Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
ABL1	EELRVLGYN	OESOPHAGUS	105	p.K106E	c.316A>G	Missense_Mutation	1	0.11	KYSE410	N	5	0	0	N
ABL1	ELRVLGYNH	OESOPHAGUS	106	p.K106E	c.316A>G	Missense_Mutation	1	0.11	KYSE410	N	0	0	0	N
ABL1	GEELRVLGY	OESOPHAGUS	104	p.K106E	c.316A>G	Missense_Mutation	1	0.11	KYSE410	Y	6	13	0	N
ABL1	ITKGEELRV	OESOPHAGUS	101	p.K106E	c.316A>G	Missense_Mutation	1	0.11	KYSE410	N	2	0	0	N
ABL1	KGEELRVLG	OESOPHAGUS	103	p.K106E	c.316A>G	Missense_Mutation	1	0.11	KYSE410	N	0	0	0	N
ABL1	LSITKGEEL	OESOPHAGUS	99	p.K106E	c.316A>G	Missense_Mutation	1	0.11	KYSE410	N	14	0	2	N
ABL1	SITKGEELR	OESOPHAGUS	100	p.K106E	c.316A>G	Missense_Mutation	1	0.11	KYSE410	N	4	0	0	N
ABL1	TKGEELRVL	OESOPHAGUS	102	p.K106E	c.316A>G	Missense_Mutation	1	0.11	KYSE410	N	3	0	0	N
ABL1	TLSITKGEE	OESOPHAGUS	98	p.K106E	c.316A>G	Missense_Mutation	1	0.11	KYSE410	N	0	0	0	N
AKAP12	AVEECKEEE	OESOPHAGUS	261	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	OE19	N	0	0	0	N
AKAP12	CKEEEEKQE	OESOPHAGUS	265	p.G269del	c.804_806delAGG	In_Frame_Del	3	0.88	OE19	N	0	0	0	Y
AKAP12	ECKEEEEKQ	OESOPHAGUS	264	p.G269del	c.804_806delAGG	In_Frame_Del	3	0.88	OE19	N	0	0	0	N
AKAP12	EECKEEEEK	OESOPHAGUS	263	p.G269del	c.804_806delAGG	In_Frame_Del	2	0.88	OE19	N	0	0	0	N
AKAP12	EEEEKQEKE	OESOPHAGUS	267	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	OE19	N	0	0	0	N
AKAP12	EEEKQEKEP	OESOPHAGUS	268	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	OE19	N	0	0	0	N
AKAP12	KEEEEKQEK	OESOPHAGUS	266	p.G269del	c.804_806delAGG	In_Frame_Del	2	0.88	OE19	N	3	0	0	N
AKAP12	VEECKEEEE	OESOPHAGUS	262	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	OE19	N	0	0	0	N
AKAP12	AIEEDLEPE	OESOPHAGUS	1529	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	3	80.86	COLO680N	N	0	0	0	N
AKAP12	AIEEDLEPE	OESOPHAGUS	1529	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	3	80.86	KYSE140	N	0	0	0	N
AKAP12	AIEEDLEPE	OESOPHAGUS	1529	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	3	80.86	KYSE180	N	0	0	0	N
AKAP12	AIEEDLEPE	OESOPHAGUS	1529	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	3	80.86	KYSE270	N	0	0	0	N
AKAP12	AIEEDLEPE	OESOPHAGUS	1529	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	3	80.86	KYSE30	N	0	0	0	N
AKAP12	AIEEDLEPE	OESOPHAGUS	1529	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	3	80.86	KYSE410	N	0	0	0	N
AKAP12	AIEEDLEPE	OESOPHAGUS	1529	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	3	80.86	KYSE450	N	0	0	0	N
AKAP12	AIEEDLEPE	OESOPHAGUS	1529	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	3	80.86	KYSE520	N	0	0	0	N
AKAP12	AIEEDLEPE	OESOPHAGUS	1529	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	3	80.86	KYSE70	N	0	0	0	N
AKAP12	AIEEDLEPE	OESOPHAGUS	1529	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	3	80.86	OE19	N	0	0	0	N
AKAP12	AIEEDLEPE	OESOPHAGUS	1529	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	3	80.86	OE21	N	0	0	0	N
AKAP12	AIEEDLEPE	OESOPHAGUS	1529	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	3	80.86	TE10	N	0	0	0	N
AKAP12	AIEEDLEPE	OESOPHAGUS	1529	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	3	80.86	TE11	N	0	0	0	N
AKAP12	AIEEDLEPE	OESOPHAGUS	1529	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	3	80.86	TE14	N	0	0	0	N
AKAP12	AIEEDLEPE	OESOPHAGUS	1529	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	3	80.86	TE1	N	0	0	0	N
AKAP12	AIEEDLEPE	OESOPHAGUS	1529	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	3	80.86	TE5	N	0	0	0	N
AKAP12	AIEEDLEPE	OESOPHAGUS	1529	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	3	80.86	TE6	N	0	0	0	N
AKAP12	AIEEDLEPE	OESOPHAGUS	1529	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	3	80.86	TE8	N	0	0	0	N
AKAP12	EEDLEPENG	OESOPHAGUS	1531	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	1	80.86	COLO680N	N	0	0	0	N
AKAP12	EEDLEPENG	OESOPHAGUS	1531	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	1	80.86	KYSE140	N	0	0	0	N
AKAP12	EEDLEPENG	OESOPHAGUS	1531	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	1	80.86	KYSE180	N	0	0	0	N
AKAP12	EEDLEPENG	OESOPHAGUS	1531	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	1	80.86	KYSE270	N	0	0	0	N
AKAP12	EEDLEPENG	OESOPHAGUS	1531	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	1	80.86	KYSE30	N	0	0	0	N
AKAP12	EEDLEPENG	OESOPHAGUS	1531	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	1	80.86	KYSE410	N	0	0	0	N
AKAP12	EEDLEPENG	OESOPHAGUS	1531	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	1	80.86	KYSE450	N	0	0	0	N
AKAP12	EEDLEPENG	OESOPHAGUS	1531	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	1	80.86	KYSE520	N	0	0	0	N
AKAP12	EEDLEPENG	OESOPHAGUS	1531	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	1	80.86	KYSE70	N	0	0	0	N
AKAP12	EEDLEPENG	OESOPHAGUS	1531	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	1	80.86	OE19	N	0	0	0	N
AKAP12	EEDLEPENG	OESOPHAGUS	1531	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	1	80.86	OE21	N	0	0	0	N
AKAP12	EEDLEPENG	OESOPHAGUS	1531	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	1	80.86	TE10	N	0	0	0	N
AKAP12	EEDLEPENG	OESOPHAGUS	1531	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	1	80.86	TE11	N	0	0	0	N
AKAP12	EEDLEPENG	OESOPHAGUS	1531	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	1	80.86	TE14	N	0	0	0	N
AKAP12	EEDLEPENG	OESOPHAGUS	1531	p.1531_1532insE	c.4590_4591insGAG	In_Frame_Ins	1	80.86	TE1	N	0	0	0	N