Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
MLL3	GTRKQNSGS	OVARY	2797	p.K2797fs	c.8389_8390delAA	Frame_Shift_Del	4	1.11	IGROV1	N	0	0	0	Y
MLL3	GTRKQNSGS	STOMACH	2797	p.K2797fs	c.8389_8390delAA	Frame_Shift_Del	4	1.11	SNU1	N	0	0	0	Y
MLL3	GTRKQNSGS	LARGE_INTESTINE	2797	p.K2797fs	c.8389_8390delAA	Frame_Shift_Del	4	1.11	SNUC4	N	0	0	0	Y
MLL3	KGTRKQNSG	OVARY	2796	p.K2797fs	c.8389_8390delAA	Frame_Shift_Del	5	1.11	IGROV1	N	0	0	0	N
MLL3	KGTRKQNSG	STOMACH	2796	p.K2797fs	c.8389_8390delAA	Frame_Shift_Del	5	1.11	SNU1	N	0	0	0	N
MLL3	KGTRKQNSG	LARGE_INTESTINE	2796	p.K2797fs	c.8389_8390delAA	Frame_Shift_Del	5	1.11	SNUC4	N	0	0	0	N
MLL3	KKGTRKQNS	OVARY	2795	p.K2797fs	c.8389_8390delAA	Frame_Shift_Del	4	1.11	IGROV1	N	1	0	0	N
MLL3	KKGTRKQNS	STOMACH	2795	p.K2797fs	c.8389_8390delAA	Frame_Shift_Del	4	1.11	SNU1	N	1	0	0	N
MLL3	KKGTRKQNS	LARGE_INTESTINE	2795	p.K2797fs	c.8389_8390delAA	Frame_Shift_Del	4	1.11	SNUC4	N	1	0	0	N
MLL3	TRKQNSGSL	OVARY	2798	p.K2797fs	c.8389_8390delAA	Frame_Shift_Del	4	1.11	IGROV1	N	5	0	0	Y
MLL3	TRKQNSGSL	STOMACH	2798	p.K2797fs	c.8389_8390delAA	Frame_Shift_Del	4	1.11	SNU1	N	5	0	0	Y
MLL3	TRKQNSGSL	LARGE_INTESTINE	2798	p.K2797fs	c.8389_8390delAA	Frame_Shift_Del	4	1.11	SNUC4	N	5	0	0	Y
MLL3	CVSVEPKKR	URINARY_TRACT	2789	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	1	2.1	639V	N	4	0	0	N
MLL3	CVSVEPKKR	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	2789	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	1	2.1	CMLT1	N	4	0	0	N
MLL3	CVSVEPKKR	LUNG	2789	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	1	2.1	DV90	N	4	0	0	N
MLL3	CVSVEPKKR	LARGE_INTESTINE	2789	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	1	2.1	GP2D	N	4	0	0	N
MLL3	CVSVEPKKR	LARGE_INTESTINE	2789	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	1	2.1	HCT116	N	4	0	0	N
MLL3	CVSVEPKKR	ENDOMETRIUM	2789	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	1	2.1	HEC108	N	4	0	0	N
MLL3	CVSVEPKKR	ENDOMETRIUM	2789	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	1	2.1	HEC151	N	4	0	0	N
MLL3	CVSVEPKKR	ENDOMETRIUM	2789	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	1	2.1	HEC59	N	4	0	0	N
MLL3	CVSVEPKKR	LARGE_INTESTINE	2789	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	1	2.1	LOVO	N	4	0	0	N
MLL3	CVSVEPKKR	LARGE_INTESTINE	2789	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	1	2.1	LS411N	N	4	0	0	N
MLL3	CVSVEPKKR	ENDOMETRIUM	2789	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	1	2.1	MFE296	N	4	0	0	N
MLL3	CVSVEPKKR	ENDOMETRIUM	2789	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	1	2.1	MFE319	N	4	0	0	N
MLL3	CVSVEPKKR	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	2789	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	1	2.1	NALM6	N	4	0	0	N
MLL3	CVSVEPKKR	LUNG	2789	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	1	2.1	NCIH1048	N	4	0	0	N
MLL3	CVSVEPKKR	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	2789	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	1	2.1	REH	N	4	0	0	N
MLL3	CVSVEPKKR	PANCREAS	2789	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	1	2.1	SNU324	N	4	0	0	N
MLL3	CVSVEPKKR	LARGE_INTESTINE	2789	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	1	2.1	SNU407	N	4	0	0	N
MLL3	CVSVEPKKR	STOMACH	2789	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	1	2.1	SNU520	N	4	0	0	N
MLL3	CVSVEPKKR	LARGE_INTESTINE	2789	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	1	2.1	SW48	N	4	0	0	N
MLL3	EPKKRNKKT	URINARY_TRACT	2793	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	5	2.1	639V	N	6	0	0	N
MLL3	EPKKRNKKT	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	2793	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	5	2.1	CMLT1	N	6	0	0	N
MLL3	EPKKRNKKT	LUNG	2793	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	5	2.1	DV90	N	6	0	0	N
MLL3	EPKKRNKKT	LARGE_INTESTINE	2793	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	5	2.1	GP2D	N	6	0	0	N
MLL3	EPKKRNKKT	LARGE_INTESTINE	2793	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	5	2.1	HCT116	N	6	0	0	N
MLL3	EPKKRNKKT	ENDOMETRIUM	2793	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	5	2.1	HEC108	N	6	0	0	N
MLL3	EPKKRNKKT	ENDOMETRIUM	2793	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	5	2.1	HEC151	N	6	0	0	N
MLL3	EPKKRNKKT	ENDOMETRIUM	2793	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	5	2.1	HEC59	N	6	0	0	N
MLL3	EPKKRNKKT	LARGE_INTESTINE	2793	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	5	2.1	LOVO	N	6	0	0	N
MLL3	EPKKRNKKT	LARGE_INTESTINE	2793	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	5	2.1	LS411N	N	6	0	0	N
MLL3	EPKKRNKKT	ENDOMETRIUM	2793	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	5	2.1	MFE296	N	6	0	0	N
MLL3	EPKKRNKKT	ENDOMETRIUM	2793	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	5	2.1	MFE319	N	6	0	0	N
MLL3	EPKKRNKKT	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	2793	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	5	2.1	NALM6	N	6	0	0	N
MLL3	EPKKRNKKT	LUNG	2793	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	5	2.1	NCIH1048	N	6	0	0	N
MLL3	EPKKRNKKT	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	2793	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	5	2.1	REH	N	6	0	0	N
MLL3	EPKKRNKKT	PANCREAS	2793	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	5	2.1	SNU324	N	6	0	0	N
MLL3	EPKKRNKKT	LARGE_INTESTINE	2793	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	5	2.1	SNU407	N	6	0	0	N
MLL3	EPKKRNKKT	STOMACH	2793	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	5	2.1	SNU520	N	6	0	0	N
MLL3	EPKKRNKKT	LARGE_INTESTINE	2793	p.K2797fs	c.8390_8390delA	Frame_Shift_Del	5	2.1	SW48	N	6	0	0	N