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This page gives details of CPPsite entry with ID 2250 |
| Primary information | |
|---|---|
| CPPsite ID | 2250 |
| PEPTIDE SEQUENCE | RQIKIWFQNRRMKWKK |
| PEPTIDE NAME | Antp-PCP |
| CHIRALITY | L |
| LINEAR/CYCLIC | Linear |
| SOURCE | Protein derived |
| CATEGORY | Cationic and amphipathic |
| SUB CELLULAR LOCALIZATION | Cytoplasm and Nucleus |
| N-TERMINAL MODIFICATION | Acetylation |
| C-TERMINAL MODIFICATION | Amidation |
| CHEMICAL MODIFICATION | Φ, L-2-naphthylalanine,miniPEG, 8-amino-3,6-dioxaoctanoic acid |
| UPTAKE EFFICIENCY | Lower efficiency |
| PROPOSED UPTAKE MECHANISM | Endocytic pathway |
| INVITRO/INVIVO | In vitro |
| CELL LINE | HEK293, HeLa, MCF-7, NIH 3T3, A549, Jurkat, H1650, and H1299 cells |
| CARGO | Peptide [PCP, miniPEG-DE(pCAP)LI-NH2] |
| PMID | 24896852 |
| PATENT | Unknown |
| LENGTH | 16 |
| Secondary Structure | CCCSSHHHHHHSSSCC |
| SMILES | [NH3][C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CCCC[NH3])CCCC[NH3])Cc1c[nH]c2c1cccc2)CCCC[NH3])CCSC)CCCNC(=[NH2])N)CCCNC(=[NH2])N)CC(=O)N)CCC(=O)N)Cc1ccccc1)Cc1c[nH]c2c1cccc2)[C@H](CC)C)CCCC[NH3])[C@H](CC)C)CCC(=O)N)CCCNC(=[NH2])N |
| Tertiary Structure (Technique) | View in Jmol OR Download Structure (Experimentally determined structure from PDB) |