Detailed description page of Selected OV_ID


OV_5763 details
Primary information
OV_IDOV_5763
Virus Name Vaccinia virus
StrainGLV-1h22
Virus typeDNA
Virus familyPoxviridae
Modification in virus genomeInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectively
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5 ×10⁶)
In-vivo virus concentration5 ×10⁶ pfu
In-vivo toxicityNA
In-vivo resultTumor volume becomes 1887.6mm after 89 days
Mode of deliveryIntravenously
Pathway inductionInduction of apoptosis
Immunogenic effectNA
Clinical trialNA
PMIDUS8052968