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This page gives details of CPPsite entry with ID 2757
Primary information
CPPsite ID2757
PEPTIDE SEQUENCERQIKIWFQNRRMKWKK
PEPTIDE NAMEpenetratin
CHIRALITYL
LINEAR/CYCLICLinear
SOURCEProtein derived
CATEGORYCationic and amphipathic
CHEMICAL MODIFICATIONPEGylation
UPTAKE EFFICIENCYIn MDCKMDR cell model, penetratin-NP presented enhanced cel- lular accumulation
PROPOSED UPTAKE MECHANISMlipid raft-mediated Endocytosis and direct translocation processes
INVITRO/INVIVOIn vitro and in vivo
CELL LINEMDCK-MDR cells
In VIVO MODELAdult male nude mice, ICR mice and Sprague-Dawley rats
CARGONanoparticle (PEG-PLA)
PMID22841849
PATENTUnknown
LENGTH16
Secondary StructureCCCSSHHHHHHSSSCC
SMILES[NH3][C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CCCC[NH3])CCCC[NH3])Cc1c[nH]c2c1cccc2)CCCC[NH3])CCSC)CCCNC(=[NH2])N)CCCNC(=[NH2])N)CC(=O)N)CCC(=O)N)Cc1ccccc1)Cc1c[nH]c2c1cccc2)[C@H](CC)C)CCCC[NH3])[C@H](CC)C)CCC(=O)N)CCCNC(=[NH2])N
Tertiary Structure
(Technique)		View in Jmol  OR Download Structure
  (Experimentally determined structure from PDB)