Detailed description page of Selected OV_ID


OV_5898 details
Primary information
OV_IDOV_5898
Virus Name Vaccinia virus
StrainVVTK-FCU1
Virus typeDNA
Virus familyPoxviridae
Modification in virus genomeDefective in J2R gene, expressing FCU1 gene, defective in I4L gene
Virus aloneNo
Virus in combination iwth drug/radiationVirus in combination with 5FU (100mg/kg)
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismSwiss nude mice xenograft for LoVo cell line (5 ×10⁶)
In-vivo virus concentration1 ×10⁷ pfu
In-vivo toxicityNA
In-vivo resultTumor volume reduced to nearly 1000mm compared to control 2400mm
Mode of deliveryIntravenously
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMIDUS9687515