Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_0032 | Acetylated LDL Click for more detail | Endogenous (others) | CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1 | NA | Lipoprotein | Natural | Immunostimulant | dSR-C1 | Scavenger receptor (SR) | Drosophila melanogaster | NA | two complement control protein (CCP) domains and somatomedin B, MAM, and mucin-like domains | NA | NA | NA | NA | NA | 7732030 | 1995 | NA |
| PRRID_0032 | Acetylated LDL Click for more detail | Endogenous (others) | CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1 | NA | Lipoprotein | Natural | Immunostimulant | dSR-C1 | Scavenger receptor (SR) | Drosophila melanogaster | NA | two complement control protein (CCP) domains and somatomedin B, MAM, and mucin-like domains | NA | NA | NA | NA | NA | 7732030 | 1995 | NA |
| PRRID_0038 | Laminarin Click for more detail | laminaria (others) | C(C1C(C(C(C(O1)O)O)OC2C(C(C(C(O2)CO)O)OC3C(C(C(C(O3)CO)O)O)O)O)O)O | NA | Carbohydrate | Natural | Immunostimulant | Scavenger receptor C-1 (SR-C1) | Scavenger receptor (SR) | Drosophila melanogaster | NA | two complement control protein (CCP) domains and somatomedin B, MAM, and mucin-like domains | NA | NA | NA | NA | NA | 7732030 | 1995 | NA |
| PRRID_0038 | Laminarin Click for more detail | laminaria (others) | C(C1C(C(C(C(O1)O)O)OC2C(C(C(C(O2)CO)O)OC3C(C(C(C(O3)CO)O)O)O)O)O)O | NA | Carbohydrate | Natural | Immunostimulant | Scavenger receptor C-1 (SR-C1) | Scavenger receptor (SR) | Drosophila melanogaster | NA | two complement control protein (CCP) domains and somatomedin B, MAM, and mucin-like domains | NA | NA | NA | NA | NA | 7732030 | 1995 | NA |
| PRRID_0042 | poly D-glutamic acid Click for more detail | synthetic polypeptyide (others) | C(CC(=O)O)C(C(=O)O)N | NA | Peptide | Natural | Immunostimulant | Scavenger receptor C-1 (SR-C1) | Scavenger receptor (SR) | Drosophila melanogaster | NA | two complement control protein (CCP) domains and somatomedin B, MAM, and mucin-like domains | NA | NA | NA | NA | NA | 7732030 | 1995 | NA |
| PRRID_0042 | poly D-glutamic acid Click for more detail | synthetic polypeptyide (others) | C(CC(=O)O)C(C(=O)O)N | NA | Peptide | Natural | Immunostimulant | Scavenger receptor C-1 (SR-C1) | Scavenger receptor (SR) | Drosophila melanogaster | NA | two complement control protein (CCP) domains and somatomedin B, MAM, and mucin-like domains | NA | NA | NA | NA | NA | 7732030 | 1995 | NA |
| PRRID_0668 | Lipopolysaccharide (LPS) Click for more detail | Bacteria and fungi | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS and β-glucan binds to the LGBP and induce innate immunity | Lipopolysaccharide and b-1, 3-glucan binding protein (LGBP) | Pattern recognition receptor (PRR) | Drosophila melanogaster | NA | NA | NA | NA | NA | It helps in pathogen recognition, activation of proPO system, induction of antimicrobial peptide | NA | 20659562 | 2010 | NA |
| PRRID_0668 | Lipopolysaccharide (LPS) Click for more detail | Bacteria and fungi | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS and β-glucan binds to the LGBP and induce innate immunity | Lipopolysaccharide and b-1, 3-glucan binding protein (LGBP) | Pattern recognition receptor (PRR) | Drosophila melanogaster | NA | NA | NA | NA | NA | It helps in pathogen recognition, activation of proPO system, induction of antimicrobial peptide | NA | 20659562 | 2010 | NA |
| PRRID_0864 | β- 1,3-glucan Click for more detail | Gram-negative bacteria | C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | DmGNBP1 | Gram-negative Bacteria-binding Protein (GNBPs) | Drosophila melanogaster | NA | NA | Q9NHB0.fasta | Q9NHB0 | 494 | It induces the proteolytic cascade | NA | 20699104 | 2010 | Pubchem Assay |
| PRRID_0864 | β- 1,3-glucan Click for more detail | Gram-negative bacteria | C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | DmGNBP1 | Gram-negative Bacteria-binding Protein (GNBPs) | Drosophila melanogaster | NA | NA | Q9NHB0.fasta | Q9NHB0 | 494 | It induces the proteolytic cascade | NA | 20699104 | 2010 | Pubchem Assay |
| PRRID_0867 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | DmGNBP1 | Gram-negative Bacteria-binding Protein (GNBPs) | Drosophila melanogaster | NA | NA | Q9NHB0.fasta | Q9NHB0 | 494 | It induces the proteolytic cascade | NA | 20699104 | 2010 | Pubchem Assay |
| PRRID_0867 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | DmGNBP1 | Gram-negative Bacteria-binding Protein (GNBPs) | Drosophila melanogaster | NA | NA | Q9NHB0.fasta | Q9NHB0 | 494 | It induces the proteolytic cascade | NA | 20699104 | 2010 | Pubchem Assay |
| PRRID_0920 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Drosophila melanogaster | NA | Intracellular TIR domains | NA | NA | NA | TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands | NA | 21959264 | 2011 | NA |
| PRRID_0920 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Drosophila melanogaster | NA | Intracellular TIR domains | NA | NA | NA | TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands | NA | 21959264 | 2011 | NA |
| PRRID_0941 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS was also shown to play a role in alloimmune lung injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Drosophila melanogaster | NA | Intracellular TIR domains | NA | NA | NA | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21959264 | 2011 | NA |
| PRRID_0941 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS was also shown to play a role in alloimmune lung injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Drosophila melanogaster | NA | Intracellular TIR domains | NA | NA | NA | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21959264 | 2011 | NA |
| PRRID_0944 | Pam2CSK4 Click for more detail | NA | CCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC | NA | diacylated lipopeptide | Synthetic | Bacterial lipoproteins are strong immune modulators that activate early innate host responses after infection | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Drosophila melanogaster | NA | Intracellular TIR domains | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity | N | 21959264 | 2011 | NA |
| PRRID_0944 | Pam2CSK4 Click for more detail | NA | CCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC | NA | diacylated lipopeptide | Synthetic | Bacterial lipoproteins are strong immune modulators that activate early innate host responses after infection | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Drosophila melanogaster | NA | Intracellular TIR domains | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity | N | 21959264 | 2011 | NA |
| PRRID_1937 | b-1,3-glucan and lipopolysaccharide Click for more detail | Gram positive bacteria | C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O | NA | Peptidoglycan | Natural | NA | DmGNBP1 | Gram-negative Bacteria-binding Protein (GNBPs) | Drosophila melanogaster | membrane localised | NA | Q9NHB0.fasta | Q9NHB0 | 494 | NA | NA | 29229443 | 2017 | Pubchem_assay |
| PRRID_1937 | b-1,3-glucan and lipopolysaccharide Click for more detail | Gram positive bacteria | C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O | NA | Peptidoglycan | Natural | NA | DmGNBP1 | Gram-negative Bacteria-binding Protein (GNBPs) | Drosophila melanogaster | membrane localised | NA | Q9NHB0.fasta | Q9NHB0 | 494 | NA | NA | 29229443 | 2017 | Pubchem_assay |
| PRRID_1941 | b-1,3-glucans. Click for more detail | Bacteria | C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O | NA | Glycoprotein | Natural | NA | DmGNBP2 | Gram-negative Bacteria-binding Protein (GNBPs) | Drosophila melanogaster | membrane localised | NA | NA | NA | NA | NA | NA | 29229443 | 2017 | NA |
| PRRID_1941 | b-1,3-glucans. Click for more detail | Bacteria | C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O | NA | Glycoprotein | Natural | NA | DmGNBP2 | Gram-negative Bacteria-binding Protein (GNBPs) | Drosophila melanogaster | membrane localised | NA | NA | NA | NA | NA | NA | 29229443 | 2017 | NA |
| PRRID_1942 | b-1,3-glucans. Click for more detail | Bacteria | C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O | NA | Glycoprotein | Natural | NA | DmGNBP3 | Gram-negative Bacteria-binding Protein (GNBPs) | Drosophila melanogaster | membrane localised | β-1,3-glucan binding domain | NA | NA | NA | NA | NA | 29229443 | 2017 | NA |
| PRRID_1942 | b-1,3-glucans. Click for more detail | Bacteria | C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O | NA | Glycoprotein | Natural | NA | DmGNBP3 | Gram-negative Bacteria-binding Protein (GNBPs) | Drosophila melanogaster | membrane localised | β-1,3-glucan binding domain | NA | NA | NA | NA | NA | 29229443 | 2017 | NA |