Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001120690                                                           20     509
NP_006221                                                              20     509
NP_001243808                                                           20     509
XP_006715808                                                           20     509
XP_005249931                                                           17    4312
XP_005249930                                                           17    4312
XP_005249928                                                           17    4312
NP_002970                                                              16    7355
NP_775792                                                              16    7355
NP_653292                                                              16    7355
NP_001074020                                                           16    7355
NP_001007099                                                           16    7355
NP_001180529                                                           16    7355
XP_006717039                                                           16    7355
XP_006717038                                                           16    7355
XP_005251795                                                           16    7355
XP_006717037                                                           16    7355
XP_005271161                                                           16    7355
XP_005271160                                                           16    7355
NP_000956                                                              15    9605
NP_001277206                                                           15    9605
NP_000020                                                              15    9605
NP_001092882                                                           15    9605
NP_006757                                                              15    9605
NP_001092883                                                           15    9605
NP_001263180                                                           15    9605
NP_056243                                                              15    9605
NP_001273700                                                           15    9605
NP_444514                                                              15    9605
NP_115593                                                              15    9605
NP_004361                                                              15    9605
NP_001006657                                                           15    9605
NP_942592                                                              15    9605
XP_005273706                                                           15    9605
XP_006715397                                                           15    9605
XP_005265728                                                           15    9605
XP_005265724                                                           15    9605
XP_006712378                                                           15    9605
XP_005263945                                                           15    9605
XP_006712376                                                           15    9605
XP_006712375                                                           15    9605
XP_006712374                                                           15    9605
XP_006712371                                                           15    9605
>NP_001120690
          Length = 469

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   YSATQSACL 9
           +SATQ+ACL
Sbjct: 431 FSATQTACL 439
>NP_006221
          Length = 504

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   YSATQSACL 9
           +SATQ+ACL
Sbjct: 466 FSATQTACL 474
>NP_001243808
          Length = 469

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   YSATQSACL 9
           +SATQ+ACL
Sbjct: 431 FSATQTACL 439
>XP_006715808
          Length = 488

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   YSATQSACL 9
           +SATQ+ACL
Sbjct: 450 FSATQTACL 458
>XP_005249931
          Length = 862

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  SATQSACL 9
          +ATQS CL
Sbjct: 50 NATQSQCL 57
>XP_005249930
          Length = 888

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  SATQSACL 9
          +ATQS CL
Sbjct: 50 NATQSQCL 57
>XP_005249928
          Length = 897

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  SATQSACL 9
          +ATQS CL
Sbjct: 50 NATQSQCL 57
>NP_002970
          Length = 547

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  YSATQSACL 9
          YSA   AC+
Sbjct: 54 YSAVDQACV 62
>NP_775792
          Length = 1444

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    YSATQSAC 8
            Y A Q+AC
Sbjct: 1312 YGAQQTAC 1319
>NP_653292
          Length = 719

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  YSATQSACL 9
          Y A ++ACL
Sbjct: 32 YEAIRAACL 40
>NP_001074020
          Length = 1405

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    YSATQSAC 8
            Y A Q+AC
Sbjct: 1273 YGAQQTAC 1280
>NP_001007099
          Length = 322

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  YSATQSACL 9
          YSA   AC+
Sbjct: 54 YSAVDQACV 62
>NP_001180529
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  YSATQSACL 9
          YSA   AC+
Sbjct: 54 YSAVDQACV 62
>XP_006717039
          Length = 1370

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    YSATQSAC 8
            Y A Q+AC
Sbjct: 1238 YGAQQTAC 1245
>XP_006717038
          Length = 1473

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    YSATQSAC 8
            Y A Q+AC
Sbjct: 1341 YGAQQTAC 1348
>XP_005251795
          Length = 1508

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    YSATQSAC 8
            Y A Q+AC
Sbjct: 1376 YGAQQTAC 1383
>XP_006717037
          Length = 1508

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    YSATQSAC 8
            Y A Q+AC
Sbjct: 1376 YGAQQTAC 1383
>XP_005271161
          Length = 366

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  YSATQSACL 9
          YSA   AC+
Sbjct: 54 YSAVDQACV 62
>XP_005271160
          Length = 463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  YSATQSACL 9
          YSA   AC+
Sbjct: 54 YSAVDQACV 62
>NP_000956
          Length = 448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  YSATQSACL 9
          Y+A+ S+C+
Sbjct: 19 YTASPSSCM 27
>NP_001277206
          Length = 402

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  YSATQSACL 9
          Y+A+ S+C+
Sbjct: 19 YTASPSSCM 27
>NP_000020
          Length = 485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TQSACL 9
           T+SACL
Sbjct: 337 TESACL 342
>NP_001092882
          Length = 2004

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SATQSACL 9
            S TQS+C+
Sbjct: 1597 SLTQSSCV 1604
>NP_006757
          Length = 2004

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SATQSACL 9
            S TQS+C+
Sbjct: 1597 SLTQSSCV 1604
>NP_001092883
          Length = 2004

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SATQSACL 9
            S TQS+C+
Sbjct: 1597 SLTQSSCV 1604
>NP_001263180
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  SATQSACL 9
          S+TQ  CL
Sbjct: 11 SSTQEGCL 18
>NP_056243
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TQSACL 9
           TQS+CL
Sbjct: 768 TQSSCL 773
>NP_001273700
          Length = 2490

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    ATQSAC 8
            +TQSAC
Sbjct: 2112 STQSAC 2117
>NP_444514
          Length = 548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1   YSATQSAC 8
           Y A Q AC
Sbjct: 344 YEACQQAC 351
>NP_115593
          Length = 2603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    ATQSAC 8
            +TQSAC
Sbjct: 2225 STQSAC 2230
>NP_004361
          Length = 3063

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YSATQSACL 9
           +  TQS CL
Sbjct: 610 FELTQSICL 618
>NP_001006657
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TQSACL 9
           TQS+CL
Sbjct: 768 TQSSCL 773
>NP_942592
          Length = 2352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    ATQSAC 8
            +TQSAC
Sbjct: 1974 STQSAC 1979
>XP_005273706
          Length = 1997

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SATQSACL 9
            S TQS+C+
Sbjct: 1590 SLTQSSCV 1597
>XP_006715397
          Length = 2972

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   YSATQSACL 9
           +  TQS CL
Sbjct: 610 FELTQSICL 618
>XP_005265728
          Length = 2351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    ATQSAC 8
            +TQSAC
Sbjct: 1973 STQSAC 1978
>XP_005265724
          Length = 2602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    ATQSAC 8
            +TQSAC
Sbjct: 2224 STQSAC 2229
>XP_006712378
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   ATQSAC 8
           ATQS+C
Sbjct: 635 ATQSSC 640
>XP_005263945
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   ATQSAC 8
           ATQS+C
Sbjct: 635 ATQSSC 640
>XP_006712376
          Length = 677

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   ATQSAC 8
           ATQS+C
Sbjct: 641 ATQSSC 646
>XP_006712375
          Length = 685

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   ATQSAC 8
           ATQS+C
Sbjct: 641 ATQSSC 646
>XP_006712374
          Length = 721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   ATQSAC 8
           ATQS+C
Sbjct: 685 ATQSSC 690
>XP_006712371
          Length = 729

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   ATQSAC 8
           ATQS+C
Sbjct: 685 ATQSSC 690
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.315    0.111    0.329 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 468,071
Number of extensions: 862
Number of successful extensions: 43
Number of sequences better than 10000.0: 43
Number of HSP's gapped: 43
Number of HSP's successfully gapped: 43
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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