Welcome to the Home Page of imRNA

imRNA is a web server developed for designing a single-strand RNA sequence with desired immunomodulatory potentials in order to develop RNA-based therapeutics, immunotherapy and vaccine-adjuvants. This server also facilitates the users in computer-aided designing of siRNAs with desired toxicity.
The Concept of Immunomodulation : Innate immune system of mammals (or higher eukaryotes) reconize single strand oligoribonucleotides (ORNs) as pathogenic patterns and activate cells of immune system through Pattern Recognition Receptors (PRRs). These ORNs are mainly recognized via the Toll-like Receptor 7 (TLR 7) that induces cytokine production.

References:

Chaudhary K., Nagpal G., Dhanda S.K. and Raghava, G.P. (2016) Prediction of Immunomodulatory potential of an RNA sequence for designing non-toxic siRNAs and RNA-based vaccine adjuvants. Scientific Reports 6, 20678
Nagpal G, Chaudhary K, Dhanda SK, Raghava GPS. (2017) Computational Prediction of the Immunomodulatory Potential of RNA Sequences. Methods Mol Biol. 1632:75-90.