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Details of CPPsite entry with Sequence RQIKIWFQNRRMKWKK
Primary information
PEPTIDE SEQUENCERQIKIWFQNRRMKWKK
CPPsite ID 2096, 2126, 2161, 2174, 2222, 2250, 2294, 2295, 2312, 2319, 2323, 2450, 2495, 2564, 2660, 2757, 2772, 2831, 2842, 2899, 2955, 3007, 1087, 1090, 1095, 1133, 1202, 1415, 1448, 1466, 1467, 1468, 1479, 1485, 1490, 1497, 1518, 1643, 1754, 1755, 1803, 1820, 1821,
PEPTIDE NAMEPen-GFP, L-Penetratin, Penetratin, pAntp, EGFP-Antp, Antp-PCP, F(SG)4Pen, G(SG)4Pen, Penetratin, Penetratin, Penetratin (Antennapedia), Penetratin, pAntp, Antp-EGFP, Penetratin, penetratin, Penetratin, Penetratin, Biotinyl-penetratin, L-Penetratin, Antp, Pen, XV, pAntpHD (43-58), pAntp (43-58), Penetratin (pAntp) (43-58), Penetratin (pAntp), Penetratin {pAntp-(43-58)}, Penetratin (pAntp) (43-58), Penetratin {pAntp-(43-58)}, Penetratin {pAntp-(43-58)}, Penetratin {pAntp-(43-58)}, Penetratin {pAnt
CHIRALITYL, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L, L
LINEAR/CYCLICLinear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear
SOURCEProtein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Synthetic, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Protein derived, Synthetic, Synthetic, Protein derived, Protein derived, Protein derived
CATEGORYAmphipathic, Amphipathic, Cationic and amphipathic, Cationic and amphipathic, Cationic and amphipathic, Cationic and amphipathic, Cationic and amphipathic, Cationic and amphipathic, Cationic and amphipathic, Cationic and amphipathic, Cationic, Cationic and amphipathic, Cationic and amphipathic, Cationic and amphipathic, Cationic and amphipathic, Cationic and amphipathic, Cationic and amphipathic, Cationic and amphipathic, NA, Cationic and amphipathic, Cationic and amphipathic, Cationic and mphipathic, Amphipathic, Amphipathic, Probably Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic, Unknown, Unknown, Unknown, Amphipathic, Amphipathic, Amphipathic
SUB CELLULAR LOCALIZATIONNA, NA, NA, Vesicles, NA, Cytoplasm and Nucleus, NA, NA, NA, Cytoplasm, Nucleus, NA, NA, NA, Cytoplasm, NA, NA, NA, NA, NA, NA, NA, Cytoplasm and nucleus, Cytoplasm and nucleus, Cytosol and nucleus, nucleoi, Uneven distribution of peptide with accumulation in centrosmal area and in, Vesicles, Unknown, Unknown, Surface of the plasma membrane and intracellular vesicles, Punctuated cytoplasmic (vesicles) as well as extracellular staining, Punctuated cytoplasmic pattern (vesicles), Unknown, Endocytic vesicles, Cytoplasm and nucleus, Unknown, Cytoplasm and nucleus, Cytoplasm and nucleus, Unknown, Unknown, Unknown, Vesicles, Cytoplasm
N-TERMINAL MODIFICATIONFree, Free, Free, Conjugation with fluorescein, Conjugated with EGFP, Acetylation, Acetylation, Acetylation, Free, Biotinylation, Free, Free, Conjugation with fluorescein, Conjugation with EGFP, NA, NA, Free, Free, Free, Free, Conjugation with 5(6)-Carboxyfluorescein, NA, Conjugation with fluorescein, Biotinylation, Biotinylation (Labeled with Biotinyl-beta-Alanine), Conjugation with fluorescein, Conjugation with K-FITC, Conjugation with fluorescein, Conjugation with fluorescein, Conjugation with fluorescein, Conjugation with fluorescein, Conjugation with fluorescein, Conjugation with fluorescein, Conjugation with NBD and TAMRA, Biotinylation, Free, Conjugation with hca (4-(7-hydroxycoumaryl)-acetyl), Free, Maleimide addition, Free, Conjugation with rhodamine B, Conjugation with fluorescein, Conjugation with fluorescein
C-TERMINAL MODIFICATIONFree, Free, Free, Amidation, Free, Amidation, Amidation, Amidation, Free, Amidation, Free, Free, Amidation, Free, NA, NA, Free, Amidation, Amidation, Free, Free, Amidation, Amidation, Amidation, Amidation, Amidation, Free, Amidation, Amidation, Amidation, Amidation, Amidation, Amidation, Free, Amidation, Conjugation with GFP, Amidation, Conjugation with nanoparticle, Amidation, Amidation, Free, Amidation, Amidation
CHEMICAL MODIFICATIONNA, NA, NA, NA, NA, ?, L-2-naphthylalanine,miniPEG, 8-amino-3,6-dioxaoctanoic acid, NA, NA, NA, NA, NA, NA, NA, NA, NA, PEGylation, NA, NA, Biotinylation, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA
UPTAKE EFFICIENCYAble to penetrate PC-3 cells at 5 mM concentration, Less permeability than PenetraMax, Higher than control, NA, NA, Lower efficiency, Higher uptake efficiency for BSA, Higher uptake efficiency for BSA, Lower uptake efficiency, Higher than R9, Tat and R6L3, NA, Higher degradation rate, Lower uptake efficiency, NA, NA, In MDCKMDR cell model, penetratin-NP presented enhanced cel- lular accumulation, NA, NA, NA, NA, Low, NA, Unknown, High, High, Unknown, Lower than CyLoP1, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Higher than Tat, Unknown, Unknown, Unknown, Unknown, Less than polyarginine but greater tha Tat and tra, Unknown, Unknown
PROPOSED UPTAKE MECHANISMEndocytic pathway, NA, NA, Non-endocytosis, NA, Endocytic pathway, Endocytic pathway, Endocytic pathway, NA, Selectively driven by the presence of GAGs and is likely distinct from macropinocytosis and general endocytosis, NA, Energy-independent pathway, Non endocytosis pathway, NA, Endocytosis, lipid raft-mediated Endocytosis and direct translocation processes, NA, Direct Translocation, Direct Translocation, NA, NA, Endocytosis, Non-endocytic pathway, Non-receptor mdiated endocytic pathway, Non-endocytic pathway, Endocytic pathway, Probably endocytic process, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Adsorptive-mediated endocytic process, Non-endocytic pathway, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown
INVITRO/INVIVOIn vitro, In vivo, In vivo, In vivo, In vitro, In vitro, In vitro, In vitro, In vitro and in vivo, In vitro, In vitro, In vitro, In vitro, In vitro and in vivo, In vitro, In vitro and in vivo, In vivo, In vitro, In vitro, In vivo, In vivo, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro
CELL LINEPC-3 cells, NA, NA, RBL-2H3 cells, CHO-K1, Mouse macrophage-like cell line J774 A.2, HEK293, HeLa, MCF-7, NIH 3T3, A549, Jurkat, H1650, and H1299 cells, HeLa, KG1a cells, HeLa, KG1a cells, CT26 mouse colon cancer cells, HeLa and Hep3B cells, CHO-K1 (WT) and xylose transferase- or GAG-deficient CHO-pgsA745 cells (GAGneg), HeLa, COS-7, NIH-3T3, Jurkat, NB-4, Kasumi-1, Leishmania tarentolae cell line, None, Rat basophilic leukemia RBL-2H3 cells and CHO-K1, The mouse macrophage J774 A.1 cells, HEK293T cells, MDCK-MDR cells, NA, Swiss 3T3 cells and bovine spermatozoa, Swiss 3T3 cells and bovine spermatozoa, NA, NA, HeLa cells, Aortic endothelial cells, Cortical striatal cells, HaCat/ A549 cells, PC-12 and V79 cells, NIH-3T3, HeLa, HeLa, CHO K1, MDCK cells, Calu-3 cells, TR146 cells, Human SH-SY5Y, N2A and Human bowes melanoma cells, K562 cells, Human bowes melanoma cells, Drosophila S2 cells, NIH-3T3, HeLa, 9 L/LacZ cells, 9 L/LacZ cells, CHO K1, HeLa, A549 cells, HeLa, MC57
In VIVO MODELNA, Male Sprague Dawley rats, Seven weeks old male ddY mice, male Sprague Dawley rats, NA, NA, NA, NA, NA, Male Balb/c mice, NA, NA, Male ddY mice, NA, Zebrafish, NA, Adult male nude mice, ICR mice and Sprague-Dawley rats, C57BL/6 male mice, NA, NA, Male ddY mice, Adult zebrafish, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA
CARGOProtein (eGFP), Protein (Insulin), Protein (Insulin), Fluorophore (Fluorescein), Protein (eGFP), Peptide [PCP, miniPEG-DE(pCAP)LI-NH2], Fluorophore (Alexa488), Protein (bovine serum albumin) and Nanoparticle (quantum dots), Fluorophore (Alexa488), Protein (bovine serum albumin) and Nanoparticle (quantum dots), Peptide (Mitochondrial Target Domain of NOXA), Biotin-gly4, Protein (ATTO488-BSA, ?-galactosidase), Protein (Insulin), Fluorophore (Fluorescein), Protein (eGFP), Nucleic acid (Plasmid DNA), Nanoparticle (PEG-PLA), Protein (Single-Chain Antibody), Fluorophore (TAMRA), Fluorophore (TAMRA), Protein (Insulin), Fluorophore (5-Carboxyfluorescein), Nucleic acid (SCO), Fluorophore (fluorescein), Biotin, Biotin, Fluorophore (fluorescein), Fluorophore (FITC), Fluorophore (fluorescein), Fluorophore (fluorescein), Fluorophore (fluorescein), Fluorophore (fluorescein), Fluorophore (fluorescein), Fluorophore (fluorescein), Fluorophore (NBD and TAMRA), Biotin, Protein (GFP), Fluorophore [hca (4-(7-hydroxycoumaryl)-acetyl)], Nanoparticle, Nucleic acid (siRNA), Nucleic acid (siRNA), Fluorophore (rhodamine), Fluorophore (fluorescein), Fluorophore (fluorescein)
PMID23521800, 24060698, 24973720, 25016968, 24746937, 24896852, 25108152, 25108152, 24416126, 25112713, 24275947, 24973720, 25016968, 24746937, 22281502, 22841849, 23160949, 23585561, 23585561, 25445695, 25894337, 10323198, 8663410, 10784032, 12849987, 21319732, 19858187, 17622242, 15290867, 15290867, 15290867, 12783857, 11716681, 11211880, 19552459, 15937518, 21867915, 21867915
PATENTUnknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, US 2014/0140929 A1, Unknown, Unknown, US 7153931, US 7153931, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, US 20100203611, US 20060035815, US 20060035815, Un
Tertiary Structure
(Technique)		2096 (Experimentally determined structure from PDB), 2126 (Experimentally determined structure from PDB), 2161 (Experimentally determined structure from PDB), 2174 (Experimentally determined structure from PDB), 2222 (Experimentally determined structure from PDB), 2250 (Experimentally determined structure from PDB), 2294 (Experimentally determined structure from PDB), 2295 (Experimentally determined structure from PDB), 2312 (Experimentally determined structure from PDB), 2319 (Experimentally determined structure from PDB), 2323 (Experimentally determined structure from PDB), 2450 (Experimentally determined structure from PDB), 2495 (Experimentally determined structure from PDB), 2564 (Experimentally determined structure from PDB), 2660 (Experimentally determined structure from PDB), 2757 (Experimentally determined structure from PDB), 2772 (Experimentally determined structure from PDB), 2831 (Experimentally determined structure from PDB), 2842 (Experimentally determined structure from PDB), 2899 (PEPstrMOD), 2955 (Experimentally determined structure from PDB), 3007 (Experimentally determined structure from PDB), 1087 (Experimentally determined structure from PDB), 1090 (Experimentally determined structure from PDB), 1095 (Experimentally determined structure from PDB), 1133 (Experimentally determined structure from PDB), 1202 (Experimentally determined structure from PDB), 1415 (Experimentally determined structure from PDB), 1448 (Experimentally determined structure from PDB), 1466 (Experimentally determined structure from PDB), 1467 (Experimentally determined structure from PDB), 1468 (Experimentally determined structure from PDB), 1479 (Experimentally determined structure from PDB), 1485 (Experimentally determined structure from PDB), 1490 (Experimentally determined structure from PDB), 1497 (Experimentally determined structure from PDB), 1518 (Experimentally determined structure from PDB), 1643 (Experimentally determined structure from PDB), 1754 (Experimentally determined structure from PDB), 1755 (Experimentally determined structure from PDB), 1803 (Experimentally determined structure from PDB), 1820 (Experimentally determined structure from PDB), 1821 (Experimentally determined structure from PDB),