Welcome to Entry Card of Peptide


This page gives details of CPPsite entry with ID 2319
Primary information
CPPsite ID2319
PEPTIDE SEQUENCERQIKIWFQNRRMKWKK
PEPTIDE NAMEPenetratin
CHIRALITYL
LINEAR/CYCLICLinear
SOURCEProtein derived
CATEGORYCationic and amphipathic
SUB CELLULAR LOCALIZATIONCytoplasm
N-TERMINAL MODIFICATIONBiotinylation
C-TERMINAL MODIFICATIONAmidation
UPTAKE EFFICIENCYHigher than R9, Tat and R6L3
PROPOSED UPTAKE MECHANISMSelectively driven by the presence of GAGs and is likely distinct from macropinocytosis and general endocytosis
INVITRO/INVIVOIn vitro
CELL LINECHO-K1 (WT) and xylose transferase- or GAG-deficient CHO-pgsA745 cells (GAGneg)
CARGOBiotin-gly4
PMID25112713
PATENTUnknown
LENGTH16
Secondary StructureCCCSSHHHHHHSSSCC
SMILES[NH3][C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CCCC[NH3])CCCC[NH3])Cc1c[nH]c2c1cccc2)CCCC[NH3])CCSC)CCCNC(=[NH2])N)CCCNC(=[NH2])N)CC(=O)N)CCC(=O)N)Cc1ccccc1)Cc1c[nH]c2c1cccc2)[C@H](CC)C)CCCC[NH3])[C@H](CC)C)CCC(=O)N)CCCNC(=[NH2])N
Tertiary Structure
(Technique)		View in Jmol  OR Download Structure
  (Experimentally determined structure from PDB)