Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

XP_005260237                                                           17    2528
NP_000078                                                              17    3301
NP_001136036                                                           17    3301
NP_848622                                                              17    3301
XP_005248106                                                           17    3301
NP_001277137                                                           17    4312
NP_001277138                                                           17    4312
NP_001121695                                                           17    4312
XP_006712976                                                           17    4312
XP_006712975                                                           17    4312
XP_006712974                                                           17    4312
XP_005264770                                                           17    4312
XP_005264768                                                           17    4312
XP_005264767                                                           17    4312
XP_006712973                                                           17    4312
NP_689916                                                              16    5631
NP_001265593                                                           16    5631
NP_975011                                                              16    5631
NP_001265606                                                           16    5631
NP_001265592                                                           16    5631
NP_001265607                                                           16    5631
NP_001265590                                                           16    5631
NP_001265591                                                           16    5631
NP_003421                                                              16    5631
NP_001243102                                                           16    5631
NP_001243100                                                           16    5631
NP_001230967                                                           16    5631
NP_003420                                                              16    5631
XP_006726294                                                           16    5631
XP_006726293                                                           16    5631
XP_005260226                                                           16    5631
XP_006723012                                                           16    5631
XP_006723011                                                           16    5631
XP_005260225                                                           16    5631
XP_005260224                                                           16    5631
XP_005260223                                                           16    5631
XP_006722944                                                           16    5631
XP_006722943                                                           16    5631
XP_006722942                                                           16    5631
XP_006722941                                                           16    5631
XP_006722940                                                           16    5631
XP_006722939                                                           16    5631
XP_006715953                                                           16    5631
XP_006715952                                                           16    5631
XP_005250250                                                           16    5631
XP_006715951                                                           16    5631
XP_005250248                                                           16    5631
NP_056144                                                              16    7355
NP_003638                                                              16    7355
XP_006722774                                                           16    7355
XP_005259895                                                           16    7355
XP_005259894                                                           16    7355
XP_005257806                                                           16    7355
XP_006722206                                                           16    7355
NP_955806                                                              15    9605
NP_055247                                                              15    9605
NP_001135796                                                           15    9605
NP_003044                                                              15    9605
NP_001129163                                                           15    9605
NP_002516                                                              15    9605
NP_001265651                                                           15    9605
NP_001265653                                                           15    9605
NP_001265652                                                           15    9605
NP_001095132                                                           15    9605
NP_955805                                                              15    9605
NP_714544                                                              15    9605
NP_001229290                                                           15    9605
XP_006720470                                                           15    9605
XP_006715569                                                           15    9605
XP_006715568                                                           15    9605
XP_005247192                                                           15    9605
XP_005270960                                                           15    9605
XP_006710049                                                           15    9605
>XP_005260237
          Length = 356

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  YRWSMVITN 9
          + WS ++TN
Sbjct: 27 FNWSSILTN 35
>NP_000078
          Length = 690

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YRWSMVI 7
           Y W+MVI
Sbjct: 178 YNWTMVI 184
>NP_001136036
          Length = 759

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YRWSMVI 7
           Y W+MVI
Sbjct: 247 YNWTMVI 253
>NP_848622
          Length = 1124

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YRWSMVIT 8
           +RW +VIT
Sbjct: 369 WRWGVVIT 376
>XP_005248106
          Length = 690

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YRWSMVI 7
           Y W+MVI
Sbjct: 178 YNWTMVI 184
>NP_001277137
          Length = 914

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   WSMVITN 9
           W +VITN
Sbjct: 113 WQIVITN 119
>NP_001277138
          Length = 864

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  WSMVITN 9
          W +VITN
Sbjct: 63 WQIVITN 69
>NP_001121695
          Length = 914

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   WSMVITN 9
           W +VITN
Sbjct: 113 WQIVITN 119
>XP_006712976
          Length = 635

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   WSMVITN 9
           W +VITN
Sbjct: 113 WQIVITN 119
>XP_006712975
          Length = 907

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   WSMVITN 9
           W +VITN
Sbjct: 106 WQIVITN 112
>XP_006712974
          Length = 914

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   WSMVITN 9
           W +VITN
Sbjct: 113 WQIVITN 119
>XP_005264770
          Length = 914

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   WSMVITN 9
           W +VITN
Sbjct: 113 WQIVITN 119
>XP_005264768
          Length = 914

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   WSMVITN 9
           W +VITN
Sbjct: 113 WQIVITN 119
>XP_005264767
          Length = 914

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   WSMVITN 9
           W +VITN
Sbjct: 113 WQIVITN 119
>XP_006712973
          Length = 914

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   WSMVITN 9
           W +VITN
Sbjct: 113 WQIVITN 119
>NP_689916
          Length = 1584

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YRWSMVITN 9
           Y W +++TN
Sbjct: 414 YDWYILVTN 422
>NP_001265593
          Length = 586

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YRWSMVITN 9
           + WS  +TN
Sbjct: 146 FNWSSTLTN 154
>NP_975011
          Length = 659

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YRWSMVITN 9
           + WS  +TN
Sbjct: 219 FNWSSTLTN 227
>NP_001265606
          Length = 618

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YRWSMVITN 9
           + WS  +TN
Sbjct: 178 FNWSSTLTN 186
>NP_001265592
          Length = 574

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YRWSMVITN 9
           + WS  +TN
Sbjct: 134 FNWSSTLTN 142
>NP_001265607
          Length = 574

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YRWSMVITN 9
           + WS  +TN
Sbjct: 134 FNWSSTLTN 142
>NP_001265590
          Length = 618

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YRWSMVITN 9
           + WS  +TN
Sbjct: 178 FNWSSTLTN 186
>NP_001265591
          Length = 618

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YRWSMVITN 9
           + WS  +TN
Sbjct: 178 FNWSSTLTN 186
>NP_003421
          Length = 1191

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YRWSMVITN 9
           + WS  +TN
Sbjct: 219 FHWSSTLTN 227
>NP_001243102
          Length = 531

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YRWSMVIT 8
           ++WS V+T
Sbjct: 511 FKWSSVLT 518
>NP_001243100
          Length = 625

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YRWSMVIT 8
           ++WS V+T
Sbjct: 605 FKWSSVLT 612
>NP_001230967
          Length = 616

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YRWSMVITN 9
           + WS  +TN
Sbjct: 210 FNWSSTLTN 218
>NP_003420
          Length = 595

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YRWSMVIT 8
           ++WS V+T
Sbjct: 575 FKWSSVLT 582
>XP_006726294
          Length = 597

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YRWSMVIT 8
           ++WS V+T
Sbjct: 577 FKWSSVLT 584
>XP_006726293
          Length = 597

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YRWSMVIT 8
           ++WS V+T
Sbjct: 577 FKWSSVLT 584
>XP_005260226
          Length = 491

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YRWSMVITN 9
           + WS  +TN
Sbjct: 219 FNWSSTLTN 227
>XP_006723012
          Length = 574

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YRWSMVITN 9
           + WS  +TN
Sbjct: 134 FNWSSTLTN 142
>XP_006723011
          Length = 574

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YRWSMVITN 9
           + WS  +TN
Sbjct: 134 FNWSSTLTN 142
>XP_005260225
          Length = 574

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YRWSMVITN 9
           + WS  +TN
Sbjct: 134 FNWSSTLTN 142
>XP_005260224
          Length = 574

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YRWSMVITN 9
           + WS  +TN
Sbjct: 134 FNWSSTLTN 142
>XP_005260223
          Length = 631

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YRWSMVITN 9
           + WS  +TN
Sbjct: 219 FNWSSTLTN 227
>XP_006722944
          Length = 883

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YRWSMVITN 9
           + WS  +TN
Sbjct: 219 FHWSSTLTN 227
>XP_006722943
          Length = 1092

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YRWSMVITN 9
           + WS  +TN
Sbjct: 120 FHWSSTLTN 128
>XP_006722942
          Length = 1159

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YRWSMVITN 9
           + WS  +TN
Sbjct: 187 FHWSSTLTN 195
>XP_006722941
          Length = 1163

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YRWSMVITN 9
           + WS  +TN
Sbjct: 219 FHWSSTLTN 227
>XP_006722940
          Length = 597

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YRWSMVIT 8
           ++WS V+T
Sbjct: 577 FKWSSVLT 584
>XP_006722939
          Length = 597

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YRWSMVIT 8
           ++WS V+T
Sbjct: 577 FKWSSVLT 584
>XP_006715953
          Length = 1584

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YRWSMVITN 9
           Y W +++TN
Sbjct: 414 YDWYILVTN 422
>XP_006715952
          Length = 1584

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YRWSMVITN 9
           Y W +++TN
Sbjct: 414 YDWYILVTN 422
>XP_005250250
          Length = 1584

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YRWSMVITN 9
           Y W +++TN
Sbjct: 414 YDWYILVTN 422
>XP_006715951
          Length = 1584

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YRWSMVITN 9
           Y W +++TN
Sbjct: 414 YDWYILVTN 422
>XP_005250248
          Length = 1584

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   YRWSMVITN 9
           Y W +++TN
Sbjct: 414 YDWYILVTN 422
>NP_056144
          Length = 613

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/7 (42%), Positives = 6/7 (85%)

Query: 3   WSMVITN 9
           W+ ++TN
Sbjct: 415 WAFIVTN 421
>NP_003638
          Length = 567

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   RWSMVITN 9
           RW + +TN
Sbjct: 349 RWKVQVTN 356
>XP_006722774
          Length = 531

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/7 (42%), Positives = 6/7 (85%)

Query: 3   WSMVITN 9
           W+ ++TN
Sbjct: 454 WAFIVTN 460
>XP_005259895
          Length = 624

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/7 (42%), Positives = 6/7 (85%)

Query: 3   WSMVITN 9
           W+ ++TN
Sbjct: 426 WAFIVTN 432
>XP_005259894
          Length = 651

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/7 (42%), Positives = 6/7 (85%)

Query: 3   WSMVITN 9
           W+ ++TN
Sbjct: 454 WAFIVTN 460
>XP_005257806
          Length = 409

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   RWSMVITN 9
           RW + +TN
Sbjct: 349 RWKVQVTN 356
>XP_006722206
          Length = 434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   RWSMVITN 9
           RW + +TN
Sbjct: 349 RWKVQVTN 356
>NP_955806
          Length = 950

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   WSMVI 7
           WSMVI
Sbjct: 884 WSMVI 888
>NP_055247
          Length = 553

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 3   WSMVITN 9
           WS  +TN
Sbjct: 194 WSQCVTN 200
>NP_001135796
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YRWSMVIT 8
           + W MVIT
Sbjct: 425 FPWLMVIT 432
>NP_003044
          Length = 525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YRWSMVIT 8
           + W MVIT
Sbjct: 457 FPWLMVIT 464
>NP_001129163
          Length = 525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YRWSMVIT 8
           + W MVIT
Sbjct: 457 FPWLMVIT 464
>NP_002516
          Length = 1219

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 2   RWSMV 6
           RWSM+
Sbjct: 893 RWSMI 897
>NP_001265651
          Length = 504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 3   WSMVITN 9
           WS  +TN
Sbjct: 145 WSQCVTN 151
>NP_001265653
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 3  WSMVITN 9
          WS  +TN
Sbjct: 61 WSQCVTN 67
>NP_001265652
          Length = 442

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 3  WSMVITN 9
          WS  +TN
Sbjct: 83 WSQCVTN 89
>NP_001095132
          Length = 1151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 2   RWSMV 6
           RWSM+
Sbjct: 825 RWSMI 829
>NP_955805
          Length = 950

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   WSMVI 7
           WSMVI
Sbjct: 884 WSMVI 888
>NP_714544
          Length = 1775

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3    WSMVIT 8
            WS+V+T
Sbjct: 1762 WSLVLT 1767
>NP_001229290
          Length = 1087

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 2   RWSMV 6
           RWSM+
Sbjct: 761 RWSMI 765
>XP_006720470
          Length = 1017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3    WSMVIT 8
            WS+V+T
Sbjct: 1004 WSLVLT 1009
>XP_006715569
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 3  WSMVITN 9
          WS  +TN
Sbjct: 61 WSQCVTN 67
>XP_006715568
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 3   WSMVITN 9
           WS  +TN
Sbjct: 172 WSQCVTN 178
>XP_005247192
          Length = 961

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   WSMVI 7
           WSMVI
Sbjct: 895 WSMVI 899
>XP_005270960
          Length = 914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 2   RWSMV 6
           RWSM+
Sbjct: 588 RWSMI 592
>XP_006710049
          Length = 293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   WSMVIT 8
           WS+V+T
Sbjct: 280 WSLVLT 285
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.129    0.486 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 575,601
Number of extensions: 622
Number of successful extensions: 73
Number of sequences better than 10000.0: 73
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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