732030	1995	NA
PRRID_0668	Lipopolysaccharide (LPS) Click for more detail	Bacteria and fungi	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	LPS and Œ≤-glucan binds to the LGBP and induce innate immunity	Lipopolysaccharide and b-1, 3-glucan binding protein (LGBP)	Pattern recognition receptor (PRR)	Drosophila melanogaster	NA	NA	NA	NA	NA	It helps in pathogen recognition, activation of proPO system, induction of antimicrobial peptide	NA	20659562	2010	NA
PRRID_0668	Lipopolysaccharide (LPS) Click for more detail	Bacteria and fungi	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	LPS and Œ≤-glucan binds to the LGBP and induce innate immunity	Lipopolysaccharide and b-1, 3-glucan binding protein (LGBP)	Pattern recognition receptor (PRR)	Drosophila melanogaster	NA	NA	NA	NA	NA	It helps in pathogen recognition, activation of proPO system, induction of antimicrobial peptide	NA	20659562	2010	NA
PRRID_0864	Œ≤- 1,3-glucan Click for more detail	Gram-negative bacteria	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	DmGNBP1	Gram-negative Bacteria-binding Protein (GNBPs)	Drosophila melanogaster	NA	NA	Q9NHB0.fasta	Q9NHB0	494	It induces the proteolytic cascade	NA	20699104	2010	Pubchem Assay
PRRID_0864	Œ≤- 1,3-glucan Click for more detail	Gram-negative bacteria	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	DmGNBP1	Gram-negative Bacteria-binding Protein (GNBPs)	Drosophila melanogaster	NA	NA	Q9NHB0.fasta	Q9NHB0	494	It induces the proteolytic cascade	NA	20699104	2010	Pubchem Assay
PRRID_0867	Lipopolysaccharide (LPS) Click for more detail	Gram-negative bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	NA	DmGNBP1	Gram-negative Bacteria-binding Protein (GNBPs)	Drosophila melanogaster	NA	NA	Q9NHB0.fasta	Q9NHB0	494	It induces the proteolytic cascade	NA	20699104	2010	Pubchem Assay
PRRID_0867	Lipopolysaccharide (LPS) Click for more detail	Gram-negative bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	NA	DmGNBP1	Gram-negative Bacteria-binding Protein (GNBPs)	Drosophila melanogaster	NA	NA	Q9NHB0.fasta	Q9NHB0	494	It induces the proteolytic cascade	NA	20699104	2010	Pubchem Assay
PRRID_0920	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Drosophila melanogaster	NA	Intracellular TIR domains	NA	NA	NA	TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands	NA	21959264	2011	NA
PRRID_0920	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Drosophila melanogaster	NA	Intracellular TIR domains	NA	NA	NA	TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands	NA	21959264	2011	NA
PRRID_0941	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	LPS was also shown to play a role in alloimmune lung injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Drosophila melanogaster	NA	Intracellular TIR domains	NA	NA	NA	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21959264	2011	NA
PRRID_0941	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	LPS was also shown to play a role in alloimmune lung injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Drosophila melanogaster	NA	Intracellular TIR domains	NA	NA	NA	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21959264	2011	NA
PRRID_0944	Pam2CSK4 Click for more detail	NA	CCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC	NA	diacylated lipopeptide	Synthetic	Bacterial lipoproteins are strong immune modulators that activate early innate host responses after infection	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Drosophila melanogaster	NA	Intracellular TIR domains	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity	N	21959264	2011	NA
PRRID_0944	Pam2CSK4 Click for more detail	NA	CCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC	NA	diacylated lipopeptide	Synthetic	Bacterial lipoproteins are strong immune modulators that activate early innate host responses after infection	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Drosophila melanogaster	NA	Intracellular TIR domains	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity	N	21959264	2011	NA
PRRID_1937	b-1,3-glucan and lipopolysaccharide Click for more detail	Gram positive bacteria	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Peptidoglycan	Natural	NA	DmGNBP1	Gram-negative Bacteria-binding Protein (GNBPs)	Drosophila melanogaster	membrane localised	NA	Q9NHB0.fasta	Q9NHB0	494	NA	NA	29229443	2017	Pubchem_assay
PRRID_1937	b-1,3-glucan and lipopolysaccharide Click for more detail	Gram positive bacteria	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Peptidoglycan	Natural	NA	DmGNBP1	Gram-negative Bacteria-binding Protein (GNBPs)	Drosophila melanogaster	membrane localised	NA	Q9NHB0.fasta	Q9NHB0	494	NA	NA	29229443	2017	Pubchem_assay
PRRID_1941	b-1,3-glucans. Click for more detail	Bacteria	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Glycoprotein	Natural	NA	DmGNBP2	Gram-negative Bacteria-binding Protein (GNBPs)	Drosophila melanogaster	membrane localised	NA	NA	NA	NA	NA	NA	29229443	2017	NA
PRRID_1941	b-1,3-glucans. Click for more detail	Bacteria	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Glycoprotein	Natural	NA	DmGNBP2	Gram-negative Bacteria-binding Protein (GNBPs)	Drosophila melanogaster	membrane localised	NA	NA	NA	NA	NA	NA	29229443	2017	NA
PRRID_1942	b-1,3-glucans. Click for more detail	Bacteria	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Glycoprotein	Natural	NA	DmGNBP3	Gram-negative Bacteria-binding Protein (GNBPs)	Drosophila melanogaster	membrane localised	Œ≤-1,3-glucan binding domain	NA	NA	NA	NA	NA	29229443	2017	NA
PRRID_1942	b-1,3-glucans. Click for more detail	Bacteria	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Glycoprotein	Natural	NA	DmGNBP3	Gram-negative Bacteria-binding Protein (GNBPs)	Drosophila melanogaster	membrane localised	Œ≤-1,3-glucan binding domain	NA	NA	NA	NA	NA	29229443	2017	NA