Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005219                                                              20     299
NP_001186704                                                           18    1135
NP_001295                                                              18    1135
NP_001120652" target = "next">NP_001120652                                                           18    1482
NP_000251                                                              18    1482
XP_006718624                                                           18    1482
XP_005274069                                                           18    1482
XP_006718623                                                           18    1482
XP_006718622                                                           18    1482
XP_006718621                                                           18    1482
XP_005248564                                                           17    2528
NP_005900                                                              17    2528
NP_001120                                                              17    3301
NP_776256                                                              17    4312
NP_001032900                                                           16    5631
NP_569118                                                              16    5631
NP_932065                                                              16    5631
NP_932064                                                              16    5631
NP_004484                                                              16    5631
XP_005254562                                                           16    5631
XP_006720650                                                           16    5631
XP_005254559                                                           16    5631
XP_006720649                                                           16    5631
XP_005254557                                                           16    5631
NP_001460                                                              16    7355
NP_001275905                                                           16    7355
NP_001275907                                                           16    7355
NP_004590                                                              16    7355
NP_001180380                                                           16    7355
XP_006724373                                                           16    7355
XP_005253558                                                           16    7355
XP_005253557                                                           16    7355
XP_006719219                                                           16    7355
XP_005253556                                                           16    7355
XP_005253555                                                           16    7355
NP_631899                                                              16    7355
NP_001070710                                                           16    7355
NP_003550                                                              15    9605
NP_005019                                                              15    9605
XP_006725428                                                           15    9605
XP_006725427                                                           15    9605
XP_006725426                                                           15    9605
XP_006722195                                                           15    9605
XP_006722194                                                           15    9605
XP_006722193                                                           15    9605
XP_006717513                                                           15    9605
>NP_005219
          Length = 1210

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YVMAIVDNP 9
           YVMA VDNP
Sbjct: 764 YVMASVDNP 772
>NP_001186704
          Length = 1133

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   YVMAIVDNP 9
           YVM I DNP
Sbjct: 292 YVMEISDNP 300
>NP_001295
          Length = 1380

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   YVMAIVDNP 9
           YVM I DNP
Sbjct: 539 YVMEISDNP 547
>NP_001120652" target = "next">NP_001120652
          Length = 2175

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YVMAIVDNP 9
            YV+A+ DNP
Sbjct: 1569 YVVALQDNP 1577
>NP_000251
          Length = 2215

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YVMAIVDNP 9
            YV+A+ DNP
Sbjct: 1607 YVVALQDNP 1615
>XP_006718624
          Length = 2177

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YVMAIVDNP 9
            YV+A+ DNP
Sbjct: 1569 YVVALQDNP 1577
>XP_005274069
          Length = 2176

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YVMAIVDNP 9
            YV+A+ DNP
Sbjct: 1569 YVVALQDNP 1577
>XP_006718623
          Length = 2189

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YVMAIVDNP 9
            YV+A+ DNP
Sbjct: 1569 YVVALQDNP 1577
>XP_006718622
          Length = 2190

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YVMAIVDNP 9
            YV+A+ DNP
Sbjct: 1569 YVVALQDNP 1577
>XP_006718621
          Length = 2225

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YVMAIVDNP 9
            YV+A+ DNP
Sbjct: 1605 YVVALQDNP 1613
>XP_005248564
          Length = 2342

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   YVMAIVD 7
           YVMA+VD
Sbjct: 918 YVMAVVD 924
>NP_005900
          Length = 2468

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    YVMAIVD 7
            YVMA+VD
Sbjct: 1044 YVMAVVD 1050
>NP_001120
          Length = 1158

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   YVMAIVDNP 9
           Y M I DNP
Sbjct: 600 YAMEISDNP 608
>NP_776256
          Length = 301

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MAIVDNP 9
           MA++DNP
Sbjct: 256 MALLDNP 262
>NP_001032900
          Length = 252

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VMAIVDNP 9
           V AI++NP
Sbjct: 228 VQAIIENP 235
>NP_569118
          Length = 882

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YVMAIVDN 8
           YV+ ++DN
Sbjct: 681 YVVVVIDN 688
>NP_932065
          Length = 847

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YVMAIVDN 8
           YV+ ++DN
Sbjct: 697 YVVVVIDN 704
>NP_932064
          Length = 898

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YVMAIVDN 8
           YV+ ++DN
Sbjct: 697 YVVVVIDN 704
>NP_004484
          Length = 261

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VMAIVDNP 9
           V AI++NP
Sbjct: 237 VQAIIENP 244
>XP_005254562
          Length = 479

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YVMAIVDN 8
           YV+ ++DN
Sbjct: 278 YVVVVIDN 285
>XP_006720650
          Length = 729

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YVMAIVDN 8
           YV+ ++DN
Sbjct: 697 YVVVVIDN 704
>XP_005254559
          Length = 829

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YVMAIVDN 8
           YV+ ++DN
Sbjct: 697 YVVVVIDN 704
>XP_006720649
          Length = 855

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YVMAIVDN 8
           YV+ ++DN
Sbjct: 654 YVVVVIDN 661
>XP_005254557
          Length = 898

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YVMAIVDN 8
           YV+ ++DN
Sbjct: 697 YVVVVIDN 704
>NP_001460
          Length = 609

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YVMAIVDNP 9
           YV+  +DNP
Sbjct: 103 YVLQELDNP 111
>NP_001275905
          Length = 609

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YVMAIVDNP 9
           YV+  +DNP
Sbjct: 103 YVLQELDNP 111
>NP_001275907
          Length = 559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  YVMAIVDNP 9
          YV+  +DNP
Sbjct: 53 YVLQELDNP 61
>NP_004590
          Length = 1141

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   VMAIVDNP 9
           VMA V NP
Sbjct: 265 VMAAVQNP 272
>NP_001180380
          Length = 882

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VMAIVDNP 9
          V AIV+NP
Sbjct: 54 VWAIVNNP 61
>XP_006724373
          Length = 1111

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   VMAIVDNP 9
           VMA V NP
Sbjct: 235 VMAAVQNP 242
>XP_005253558
          Length = 897

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VMAIVDNP 9
          V AIV+NP
Sbjct: 54 VWAIVNNP 61
>XP_005253557
          Length = 904

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VMAIVDNP 9
          V AIV+NP
Sbjct: 54 VWAIVNNP 61
>XP_006719219
          Length = 910

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VMAIVDNP 9
          V AIV+NP
Sbjct: 54 VWAIVNNP 61
>XP_005253556
          Length = 944

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VMAIVDNP 9
          V AIV+NP
Sbjct: 54 VWAIVNNP 61
>XP_005253555
          Length = 966

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VMAIVDNP 9
          V AIV+NP
Sbjct: 54 VWAIVNNP 61
>NP_631899
          Length = 502

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YVMAIVDNP 9
           Y MA+  NP
Sbjct: 354 YFMAVAANP 362
>NP_001070710
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YVMAIVDNP 9
           Y MA+  NP
Sbjct: 363 YFMAVAANP 371
>NP_003550
          Length = 416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YVMAIVD 7
           Y MAI+D
Sbjct: 363 YFMAIID 369
>NP_005019
          Length = 406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YVMAIVD 7
           Y MAI+D
Sbjct: 353 YFMAIID 359
>XP_006725428
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YVMAIVD 7
           Y MAI+D
Sbjct: 204 YFMAIID 210
>XP_006725427
          Length = 352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YVMAIVD 7
           Y MAI+D
Sbjct: 299 YFMAIID 305
>XP_006725426
          Length = 352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YVMAIVD 7
           Y MAI+D
Sbjct: 299 YFMAIID 305
>XP_006722195
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YVMAIVD 7
           Y MAI+D
Sbjct: 204 YFMAIID 210
>XP_006722194
          Length = 352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YVMAIVD 7
           Y MAI+D
Sbjct: 299 YFMAIID 305
>XP_006722193
          Length = 352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YVMAIVD 7
           Y MAI+D
Sbjct: 299 YFMAIID 305
>XP_006717513
          Length = 355

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YVMAIVD 7
           Y MAI+D
Sbjct: 302 YFMAIID 308
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.141    0.424 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 404,020
Number of extensions: 499
Number of successful extensions: 46
Number of sequences better than 10000.0: 46
Number of HSP's gapped: 46
Number of HSP's successfully gapped: 46
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package