Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              20     509
XP_006718908                                                           20     509
XP_005271621                                                           20     509
XP_006718907                                                           20     509
XP_006718906                                                           20     509
XP_005271619                                                           20     509
XP_005271618                                                           20     509
NP_001093143                                                           16    5631
NP_001093142                                                           16    5631
NP_001093141                                                           16    5631
NP_001093140                                                           16    5631
NP_061759                                                              16    5631
NP_001240813                                                           16    7355
NP_006085                                                              16    7355
NP_001157743                                                           16    7355
NP_872584                                                              16    7355
NP_061757                                                              16    7355
NP_079420                                                              16    7355
NP_001095876                                                           16    7355
XP_005253689                                                           16    7355
XP_006719761                                                           16    7355
XP_005273432                                                           16    7355
XP_005273431                                                           16    7355
XP_005263305                                                           16    7355
XP_005263304                                                           16    7355
XP_006714389                                                           16    7355
XP_005263303                                                           16    7355
XP_005263302                                                           16    7355
NP_001177900                                                           16    7355
NP_004755                                                              16    7355
NP_001154803                                                           15    9605
NP_001154802                                                           15    9605
NP_061857                                                              15    9605
NP_055507                                                              15    9605
NP_203747                                                              15    9605
NP_001269058                                                           15    9605
NP_694984                                                              15    9605
NP_775885                                                              15    9605
NP_659570                                                              15    9605
NP_001004060                                                           15    9605
NP_001004067                                                           15    9605
XP_006725258                                                           15    9605
XP_006724701                                                           15    9605
XP_005262172                                                           15    9605
XP_005262170                                                           15    9605
XP_006722212                                                           15    9605
XP_005258116                                                           15    9605
XP_005258115                                                           15    9605
XP_005255375                                                           15    9605
XP_005269043                                                           15    9605
XP_006719529                                                           15    9605
XP_005269042                                                           15    9605
XP_005269041                                                           15    9605
XP_005250299                                                           15    9605
XP_006715978                                                           15    9605
XP_006715977                                                           15    9605
XP_006715976                                                           15    9605
XP_006715975                                                           15    9605
NP_055384                                                              15    9605
NP_055102                                                              15    9605
>NP_000042
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    YTVNVQREL 9
            YTV VQREL
Sbjct: 2437 YTVKVQREL 2445
>XP_006718908
          Length = 1708

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    YTVNVQREL 9
            YTV VQREL
Sbjct: 1089 YTVKVQREL 1097
>XP_005271621
          Length = 2708

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    YTVNVQREL 9
            YTV VQREL
Sbjct: 2089 YTVKVQREL 2097
>XP_006718907
          Length = 3050

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    YTVNVQREL 9
            YTV VQREL
Sbjct: 2431 YTVKVQREL 2439
>XP_006718906
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    YTVNVQREL 9
            YTV VQREL
Sbjct: 2437 YTVKVQREL 2445
>XP_005271619
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    YTVNVQREL 9
            YTV VQREL
Sbjct: 2437 YTVKVQREL 2445
>XP_005271618
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    YTVNVQREL 9
            YTV VQREL
Sbjct: 2437 YTVKVQREL 2445
>NP_001093143
          Length = 100

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  VNVQREL 9
          VNVQ+EL
Sbjct: 55 VNVQKEL 61
>NP_001093142
          Length = 100

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  VNVQREL 9
          VNVQ+EL
Sbjct: 55 VNVQKEL 61
>NP_001093141
          Length = 100

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  VNVQREL 9
          VNVQ+EL
Sbjct: 55 VNVQKEL 61
>NP_001093140
          Length = 100

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  VNVQREL 9
          VNVQ+EL
Sbjct: 55 VNVQKEL 61
>NP_061759
          Length = 798

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YTVNVQ 6
           YTVN+Q
Sbjct: 317 YTVNIQ 322
>NP_001240813
          Length = 1166

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NVQREL 9
           NVQREL
Sbjct: 448 NVQREL 453
>NP_006085
          Length = 1091

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TVNVQR 7
           TVNVQR
Sbjct: 644 TVNVQR 649
>NP_001157743
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TVNVQR 7
           TVNVQR
Sbjct: 570 TVNVQR 575
>NP_872584
          Length = 1528

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    TVNVQR 7
            TVNVQR
Sbjct: 1081 TVNVQR 1086
>NP_061757
          Length = 798

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   YTVNVQ 6
           YT+N+Q
Sbjct: 315 YTINIQ 320
>NP_079420
          Length = 1244

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NVQREL 9
           NVQREL
Sbjct: 526 NVQREL 531
>NP_001095876
          Length = 1244

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NVQREL 9
           NVQREL
Sbjct: 526 NVQREL 531
>XP_005253689
          Length = 861

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NVQREL 9
           NVQREL
Sbjct: 433 NVQREL 438
>XP_006719761
          Length = 861

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NVQREL 9
           NVQREL
Sbjct: 433 NVQREL 438
>XP_005273432
          Length = 1125

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TVNVQR 7
           TVNVQR
Sbjct: 678 TVNVQR 683
>XP_005273431
          Length = 1528

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    TVNVQR 7
            TVNVQR
Sbjct: 1081 TVNVQR 1086
>XP_005263305
          Length = 1167

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NVQREL 9
           NVQREL
Sbjct: 448 NVQREL 453
>XP_005263304
          Length = 1167

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NVQREL 9
           NVQREL
Sbjct: 448 NVQREL 453
>XP_006714389
          Length = 1225

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NVQREL 9
           NVQREL
Sbjct: 506 NVQREL 511
>XP_005263303
          Length = 1245

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NVQREL 9
           NVQREL
Sbjct: 526 NVQREL 531
>XP_005263302
          Length = 1245

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NVQREL 9
           NVQREL
Sbjct: 526 NVQREL 531
>NP_001177900
          Length = 829

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NVQREL 9
           NVQREL
Sbjct: 433 NVQREL 438
>NP_004755
          Length = 861

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NVQREL 9
           NVQREL
Sbjct: 433 NVQREL 438
>NP_001154803
          Length = 703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YTVNVQREL 9
           Y +NV RE+
Sbjct: 348 YILNVTREI 356
>NP_001154802
          Length = 692

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YTVNVQREL 9
           Y +NV RE+
Sbjct: 337 YILNVTREI 345
>NP_061857
          Length = 1049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YTVNVQREL 9
           Y +NV RE+
Sbjct: 337 YILNVTREI 345
>NP_055507
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YTVNVQR 7
           YT NV+R
Sbjct: 152 YTANVKR 158
>NP_203747
          Length = 1423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YTVNVQREL 9
           Y +NV RE+
Sbjct: 336 YILNVTREI 344
>NP_001269058
          Length = 1450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YTVNVQREL 9
           Y +NV RE+
Sbjct: 363 YILNVTREI 371
>NP_694984
          Length = 1802

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   YTVNVQRE 8
           Y+VN+Q++
Sbjct: 966 YSVNLQKQ 973
>NP_775885
          Length = 1222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YTVNVQRE 8
           YT++ Q+E
Sbjct: 375 YTIHAQKE 382
>NP_659570
          Length = 839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NVQREL 9
           N+QREL
Sbjct: 127 NIQREL 132
>NP_001004060
          Length = 1267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YTVNVQRE 8
           YT++ Q+E
Sbjct: 375 YTIHAQKE 382
>NP_001004067
          Length = 1222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YTVNVQRE 8
           YT++ Q+E
Sbjct: 375 YTIHAQKE 382
>XP_006725258
          Length = 1267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YTVNVQRE 8
           YT++ Q+E
Sbjct: 375 YTIHAQKE 382
>XP_006724701
          Length = 1398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   YTVNVQRE 8
           Y+VN+Q++
Sbjct: 562 YSVNLQKQ 569
>XP_005262172
          Length = 1631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   YTVNVQRE 8
           Y+VN+Q++
Sbjct: 795 YSVNLQKQ 802
>XP_005262170
          Length = 1752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   YTVNVQRE 8
           Y+VN+Q++
Sbjct: 916 YSVNLQKQ 923
>XP_006722212
          Length = 1401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YTVNVQREL 9
           Y +NV RE+
Sbjct: 314 YILNVTREI 322
>XP_005258116
          Length = 1430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YTVNVQREL 9
           Y +NV RE+
Sbjct: 343 YILNVTREI 351
>XP_005258115
          Length = 1450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YTVNVQREL 9
           Y +NV RE+
Sbjct: 363 YILNVTREI 371
>XP_005255375
          Length = 1267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YTVNVQRE 8
           YT++ Q+E
Sbjct: 375 YTIHAQKE 382
>XP_005269043
          Length = 737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  YTVNVQREL 9
          Y +NV RE+
Sbjct: 25 YILNVTREI 33
>XP_006719529
          Length = 923

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YTVNVQREL 9
           Y +NV RE+
Sbjct: 211 YILNVTREI 219
>XP_005269042
          Length = 969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YTVNVQREL 9
           Y +NV RE+
Sbjct: 257 YILNVTREI 265
>XP_005269041
          Length = 1049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YTVNVQREL 9
           Y +NV RE+
Sbjct: 337 YILNVTREI 345
>XP_005250299
          Length = 766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NVQREL 9
           N+QREL
Sbjct: 127 NIQREL 132
>XP_006715978
          Length = 766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NVQREL 9
           N+QREL
Sbjct: 127 NIQREL 132
>XP_006715977
          Length = 838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NVQREL 9
           N+QREL
Sbjct: 127 NIQREL 132
>XP_006715976
          Length = 839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NVQREL 9
           N+QREL
Sbjct: 127 NIQREL 132
>XP_006715975
          Length = 839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NVQREL 9
           N+QREL
Sbjct: 127 NIQREL 132
>NP_055384
          Length = 839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NVQREL 9
           N+QREL
Sbjct: 127 NIQREL 132
>NP_055102
          Length = 1222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YTVNVQRE 8
           YT++ Q+E
Sbjct: 375 YTIHAQKE 382
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.132    0.346 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 452,005
Number of extensions: 674
Number of successful extensions: 60
Number of sequences better than 10000.0: 60
Number of HSP's gapped: 60
Number of HSP's successfully gapped: 60
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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