Browse By Cell Line Result Page of OvirusTdb

The total number of records retrieved from this search are 55. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_1443	Reovirus	ReoT3D	RNA	Reoviridae	None	Yes	No	No	NCI	Human NSCLC cell line	NCIH460	NA	NA	XTT assay	Log10 pfu/cell	20% cell survived 48 hours after post infection	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1452	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus strain in combination with palcitaxel (100 micromolar)	No	NCI	Human NSCLC cell line	NCIH460	NA	NA	Dose response analysis curve	Log10 pfu/cell	100% cell death after 4 days	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1453	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus in combination with palcitaxel (0.003 +/- 0.001 micromolar, 1:53)	No	NCI	Human NSCLC cell line	NCIH460	NA	NA	chou-Talay analysis	Log10 pfu/cell	50% cell death occurs at 0.903 CI value	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1459	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus in combination with palcitaxel (0.003 +/- 0.001 micromolar, 1:53)	No	NCI	Human NSCLC cell line	NCIH460	NA	NA	chou-Talay analysis	Log10 pfu/cell	75% cell death at CI value 0.221	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1465	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus in combination with palcitaxel (0.003 +/- 0.001 micromolar, 1:53)	No	NCI	Human NSCLC cell line	NCIH460	NA	NA	chou-Talay analysis	Log10 pfu/cell	90% cell death at CI value 0.057	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1471	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus in combination with palcitaxel (0.003 +/- 0.001 micromolar, 1:533)	No	NCI	Human NSCLC cell line	NCIH460	NA	NA	chou-Talay analysis	Log10 pfu/cell	50% cell death occurs at 0.193 CI value	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1477	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus in combination with palcitaxel (0.003 +/- 0.001 micromolar, 1:533)	No	NCI	Human NSCLC cell line	NCIH460	NA	NA	chou-Talay analysis	Log10 pfu/cell	75% cell death at CI value 0.042	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1483	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus in combination with palcitaxel (0.003 +/- 0.001 micromolar, 1:533)	No	NCI	Human NSCLC cell line	NCIH460	NA	NA	chou-Talay analysis	Log10 pfu/cell	90% cell death at CI value 0.013	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1489	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus combination with cisplatin (5.31+/-1.21, ratio is 1:53)	No	NCI	Human NSCLC cell line	NCIH460	NA	NA	chou-Talay analysis	Log10 pfu/cell	50% cell death at CI value 0.875	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1495	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus combination with cisplatin (5.31+/-1.21, ratio is 1:53)	No	NCI	Human NSCLC cell line	NCIH460	NA	NA	chou-Talay analysis	Log10 pfu/cell	75% death at CI value 0.313	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1501	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus combination with cisplatin (5.31+/-1.21, ratio is 1:53)	No	NCI	Human NSCLC cell line	NCIH460	NA	NA	chou-Talay analysis	Log10 pfu/cell	90% cell death at CI value 0.112	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1507	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus combination with cisplatin (5.31+/-1.21, ratio is 1:533)	No	NCI	Human NSCLC cell line	NCIH460	NA	NA	chou-Talay analysis	Log10 pfu/cell	50% cell death at CI value 0.061	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1513	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus combination with cisplatin (5.31+/-1.21, ratio is 1:533)	No	NCI	Human NSCLC cell line	NCIH460	NA	NA	chou-Talay analysis	Log10 pfu/cell	75% death at CI value 0.006	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1519	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus combination with cisplatin (5.31+/-1.21, ratio is 1:533)	No	NCI	Human NSCLC cell line	NCIH460	NA	NA	chou-Talay analysis	Log10 pfu/cell	90% cell death at CI value 0.129	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1525	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus in combination with Gemcitabine (0.01+/- 0.003, 1:53)	No	NCI	Human NSCLC cell line	NCIH460	NA	NA	chou-Talay analysis	Log10 pfu/cell	50% cell death at CI value 0.199	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1531	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus in combination with Gemcitabine (0.01+/- 0.003, 1:53)	No	NCI	Human NSCLC cell line	NCIH460	NA	NA	chou-Talay analysis	Log10 pfu/cell	75 % cell death at CI 0.126	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1537	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus in combination with Gemcitabine (0.01+/- 0.003, 1:53)	No	NCI	Human NSCLC cell line	NCIH460	NA	NA	chou-Talay analysis	Log10 pfu/cell	90% cell killing at CI 0.126	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1543	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus in combination with Gemcitabine (0.01+/- 0.003, 1:533)	No	NCI	Human NSCLC cell line	NCIH460	NA	NA	chou-Talay analysis	Log10 pfu/cell	50% cell killing at CI 0.006	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1549	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus in combination with Gemcitabine (0.01+/- 0.003, 1:533)	No	NCI	Human NSCLC cell line	NCIH460	NA	NA	chou-Talay analysis	Log10 pfu/cell	75% cell killing at CI 0.017	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1555	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus in combination with Gemcitabine (0.01+/- 0.003, 1:533)	No	NCI	Human NSCLC cell line	NCIH460	NA	NA	chou-Talay analysis	Log10 pfu/cell	90% cell killing at CI 0.054	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1561	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus combination with vinblastine(0.92+/-0.35nm, 1:5.3)	No	NCI	Human NSCLC cell line	NCIH460	NA	NA	chou-Talay analysis	Log10 pfu/cell	50% cell killing at CI 0.255	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1567	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus combination with vinblastine(0.92+/-0.35nm, 1:5.3)	No	NCI	Human NSCLC cell line	NCIH460	NA	NA	chou-Talay analysis	Log10 pfu/cell	75% cell killing at CI 0.149	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1573	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus combination with vinblastine(0.92+/-0.35nm, 1:5.3)	No	NCI	Human NSCLC cell line	NCIH460	NA	NA	chou-Talay analysis	Log10 pfu/cell	90% cell killing at CI 0.089	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1579	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus combination with vinblastine(0.92+/-0.35nm, 1:53.3)	No	NCI	Human NSCLC cell line	NCIH460	NA	NA	chou-Talay analysis	Log10 pfu/cell	50% cell killing at CI 0.069	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1585	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus combination with vinblastine(0.92+/-0.35nm, 1:53.3)	No	NCI	Human NSCLC cell line	NCIH460	NA	NA	chou-Talay analysis	Log10 pfu/cell	75% cell killing at CI 0.045	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_1591	Reovirus	ReoT3D	RNA	Reoviridae	None	No	Virus combination with vinblastine(0.92+/-0.35nm, 1:53.3)	No	NCI	Human NSCLC cell line	NCIH460	NA	NA	chou-Talay analysis	Log10 pfu/cell	90% cell killing at CI 0.031	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19594950
OV_2775	Adenovirus	Ad.sp-E1A-TSLC1	DNA	Adenoviridae	Deletion of 24bp with in E1A gene and insertion of TSLC1 gene	Yes	No	No	ATCC	Human lung cancer cell line	NCI-H460	NA	NA	Crystal violet staining	0.1 MOI	Moderate cell death	No	No	NA	No response	NA	Induction of apotosis by virus in cancer cell line as measured by TUNEL assay	NA	NA	23503473
OV_2776	Adenovirus	Ad.sp-E1A-TSLC1	DNA	Adenoviridae	Deletion of 24bp with in E1A gene and insertion of TSLC1 gene	Yes	No	No	ATCC	Human lung cancer cell line	NCI-H460	NA	NA	Crystal violet staining	0.5 MOI	Moderate cell death	No	No	NA	No response	NA	Induction of apotosis by virus in cancer cell line as measured by TUNEL assay	NA	NA	23503473
OV_2777	Adenovirus	Ad.sp-E1A-TSLC1	DNA	Adenoviridae	Deletion of 24bp with in E1A gene and insertion of TSLC1 gene	Yes	No	No	ATCC	Human lung cancer cell line	NCI-H460	NA	NA	Crystal violet staining	1 MOI	Significant cell death	No	No	NA	No response	NA	Induction of apotosis by virus in cancer cell line as measured by TUNEL assay	NA	NA	23503473
OV_2778	Adenovirus	Ad.sp-E1A-TSLC1	DNA	Adenoviridae	Deletion of 24bp with in E1A gene and insertion of TSLC1 gene	Yes	No	No	ATCC	Human lung cancer cell line	NCI-H460	NA	NA	Crystal violet staining	5 MOI	All cells was dead	No	No	NA	No response	NA	Induction of apotosis by virus in cancer cell line as measured by TUNEL assay	NA	NA	23503473
OV_2779	Adenovirus	Ad.sp-E1A-TSLC1	DNA	Adenoviridae	Deletion of 24bp with in E1A gene and insertion of TSLC1 gene	Yes	No	No	ATCC	Human lung cancer cell line	NCI-H460	NA	NA	Crystal violet staining	10 MOI	All cells was dead	No	No	NA	No response	NA	Induction of apotosis by virus in cancer cell line as measured by TUNEL assay	NA	NA	23503473
OV_2800	Adenovirus	Ad.sp-E1A-TSLC1	DNA	Adenoviridae	Deletion of 24bp with in E1A gene and insertion of TSLC1 gene	Yes	No	No	ATCC	Human lung cancer cell line	NCI-H460	NA	NA	MTT assay	0.5 MOI	90% cells are viable	No	No	NA	No response	NA	Induction of apotosis by virus in cancer cell line as measured by TUNEL assay	NA	NA	23503473
OV_2801	Adenovirus	Ad.sp-E1A-TSLC1	DNA	Adenoviridae	Deletion of 24bp with in E1A gene and insertion of TSLC1 gene	Yes	No	No	ATCC	Human lung cancer cell line	NCI-H460	NA	NA	MTT assay	1 MOI	80% cells are viable	No	No	NA	No response	NA	Induction of apotosis by virus in cancer cell line as measured by TUNEL assay	NA	NA	23503473
OV_2802	Adenovirus	Ad.sp-E1A-TSLC1	DNA	Adenoviridae	Deletion of 24bp with in E1A gene and insertion of TSLC1 gene	Yes	No	No	ATCC	Human lung cancer cell line	NCI-H460	NA	NA	MTT assay	2 MOI	80% cells are viable	No	No	NA	No response	NA	Induction of apotosis by virus in cancer cell line as measured by TUNEL assay	NA	NA	23503473
OV_2803	Adenovirus	Ad.sp-E1A-TSLC1	DNA	Adenoviridae	Deletion of 24bp with in E1A gene and insertion of TSLC1 gene	Yes	No	No	ATCC	Human lung cancer cell line	NCI-H460	NA	NA	MTT assay	5 MOI	70% cells are viable	No	No	NA	No response	NA	Induction of apotosis by virus in cancer cell line as measured by TUNEL assay	NA	NA	23503473
OV_2804	Adenovirus	Ad.sp-E1A-TSLC1	DNA	Adenoviridae	Deletion of 24bp with in E1A gene and insertion of TSLC1 gene	Yes	No	No	ATCC	Human lung cancer cell line	NCI-H460	NA	NA	MTT assay	10 MOI	60% cells are viable	No	No	NA	No response	NA	Induction of apotosis by virus in cancer cell line as measured by TUNEL assay	NA	NA	23503473
OV_4331	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human large cell lung cancer	NCI-H460	4000 cells per well	NA	MTT assay	10 pfu	99.5 % cell viability after 72 hours	No	No	NA	No response	NA	Activation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	NA	NA	26373347
OV_4555	Adenovirus	CD55-TRAIL+ CD55-MnSOD	DNA	Adenoviridae	virus containing TRAIl and MnSOD gene	Yes	No	No	Shanghai cell collection	Human lung carcinoma cell line	NCI-H460	5.0E+4 cells per well	NA	MTT assay	10 MOI	90% cancer cell survival after 24 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	27080225
OV_4556	Adenovirus	CD55-MnSOD	DNA	Adenoviridae	virus containing MnSOD gene	Yes	No	No	Shanghai cell collection	Human lung carcinoma cell line	NCI-H460	5.0E+4 cells per well	NA	MTT assay	10 MOI	100% cancer cell survival after 24 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	27080225
OV_4557	Adenovirus	CD55-TRAIL	DNA	Adenoviridae	virus containing TRAIL gene	Yes	No	No	Shanghai cell collection	Human lung carcinoma cell line	NCI-H460	5.0E+4 cells per well	NA	MTT assay	10 MOI	100% cancer cell survival after 24 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	27080225
OV_4558	Adenovirus	CD55-TRAIL-IETD-MnSOD	DNA	Adenoviridae	Virus having TRAIL, MnSOD gene linked via IETD caspase 8 cleavage site	Yes	No	No	Shanghai cell collection	Human lung carcinoma cell line	NCI-H460	5.0E+4 cells per well	NA	MTT assay	10 MOI	90% cancer cell survival after 24 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	27080225
OV_4559	Adenovirus	CD55-TRAIL+ CD55-MnSOD	DNA	Adenoviridae	virus containing TRAIl and MnSOD gene	Yes	No	No	Shanghai cell collection	Human lung carcinoma cell line	NCI-H460	5.0E+4 cells per well	NA	MTT assay	10 MOI	100% cancer cell survival after 48 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	27080225
OV_4560	Adenovirus	CD55-MnSOD	DNA	Adenoviridae	virus containing MnSOD gene	Yes	No	No	Shanghai cell collection	Human lung carcinoma cell line	NCI-H460	5.0E+4 cells per well	NA	MTT assay	10 MOI	100% cancer cell survival after 48 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	27080225
OV_4561	Adenovirus	CD55-TRAIL	DNA	Adenoviridae	virus containing TRAIL gene	Yes	No	No	Shanghai cell collection	Human lung carcinoma cell line	NCI-H460	5.0E+4 cells per well	NA	MTT assay	10 MOI	100% cancer cell survival after 48 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	27080225
OV_4562	Adenovirus	CD55-TRAIL-IETD-MnSOD	DNA	Adenoviridae	Virus having TRAIL, MnSOD gene linked via IETD caspase 8 cleavage site	Yes	No	No	Shanghai cell collection	Human lung carcinoma cell line	NCI-H460	5.0E+4 cells per well	NA	MTT assay	10 MOI	100% cancer cell survival after 48 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	27080225
OV_4563	Adenovirus	CD55-TRAIL+ CD55-MnSOD	DNA	Adenoviridae	virus containing TRAIl and MnSOD gene	Yes	No	No	Shanghai cell collection	Human lung carcinoma cell line	NCI-H460	5.0E+4 cells per well	NA	MTT assay	10 MOI	100% cancer cell survival after 72 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	27080225
OV_4564	Adenovirus	CD55-MnSOD	DNA	Adenoviridae	virus containing MnSOD gene	Yes	No	No	Shanghai cell collection	Human lung carcinoma cell line	NCI-H460	5.0E+4 cells per well	NA	MTT assay	10 MOI	100% cancer cell survival after 72 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	27080225
OV_4565	Adenovirus	CD55-TRAIL	DNA	Adenoviridae	virus containing TRAIL gene	Yes	No	No	Shanghai cell collection	Human lung carcinoma cell line	NCI-H460	5.0E+4 cells per well	NA	MTT assay	10 MOI	100% cancer cell survival after 72 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	27080225
OV_4566	Adenovirus	CD55-TRAIL-IETD-MnSOD	DNA	Adenoviridae	Virus having TRAIL, MnSOD gene linked via IETD caspase 8 cleavage site	Yes	No	No	Shanghai cell collection	Human lung carcinoma cell line	NCI-H460	5.0E+4 cells per well	NA	MTT assay	10 MOI	100% cancer cell survival after 72 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	27080225
OV_4567	Adenovirus	CD55-TRAIL+ CD55-MnSOD	DNA	Adenoviridae	virus containing TRAIl and MnSOD gene	Yes	No	No	Shanghai cell collection	Human lung carcinoma cell line	NCI-H460	5.0E+4 cells per well	NA	MTT assay	10 MOI	78% cancer cell survival after 96 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	27080225
OV_4568	Adenovirus	CD55-MnSOD	DNA	Adenoviridae	virus containing MnSOD gene	Yes	No	No	Shanghai cell collection	Human lung carcinoma cell line	NCI-H460	5.0E+4 cells per well	NA	MTT assay	10 MOI	82% cancer cell survival after 96 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	27080225
OV_4569	Adenovirus	CD55-TRAIL	DNA	Adenoviridae	virus containing TRAIL gene	Yes	No	No	Shanghai cell collection	Human lung carcinoma cell line	NCI-H460	5.0E+4 cells per well	NA	MTT assay	10 MOI	80% cancer cell survival after 96 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	27080225
OV_4570	Adenovirus	CD55-TRAIL-IETD-MnSOD	DNA	Adenoviridae	Virus having TRAIL, MnSOD gene linked via IETD caspase 8 cleavage site	Yes	No	No	Shanghai cell collection	Human lung carcinoma cell line	NCI-H460	5.0E+4 cells per well	NA	MTT assay	10 MOI	62% cancer cell survival after 96 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	27080225
OV_5538	Herpes simplex virus	1716	DNA	Herpesviridae	Double deletion mutant in ICP34.5 gene	No	Virus in combination with mitomycin drug	No	ATCC	Human large cell carcinoma cell line H460	H460	NA	NA	NA	NA	NA	Mouse model xenograft for H460 cell line	4.0E+6 pfu	NA	Reduction in tumor volume to 0.793 +/- 0.047	Intravenously	NA	NA	NA	US6428968
OV_5539	Herpes simplex virus	1716	DNA	Herpesviridae	Double deletion mutant in ICP34.5 gene	Yes	No	No	ATCC	Human large cell carcinoma cell line H460	H460	NA	NA	NA	NA	NA	Mouse model xenograft for H460 cell line	4.0E+6 pfu	NA	Reduction in tumor volume to 1.127 +/- 0.139	Intravenously	NA	NA	NA	US6428968