Browse By Oncolytic Virus Species Result Page of OvirusTdb

The Total number of records shown on this page is 81. Click on ID to see further detail.
IDOV_5744Virus nameVaccinia virusVirus strainGLV-1h84Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of F14.5L gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 604.3mm after 47 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5745Virus nameVaccinia virusVirus strainGLV-1h85Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA into F14.5L gene, TK gene at place of LacZ and gusA gene at place of HA geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 914mm after 47 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5746Virus nameVaccinia virusVirus strainGLV-1h86Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP into F14.5L gene, noncoding DNA at place of LacZ and HA geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 962.1mm after 47 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5747Virus nameVaccinia virusVirus strainGLV-1h22Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1424.4mm after 62 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5748Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1390.35mm after 62 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5749Virus nameVaccinia virusVirus strainGLV-1h73Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, LacZ gene at TK gene, noncoding DNA into HA locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 983.2mm after 62 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5750Virus nameVaccinia virusVirus strainGLV-1h82Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of HA gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1319.2mm after 62 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5751Virus nameVaccinia virusVirus strainGLV-1h83Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of HA gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1686.05mm after 62 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5752Virus nameVaccinia virusVirus strainGLV-1h84Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of F14.5L gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 982mm after 62 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5753Virus nameVaccinia virusVirus strainGLV-1h85Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA into F14.5L gene, TK gene at place of LacZ and gusA gene at place of HA geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 947.2mm after 62 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5754Virus nameVaccinia virusVirus strainGLV-1h86Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP into F14.5L gene, noncoding DNA at place of LacZ and HA geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1397.55mm after 62 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5755Virus nameVaccinia virusVirus strainGLV-1h22Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1907.5mm after 75 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5756Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1528.95mm after 75 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5757Virus nameVaccinia virusVirus strainGLV-1h73Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, LacZ gene at TK gene, noncoding DNA into HA locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 517.3mm after 75 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5758Virus nameVaccinia virusVirus strainGLV-1h82Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of HA gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1211.8mm after 75 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5759Virus nameVaccinia virusVirus strainGLV-1h83Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of HA gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1856.35mm after 75 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5760Virus nameVaccinia virusVirus strainGLV-1h84Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of F14.5L gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 614.25mm after 75 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5761Virus nameVaccinia virusVirus strainGLV-1h85Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA into F14.5L gene, TK gene at place of LacZ and gusA gene at place of HA geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 255.25mm after 75 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5762Virus nameVaccinia virusVirus strainGLV-1h86Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP into F14.5L gene, noncoding DNA at place of LacZ and HA geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 689.6mm after 75 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5763Virus nameVaccinia virusVirus strainGLV-1h22Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1887.6mm after 89 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5764Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1181.4mm after 89 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5765Virus nameVaccinia virusVirus strainGLV-1h73Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, LacZ gene at TK gene, noncoding DNA into HA locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 74.4mm after 89 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5766Virus nameVaccinia virusVirus strainGLV-1h82Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of HA gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 855.9mm after 89 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5767Virus nameVaccinia virusVirus strainGLV-1h83Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of HA gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1392mm after 89 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5768Virus nameVaccinia virusVirus strainGLV-1h86Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP into F14.5L gene, noncoding DNA at place of LacZ and HA geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 187.5mm after 89 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5769Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 264.9mm compared to control 204.3 mm after 32 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5770Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 365.7mm compared to control 333.9 mm after 42 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5771Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 155.3mm compared to control 646.6 mm after 50 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5772Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 62mm compared to control 886.4 mm after 56 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5773Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneNoVirus in combination with drug/radiationVirus in combination with cidofovir (25mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 291.1mm compared to control 204.3 mm after 32 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5774Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneNoVirus in combination with drug/radiationVirus in combination with cidofovir (25mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 314.2mm compared to control 333.9 mm after 42 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5775Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneNoVirus in combination with drug/radiationVirus in combination with cidofovir (25mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 238.3mm compared to control 646.6 mm after 50 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5776Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneNoVirus in combination with drug/radiationVirus in combination with cidofovir (25mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 117.4mm compared to control 886.4 mm after 56 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5777Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneNoVirus in combination with drug/radiationVirus in combination with cidofovir (50mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 279.8mm compared to control 204.3 mm after 32 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5778Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneNoVirus in combination with drug/radiationVirus in combination with cidofovir (50mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 395.5mm compared to control 333.9 mm after 42 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5779Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneNoVirus in combination with drug/radiationVirus in combination with cidofovir (50mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 206.5mm compared to control 646.6 mm after 50 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5780Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneNoVirus in combination with drug/radiationVirus in combination with cidofovir (50mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 61mm compared to control 886.4 mm after 56 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5781Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneNoVirus in combination with drug/radiationVirus in combination with cidofovir (100mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 587.1mm compared to control 204.3 mm after 32 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5782Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneNoVirus in combination with drug/radiationVirus in combination with cidofovir (100mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 391.1mm compared to control 333.9 mm after 42 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5783Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneNoVirus in combination with drug/radiationVirus in combination with cidofovir (100mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 184mm compared to control 646.6 mm after 50 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5784Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneNoVirus in combination with drug/radiationVirus in combination with cidofovir (100mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 58mm compared to control 886.4 mm after 56 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5785Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to 176.9 mm compared to control 278.1 after 53 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5786Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to 598.8mm compared to control 755 after 63 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5787Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to 668.4 mm compared to control 1169.9 after 69 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5788Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to 896.6 mm compared to control 2512.7 after 77 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5789Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 298.8 after 41 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5790Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1448.3 after 55 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5791Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 2512.4 after 64 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5792Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 34.07 after 71 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5793Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 415.1 after 41 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5794Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1403.1 after 55 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5795Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1163.7 after 64 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5796Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 993 after 71 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5797Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 757.5 after 79 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5798Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 667 after 87 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5799Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 547 after 93 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5800Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 549 after 99 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5801Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 511 after 106 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5802Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 465.3 after 113 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5803Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 441.3 after 119 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5804Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes to 268.4 after 55 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5805Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes to 623.7 after 62 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5806Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes to 1232.5 after 70 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5807Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes to 1277.05 after 75 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5808Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to 1189.55 mm after 81 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5809Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to 744.4mm after 89 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5810Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes to 402.1 after 55 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5811Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes to 1128.15 after 62 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5812Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes to 1485.05 after 70 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5813Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes to 1599.35 after 75 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5814Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to 1411.4mm after 81 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5815Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to 1040mm after 89 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5816Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to 906.75 mm after 96 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5885Virus nameVaccinia virusVirus strainMutantVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationMutant in F2L geneVirus aloneNoVirus in combination with drug/radiationVirus in combination with 5FC(100mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismNude mice xenograft for LoVo cellIn-vivo virus concentration1.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to 1000mm compared to control 2500mm after 40 daysMode of deliveryIntratumoralPathway inducedNAImmunogenic effectNAClinical trialNAPMIDUS9180150
IDOV_5886Virus nameVaccinia virusVirus strainMutantVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationMutant in F2L geneVirus aloneNoVirus in combination with drug/radiationVirus in combination with 5FC(100mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismNude mice xenograft for HepG2In-vivo virus concentration1.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to 1000mm compared to control 2500mm after 40 daysMode of deliveryIntratumoralPathway inducedNAImmunogenic effectNAClinical trialNAPMIDUS9180150
IDOV_5896Virus nameVaccinia virusVirus strainVVTK-FCU1Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDefective in J2R gene, expressing FCU1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman colon tumor cell lineCell lineLoVoConcentration of cell line3.0E+5 pfuIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.00001 MOIIn-vitro result60% of cancer cell death occursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMIDUS9687515
IDOV_5897Virus nameVaccinia virusVirus strainVVTK-FCU1Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDefective in J2R gene, expressing FCU1 gene, defective in I4L geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman colon tumor cell lineCell lineLoVoConcentration of cell line3.0E+5 pfuIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.00001 MOIIn-vitro result58% of cancer cell death occursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMIDUS9687515
IDOV_5898Virus nameVaccinia virusVirus strainVVTK-FCU1Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDefective in J2R gene, expressing FCU1 gene, defective in I4L geneVirus aloneNoVirus in combination with drug/radiationVirus in combination with 5FU (100mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismSwiss nude mice xenograft for LoVo cell line (5.0E+6)In-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to nearly 1000mm compared to control 2400mmMode of deliveryIntravenouslyPathway inducedNAImmunogenic effectNAClinical trialNAPMIDUS9687515
IDOV_5899Virus nameVaccinia virusVirus strainVVTK-FCU1Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDefective in J2R gene, expressing FCU1 gene, defective in F4L geneVirus aloneNoVirus in combination with drug/radiationVirus in combination with 5FU (100mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismSwiss nude mice xenograft for LoVo cell line (5.0E+6)In-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to below 1000mm compared to control 2400mmMode of deliveryIntravenouslyPathway inducedNAImmunogenic effectNAClinical trialNAPMIDUS9687515
IDOV_5900Virus nameVaccinia virusVirus strainVVTK-FCU1Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDefective in J2R gene, expressing FCU1 gene, defective in I4L geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismSwiss nude mice xenograft for U87MG(5.0E+6)In-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to below 500mm comapred to control 3500mm after 60 daysMode of deliveryIntravenouslyPathway inducedNAImmunogenic effectNAClinical trialNAPMIDUS9687515
IDOV_5901Virus nameVaccinia virusVirus strainVVTK-FCU1Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDefective in J2R gene, expressing FCU1 gene, defective in I4L geneVirus aloneNoVirus in combination with drug/radiationVirus in combination with 5FU (100mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismSwiss nude mice xenograft for U87MG(5.0E+6)In-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to below 500mm comapred to control 3500mm after 60 daysMode of deliveryIntravenouslyPathway inducedNAImmunogenic effectNAClinical trialNAPMIDUS9687515