| Primary information |
|---|
| OV_ID | OV_5900 |
| Virus Name | Vaccinia virus |
| Strain | VVTK-FCU1 |
| Virus type | DNA |
| Virus family | Poxviridae |
| Modification in virus genome | Defective in J2R gene, expressing FCU1 gene, defective in I4L gene |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | NA |
| Origin of cell line | NA |
| Cell line | NA |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | Swiss nude mice xenograft for U87MG(5 ×10â¶) |
| In-vivo virus concentration | 1 ×10ⷠpfu |
| In-vivo toxicity | NA |
| In-vivo result | Tumor volume reduced to below 500mm comapred to control 3500mm after 60 days |
| Mode of delivery | Intravenously |
| Pathway induction | NA |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | US9687515 |