Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245202                                                           22     134
NP_001245200                                                           22     134
NP_001161091                                                           22     134
NP_000240                                                              22     134
NP_001161090                                                           22     134
NP_001161089                                                           22     134
NP_001245203                                                           22     134
XP_005265221                                                           22     134
XP_005265220                                                           22     134
NP_009184                                                              18    1935
NP_076433                                                              18    1935
XP_005260095                                                           18    1935
XP_006722913                                                           18    1935
XP_006722912                                                           18    1935
XP_006722911                                                           18    1935
NP_775754                                                              17    2528
NP_001073                                                              17    2528
NP_001122404                                                           17    2528
NP_067010                                                              17    2528
NP_000887                                                              17    2528
NP_001186137                                                           17    2528
XP_005259968                                                           17    2528
XP_006722814                                                           17    2528
NP_001186138                                                           17    2528
NP_066923                                                              17    4312
NP_001185918                                                           17    4312
NP_060918                                                              16    5631
NP_056976                                                              16    7355
NP_001035362                                                           16    7355
NP_001073865                                                           16    7355
NP_055678                                                              16    7355
NP_001257694                                                           16    7355
NP_001257693                                                           16    7355
NP_149991                                                              16    7355
NP_443098                                                              16    7355
XP_005269951                                                           16    7355
XP_005269950                                                           16    7355
XP_005269949                                                           16    7355
XP_005269948                                                           16    7355
XP_006717954                                                           16    7355
NP_001191243                                                           15    9605
NP_000940                                                              15    9605
NP_000383                                                              15    9605
NP_001191245                                                           15    9605
NP_001191246                                                           15    9605
NP_001191244                                                           15    9605
NP_073625                                                              15    9605
NP_795345                                                              15    9605
NP_671766                                                              15    9605
NP_671756                                                              15    9605
NP_055496                                                              15    9605
NP_003734                                                              15    9605
NP_940870                                                              15    9605
XP_006724409                                                           15    9605
XP_005261851                                                           15    9605
XP_005261850                                                           15    9605
XP_005259500                                                           15    9605
XP_006717693                                                           15    9605
XP_005250861                                                           15    9605
XP_006715494                                                           15    9605
XP_006715493                                                           15    9605
XP_006714547                                                           15    9605
XP_005264685                                                           15    9605
XP_005264684                                                           15    9605
XP_005264683                                                           15    9605
XP_005264682                                                           15    9605
NP_620172                                                              15    9605
NP_001138678                                                           15    9605
>NP_001245202
          Length = 515

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  YSVKKCIF 8
          YSVKKCIF
Sbjct: 10 YSVKKCIF 17
>NP_001245200
          Length = 687

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   YSVKKCIF 8
           YSVKKCIF
Sbjct: 251 YSVKKCIF 258
>NP_001161091
          Length = 515

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  YSVKKCIF 8
          YSVKKCIF
Sbjct: 10 YSVKKCIF 17
>NP_000240
          Length = 756

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   YSVKKCIF 8
           YSVKKCIF
Sbjct: 251 YSVKKCIF 258
>NP_001161090
          Length = 515

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  YSVKKCIF 8
          YSVKKCIF
Sbjct: 10 YSVKKCIF 17
>NP_001161089
          Length = 658

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   YSVKKCIF 8
           YSVKKCIF
Sbjct: 153 YSVKKCIF 160
>NP_001245203
          Length = 515

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  YSVKKCIF 8
          YSVKKCIF
Sbjct: 10 YSVKKCIF 17
>XP_005265221
          Length = 515

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  YSVKKCIF 8
          YSVKKCIF
Sbjct: 10 YSVKKCIF 17
>XP_005265220
          Length = 515

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  YSVKKCIF 8
          YSVKKCIF
Sbjct: 10 YSVKKCIF 17
>NP_009184
          Length = 520

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SVKKCIFS 9
           S++KCIFS
Sbjct: 202 SLQKCIFS 209
>NP_076433
          Length = 524

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SVKKCIFS 9
           S++KCIFS
Sbjct: 202 SLQKCIFS 209
>XP_005260095
          Length = 334

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  SVKKCIFS 9
          S++KCIFS
Sbjct: 12 SLQKCIFS 19
>XP_006722913
          Length = 375

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  SVKKCIFS 9
          S++KCIFS
Sbjct: 53 SLQKCIFS 60
>XP_006722912
          Length = 375

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  SVKKCIFS 9
          S++KCIFS
Sbjct: 53 SLQKCIFS 60
>XP_006722911
          Length = 411

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SVKKCIFS 9
           S++KCIFS
Sbjct: 202 SLQKCIFS 209
>NP_775754
          Length = 531

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SVKKCIFS 9
           S++KC+FS
Sbjct: 210 SLQKCVFS 217
>NP_001073
          Length = 520

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SVKKCIFS 9
           S++KC+FS
Sbjct: 202 SLQKCVFS 209
>NP_001122404
          Length = 524

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SVKKCIFS 9
           S++KC+FS
Sbjct: 202 SLQKCVFS 209
>NP_067010
          Length = 524

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SVKKCIFS 9
           S++KC+FS
Sbjct: 202 SLQKCVFS 209
>NP_000887
          Length = 520

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SVKKCIFS 9
           S++KC+FS
Sbjct: 202 SLQKCVFS 209
>NP_001186137
          Length = 520

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SVKKCIFS 9
           S++KC+FS
Sbjct: 202 SLQKCVFS 209
>XP_005259968
          Length = 371

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  SVKKCIFS 9
          S++KC+FS
Sbjct: 53 SLQKCVFS 60
>XP_006722814
          Length = 391

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SVKKCIFS 9
           S++KC+FS
Sbjct: 202 SLQKCVFS 209
>NP_001186138
          Length = 520

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SVKKCIFS 9
           S++KC+FS
Sbjct: 202 SLQKCVFS 209
>NP_066923
          Length = 457

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   YSVKKCI 7
           Y+V+KCI
Sbjct: 421 YTVEKCI 427
>NP_001185918
          Length = 406

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   YSVKKCI 7
           Y+V+KCI
Sbjct: 370 YTVEKCI 376
>NP_060918
          Length = 1230

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   YSVKKCI 7
           YS+ KC+
Sbjct: 797 YSIAKCV 803
>NP_056976
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   YSVKKCIFS 9
           YS++ C+++
Sbjct: 433 YSLRACVYN 441
>NP_001035362
          Length = 1762

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  YSVKKCIFS 9
          YS+++C+ S
Sbjct: 55 YSLRRCLSS 63
>NP_001073865
          Length = 458

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   YSVKKC 6
           YSVK C
Sbjct: 295 YSVKSC 300
>NP_055678
          Length = 506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   YSVKKCIFS 9
           YS++ C+++
Sbjct: 433 YSLRACVYN 441
>NP_001257694
          Length = 506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   YSVKKCIFS 9
           YS++ C+++
Sbjct: 433 YSLRACVYN 441
>NP_001257693
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   YSVKKCIFS 9
           YS++ C+++
Sbjct: 433 YSLRACVYN 441
>NP_149991
          Length = 553

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   KKCIFS 9
           +KC+FS
Sbjct: 291 RKCVFS 296
>NP_443098
          Length = 525

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  YSVKKCIFS 9
          YS+++C+ S
Sbjct: 55 YSLRRCLSS 63
>XP_005269951
          Length = 501

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   YSVKKCIFS 9
           YS++ C+++
Sbjct: 433 YSLRACVYN 441
>XP_005269950
          Length = 509

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   YSVKKCIFS 9
           YS++ C+++
Sbjct: 433 YSLRACVYN 441
>XP_005269949
          Length = 510

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   YSVKKCIFS 9
           YS++ C+++
Sbjct: 433 YSLRACVYN 441
>XP_005269948
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   YSVKKCIFS 9
           YS++ C+++
Sbjct: 433 YSLRACVYN 441
>XP_006717954
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   YSVKKCIFS 9
           YS++ C+++
Sbjct: 433 YSLRACVYN 441
>NP_001191243
          Length = 521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YSVKKCIF 8
           YS+  CIF
Sbjct: 160 YSMVTCIF 167
>NP_000940
          Length = 622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YSVKKCIF 8
           YS+  CIF
Sbjct: 261 YSMVTCIF 268
>NP_000383
          Length = 1545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4    KKCIFS 9
            +KC+FS
Sbjct: 1194 QKCVFS 1199
>NP_001191245
          Length = 376

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YSVKKCIF 8
           YS+  CIF
Sbjct: 261 YSMVTCIF 268
>NP_001191246
          Length = 288

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YSVKKCIF 8
           YS+  CIF
Sbjct: 261 YSMVTCIF 268
>NP_001191244
          Length = 349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YSVKKCIF 8
           YS+  CIF
Sbjct: 261 YSMVTCIF 268
>NP_073625
          Length = 342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SVKKCIF 8
           +VKKC F
Sbjct: 171 NVKKCSF 177
>NP_795345
          Length = 342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SVKKCIF 8
           +VKKC F
Sbjct: 171 NVKKCSF 177
>NP_671766
          Length = 1440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VKKCIFS 9
           V+KCI++
Sbjct: 292 VRKCIYA 298
>NP_671756
          Length = 1399

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VKKCIFS 9
           V+KCI++
Sbjct: 292 VRKCIYA 298
>NP_055496
          Length = 1143

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VKKCIFS 9
           V+KCI S
Sbjct: 433 VRKCILS 439
>NP_003734
          Length = 1441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VKKCIFS 9
           V+KCI++
Sbjct: 292 VRKCIYA 298
>NP_940870
          Length = 1243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SVKKCI 7
            S+KKCI
Sbjct: 1064 SLKKCI 1069
>XP_006724409
          Length = 1806

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SVKKCI 7
           SV+KCI
Sbjct: 436 SVRKCI 441
>XP_005261851
          Length = 1806

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SVKKCI 7
           SV+KCI
Sbjct: 436 SVRKCI 441
>XP_005261850
          Length = 1806

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SVKKCI 7
           SV+KCI
Sbjct: 436 SVRKCI 441
>XP_005259500
          Length = 1143

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VKKCIFS 9
           V+KCI S
Sbjct: 433 VRKCILS 439
>XP_006717693
          Length = 1313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   KKCIFS 9
           +KC+FS
Sbjct: 962 QKCVFS 967
>XP_005250861
          Length = 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   SVKKCIFS 9
           ++ KCIF+
Sbjct: 228 TIPKCIFT 235
>XP_006715494
          Length = 1017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SVKKCI 7
           S+KKCI
Sbjct: 838 SLKKCI 843
>XP_006715493
          Length = 1243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SVKKCI 7
            S+KKCI
Sbjct: 1064 SLKKCI 1069
>XP_006714547
          Length = 622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YSVKKCIF 8
           YS+  CIF
Sbjct: 261 YSMVTCIF 268
>XP_005264685
          Length = 1399

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VKKCIFS 9
           V+KCI++
Sbjct: 292 VRKCIYA 298
>XP_005264684
          Length = 1399

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VKKCIFS 9
           V+KCI++
Sbjct: 292 VRKCIYA 298
>XP_005264683
          Length = 1440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VKKCIFS 9
           V+KCI++
Sbjct: 292 VRKCIYA 298
>XP_005264682
          Length = 1441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VKKCIFS 9
           V+KCI++
Sbjct: 292 VRKCIYA 298
>NP_620172
          Length = 470

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   SVKKCIFS 9
           ++ KCIF+
Sbjct: 237 TIPKCIFT 244
>NP_001138678
          Length = 1806

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SVKKCI 7
           SV+KCI
Sbjct: 436 SVRKCI 441
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.332    0.137    0.439 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 616,590
Number of extensions: 842
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package