Detailed description page of Selected OV_ID


OV_5774 details
Primary information
OV_IDOV_5774
Virus Name Vaccinia virus
StrainGLV-1h74
Virus typeDNA
Virus familyPoxviridae
Modification in virus genomeInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusA
Virus aloneNo
Virus in combination iwth drug/radiationVirus in combination with cidofovir (25mg/kg)
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5 ×10⁶)
In-vivo virus concentration5 ×10⁶ pfu
In-vivo toxicityNA
In-vivo resultTumor volume become 314.2mm compared to control 333.9 mm after 42 days
Mode of deliveryIntravenously
Pathway inductionInduction of apoptosis
Immunogenic effectNA
Clinical trialNA
PMIDUS8052968