The total number of records retrieved from this search are 100. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_133	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁶ MOI	1% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_134	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁶ MOI	1% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_135	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 2 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁶ MOI	25% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_136	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 5 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁶ MOI	16% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_137	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁵ MOI	1% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_138	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁵ MOI	5% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_139	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 2 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁵ MOI	20% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_140	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 5 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁵ MOI	32% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_141	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁴ MOI	3% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_142	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁴ MOI	10% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_143	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 2 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁴ MOI	30% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_144	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 5 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁴ MOI	32% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_145	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻³ MOI	15% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_146	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻³ MOI	10% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_147	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 2 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻³ MOI	33% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_148	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 5 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻³ MOI	51% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_149	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻² MOI	20% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_150	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻² MOI	26% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_151	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 2 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻² MOI	49% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_152	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 5 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻² MOI	98% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_153	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻¹ MOI	25% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_154	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻¹ MOI	40% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_155	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 2 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻¹ MOI	54% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_156	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 5 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻¹ MOI	58% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_157	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	1 MOI	28% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_158	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	1 MOI	45% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_159	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 2 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	1 MOI	50% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_160	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 5 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	1 MOI	58% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_161	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3 MOI	30% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_162	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3 MOI	40% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_163	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 2 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3 MOI	50% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_164	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 5 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3 MOI	70% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_165	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁷ MOI	5% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_166	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁷ MOI	10% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_167	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 3 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁷ MOI	10% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_168	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁶ MOI	9% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_169	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁶ MOI	6% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_170	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 3 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁶ MOI	3% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_171	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁵ MOI	15% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_172	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁵ MOI	10% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_173	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 3 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁵ MOI	5% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_174	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁴ MOI	40% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_175	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁴ MOI	44% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_176	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 3 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁴ MOI	43% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_177	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻³ MOI	49% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_178	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻³ MOI	46% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_179	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 3 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻³ MOI	42% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_180	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻² MOI	51% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_181	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻² MOI	52% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_182	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 3 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻² MOI	52% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_183	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻¹ MOI	51% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_184	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻¹ MOI	52% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_185	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 3 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻¹ MOI	52% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_186	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	1 MOI	51% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_187	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	1 MOI	52% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_188	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 3 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	1 MOI	52% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_189	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3 MOI	54% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_190	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3 MOI	52% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_191	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 3 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3 MOI	60% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_886	Herpes simplex virus	Mutant	DNA	Herpesviridae	Deletion mutant for Gamma 34.5	Yes	No	No	ATCC	Glioblastoma cell line	U-87 MG	3.0E+4 cells per well	NA	Trypan blue staining and hematocytometer	0.1 pfu/ml	85% cncer cell killing after 24 hours	No	No	NA	No response	NA	NA	NA	NA	12788648
OV_889	Herpes simplex virus	Mutant	DNA	Herpesviridae	Deletion mutant for Gamma 34.5	Yes	No	No	ATCC	Glioblastoma cell line	U-87 MG	3.0E+4 cells per well	NA	Trypan blue staining and hematocytometer	0.1 pfu/ml	90% cncer cell killing after 48 hours	No	No	NA	No response	NA	NA	NA	NA	12788648
OV_892	Herpes simplex virus	Mutant	DNA	Herpesviridae	Deletion mutant for Gamma 34.5	Yes	No	No	ATCC	Glioblastoma cell line	U-87 MG	3.0E+4 cells per well	NA	Trypan blue staining and hematocytometer	0.01 pfu/ml	75% cncer cell killing after 24 hours	No	No	NA	No response	NA	NA	NA	NA	12788648
OV_895	Herpes simplex virus	Mutant	DNA	Herpesviridae	Deletion mutant for Gamma 34.5	Yes	No	No	ATCC	Glioblastoma cell line	U-87 MG	3.0E+4 cells per well	NA	Trypan blue staining and hematocytometer	0.01 pfu/ml	80% cncer cell killing after 48 hours	No	No	NA	No response	NA	NA	NA	NA	12788648
OV_1170	Adenovirus	ICOVIR-5	DNA	Adenoviridae	None	No	ICOVIR-5 in combination with RAD001 drug (0.001 micromolar)	No	ATCC	Human glioblastoma cell line	U-87 MG	5.0E+3 cells per well	NA	MTT assay	0.1 MOI	85% cell survival	No	No	NA	No response	NA	NA	NA	NA	17557108
OV_1171	Adenovirus	ICOVIR-5	DNA	Adenoviridae	None	No	ICOVIR-5 in combination with RAD001 drug (0.01 micromolar)	No	ATCC	Human glioblastoma cell line	U-87 MG	5.0E+3 cells per well	NA	MTT assay	0.1 MOI	75% cell survival	No	No	NA	No response	NA	NA	NA	NA	17557108
OV_1172	Adenovirus	ICOVIR-5	DNA	Adenoviridae	None	No	ICOVIR-5 in combination with RAD001 drug (0.1 micromolar)	No	ATCC	Human glioblastoma cell line	U-87 MG	5.0E+3 cells per well	NA	MTT assay	0.1 MOI	65% cell survival	No	No	NA	No response	NA	NA	NA	NA	17557108
OV_1173	Adenovirus	ICOVIR-5	DNA	Adenoviridae	None	No	ICOVIR-5 in combination with RAD001 drug (10 micromolar)	No	ATCC	Human glioblastoma cell line	U-87 MG	5.0E+3 cells per well	NA	MTT assay	0.1 MOI	40% cell survival	No	No	NA	No response	NA	NA	NA	NA	17557108
OV_1174	Adenovirus	ICOVIR-5	DNA	Adenoviridae	None	No	ICOVIR-5 in combination with RAD001 drug (100 micromolar)	No	ATCC	Human glioblastoma cell line	U-87 MG	5.0E+3 cells per well	NA	MTT assay	0.1 MOI	100% cell death	No	No	NA	No response	NA	NA	NA	NA	17557108
OV_1175	Adenovirus	ICOVIR-5	DNA	Adenoviridae	None	No	ICOVIR-5 in combination with RAD001 drug (1000 micromolar)	No	ATCC	Human glioblastoma cell line	U-87 MG	5.0E+3 cells per well	NA	MTT assay	0.1 MOI	100% cell death	No	No	NA	No response	NA	NA	NA	NA	17557108
OV_1176	Adenovirus	ICOVIR-5	DNA	Adenoviridae	None	No	ICOVIR-5 in combination with RAD001 drug (0.001 micromolar)	No	ATCC	Human glioblastoma cell line	U-87 MG	5.0E+3 cells per well	NA	MTT assay	1 MOI	65% cell survival	No	No	NA	No response	NA	NA	NA	NA	17557108
OV_1177	Adenovirus	ICOVIR-5	DNA	Adenoviridae	None	No	ICOVIR-5 in combination with RAD001 drug (0.01 micromolar)	No	ATCC	Human glioblastoma cell line	U-87 MG	5.0E+3 cells per well	NA	MTT assay	1 MOI	55% cell survival	No	No	NA	No response	NA	NA	NA	NA	17557108
OV_1178	Adenovirus	ICOVIR-5	DNA	Adenoviridae	None	No	ICOVIR-5 in combination with RAD001 drug (0.1 micromolar)	No	ATCC	Human glioblastoma cell line	U-87 MG	5.0E+3 cells per well	NA	MTT assay	1 MOI	30% cell survival	No	No	NA	No response	NA	NA	NA	NA	17557108
OV_1179	Adenovirus	ICOVIR-5	DNA	Adenoviridae	None	No	ICOVIR-5 in combination with RAD001 drug (10 micromolar)	No	ATCC	Human glioblastoma cell line	U-87 MG	5.0E+3 cells per well	NA	MTT assay	1 MOI	10% cell survival	No	No	NA	No response	NA	NA	NA	NA	17557108
OV_1180	Adenovirus	ICOVIR-5	DNA	Adenoviridae	None	No	ICOVIR-5 in combination with RAD001 drug (100 micromolar)	No	ATCC	Human glioblastoma cell line	U-87 MG	5.0E+3 cells per well	NA	MTT assay	1 MOI	100% cell death	No	No	NA	No response	NA	NA	NA	NA	17557108
OV_1181	Adenovirus	ICOVIR-5	DNA	Adenoviridae	None	No	ICOVIR-5 in combination with RAD001 drug (1000 micromolar)	No	ATCC	Human glioblastoma cell line	U-87 MG	5.0E+3 cells per well	NA	MTT assay	1 MOI	100% cell death	No	No	NA	No response	NA	NA	NA	NA	17557108
OV_1182	Adenovirus	ICOVIR-5	DNA	Adenoviridae	None	No	ICOVIR-5 in combination with Temozolomide drug (0.01 micromolar)	No	ATCC	Human glioblastoma cell line	U-87 MG	5.0E+3 cells per well	NA	MTT assay	0.1 MOI	90% cell survival	No	No	NA	No response	NA	NA	NA	NA	17557108
OV_1183	Adenovirus	ICOVIR-5	DNA	Adenoviridae	None	No	ICOVIR-5 in combination with Temozolomide drug (0.1 micromolar)	No	ATCC	Human glioblastoma cell line	U-87 MG	5.0E+3 cells per well	NA	MTT assay	0.1 MOI	60% cell survival	No	No	NA	No response	NA	NA	NA	NA	17557108
OV_1184	Adenovirus	ICOVIR-5	DNA	Adenoviridae	None	No	ICOVIR-5 in combination with Temozolomide drug (10 micromolar)	No	ATCC	Human glioblastoma cell line	U-87 MG	5.0E+3 cells per well	NA	MTT assay	0.1 MOI	30% cell survival	No	No	NA	No response	NA	NA	NA	NA	17557108
OV_1185	Adenovirus	ICOVIR-5	DNA	Adenoviridae	None	No	ICOVIR-5 in combination with Temozolomide drug (1000 micromolar)	No	ATCC	Human glioblastoma cell line	U-87 MG	5.0E+3 cells per well	NA	MTT assay	0.1 MOI	100% cell death	No	No	NA	No response	NA	NA	NA	NA	17557108
OV_1186	Adenovirus	ICOVIR-5	DNA	Adenoviridae	None	No	ICOVIR-5 in combination with Temozolomide drug (0.01 micromolar)	No	ATCC	Human glioblastoma cell line	U-87 MG	5.0E+3 cells per well	NA	MTT assay	1 MOI	70% cell survival	No	No	NA	No response	NA	NA	NA	NA	17557108
OV_1187	Adenovirus	ICOVIR-5	DNA	Adenoviridae	None	No	ICOVIR-5 in combination with Temozolomide drug (0.1 micromolar)	No	ATCC	Human glioblastoma cell line	U-87 MG	5.0E+3 cells per well	NA	MTT assay	1 MOI	30% cell survival	No	No	NA	No response	NA	NA	NA	NA	17557108
OV_1188	Adenovirus	ICOVIR-5	DNA	Adenoviridae	None	No	ICOVIR-5 in combination with Temozolomide drug (10 micromolar)	No	ATCC	Human glioblastoma cell line	U-87 MG	5.0E+3 cells per well	NA	MTT assay	1 MOI	20% cell survival	No	No	NA	No response	NA	NA	NA	NA	17557108
OV_1189	Adenovirus	ICOVIR-5	DNA	Adenoviridae	None	No	ICOVIR-5 in combination with Temozolomide drug (1000 micromolar)	No	ATCC	Human glioblastoma cell line	U-87 MG	5.0E+3 cells per well	NA	MTT assay	1 MOI	100% cell death	No	No	NA	No response	NA	NA	NA	NA	17557108
OV_1190	Adenovirus	ICOVIR-5	DNA	Adenoviridae	None	No	ICOVIR-5 in combination with RAD001 drug (5mg/kg for 5 days)	No	ATCC	Human glioblastoma cell line	U-87 MG	NA	NA	NA	NA	NA	Athymic nude mice xenograft for U87MG cells	1.0E+7 pfu	NA	Complete reduction of tumor after 90 days in 20-40% of animals	NA	NA	NA	NA	17557108
OV_1191	Adenovirus	ICOVIR-5	DNA	Adenoviridae	None	No	ICOVIR-5 in combination with Temozolomide drug (7.5mg/kg for 5 days)	No	ATCC	Human glioblastoma cell line	U-87 MG	NA	NA	NA	NA	NA	Athymic nude mice xenograft for U87MG cells	1.0E+7 pfu	NA	Complete reduction of tumor after 90 days in 20-40% of animals	NA	NA	NA	NA	17557108
OV_1649	Herpes simplex virus	HSV-1	DNA	Herpesviridae	None	Yes	No	Virus expressing vstat120 gene	ATCC	Human glioma cell line	LN22	NA	NA	Crystal violet staining	0.05 MOI	90% cell survival after 3 days	No	No	NA	No response	NA	NA	NA	NA	19844198
OV_1650	Herpes simplex virus	HSV-1	DNA	Herpesviridae	None	Yes	No	Virus expressing vstat120 gene	ATCC	Human glioma cell line	LN22	NA	NA	Crystal violet staining	0.1 MOI	90% cell survival after 3 days	No	No	NA	No response	NA	NA	NA	NA	19844198
OV_1651	Herpes simplex virus	HSV-1	DNA	Herpesviridae	None	Yes	No	Virus expressing vstat120 gene	ATCC	Human glioma cell line	LN22	NA	NA	Crystal violet staining	0.5 MOI	30% cell survival after 3 days	No	No	NA	No response	NA	NA	NA	NA	19844198
OV_1652	Herpes simplex virus	HSV-1	DNA	Herpesviridae	None	Yes	No	Virus expressing vstat120 gene	ATCC	Human glioma cell line	LN22	NA	NA	Crystal violet staining	1 MOI	20% cell survival after 3 days	No	No	NA	No response	NA	NA	NA	NA	19844198
OV_1653	Herpes simplex virus	HSV-1	DNA	Herpesviridae	None	Yes	No	Virus expressing vstat120 gene	ATCC	Human glioma cell line	U87deltaEGFR	NA	NA	Crystal violet staining	0.05 MOI	70% cell survival after 3 days	No	No	NA	No response	NA	NA	NA	NA	19844198
OV_1654	Herpes simplex virus	HSV-1	DNA	Herpesviridae	None	Yes	No	Virus expressing vstat120 gene	ATCC	Human glioma cell line	U87deltaEGFR	NA	NA	Crystal violet staining	0.1 MOI	60% cell survival after 3 days	No	No	NA	No response	NA	NA	NA	NA	19844198
OV_1655	Herpes simplex virus	HSV-1	DNA	Herpesviridae	None	Yes	No	Virus expressing vstat120 gene	ATCC	Human glioma cell line	U87deltaEGFR	NA	NA	Crystal violet staining	0.5 MOI	10% cell survival after 3 days	No	No	NA	No response	NA	NA	NA	NA	19844198
OV_1656	Herpes simplex virus	HSV-1	DNA	Herpesviridae	None	Yes	No	Virus expressing vstat120 gene	ATCC	Human glioma cell line	U87deltaEGFR	NA	NA	Crystal violet staining	1 MOI	100% cell death after 3 days	No	No	NA	No response	NA	NA	NA	NA	19844198
OV_1657	Herpes simplex virus	HSV-1	DNA	Herpesviridae	None	Yes	No	Virus expressing vstat120 gene	ATCC	Human glioma cell line	GlideltaEGFR-H2B-RFP	NA	NA	Crystal violet staining	0.05 MOI	70% cell survival after day 3	No	No	NA	No response	NA	NA	NA	NA	19844198
OV_1658	Herpes simplex virus	HSV-1	DNA	Herpesviridae	None	Yes	No	Virus expressing vstat120 gene	ATCC	Human glioma cell line	GlideltaEGFR-H2B-RFP	NA	NA	Crystal violet staining	0.1 MOI	40% cell survival after day 3	No	No	NA	No response	NA	NA	NA	NA	19844198
OV_1659	Herpes simplex virus	HSV-1	DNA	Herpesviridae	None	Yes	No	Virus expressing vstat120 gene	ATCC	Human glioma cell line	GlideltaEGFR-H2B-RFP	NA	NA	Crystal violet staining	0.5 MOI	100% cell death after 3 days	No	No	NA	No response	NA	NA	NA	NA	19844198
OV_1660	Herpes simplex virus	HSV-1	DNA	Herpesviridae	None	Yes	No	Virus expressing vstat120 gene	ATCC	Human glioma cell line	GlideltaEGFR-H2B-RFP	NA	NA	Crystal violet staining	1 MOI	100% cell death after 3 days	No	No	NA	No response	NA	NA	NA	NA	19844198
OV_1661	Herpes simplex virus	HSV-1	DNA	Herpesviridae	None	Yes	No	Virus expressing vstat120 gene	ATCC	Human glioma cell line	U343	NA	NA	Crystal violet staining	0.05 MOI	100% cell survival after day 3	No	No	NA	No response	NA	NA	NA	NA	19844198
OV_1662	Herpes simplex virus	HSV-1	DNA	Herpesviridae	None	Yes	No	Virus expressing vstat120 gene	ATCC	Human glioma cell line	U343	NA	NA	Crystal violet staining	0.1 MOI	90% cell survival after 3 days	No	No	NA	No response	NA	NA	NA	NA	19844198
OV_1663	Herpes simplex virus	HSV-1	DNA	Herpesviridae	None	Yes	No	Virus expressing vstat120 gene	ATCC	Human glioma cell line	U343	NA	NA	Crystal violet staining	0.5 MOI	40% cell survival after day 3	No	No	NA	No response	NA	NA	NA	NA	19844198