Detailed description page of Selected OV_ID


OV_5801 details
Primary information
OV_IDOV_5801
Virus Name Vaccinia virus
StrainGLV-1h68
Virus typeDNA
Virus familyPoxviridae
Modification in virus genomeInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectively
Virus aloneNo
Virus in combination iwth drug/radiationVirus in combination with cisplatin (5mg/kg)
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismHsd athymic nude mice xenograft for OVCAR-3 (5 ×10⁶)
In-vivo virus concentration2 ×10⁶ pfu
In-vivo toxicityNA
In-vivo resultTumor volume becomes 511 after 106 days
Mode of deliveryIntravenously
Pathway inductionInduction of apoptosis
Immunogenic effectNA
Clinical trialNA
PMIDUS8052968