Browse By Cell Line Result Page of OvirusTdb

The total number of records retrieved from this search are 49. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_397	Herpes simplex virus	ICP10PK	DNA	Herpesviridae	Deletion mutant with R1 domain poorly functional in HSV-1	Yes	No	No	ATCC	Human malignant melanoma cell lines	A375	NA	NA	Trypan blue staining	1 MOI	55% cancer cell death at 48 hours after post infection	No	No	NA	No response	NA	Induces JNK/c-Jun, autophagy and pyroptosis activation	ICP10PK upregulates of caspase-1, -4, and -5, the cytokines IL-1alpha, IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, lymphotoxina and GM-CSF, and mitogen-activated protein kinases (MAPKs) involved in both PCD and inflammatory processes	NA	26602205
OV_398	Herpes simplex virus	ICP10PK	DNA	Herpesviridae	Deletion mutant with R1 domain poorly functional in HSV-1	No	Viral strain in combination with SP600125 (100 Î¼M)	No	ATCC	Human malignant melanoma cell lines	A375	NA	NA	Trypan blue staining	1 MOI	35% cancer cell death at 48 hours after post infection	No	No	NA	No response	NA	Induces JNK/c-Jun, autophagy and pyroptosis activation	ICP10PK upregulates of caspase-1, -4, and -5, the cytokines IL-1alpha, IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, lymphotoxina and GM-CSF, and mitogen-activated protein kinases (MAPKs) involved in both PCD and inflammatory processes	NA	26602205
OV_399	Herpes simplex virus	ICP10PK	DNA	Herpesviridae	Deletion mutant with R1 domain poorly functional in HSV-1	No	Viral strain in combination with 3-MA (5 mM)	No	ATCC	Human malignant melanoma cell lines	A375	NA	NA	Trypan blue staining	1 MOI	44% cancer cell death at 48 hours after post infection	No	No	NA	No response	NA	Induces JNK/c-Jun, autophagy and pyroptosis activation	ICP10PK upregulates of caspase-1, -4, and -5, the cytokines IL-1alpha, IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, lymphotoxina and GM-CSF, and mitogen-activated protein kinases (MAPKs) involved in both PCD and inflammatory processes	NA	26602205
OV_400	Herpes simplex virus	ICP10PK	DNA	Herpesviridae	Deletion mutant with R1 domain poorly functional in HSV-1	No	Viral strain in combination with z-YVAD- fmk (100 Î¼M)	No	ATCC	Human malignant melanoma cell lines	A375	NA	NA	Trypan blue staining	1 MOI	42% cancer cell death at 48 hours after post infection	No	No	NA	No response	NA	Induces JNK/c-Jun, autophagy and pyroptosis activation	ICP10PK upregulates of caspase-1, -4, and -5, the cytokines IL-1alpha, IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, lymphotoxina and GM-CSF, and mitogen-activated protein kinases (MAPKs) involved in both PCD and inflammatory processes	NA	26602205
OV_619	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	77% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_620	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	77% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_621	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	52% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_622	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	48% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_623	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	1 MOI	40% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_624	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	60% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_625	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	50% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_626	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	48% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_627	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	40% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_628	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	1 MOI	38% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_679	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	120% cancer cell viability (calculated as relative to mock-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_680	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	105% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_681	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	100% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_682	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	70% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_683	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	1 MOI	50% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_1437	Adenovirus	ZD-55-IL-18	DNA	Adenoviridae	None	Yes	No	Virus expressing IL-18 gene	Shanghai cell collection	Human melanoma cell line	A375	NA	NA	Crystal violet staining	0.01 MOI	Cell survival observerd	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19498459
OV_1438	Adenovirus	ZD-55-IL-18	DNA	Adenoviridae	None	Yes	No	Virus expressing IL-18 gene	Shanghai cell collection	Human melanoma cell line	A375	NA	NA	Crystal violet staining	0.1 MOI	Cell survival observerd	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19498459
OV_1439	Adenovirus	ZD-55-IL-18	DNA	Adenoviridae	None	Yes	No	Virus expressing IL-18 gene	Shanghai cell collection	Human melanoma cell line	A375	NA	NA	Crystal violet staining	1 MOI	Cell survival observerd	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19498459
OV_1440	Adenovirus	ZD-55-IL-18	DNA	Adenoviridae	None	Yes	No	Virus expressing IL-18 gene	Shanghai cell collection	Human melanoma cell line	A375	NA	NA	Crystal violet staining	10 MOI	100% cell death	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19498459
OV_1441	Adenovirus	ZD-55-IL-18	DNA	Adenoviridae	None	Yes	No	Virus expressing IL-18 gene	Shanghai cell collection	Human melanoma cell line	A375	NA	NA	Crystal violet staining	100 MOI	100% cell death	No	No	NA	No response	NA	Induction of apoptosis, activation of caspase 3	NA	NA	19498459
OV_4294	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human skin malignant melanoma	A375	4000 cells per well	NA	MTT assay	10 pfu	47.3 % cell viability after 72 hours	No	No	NA	No response	NA	Activation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	NA	NA	26373347
OV_4379	Newcastle disease virus	MTH-68/H	RNA	Paramyxoviridae	None	Yes	No	No	ATCC	Human primary melanoma cell line	A375	250 cells per well	NA	Luciferase based ATP assay	0.948 MOI	50% cancer cell death	No	No	NA	No response	NA	ER stress and apoptotic pathway	IFN production increased	NA	26408702
OV_4392	Newcastle disease virus	MTH-68/H	RNA	Paramyxoviridae	None	Yes	No	No	ATCC	Human primary melanoma cell line	A375	250 cells per well	NA	Luciferase based ATP assay	4.43 MOI	80% cancer cell death	No	No	NA	No response	NA	ER stress and apoptotic pathway	IFN production increased	NA	26408702
OV_5312	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	0.1 MOI	100% cell viability on day 1	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5313	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	0.1 MOI	90% cell viability on day 2	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5314	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	0.1 MOI	87% cell viability on day 3	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5315	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	0.1 MOI	80% cell viability on day 4	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5316	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	1 MOI	90% cell viability on day 1	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5317	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	1 MOI	82% cell viability on day 2	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5318	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	1 MOI	78% cell viability on day 3	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5319	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	1 MOI	65% cell viability on day 4	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5320	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	10 MOI	82% cell viability on day 1	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5321	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	10 MOI	78% cell viability on day 2	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5322	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	10 MOI	62% cell viability on day 3	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5323	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	10 MOI	42% cell viability on day 4	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5324	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	100 MOI	70% cell viability on day 1	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5325	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	100 MOI	58% cell viability on day 2	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5326	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	100 MOI	50% cell viability on day 3	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5327	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	100 MOI	30% cell viability on day 4	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5328	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	No	Virus in combination with DTIC 200 microgram per ml	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	10 MOI	65% cell viability on day 1	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5329	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	No	Virus in combination with DTIC 200 microgram per ml	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	10 MOI	52% cell viability on day 2	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5330	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	No	Virus in combination with DTIC 200 microgram per ml	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	10 MOI	38% cell viability on day 3	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5331	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	No	Virus in combination with DTIC 200 microgram per ml	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	10 MOI	30% cell viability on day 4	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5602	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	Human melanoma cell line	A375	80% confluency	NA	MTT assay	37 pfu	50% of cancer cell death occurs	No	No	NA	No response	NA	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5821	Newcastle disease virus	NDV-PPMK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	Human melanoma cell line	A375	80% confluency	NA	NA	37 pfu	50% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	US8105578