Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004963                                                              19     665
XP_005251512                                                           19     665
NP_001186078                                                           17    2528
NP_002334                                                              17    2528
NP_001140166                                                           17    2528
XP_005260860                                                           17    2528
XP_005260859                                                           17    2528
XP_005260858                                                           17    2528
XP_005260857                                                           17    2528
XP_006723671                                                           17    2528
XP_006723670                                                           17    2528
XP_005260854                                                           17    2528
XP_006723669                                                           17    2528
NP_071927                                                              17    2528
NP_001035304                                                           17    4312
NP_065969                                                              17    4312
NP_001231878                                                           17    4312
NP_699186                                                              17    4312
XP_005270057                                                           17    4312
XP_005270056                                                           17    4312
XP_005270055                                                           17    4312
XP_005266891                                                           17    4312
NP_068800                                                              17    4312
NP_859069                                                              17    4312
NP_003879                                                              16    5631
NP_001193826                                                           16    5631
NP_733797                                                              16    5631
NP_733798                                                              16    5631
NP_001005609                                                           16    5631
NP_001005612                                                           16    5631
NP_001390                                                              16    5631
NP_001054                                                              16    5631
NP_004990                                                              16    5631
XP_006724693                                                           16    5631
XP_005248783                                                           16    5631
XP_005248782                                                           16    5631
XP_005248781                                                           16    5631
XP_005248779                                                           16    5631
XP_005248778                                                           16    5631
XP_005248777                                                           16    5631
XP_005248776                                                           16    5631
NP_066569                                                              16    7355
NP_787074                                                              16    7355
NP_001004431                                                           16    7355
XP_006723569                                                           16    7355
XP_005259486                                                           16    7355
XP_005254804                                                           16    7355
XP_006720791                                                           16    7355
XP_005254803                                                           16    7355
XP_005254800                                                           16    7355
XP_005254799                                                           16    7355
NP_001073926                                                           16    7355
NP_003913                                                              16    7355
NP_115267                                                              16    7355
NP_061746                                                              16    7355
NP_000736                                                              15    9605
NP_036547                                                              15    9605
NP_001192192                                                           15    9605
NP_001137281                                                           15    9605
NP_061195                                                              15    9605
NP_015556                                                              15    9605
NP_000493                                                              15    9605
NP_003599                                                              15    9605
NP_055289                                                              15    9605
NP_001624                                                              15    9605
NP_542391                                                              15    9605
XP_006722191                                                           15    9605
XP_005254199                                                           15    9605
XP_006716239                                                           15    9605
XP_006713319                                                           15    9605
XP_006713318                                                           15    9605
XP_006713316                                                           15    9605
XP_005265369                                                           15    9605
XP_005265368                                                           15    9605
XP_005265367                                                           15    9605
>NP_004963
          Length = 1132

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YSAGRCNLK 9
           YSAGR NLK
Sbjct: 918 YSAGRRNLK 926
>XP_005251512
          Length = 1132

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YSAGRCNLK 9
           YSAGR NLK
Sbjct: 918 YSAGRRNLK 926
>NP_001186078
          Length = 666

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YSAGRCNL 8
           Y+AG+C L
Sbjct: 375 YTAGKCGL 382
>NP_002334
          Length = 710

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YSAGRCNL 8
           Y+AG+C L
Sbjct: 419 YTAGKCGL 426
>NP_001140166
          Length = 1047

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SAGRCNL 8
            SAGRC+L
Sbjct: 1000 SAGRCHL 1006
>XP_005260860
          Length = 455

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AGRCNLK 9
           A RCNLK
Sbjct: 358 ANRCNLK 364
>XP_005260859
          Length = 545

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AGRCNLK 9
           A RCNLK
Sbjct: 358 ANRCNLK 364
>XP_005260858
          Length = 643

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AGRCNLK 9
           A RCNLK
Sbjct: 358 ANRCNLK 364
>XP_005260857
          Length = 677

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AGRCNLK 9
           A RCNLK
Sbjct: 358 ANRCNLK 364
>XP_006723671
          Length = 684

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AGRCNLK 9
           A RCNLK
Sbjct: 358 ANRCNLK 364
>XP_006723670
          Length = 711

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AGRCNLK 9
           A RCNLK
Sbjct: 358 ANRCNLK 364
>XP_005260854
          Length = 711

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AGRCNLK 9
           A RCNLK
Sbjct: 358 ANRCNLK 364
>XP_006723669
          Length = 718

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AGRCNLK 9
           A RCNLK
Sbjct: 358 ANRCNLK 364
>NP_071927
          Length = 711

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AGRCNLK 9
           A RCNLK
Sbjct: 358 ANRCNLK 364
>NP_001035304
          Length = 208

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  YSAGRCNL 8
          Y +GRC L
Sbjct: 3  YCSGRCTL 10
>NP_065969
          Length = 828

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  YSAGRC 6
          YS GRC
Sbjct: 22 YSVGRC 27
>NP_001231878
          Length = 828

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  YSAGRC 6
          YS GRC
Sbjct: 22 YSVGRC 27
>NP_699186
          Length = 141

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  YSAGRCNL 8
          Y +GRC L
Sbjct: 3  YCSGRCTL 10
>XP_005270057
          Length = 599

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  YSAGRC 6
          YS GRC
Sbjct: 22 YSVGRC 27
>XP_005270056
          Length = 789

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  YSAGRC 6
          YS GRC
Sbjct: 22 YSVGRC 27
>XP_005270055
          Length = 828

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  YSAGRC 6
          YS GRC
Sbjct: 22 YSVGRC 27
>XP_005266891
          Length = 190

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  YSAGRCNL 8
          Y +GRC L
Sbjct: 3  YCSGRCTL 10
>NP_068800
          Length = 567

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AGRCNL 8
           +GRCNL
Sbjct: 373 SGRCNL 378
>NP_859069
          Length = 390

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   YSAGRC 6
           Y AGRC
Sbjct: 255 YQAGRC 260
>NP_003879
          Length = 518

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SAGRCNLK 9
           +AGR NLK
Sbjct: 274 AAGRSNLK 281
>NP_001193826
          Length = 497

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SAGRCNLK 9
           +AGR NLK
Sbjct: 253 AAGRSNLK 260
>NP_733797
          Length = 480

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SAGRCNLK 9
           +AGR NLK
Sbjct: 236 AAGRSNLK 243
>NP_733798
          Length = 422

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SAGRCNLK 9
           +AGR NLK
Sbjct: 178 AAGRSNLK 185
>NP_001005609
          Length = 389

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YSAGRCNLK 9
           Y+AG C LK
Sbjct: 345 YTAGVCLLK 353
>NP_001005612
          Length = 386

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YSAGRCNLK 9
           Y+AG C LK
Sbjct: 342 YTAGVCLLK 350
>NP_001390
          Length = 391

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YSAGRCNLK 9
           Y+AG C LK
Sbjct: 347 YTAGVCLLK 355
>NP_001054
          Length = 698

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YSAGRCNL 8
           Y AG+C L
Sbjct: 416 YIAGKCGL 423
>NP_004990
          Length = 1285

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SAGRCNLK 9
           ++G CNLK
Sbjct: 358 TSGGCNLK 365
>XP_006724693
          Length = 388

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YSAGRCNLK 9
           Y+AG C LK
Sbjct: 344 YTAGVCLLK 352
>XP_005248783
          Length = 1253

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SAGRCNLK 9
           ++G CNLK
Sbjct: 358 TSGGCNLK 365
>XP_005248782
          Length = 1262

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SAGRCNLK 9
           ++G CNLK
Sbjct: 358 TSGGCNLK 365
>XP_005248781
          Length = 1272

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SAGRCNLK 9
           ++G CNLK
Sbjct: 358 TSGGCNLK 365
>XP_005248779
          Length = 1276

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SAGRCNLK 9
           ++G CNLK
Sbjct: 358 TSGGCNLK 365
>XP_005248778
          Length = 1281

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SAGRCNLK 9
           ++G CNLK
Sbjct: 358 TSGGCNLK 365
>XP_005248777
          Length = 1285

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SAGRCNLK 9
           ++G CNLK
Sbjct: 358 TSGGCNLK 365
>XP_005248776
          Length = 1294

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SAGRCNLK 9
           ++G CNLK
Sbjct: 358 TSGGCNLK 365
>NP_066569
          Length = 444

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YSAGRCNL 8
           Y A RCN+
Sbjct: 182 YGALRCNI 189
>NP_787074
          Length = 459

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YSAGRCNL 8
           Y A RCN+
Sbjct: 209 YGAIRCNI 216
>NP_001004431
          Length = 311

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  YSAGRCNLK 9
          YS+ RC+ K
Sbjct: 47 YSSDRCSWK 55
>XP_006723569
          Length = 713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   GRCNLK 9
           G CNLK
Sbjct: 215 GMCNLK 220
>XP_005259486
          Length = 713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   GRCNLK 9
           G CNLK
Sbjct: 215 GMCNLK 220
>XP_005254804
          Length = 4796

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SAGRCN 7
            SAGRC+
Sbjct: 4284 SAGRCH 4289
>XP_006720791
          Length = 4853

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SAGRCN 7
            SAGRC+
Sbjct: 4341 SAGRCH 4346
>XP_005254803
          Length = 4854

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SAGRCN 7
            SAGRC+
Sbjct: 4342 SAGRCH 4347
>XP_005254800
          Length = 4861

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SAGRCN 7
            SAGRC+
Sbjct: 4349 SAGRCH 4354
>XP_005254799
          Length = 4861

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SAGRCN 7
            SAGRC+
Sbjct: 4349 SAGRCH 4354
>NP_001073926
          Length = 713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   GRCNLK 9
           G CNLK
Sbjct: 215 GMCNLK 220
>NP_003913
          Length = 4861

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SAGRCN 7
            SAGRC+
Sbjct: 4349 SAGRCH 4354
>NP_115267
          Length = 811

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  SAGRCNL 8
          S+GRC L
Sbjct: 4  SSGRCGL 10
>NP_061746
          Length = 931

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  SAGRCNL 8
          S+GRC L
Sbjct: 4  SSGRCGL 10
>NP_000736
          Length = 468

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3  AGRCNL 8
          AGRC L
Sbjct: 21 AGRCGL 26
>NP_036547
          Length = 910

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   YSAGRC 6
           +S+GRC
Sbjct: 202 FSSGRC 207
>NP_001192192
          Length = 726

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1  YSAGRC 6
          +S+GRC
Sbjct: 18 FSSGRC 23
>NP_001137281
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2  SAGRC 6
          SAGRC
Sbjct: 16 SAGRC 20
>NP_061195
          Length = 502

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   YSAGRCN 7
           YS  RCN
Sbjct: 97  YSCVRCN 103
>NP_015556
          Length = 665

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3  AGRCNL 8
          AGRC L
Sbjct: 25 AGRCRL 30
>NP_000493
          Length = 715

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   GRCNLK 9
           GRCN K
Sbjct: 150 GRCNNK 155
>NP_003599
          Length = 337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 1   YSAGRCN 7
           +  GRCN
Sbjct: 307 FCTGRCN 313
>NP_055289
          Length = 455

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YSAGRCN 7
           YSAG C+
Sbjct: 400 YSAGVCD 406
>NP_001624
          Length = 352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   YSAGRC 6
           YSAG C
Sbjct: 235 YSAGPC 240
>NP_542391
          Length = 300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   GRCNLK 9
           G CNLK
Sbjct: 180 GYCNLK 185
>XP_006722191
          Length = 715

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   GRCNLK 9
           GRCN K
Sbjct: 150 GRCNNK 155
>XP_005254199
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3  AGRCNL 8
          AGRC L
Sbjct: 21 AGRCGL 26
>XP_006716239
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   GRCNLK 9
           G CNLK
Sbjct: 180 GYCNLK 185
>XP_006713319
          Length = 272

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   YSAGRCN 7
           YS  RCN
Sbjct: 97  YSCVRCN 103
>XP_006713318
          Length = 274

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   YSAGRCN 7
           YS  RCN
Sbjct: 97  YSCVRCN 103
>XP_006713316
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   YSAGRCN 7
           YS  RCN
Sbjct: 97  YSCVRCN 103
>XP_005265369
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   YSAGRCN 7
           YS  RCN
Sbjct: 97  YSCVRCN 103
>XP_005265368
          Length = 515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   YSAGRCN 7
           YS  RCN
Sbjct: 97  YSCVRCN 103
>XP_005265367
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   YSAGRCN 7
           YS  RCN
Sbjct: 97  YSCVRCN 103
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.134    0.440 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 703,800
Number of extensions: 1240
Number of successful extensions: 75
Number of sequences better than 10000.0: 75
Number of HSP's gapped: 75
Number of HSP's successfully gapped: 75
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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